WO2005020884A3 - Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses - Google Patents
Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses Download PDFInfo
- Publication number
- WO2005020884A3 WO2005020884A3 PCT/US2004/015395 US2004015395W WO2005020884A3 WO 2005020884 A3 WO2005020884 A3 WO 2005020884A3 US 2004015395 W US2004015395 W US 2004015395W WO 2005020884 A3 WO2005020884 A3 WO 2005020884A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- viruses
- nucleosides
- infection
- treatment
- toga
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04776022A EP1656093A2 (en) | 2003-05-14 | 2004-05-14 | Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47094903P | 2003-05-14 | 2003-05-14 | |
US60/470,949 | 2003-05-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005020884A2 WO2005020884A2 (en) | 2005-03-10 |
WO2005020884A3 true WO2005020884A3 (en) | 2006-06-22 |
Family
ID=34272426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/015395 WO2005020884A2 (en) | 2003-05-14 | 2004-05-14 | Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1656093A2 (en) |
WO (1) | WO2005020884A2 (en) |
Cited By (10)
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US8299038B2 (en) | 2000-05-23 | 2012-10-30 | Idenix Pharmaceuticals, Inc. | Methods and compositions for treating hepatitis C virus |
US8841275B2 (en) | 2010-11-30 | 2014-09-23 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
US8957046B2 (en) | 2007-03-30 | 2015-02-17 | Gilead Pharmasset Llc | Nucleoside phosphoramidate prodrugs |
US9045520B2 (en) | 2008-12-23 | 2015-06-02 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
US9249173B2 (en) | 2006-12-28 | 2016-02-02 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
US9393256B2 (en) | 2011-09-16 | 2016-07-19 | Gilead Pharmasset Llc | Methods for treating HCV |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9549941B2 (en) | 2011-11-29 | 2017-01-24 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
CN106573011A (en) * | 2014-06-24 | 2017-04-19 | 艾丽奥斯生物制药有限公司 | Substituted nucleosides, nucleotides and analogs thereof |
KR102532198B1 (en) * | 2012-12-21 | 2023-05-11 | 얀센 바이오파마, 인코퍼레이트. | Substituted nucleosides, nucleotides and analogs thereof |
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CZ301182B6 (en) | 2000-05-26 | 2009-12-02 | Idenix (Cayman) Limited | Use of nucleoside derivatives for preparation of pharmaceutical compositions for treating infections caused by flaviviruses and pestiviruses |
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AU2011305652B2 (en) | 2010-09-22 | 2016-10-20 | Janssen Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
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MX350809B (en) | 2011-12-20 | 2017-09-20 | Riboscience Llc | 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication. |
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WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
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WO2014052638A1 (en) | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
US10513534B2 (en) | 2012-10-08 | 2019-12-24 | Idenix Pharmaceuticals Llc | 2′-chloro nucleoside analogs for HCV infection |
US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
BR112014011938B1 (en) | 2013-01-31 | 2021-03-16 | Gilead Pharmasset Llc | pharmaceutical composition in the form of a tablet with a fixed dose combination of two antiviral compounds, a pharmaceutical dosage form comprising said composition and use of said composition |
WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
EP2970357A1 (en) | 2013-03-13 | 2016-01-20 | IDENIX Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
EP2981542B1 (en) | 2013-04-01 | 2021-09-15 | Idenix Pharmaceuticals LLC | 2',4'-fluoro nucleosides for the treatment of hcv |
WO2014186637A1 (en) | 2013-05-16 | 2014-11-20 | Riboscience Llc | 4'-fluor0-2'-methyl substituted nucleoside derivatives |
US20180200280A1 (en) | 2013-05-16 | 2018-07-19 | Riboscience Llc | 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication |
