DE60001218D1 - [1,8]-naphthyridinderivate derivate mit antiviraler wirkung - Google Patents

[1,8]-naphthyridinderivate derivate mit antiviraler wirkung

Info

Publication number
DE60001218D1
DE60001218D1 DE60001218T DE60001218T DE60001218D1 DE 60001218 D1 DE60001218 D1 DE 60001218D1 DE 60001218 T DE60001218 T DE 60001218T DE 60001218 T DE60001218 T DE 60001218T DE 60001218 D1 DE60001218 D1 DE 60001218D1
Authority
DE
Germany
Prior art keywords
derivatives
naphthyridine
antiviral effect
hepatitis
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60001218T
Other languages
English (en)
Inventor
Benoit Bachand
Nghe Nguyen-Ba
Arshad Siddiqui
Sophie Levesque
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
Shire BioChem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire BioChem Inc filed Critical Shire BioChem Inc
Application granted granted Critical
Publication of DE60001218D1 publication Critical patent/DE60001218D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60001218T 1999-02-22 2000-02-22 [1,8]-naphthyridinderivate derivate mit antiviraler wirkung Expired - Lifetime DE60001218D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12108099P 1999-02-22 1999-02-22
PCT/CA2000/000181 WO2000050424A1 (en) 1999-02-22 2000-02-22 [1,8] naphthyridine derivatives having antiviral activity

Publications (1)

Publication Number Publication Date
DE60001218D1 true DE60001218D1 (de) 2003-02-20

Family

ID=22394395

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60001218T Expired - Lifetime DE60001218D1 (de) 1999-02-22 2000-02-22 [1,8]-naphthyridinderivate derivate mit antiviraler wirkung

Country Status (8)

Country Link
US (2) US6340690B1 (de)
EP (1) EP1155017B1 (de)
JP (1) JP2002537396A (de)
AT (1) ATE231149T1 (de)
AU (1) AU777040B2 (de)
CA (1) CA2364652A1 (de)
DE (1) DE60001218D1 (de)
WO (1) WO2000050424A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3705975B2 (ja) * 1999-11-26 2005-10-12 独立行政法人科学技術振興機構 ミスマッチ認識分子
KR20100003313A (ko) * 2000-04-13 2010-01-07 파마셋 인코포레이티드 간염 바이러스 감염 치료를 위한 3'- 또는 2'-하이드록시메틸 치환된 뉴클레오시드 유도체
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
YU92202A (sh) * 2000-05-26 2006-01-16 Idenix (Cayman) Limited Metode i smeše za lečenje flavi virusa i pesti virusa
EP1321463B1 (de) * 2001-12-21 2007-08-08 Virochem Pharma Inc. Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren
WO2003082848A1 (en) * 2002-04-01 2003-10-09 Pfizer Inc. Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymerase
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
AU2003248748A1 (en) * 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
AU2003288899B2 (en) * 2002-08-23 2009-09-03 Novartis Vaccines And Diagnostics, Inc. Benzimidazole quinolinones and uses thereof
CN1849142A (zh) * 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′－支链核苷和黄病毒突变
AU2003300901A1 (en) * 2002-12-12 2004-06-30 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
DE10311563A1 (de) * 2003-03-17 2004-09-30 Bayer Healthcare Ag Replikationsassay zur Auffindung antiviraler Substanzen mit HTS Verfahren
ATE478886T1 (de) 2003-07-25 2010-09-15 Idenix Pharmaceuticals Inc Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c
WO2005033079A1 (ja) * 2003-09-30 2005-04-14 Eisai Co., Ltd. ヘテロ環化合物を含有する新規な抗真菌剤
EP1678137A1 (de) * 2003-10-15 2006-07-12 Chiron Corporation Zusammensetzungen und verfahren zur inhibierung von viren
DK2666481T3 (en) 2003-12-26 2019-02-25 Masatoshi Hagiwara A method for regulating the phosphorylation of SR protein and antiviral agents comprising an SR protein activity regulator as the active ingredient
JP2008503562A (ja) * 2004-06-23 2008-02-07 イデニクス（ケイマン）リミテツド フラビウイルス科による感染症を治療するための５−アザ−７−デアザプリン誘導体
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
TWI385169B (zh) * 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
EP1976382B1 (de) * 2005-12-23 2013-04-24 IDENIX Pharmaceuticals, Inc. Verfahren zur herstellung eines synthetischen zwischenprodukts für die herstellung von verzweigten nukleosiden
US8183264B2 (en) * 2006-09-21 2012-05-22 Eisai R&D Managment Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
EP1972627A1 (de) * 2007-03-19 2008-09-24 Technische Universität Carolo-Wilhelmina zu Braunschweig Aminonaphthyridin-Derivate
US8513420B2 (en) 2007-03-19 2013-08-20 Monika Mazik Amino-naphthyridine derivatives
TW200841879A (en) * 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
WO2008136279A1 (ja) 2007-04-27 2008-11-13 Eisai R & D Management Co., Ltd. ヘテロ環置換ピリジン誘導体の塩またはその結晶
US8513287B2 (en) * 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US8188119B2 (en) 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
JP2012176900A (ja) * 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd （（ホスホノオキシ）メチル）ピリジニウム環を有するピリジン誘導体およびそれらを含有する抗真菌剤
KR101317656B1 (ko) 2011-06-30 2013-10-15 연세대학교 산학협력단 복제효소 인산화를 조절하는 신규 ｃ형 간염 예방 또는 치료용 조성물
US9487476B2 (en) 2011-10-12 2016-11-08 Yale University Catechol diethers as potent anti-HIV agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2263752A1 (en) * 1974-03-14 1975-10-10 Rhone Poulenc Ind 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants
FR2567887B1 (fr) * 1984-07-19 1986-12-19 Rhone Poulenc Sante Nouveaux amides substitues, leur preparation et les medicaments qui les contiennent
US4720500A (en) * 1985-07-11 1988-01-19 Rhone-Poulenc Sante N-1,8-naphthyridin-2-yl amides useful as immunostimulants
FR2592882B2 (fr) * 1986-01-16 1988-03-11 Rhone Poulenc Sante Nouveaux amides substitues, leur preparation et les medicaments qui les contiennent
US4753941A (en) * 1986-01-16 1988-06-28 Rhone-Poulenc Sante Amides based on certain 1,8-naphtyridine-2-amines useful as anxiolytics
DE3907938A1 (de) * 1989-03-11 1990-09-13 Basf Ag 2,3-substituierte 1,8-naphthyridine, verfahren zu ihrer herstellung und ihre verwendung als antidots
FR2676056B1 (fr) 1991-05-03 1993-07-16 Adir Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CA2123728A1 (en) 1993-05-21 1994-11-22 Noriyoshi Sueda Urea derivatives and their use as acat inhibitors
GB9605437D0 (en) 1996-03-15 1996-05-15 Iaf Biochem Int Cytomegalovirus inhibiting compounds
EP0888300A1 (de) * 1996-03-22 1999-01-07 Neurogen Corporation Kondensierte pyrrolcarboxamide als gaba-gehirn-rezeptor-liganden

Also Published As

Publication number Publication date
EP1155017B1 (de) 2003-01-15
US20020099072A1 (en) 2002-07-25
CA2364652A1 (en) 2000-08-31
WO2000050424A1 (en) 2000-08-31
JP2002537396A (ja) 2002-11-05
ATE231149T1 (de) 2003-02-15
US6340690B1 (en) 2002-01-22
AU777040B2 (en) 2004-09-30
AU2788300A (en) 2000-09-14
EP1155017A1 (de) 2001-11-21
US6605614B2 (en) 2003-08-12

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