ES2527510T1 - Métodos para el tratamiento del VHC que comprenden al menos dos agentes antivirales de acción directa, ribavirina pero no interferón - Google Patents

Métodos para el tratamiento del VHC que comprenden al menos dos agentes antivirales de acción directa, ribavirina pero no interferón Download PDF

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Publication number
ES2527510T1
ES2527510T1 ES12189198.0T ES12189198T ES2527510T1 ES 2527510 T1 ES2527510 T1 ES 2527510T1 ES 12189198 T ES12189198 T ES 12189198T ES 2527510 T1 ES2527510 T1 ES 2527510T1
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Prior art keywords
treatment
combination
hcv
interferon
infected
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Inventor
Barry M. Bernstein
Rajeev M. Menon
Amit Khatri
Sven MENSING
Sandeep Dutta
Daniel E. Cohen
Thomas Podsadecki
Scott C. Brun
Walid M. Awni
Emily O. Dumas
Cheri E. Klein
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AbbVie Inc
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AbbVie Inc
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Application filed by AbbVie Inc filed Critical AbbVie Inc
Publication of ES2527510T1 publication Critical patent/ES2527510T1/es
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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Abstract

Una combinación de al menos dos agentes antivirales de acción directa (AAD) para su uso en el tratamiento del VHC, donde dicho tratamiento comprende la administración de ribavirina pero no interferón y dicho tratamiento dura 8, 9, 10, 11 o 12 semanas.

Claims (16)

  1. imagen1
    1. Una combinación de al menos dos agentes antivirales de acción directa (AAD) para su uso en el tratamiento del
    VHC, donde dicho tratamiento comprende la administración de ribavirina pero no interferón y dicho tratamiento dura 5 8, 9, 10, 11 o 12 semanas.
  2. 2. La combinación de la reivindicación 1, donde dicho tratamiento dura 12 semanas.
  3. 3.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden BMS-790052 y BMS-650032. 10
  4. 4. La combinación de la reivindicación 3, donde dicho tratamiento es para un paciente no tratado previamente que está infectado con el genotipo 1 del VHC.
  5. 5.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden PSI-7977 y TMC-435. 15
  6. 6. La combinación de la reivindicación 5, donde dicho tratamiento es para un paciente no tratado previamente que está infectado con el genotipo 1 del VHC.
  7. 7.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden PSI-7977 y daclatasvir. 20
  8. 8. La combinación de la reivindicación 7, donde dicho tratamiento es para un paciente no tratado previamente que está infectado por el genotipo 1 del VHC.
  9. 9.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden PSI-7977 y GS-5885. 25
  10. 10.
    La combinación de la reivindicación 9, donde dicho tratamiento es para un paciente no tratado previamente que está infectado por el genotipo 1 del VHC.
  11. 11.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden:
    30 el compuesto 1 o una sal farmacéuticamente aceptable del mismo, y el compuesto 4 o una sal farmacéuticamente aceptable del mismo,
    donde el Compuesto 1 o la sal del mismo se coadministra con ritonavir. 35
  12. 12.
    La combinación de la reivindicación 11, donde dicho tratamiento es para un paciente no tratado previamente que está infectado por el genotipo 1 del VHC.
  13. 13.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden:
    40 el compuesto 1 o una sal farmacéuticamente aceptable del mismo, el compuesto 2 o una sal farmacéuticamente aceptable del mismo, y el compuesto 4 o una sal farmacéuticamente aceptable del mismo,
    45 donde el Compuesto 1 o la sal del mismo se coadministra con ritonavir.
  14. 14. La combinación de la reivindicación 13, donde dicho tratamiento es para un paciente no tratado previamente que está infectado por el genotipo 1 del VHC.
    50 15. La combinación de la reivindicación 13, donde dicho tratamiento es para un no respondedor al interferón que está infectado por el genotipo 1 del VHC.
  15. 16. PSI-7977 para su uso en el tratamiento del VHC, donde dicho tratamiento no incluye la administración de
    ribavirina pero no interferón y dicho tratamiento dura 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 o 24 55 semanas.
  16. 17. PSI-799 de la reivindicación 16, donde dicho tratamiento dura 12 semanas.
    2
ES12189198.0T 2011-10-21 2012-10-19 Métodos para el tratamiento del VHC que comprenden al menos dos agentes antivirales de acción directa, ribavirina pero no interferón Pending ES2527510T1 (es)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201161550352P 2011-10-21 2011-10-21
US201161550352P 2011-10-21
US201161562181P 2011-11-21 2011-11-21
US201161562181P 2011-11-21
US201261587225P 2012-01-17 2012-01-17
US201261587225P 2012-01-17
US201261600276P 2012-02-17 2012-02-17
US201261600276P 2012-02-17
US201261619870P 2012-04-03 2012-04-03
US201261619870P 2012-04-03
US201261656251P 2012-06-06 2012-06-06
US201261656251P 2012-06-06
US201261711830P 2012-10-10 2012-10-10
US201261711830P 2012-10-10

Publications (1)

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ES2527510T1 true ES2527510T1 (es) 2015-01-26

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Application Number Title Priority Date Filing Date
ES201490004A Expired - Fee Related ES2529143B1 (es) 2011-10-21 2012-10-19 Combinación de al menos dos agentes antivirales de acción directa, ribavirina pero no interferón para uso de tratamiento del vhc
ES201431519A Withdrawn - After Issue ES2572329B1 (es) 2011-10-21 2012-10-19 Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para uso en el tratamientodel vhc
ES201431517A Withdrawn - After Issue ES2572328B1 (es) 2011-10-21 2012-10-19 Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para su uso en el tratamiento del vhc
ES12189198.0T Pending ES2527510T1 (es) 2011-10-21 2012-10-19 Métodos para el tratamiento del VHC que comprenden al menos dos agentes antivirales de acción directa, ribavirina pero no interferón

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Application Number Title Priority Date Filing Date
ES201490004A Expired - Fee Related ES2529143B1 (es) 2011-10-21 2012-10-19 Combinación de al menos dos agentes antivirales de acción directa, ribavirina pero no interferón para uso de tratamiento del vhc
ES201431519A Withdrawn - After Issue ES2572329B1 (es) 2011-10-21 2012-10-19 Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para uso en el tratamientodel vhc
ES201431517A Withdrawn - After Issue ES2572328B1 (es) 2011-10-21 2012-10-19 Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para su uso en el tratamiento del vhc

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US (2) US8853176B2 (es)
EP (1) EP2583677A3 (es)
JP (2) JP5677645B2 (es)
CN (2) CN103826627B (es)
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