DK2276725T3 - Hidtil ukendte rutheniumkomplekser som katalysatorer til metathese-omsætninger - Google Patents

Hidtil ukendte rutheniumkomplekser som katalysatorer til metathese-omsætninger

Info

Publication number
DK2276725T3
DK2276725T3 DK09730174.1T DK09730174T DK2276725T3 DK 2276725 T3 DK2276725 T3 DK 2276725T3 DK 09730174 T DK09730174 T DK 09730174T DK 2276725 T3 DK2276725 T3 DK 2276725T3
Authority
DK
Denmark
Prior art keywords
metathese
catalysts
translation
present unknown
ruthenium complexs
Prior art date
Application number
DK09730174.1T
Other languages
English (en)
Inventor
Kurt Puentener
Michelangelo Scalone
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK2276725T3 publication Critical patent/DK2276725T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/20Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/24Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046Ruthenium compounds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK09730174.1T 2008-04-11 2009-03-30 Hidtil ukendte rutheniumkomplekser som katalysatorer til metathese-omsætninger DK2276725T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08154367 2008-04-11
PCT/EP2009/053711 WO2009124853A1 (en) 2008-04-11 2009-03-30 New ruthenium complexes as catalysts for metathesis reactions

Publications (1)

Publication Number Publication Date
DK2276725T3 true DK2276725T3 (da) 2012-08-20

Family

ID=40578497

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09730174.1T DK2276725T3 (da) 2008-04-11 2009-03-30 Hidtil ukendte rutheniumkomplekser som katalysatorer til metathese-omsætninger

Country Status (15)

Country Link
US (1) US7939668B2 (da)
EP (1) EP2276725B1 (da)
JP (1) JP5531008B2 (da)
KR (1) KR101216900B1 (da)
CN (1) CN101970396B (da)
AU (1) AU2009235569B2 (da)
BR (1) BRPI0909205A2 (da)
CA (1) CA2719531C (da)
DK (1) DK2276725T3 (da)
ES (1) ES2388994T3 (da)
IL (1) IL208034A (da)
MX (1) MX2010010660A (da)
PL (1) PL2276725T3 (da)
SI (1) SI2276725T1 (da)
WO (1) WO2009124853A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048862B2 (en) 2008-04-15 2011-11-01 Intermune, Inc. Macrocyclic inhibitors of hepatitis C virus replication
AR075584A1 (es) 2009-02-27 2011-04-20 Intermune Inc COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
WO2010127964A1 (en) * 2009-05-07 2010-11-11 F. Hoffmann-La Roche Ag Process for the preparation of ruthenium metathesis complex catalysts
WO2011079439A1 (en) * 2009-12-30 2011-07-07 Zannan Scitech Co., Ltd. Highly active metathesis catalysts selective for romp and rcm reactions
US8592618B2 (en) * 2010-01-08 2013-11-26 Zannan Scitech Co., Ltd. Highly active metathesis catalysts selective for ROMP and RCM reactions
US20130204026A1 (en) 2010-03-24 2013-08-08 Materia, Inc. Method for in-situ formation of metathesis catalysts
US8633280B2 (en) * 2011-03-30 2014-01-21 Zannan Scitech Co., Ltd Methods of modifying polymers with highly active and selective metathesis catalysts
JP6266509B2 (ja) * 2011-06-03 2018-01-24 マサチューセッツ インスティテュート オブ テクノロジー Z選択的閉環メタセシス反応
PL220408B1 (pl) * 2011-09-26 2015-10-30 Inst Chemii Organicznej Polskiej Akademii Nauk Kompleks rutentu, sposób jego wytwarzania oraz zastosowanie
CN104169322B (zh) 2012-03-16 2016-08-31 日本瑞翁株式会社 开环易位聚合物氢化物的制造方法及树脂组合物
KR20150034679A (ko) * 2012-06-29 2015-04-03 아페이론 신세시스 에스.아. 금속 착체, 이의 용도 및 복분해 반응의 실시 방법
CN107233920A (zh) * 2016-03-29 2017-10-10 上海东杰高分子材料有限公司 一种钌络合物催化剂
CN106939026B (zh) * 2017-03-09 2020-03-20 上海克琴科技有限公司 一种钌金属烯烃复分解催化剂的制备及其应用
CN109280074A (zh) * 2017-07-20 2019-01-29 歌礼药业(浙江)有限公司 丹诺瑞韦钠晶体及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2811507A (en) * 1954-10-20 1957-10-29 Koppers Co Inc Alkenylaryloxyacetamides
US5936100A (en) * 1996-12-16 1999-08-10 Studiengesellschaft Kohle Mbh Synthesis of functionalized macrocycles by ring closing metathesis
EP0921129A1 (en) * 1997-12-03 1999-06-09 Studiengesellschaft Kohle mbH Highly active cationic ruthenium and osmium complexes for olefin metathesis reactions
CA2521835A1 (en) * 2003-04-10 2004-10-21 Boehringer Ingelheim International Gmbh Process for the preparation of macrocyclic compounds by ruthenium complex catalysed metathesis reaction
ES2320771T3 (es) 2003-04-16 2009-05-28 Bristol-Myers Squibb Company Inhibidores peptidicos de isoquinolina macrociclicos del virus de la hepatitis c.
DE10335416A1 (de) * 2003-08-02 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Metathesekatalysatoren
US7491794B2 (en) * 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
RS20110578A3 (en) * 2003-10-14 2016-02-29 F. Hoffmann-La Roche Ltd MACROCYCLIC CARBOXYLIC ACIDS AND ACYLSULPHONAMIDES AS HCV REPLICATION INHIBITORS
WO2005095403A2 (en) * 2004-03-30 2005-10-13 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
CA2578428A1 (en) * 2004-09-17 2006-03-30 Boehringer Ingelheim International Gmbh Ring-closing metathesis process in supercritical fluid
US20090148407A1 (en) 2005-07-25 2009-06-11 Intermune, Inc. Novel Macrocyclic Inhibitors of Hepatitis C Virus Replication
DE102006044699A1 (de) * 2006-09-22 2008-04-03 Bayerische Motoren Werke Ag Tragrohr einer Instrumententafel eines Kraftfahrzeugs

Also Published As

Publication number Publication date
CN101970396B (zh) 2014-06-18
CN101970396A (zh) 2011-02-09
MX2010010660A (es) 2010-10-25
WO2009124853A1 (en) 2009-10-15
BRPI0909205A2 (pt) 2015-08-11
AU2009235569A1 (en) 2009-10-15
US7939668B2 (en) 2011-05-10
IL208034A0 (en) 2010-12-30
EP2276725A1 (en) 2011-01-26
CA2719531C (en) 2013-03-19
CA2719531A1 (en) 2009-10-15
IL208034A (en) 2014-09-30
PL2276725T3 (pl) 2012-11-30
EP2276725B1 (en) 2012-07-04
ES2388994T3 (es) 2012-10-22
JP2011522778A (ja) 2011-08-04
AU2009235569B2 (en) 2012-03-29
SI2276725T1 (sl) 2012-09-28
US20090275714A1 (en) 2009-11-05
KR20100127822A (ko) 2010-12-06
JP5531008B2 (ja) 2014-06-25
KR101216900B1 (ko) 2012-12-28

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