DE602004028841D1 - Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c - Google Patents
Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis cInfo
- Publication number
- DE602004028841D1 DE602004028841D1 DE602004028841T DE602004028841T DE602004028841D1 DE 602004028841 D1 DE602004028841 D1 DE 602004028841D1 DE 602004028841 T DE602004028841 T DE 602004028841T DE 602004028841 T DE602004028841 T DE 602004028841T DE 602004028841 D1 DE602004028841 D1 DE 602004028841D1
- Authority
- DE
- Germany
- Prior art keywords
- flavividraic
- diseases
- treatment
- pentofuranonucleoside
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- -1 PURIN NUCLEOSIDE Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- XZLIYCQRASOFQM-UHFFFAOYSA-N 5h-imidazo[4,5-d]triazine Chemical class N1=NC=C2NC=NC2=N1 XZLIYCQRASOFQM-UHFFFAOYSA-N 0.000 abstract 1
- 241000710831 Flavivirus Species 0.000 abstract 1
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- 241000710778 Pestivirus Species 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49021603P | 2003-07-25 | 2003-07-25 | |
PCT/IB2004/002703 WO2005009418A2 (en) | 2003-07-25 | 2004-07-26 | Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004028841D1 true DE602004028841D1 (de) | 2010-10-07 |
Family
ID=34102969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004028841T Active DE602004028841D1 (de) | 2003-07-25 | 2004-07-26 | Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c |
Country Status (17)
Country | Link |
---|---|
US (3) | US20050075309A1 (de) |
EP (1) | EP1658302B1 (de) |
JP (1) | JP2007501185A (de) |
KR (1) | KR20060084845A (de) |
CN (1) | CN1852915A (de) |
AT (1) | ATE478886T1 (de) |
AU (1) | AU2004258750A1 (de) |
BR (1) | BRPI0412849A (de) |
CA (1) | CA2533367C (de) |
DE (1) | DE602004028841D1 (de) |
DK (1) | DK1658302T3 (de) |
ES (1) | ES2351603T3 (de) |
NO (1) | NO20060914L (de) |
PL (1) | PL1658302T3 (de) |
PT (1) | PT1658302E (de) |
RU (1) | RU2006105640A (de) |
WO (1) | WO2005009418A2 (de) |
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CN1852915A (zh) * | 2003-07-25 | 2006-10-25 | 艾登尼科斯(开曼)有限公司 | 治疗包括丙型肝炎的黄病毒科病毒所致疾病的嘌呤核苷类似物 |
CA2568379A1 (en) | 2004-06-15 | 2005-12-29 | Merck & Co., Inc. | C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase |
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ES2725457T3 (es) * | 2004-09-14 | 2019-09-24 | Gilead Pharmasset Llc | Preparación de ribofuranosil pirimidinas y purinas 2'fluoro-2'-alquil-sustituidas u otras opcionalmente sustituidas y sus derivados |
WO2007144686A1 (en) * | 2005-03-09 | 2007-12-21 | Idenix (Cayman) Limited | Nucleosides with non-natural bases as anti-viral agents |
WO2007041775A1 (en) * | 2005-10-10 | 2007-04-19 | The University Of Queensland | Cysteine protease inhibitors incorporating azide groups |
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EP2004634A1 (de) | 2006-04-04 | 2008-12-24 | F.Hoffmann-La Roche Ag | 3ý,5ý-DI-O-ACYLIERTE NUKLEOSIDE ZUR BEHANDLUNG VON HCV |
