ATE478886T1 - Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c - Google Patents
Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis cInfo
- Publication number
- ATE478886T1 ATE478886T1 AT04744307T AT04744307T ATE478886T1 AT E478886 T1 ATE478886 T1 AT E478886T1 AT 04744307 T AT04744307 T AT 04744307T AT 04744307 T AT04744307 T AT 04744307T AT E478886 T1 ATE478886 T1 AT E478886T1
- Authority
- AT
- Austria
- Prior art keywords
- flavividrae
- treatment
- diseases caused
- pentofuranonucleoside
- optionally substituted
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49021603P | 2003-07-25 | 2003-07-25 | |
PCT/IB2004/002703 WO2005009418A2 (en) | 2003-07-25 | 2004-07-26 | Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE478886T1 true ATE478886T1 (de) | 2010-09-15 |
Family
ID=34102969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04744307T ATE478886T1 (de) | 2003-07-25 | 2004-07-26 | Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c |
Country Status (17)
Country | Link |
---|---|
US (3) | US20050075309A1 (de) |
EP (1) | EP1658302B1 (de) |
JP (1) | JP2007501185A (de) |
KR (1) | KR20060084845A (de) |
CN (1) | CN1852915A (de) |
AT (1) | ATE478886T1 (de) |
AU (1) | AU2004258750A1 (de) |
BR (1) | BRPI0412849A (de) |
CA (1) | CA2533367C (de) |
DE (1) | DE602004028841D1 (de) |
DK (1) | DK1658302T3 (de) |
ES (1) | ES2351603T3 (de) |
NO (1) | NO20060914L (de) |
PL (1) | PL1658302T3 (de) |
PT (1) | PT1658302E (de) |
RU (1) | RU2006105640A (de) |
WO (1) | WO2005009418A2 (de) |
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EP1758453B1 (de) | 2004-06-15 | 2014-07-16 | Merck Sharp & Dohme Corp. | C-purin-nukleosidanaloga als hemmer der rna-abhängigen viralen rna-polymerase |
CN101023094B (zh) * | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
PL3109244T3 (pl) | 2004-09-14 | 2019-09-30 | Gilead Pharmasset Llc | Wytwarzanie 2'fluoro-2'-alkilo-podstawionych lub innych ewentualnie podstawionych rybofuranozylopirymidyn i puryn oraz ich pochodnych |
JP2008535932A (ja) * | 2005-03-09 | 2008-09-04 | イデニクス(ケイマン)リミテツド | 抗ウィルス剤としての非天然塩基を有するヌクレオシド |
WO2007041775A1 (en) * | 2005-10-10 | 2007-04-19 | The University Of Queensland | Cysteine protease inhibitors incorporating azide groups |
CN101336247B (zh) | 2005-12-09 | 2013-01-23 | 豪夫迈·罗氏有限公司 | 抗病毒核苷 |
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MX2009003795A (es) | 2006-10-10 | 2009-06-18 | Pharmasset Inc | Preparacion de pirimidinas ribofuranosil nucleosidos. |
ATE517097T1 (de) | 2006-11-09 | 2011-08-15 | Hoffmann La Roche | Thiazol- und oxazolsubstituierte arylamide |
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PL2234976T3 (pl) | 2007-12-17 | 2013-09-30 | Hoffmann La Roche | Nowe aryloamidy podstawione pirazolem |
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CN101903362B (zh) | 2007-12-17 | 2013-07-17 | 霍夫曼-拉罗奇有限公司 | 四唑取代的芳基酰胺衍生物和它们作为p2x3和/或p2x2/3嘌呤能受体拮抗物的用途 |
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TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
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JP5540087B2 (ja) | 2009-06-22 | 2014-07-02 | エフ.ホフマン−ラ ロシュ アーゲー | P2x3および/またはp2x2/3アンタゴニストとしての、新規なインドール、インダゾールおよびベンゾイミダゾールアリールアミド |
SG176640A1 (en) | 2009-06-22 | 2012-01-30 | Hoffmann La Roche | Novel oxazolone and pyrrolidinone-substituted arylamides |
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CA2780044A1 (en) | 2009-11-14 | 2011-05-19 | F. Hoffmann-La Roche Ag | Biomarkers for predicting rapid response to hcv treatment |
EP2507636A1 (de) | 2009-12-02 | 2012-10-10 | F. Hoffmann-La Roche AG | Biomarker zur vorhersage des anhaltenden ansprechens auf eine auf hcv-behandlung |
PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
PT2552930E (pt) | 2010-03-31 | 2015-11-17 | Gilead Pharmasset Llc | 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin- 1-(2h)-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2- il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropilo cristalino |
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RU2534613C2 (ru) | 2013-03-22 | 2014-11-27 | Александр Васильевич Иващенко | Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения |
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-
2004
- 2004-07-26 CN CNA2004800270217A patent/CN1852915A/zh active Pending
- 2004-07-26 CA CA2533367A patent/CA2533367C/en not_active Expired - Fee Related
- 2004-07-26 KR KR1020067001534A patent/KR20060084845A/ko not_active Application Discontinuation
- 2004-07-26 AT AT04744307T patent/ATE478886T1/de active
- 2004-07-26 JP JP2006520940A patent/JP2007501185A/ja active Pending
- 2004-07-26 ES ES04744307T patent/ES2351603T3/es active Active
- 2004-07-26 RU RU2006105640/04A patent/RU2006105640A/ru not_active Application Discontinuation
- 2004-07-26 US US10/900,008 patent/US20050075309A1/en not_active Abandoned
- 2004-07-26 AU AU2004258750A patent/AU2004258750A1/en not_active Abandoned
- 2004-07-26 DE DE602004028841T patent/DE602004028841D1/de active Active
- 2004-07-26 WO PCT/IB2004/002703 patent/WO2005009418A2/en active Application Filing
- 2004-07-26 BR BRPI0412849-4A patent/BRPI0412849A/pt not_active IP Right Cessation
- 2004-07-26 DK DK04744307.2T patent/DK1658302T3/da active
- 2004-07-26 PT PT04744307T patent/PT1658302E/pt unknown
- 2004-07-26 EP EP04744307A patent/EP1658302B1/de active Active
- 2004-07-26 PL PL04744307T patent/PL1658302T3/pl unknown
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Also Published As
Publication number | Publication date |
---|---|
CN1852915A (zh) | 2006-10-25 |
CA2533367C (en) | 2013-10-01 |
EP1658302B1 (de) | 2010-08-25 |
CA2533367A1 (en) | 2005-02-03 |
WO2005009418A2 (en) | 2005-02-03 |
BRPI0412849A (pt) | 2006-09-26 |
KR20060084845A (ko) | 2006-07-25 |
ES2351603T3 (es) | 2011-02-08 |
US9186369B2 (en) | 2015-11-17 |
NO20060914L (no) | 2006-04-25 |
PL1658302T3 (pl) | 2011-03-31 |
US20090169507A1 (en) | 2009-07-02 |
WO2005009418A3 (en) | 2005-04-07 |
US20140234251A1 (en) | 2014-08-21 |
DE602004028841D1 (de) | 2010-10-07 |
DK1658302T3 (da) | 2010-11-22 |
US8742101B2 (en) | 2014-06-03 |
PT1658302E (pt) | 2010-10-25 |
AU2004258750A1 (en) | 2005-02-03 |
EP1658302A2 (de) | 2006-05-24 |
US20050075309A1 (en) | 2005-04-07 |
RU2006105640A (ru) | 2007-09-10 |
JP2007501185A (ja) | 2007-01-25 |
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