AR075584A1 - COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. - Google Patents

COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.

Info

Publication number
AR075584A1
AR075584A1 ARP100100517A ARP100100517A AR075584A1 AR 075584 A1 AR075584 A1 AR 075584A1 AR P100100517 A ARP100100517 A AR P100100517A AR P100100517 A ARP100100517 A AR P100100517A AR 075584 A1 AR075584 A1 AR 075584A1
Authority
AR
Argentina
Prior art keywords
compound
pharmaceutically acceptable
inhibitor
hepatitis
prodrugs
Prior art date
Application number
ARP100100517A
Other languages
English (en)
Inventor
William T Symonds
La Rosa Abel De
Steven B Porter
Williamson Ziegler Bradford
Patrick F Smith
Ellen S Yetzer
Michael D Rogers
Original Assignee
Intermune Inc
Roche Palo Alto Llc
Pharmasset Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42111299&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR075584(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intermune Inc, Roche Palo Alto Llc, Pharmasset Inc filed Critical Intermune Inc
Publication of AR075584A1 publication Critical patent/AR075584A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Abstract

Composicion que puede incluir un inhibidor de la polimerasa viral de la hepatitis C, o sus sales o profármacos farmacéuticamente aceptables e inhibidor de la proteasa viral de la hepatitis C, o sus sales o profármacos farmacéuticamente aceptables. Métodos para tratar una condicion de enfermedad tal como una infeccion con virus de la hepatitis C, fibrosis hepática y/o alteracion de la funcion hepática con un inhibidor de la polimerasa viral de la hepatitis C, o sus sales o profármacos farmacéuticamente aceptables e inhibidor de la proteasa viral de la hepatitis C o sus sales o profármacos farmacéuticamente aceptables. Reivindicacion 1: Una composicion que comprende un primer compuesto, o una de sus sales o profármacos farmacéuticamente aceptables caracterizada porque el primer compuesto es el de formula (1); y un segundo compuesto, o una de sus sales o profármacos farmacéuticamente aceptables, donde el segundo compuesto es el de formula (2). Reivindicacion 11: La composicion de acuerdo con cualquiera de las reivindicaciones 1 a 2, caracterizada porque la composicion además comprende uno o más agentes terapéuticos adicionales. Reivindicacion 12: La composicion de acuerdo con la reivindicacion 11, caracterizada porque el agente terapéutico adicional se selecciona del grupo que consiste en un análogo nucleosídico, pirfenidona, un análogo de pirfenidona, un inhibidor de ARN polimerasa dependiente del ARN de NS5B, un antagonista del factor de necrosis tumoral, timosina-a, interferon-g (IFN-g), interferon-a (IFN-a), 3'-azidotimidina, 2',3'-didesoxiinosina, 2',3'-didesoxicitidina, 2-3-didehidro-2',3'-didesoxitimidina, combivir, abacavir, adefovir, dipoxil, cidofovir, ritonavir, un inhibidor de inosina monofosfato deshidrogenasa, un interferon, un inhibidor de proteasa NS3 adicional, un inhibidor de polimerasa NS5b, y un inhibidor de helicasa NS3. Reivindicacion 25: Uso de un primer compuesto o una de sus sales o profármacos farmacéuticamente aceptables, caracterizado porque se usa para la preparacion de un medicamento para mejorar o tratar una condicion de enfermedad en una poblacion de pacientes; donde el primer compuesto es de formula (1), donde el primer compuesto se fabrica para el uso en combinacion con un segundo compuesto o una de sus sales o profármacos farmacéuticamente aceptables; donde el segundo compuesto es de formula (2), y donde la condicion de enfermedad se selecciona del grupo que consiste en la infeccion con virus de la hepatitis C, fibrosis hepática, y alteracion de la funcion hepática.
ARP100100517A 2009-02-27 2010-02-23 COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. AR075584A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15641409P 2009-02-27 2009-02-27
US25736709P 2009-11-02 2009-11-02

Publications (1)

Publication Number Publication Date
AR075584A1 true AR075584A1 (es) 2011-04-20

Family

ID=42111299

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100100517A AR075584A1 (es) 2009-02-27 2010-02-23 COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.

Country Status (22)

Country Link
US (2) US8735345B2 (es)
EP (1) EP2400966A1 (es)
JP (2) JP2012519181A (es)
KR (1) KR20110135941A (es)
CN (1) CN102361641A (es)
AR (1) AR075584A1 (es)
AU (1) AU2010217818A1 (es)
BR (1) BRPI1009338A2 (es)
CA (1) CA2751220A1 (es)
CL (1) CL2011002082A1 (es)
CO (1) CO6410304A2 (es)
CR (1) CR20110453A (es)
EC (1) ECSP11011292A (es)
IL (1) IL214760A0 (es)
MA (1) MA33236B1 (es)
MX (1) MX2011008980A (es)
NZ (1) NZ594524A (es)
PE (1) PE20120777A1 (es)
RU (1) RU2011139180A (es)
SG (1) SG173774A1 (es)
TW (1) TWI473810B (es)
WO (1) WO2010099458A1 (es)

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