ES2160046A1 - Derivados pentapeptidicos. - Google Patents

Derivados pentapeptidicos.

Info

Publication number
ES2160046A1
ES2160046A1 ES009900627A ES9900627A ES2160046A1 ES 2160046 A1 ES2160046 A1 ES 2160046A1 ES 009900627 A ES009900627 A ES 009900627A ES 9900627 A ES9900627 A ES 9900627A ES 2160046 A1 ES2160046 A1 ES 2160046A1
Authority
ES
Spain
Prior art keywords
hepatitis
antiviral medicaments
antiviral
formulaand
prophylaxis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009900627A
Other languages
English (en)
Other versions
ES2160046B1 (es
Inventor
Michael Richard Attwood
David Nigel Hurst
Philip Stephen Jones
Paul Brittain Kay
Tony Michael Raynham
Francis Xavier Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES2160046A1 publication Critical patent/ES2160046A1/es
Application granted granted Critical
Publication of ES2160046B1 publication Critical patent/ES2160046B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Derivados pentapeptídicos, que corresponden a la fórmula (I), en donde E representa -CHO ó -B(OH), y R{sup,1}, R{sup,2}, R{sup,3} R{sup,4}, R{sup,5}, R{sup,6}, R{sup,7}, R{sup,8} y R{sup,9} tienen el significado expuesto en la descripción, y sus sales de compuestos acídicos de fórmula (I) con bases. La invención describe también un procedimiento para la obtención de los referidos compuestos. Los compuestos de la invención se emplean para la producción de medicamentos antivirales, especialmente contra Hepatitis C, Hepatitis G y virus GB humanos.
ES009900627A 1998-03-30 1999-03-29 Derivados pentapeptidicos. Expired - Lifetime ES2160046B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9806815.8A GB9806815D0 (en) 1998-03-30 1998-03-30 Amino acid derivatives

Publications (2)

Publication Number Publication Date
ES2160046A1 true ES2160046A1 (es) 2001-10-16
ES2160046B1 ES2160046B1 (es) 2002-05-16

Family

ID=10829559

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009900627A Expired - Lifetime ES2160046B1 (es) 1998-03-30 1999-03-29 Derivados pentapeptidicos.

Country Status (8)

Country Link
US (1) US6372883B1 (es)
JP (1) JPH11322789A (es)
CA (1) CA2264951A1 (es)
DE (1) DE19914474A1 (es)
ES (1) ES2160046B1 (es)
FR (1) FR2777891B1 (es)
GB (2) GB9806815D0 (es)
IT (1) IT1311994B1 (es)

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CA2264951A1 (en) 1999-09-30
FR2777891B1 (fr) 2003-01-31
ES2160046B1 (es) 2002-05-16
FR2777891A1 (fr) 1999-10-29
GB9806815D0 (en) 1998-05-27
DE19914474A1 (de) 1999-10-07
US6372883B1 (en) 2002-04-16
ITMI990657A1 (it) 2000-09-30
GB9907263D0 (en) 1999-05-26
GB2337262A (en) 1999-11-17
IT1311994B1 (it) 2002-03-22

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