US10005779B2 (en) | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
EA201690473A1 (en) | 2013-08-27 | 2017-03-31 | ГАЙЛИД ФАРМАССЕТ ЭлЭлСи | COMBINED COMPOSITION OF TWO ANTI-VIRUS COMPOUNDS |
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US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
US10711029B2 (en) | 2016-07-14 | 2020-07-14 | Atea Pharmaceuticals, Inc. | Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
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MY197236A (en) * | 2016-09-07 | 2023-06-07 | Atea Pharmaceuticals Inc | 2'-substituted-n6-substituted purine nucleotides for rna virus treatment |
BR112020005177A2 (en) * | 2017-09-18 | 2020-09-15 | Janssen Biopharma, Inc. | nucleosides, nucleotides and the like substituted |
US10682369B2 (en) | 2017-09-21 | 2020-06-16 | Riboscience Llc | 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication |
CN112351799A (en) | 2018-04-10 | 2021-02-09 | 阿堤亚制药公司 | Treatment of HCV infected patients with cirrhosis |
CN109265504B (en) * | 2018-11-08 | 2021-07-02 | 河南省科学院高新技术研究中心 | 4-amino acid substituted pyrimidine nucleoside compound and pharmaceutical application thereof |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
EP3901160A1 (en) * | 2020-04-25 | 2021-10-27 | Nuvamid SA | Nicotinamide mononucleotide and nicotinamide riboside derivatives and use thereof in the treatment of viral infections and respiratory complications, in particular caused by influenzavirus or coronavirus |
JP2023522383A (en) * | 2020-04-24 | 2023-05-30 | ヌヴァミド エスアー | Nicotinamide mononucleotide and nicotinamide riboside derivatives and their use in the treatment of viral infections and respiratory complications, especially caused by influenza viruses or coronaviruses |
EP3912628A1 (en) * | 2020-05-20 | 2021-11-24 | Institut de Recherche en Semiochimie et Ethologie Appliquée | Nucleoside analogues to inhibit the main protease of a coronavirus |
EP4323362A1 (en) * | 2021-04-16 | 2024-02-21 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4880784A (en) * | 1987-12-21 | 1989-11-14 | Brigham Young University | Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives |
-
2004
- 2004-05-14 WO PCT/US2004/015395 patent/WO2005020884A2/en active Application Filing
- 2004-05-14 EP EP04776022A patent/EP1656093A2/en not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4880784A (en) * | 1987-12-21 | 1989-11-14 | Brigham Young University | Antiviral methods utilizing ribofuranosylthiazolo[4,5-d]pyrimdine derivatives |
Non-Patent Citations (1)
Title |
---|
ELDRUP ET AL: "Structure-Activity Relationship of Heterobase-Modified 2'-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication", J. MEDICINAL CHEMISTRY, vol. 47, no. 21, 2004, pages 5284 - 5297, XP002998563 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8299038B2 (en) | 2000-05-23 | 2012-10-30 | Idenix Pharmaceuticals, Inc. | Methods and compositions for treating hepatitis C virus |
US9249173B2 (en) | 2006-12-28 | 2016-02-02 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
US8957046B2 (en) | 2007-03-30 | 2015-02-17 | Gilead Pharmasset Llc | Nucleoside phosphoramidate prodrugs |
US9045520B2 (en) | 2008-12-23 | 2015-06-02 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
US8841275B2 (en) | 2010-11-30 | 2014-09-23 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
US9393256B2 (en) | 2011-09-16 | 2016-07-19 | Gilead Pharmasset Llc | Methods for treating HCV |
US9549941B2 (en) | 2011-11-29 | 2017-01-24 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
KR102532198B1 (en) * | 2012-12-21 | 2023-05-11 | 얀센 바이오파마, 인코퍼레이트. | Substituted nucleosides, nucleotides and analogs thereof |
CN106573011A (en) * | 2014-06-24 | 2017-04-19 | 艾丽奥斯生物制药有限公司 | Substituted nucleosides, nucleotides and analogs thereof |
Also Published As
Publication number | Publication date |
---|---|
EP1656093A2 (en) | 2006-05-17 |
WO2005020884A2 (en) | 2005-03-10 |
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