AR082068A2 - Analogos de nucleosidos fluorados modificados - Google Patents
Analogos de nucleosidos fluorados modificadosInfo
- Publication number
- AR082068A2 AR082068A2 ARP110102358A ARP110102358A AR082068A2 AR 082068 A2 AR082068 A2 AR 082068A2 AR P110102358 A ARP110102358 A AR P110102358A AR P110102358 A ARP110102358 A AR P110102358A AR 082068 A2 AR082068 A2 AR 082068A2
- Authority
- AR
- Argentina
- Prior art keywords
- nucleosids
- fluorated
- analogs
- modified
- salt
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Abstract
Composición, uso y un método para tratar infecciones con Flaviviridae (Hepacivirus, Flavivirus, Pestivirus), incluyendo HCV, en un hospedante, incluyendo animales y especialmente humanos, utilizando un b-D o b-L nucleósido de fórmula general (1), o su sal o prodroga farmacéuticamente aceptable del mismo.Reivindicación 1: Uso de una cantidad antiviralmente efectiva de un (2’R)-2’-deoxi-2’-fluoro- 2’-C-metil nucleósido (b-D o b-L) o su sal, de la estructura de fórmula (1) en donde R1 y R7 son independientemente H, un monofosfato, un difosfato, un trifosfato, un H-fosfonato, un alquilo, un alquil sulfonilo, o un arilalquil sulfonilo; y R4 es NH2, caracterizado porque es para la preparación de un medicamento para el tratamiento de una infección por hepatitis C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47436803P | 2003-05-30 | 2003-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR082068A2 true AR082068A2 (es) | 2012-11-07 |
Family
ID=33563735
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040101821A AR044566A1 (es) | 2003-05-30 | 2004-05-27 | Analogos de nucleosidos fluorados modificados |
ARP110102356A AR082066A2 (es) | 2003-05-30 | 2011-06-30 | Metodo y uso de analogos de nucleosidos fluorados modificados |
ARP110102358A AR082068A2 (es) | 2003-05-30 | 2011-06-30 | Analogos de nucleosidos fluorados modificados |
ARP110102354A AR082064A2 (es) | 2003-05-30 | 2011-06-30 | 2’-fluoro-2’-metil nucleosidos, metodo para prepararlos y composiciones farmaceuticas que los contienen utiles para tratar infecciones por flaviviridae, en particular vhc |
ARP110102357A AR082067A2 (es) | 2003-05-30 | 2011-06-30 | Analogos de nucleosidos fluorados modificados |
ARP180101768A AR114929A2 (es) | 2003-05-30 | 2018-06-26 | Análogos de nucleósidos fluorados modificados |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040101821A AR044566A1 (es) | 2003-05-30 | 2004-05-27 | Analogos de nucleosidos fluorados modificados |
ARP110102356A AR082066A2 (es) | 2003-05-30 | 2011-06-30 | Metodo y uso de analogos de nucleosidos fluorados modificados |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110102354A AR082064A2 (es) | 2003-05-30 | 2011-06-30 | 2’-fluoro-2’-metil nucleosidos, metodo para prepararlos y composiciones farmaceuticas que los contienen utiles para tratar infecciones por flaviviridae, en particular vhc |
ARP110102357A AR082067A2 (es) | 2003-05-30 | 2011-06-30 | Analogos de nucleosidos fluorados modificados |
ARP180101768A AR114929A2 (es) | 2003-05-30 | 2018-06-26 | Análogos de nucleósidos fluorados modificados |
Country Status (29)
Country | Link |
---|---|
US (8) | US7429572B2 (es) |
EP (8) | EP3521297B1 (es) |
JP (5) | JP4958158B2 (es) |
KR (1) | KR100883703B1 (es) |
CN (1) | CN100503628C (es) |
AR (6) | AR044566A1 (es) |
AU (1) | AU2004253860B2 (es) |
BR (3) | BRPI0410846B8 (es) |
CA (5) | CA2734052A1 (es) |
CO (1) | CO5660270A2 (es) |
CY (2) | CY1118020T1 (es) |
DK (1) | DK2604620T3 (es) |
ES (3) | ES2906207T3 (es) |
HR (1) | HRP20160873T1 (es) |
HU (2) | HUE029877T2 (es) |
IL (2) | IL172259A (es) |
LT (2) | LT2604620T (es) |
MX (1) | MXPA05012788A (es) |
MY (1) | MY138477A (es) |
NO (5) | NO333700B1 (es) |
NZ (1) | NZ543867A (es) |
PL (3) | PL2604620T3 (es) |
PT (3) | PT3521297T (es) |
RU (1) | RU2358979C2 (es) |
SI (3) | SI2604620T1 (es) |
TR (1) | TR201906767T4 (es) |
TW (1) | TWI333956B (es) |
WO (1) | WO2005003147A2 (es) |
ZA (1) | ZA200509521B (es) |
Families Citing this family (211)
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US8481712B2 (en) | 2001-01-22 | 2013-07-09 | Merck Sharp & Dohme Corp. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
BR0312278A (pt) * | 2002-06-28 | 2007-06-19 | Idenix Cayman Ltd | éster 2'-c-metil-3'-o-l-valina de ribofuranosil citidina para tratamento de infecções por flaviviridae |
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