BRPI0715714A2 (pt) * | 2006-08-25 | 2014-03-11 | Wyeth Corp | Métodos para diminuir a frequência de emergência de uma infecção viral de hepatite c resistente ao tratamento, para atrasar a emergência de uma infecção viral de hepatite c resistente ao tratamento, para diminuir o nível de resistência de uma infecção viral de hepatite c resistente ao tratamento, para diminuir a emergência de uma infecção viral de hepatite c resistente a hcv-796, para identificar um indivíduo com uma probabilidade diminuída de responder a uma terapia viral anti-hepatite c, para monitorar, diagnosticar ou prognosticar a infecção viral de hepatite c resistente ao tratamento em um paciente, para monitorar o curso de tratamento de uma infecção viral de hepatite c em um paciente, para prognosticar o desenvolvimento de um ainfecção viral de hepatite c resistente ao tratamento em um paciente, para monitorar a infecção viral de hepatite c em um paciente e para diagnosticar o desenvolvimento de uma infecção viral de hepatite ao tratamento em um paciente |
US8912321B2 (en) | 2006-10-10 | 2014-12-16 | Gilead Pharmasset Llc | Preparation of nucleosides ribofuranosyl pyrimidines |
CN101528717B (zh) | 2006-11-09 | 2013-04-24 | 弗·哈夫曼-拉罗切有限公司 | 噻唑和*唑-取代的芳基酰胺类化合物 |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
AR069740A1 (es) * | 2007-11-29 | 2010-02-17 | Metabasis Therapeutics Inc | Compuestos nucleosidos antivirales |
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CN101903355B (zh) | 2007-12-17 | 2014-05-14 | 霍夫曼-拉罗奇有限公司 | 咪唑取代的芳基酰胺 |
PL2937350T3 (pl) | 2008-04-23 | 2018-06-29 | Gilead Sciences, Inc. | 1'-podstawione analogi karba-nukleozydów do leczenia przeciwwirusowego |
US8173621B2 (en) * | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
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US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
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-
2004
- 2004-07-26 CN CNA2004800270217A patent/CN1852915A/zh active Pending
- 2004-07-26 ES ES04744307T patent/ES2351603T3/es active Active
- 2004-07-26 CA CA2533367A patent/CA2533367C/en not_active Expired - Fee Related
- 2004-07-26 DK DK04744307.2T patent/DK1658302T3/da active
- 2004-07-26 RU RU2006105640/04A patent/RU2006105640A/ru not_active Application Discontinuation
- 2004-07-26 KR KR1020067001534A patent/KR20060084845A/ko not_active Application Discontinuation
- 2004-07-26 BR BRPI0412849-4A patent/BRPI0412849A/pt not_active IP Right Cessation
- 2004-07-26 PT PT04744307T patent/PT1658302E/pt unknown
- 2004-07-26 WO PCT/IB2004/002703 patent/WO2005009418A2/en active Application Filing
- 2004-07-26 JP JP2006520940A patent/JP2007501185A/ja active Pending
- 2004-07-26 AU AU2004258750A patent/AU2004258750A1/en not_active Abandoned
- 2004-07-26 US US10/900,008 patent/US20050075309A1/en not_active Abandoned
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- 2004-07-26 DE DE602004028841T patent/DE602004028841D1/de active Active
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US20050075309A1 (en) | 2005-04-07 |
CA2533367A1 (en) | 2005-02-03 |
PL1658302T3 (pl) | 2011-03-31 |
US9186369B2 (en) | 2015-11-17 |
CN1852915A (zh) | 2006-10-25 |
KR20060084845A (ko) | 2006-07-25 |
US20140234251A1 (en) | 2014-08-21 |
BRPI0412849A (pt) | 2006-09-26 |
US20090169507A1 (en) | 2009-07-02 |
WO2005009418A2 (en) | 2005-02-03 |
NO20060914L (no) | 2006-04-25 |
EP1658302A2 (de) | 2006-05-24 |
JP2007501185A (ja) | 2007-01-25 |
US8742101B2 (en) | 2014-06-03 |
WO2005009418A3 (en) | 2005-04-07 |
PT1658302E (pt) | 2010-10-25 |
ATE478886T1 (de) | 2010-09-15 |
EP1658302B1 (de) | 2010-08-25 |
ES2351603T3 (es) | 2011-02-08 |
CA2533367C (en) | 2013-10-01 |
AU2004258750A1 (en) | 2005-02-03 |
RU2006105640A (ru) | 2007-09-10 |
DK1658302T3 (da) | 2010-11-22 |
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