EA200300392A1 - Производные пиперазина с мостиковой связью - Google Patents

Производные пиперазина с мостиковой связью

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Publication number
EA200300392A1
EA200300392A1 EA200300392A EA200300392A EA200300392A1 EA 200300392 A1 EA200300392 A1 EA 200300392A1 EA 200300392 A EA200300392 A EA 200300392A EA 200300392 A EA200300392 A EA 200300392A EA 200300392 A1 EA200300392 A1 EA 200300392A1
Authority
EA
Eurasian Patent Office
Prior art keywords
piperazine
derivatives
bridge connection
inflammatory
published
Prior art date
Application number
EA200300392A
Other languages
English (en)
Inventor
Лаура Кук Блюмберг
Мэттью Фрэнк Браун
Рональд Пол Глэдью
Кристофер Стэнли Посс
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200300392A1 publication Critical patent/EA200300392A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/20—Antivirals for DNA viruses
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Rheumatology (AREA)
  • Diabetes (AREA)
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Abstract

Соединение формулы (I) или его фармацевтически приемлемая соль, где a, c, d, k, l, m, W, X, Y, Z, Rи Rимеют значения, указанные в описании изобретения, которые пригодны для лечения воспалительных и других иммунных заболеваний.Отчет о международном поиске был опубликован 2002.07.25.
EA200300392A 2000-10-19 2001-10-04 Производные пиперазина с мостиковой связью EA200300392A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24180400P 2000-10-19 2000-10-19
PCT/IB2001/001844 WO2002032901A2 (en) 2000-10-19 2001-10-04 Bridged piperazine derivatives

Publications (1)

Publication Number Publication Date
EA200300392A1 true EA200300392A1 (ru) 2003-10-30

Family

ID=22912245

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300392A EA200300392A1 (ru) 2000-10-19 2001-10-04 Производные пиперазина с мостиковой связью

Country Status (37)

Country Link
US (1) US20020119961A1 (ru)
EP (1) EP1326867A2 (ru)
JP (1) JP2004511558A (ru)
KR (1) KR20030040548A (ru)
CN (1) CN1471534A (ru)
AP (1) AP2001002306A0 (ru)
AR (1) AR035354A1 (ru)
AU (1) AU2001292160A1 (ru)
BG (1) BG107655A (ru)
BR (1) BR0114697A (ru)
CA (1) CA2423789A1 (ru)
CZ (1) CZ20031013A3 (ru)
DO (1) DOP2001000268A (ru)
EA (1) EA200300392A1 (ru)
EC (1) ECSP034561A (ru)
EE (1) EE200300189A (ru)
GE (1) GEP20053617B (ru)
GT (1) GT200100209A (ru)
HN (1) HN2001000235A (ru)
HR (1) HRP20030298A2 (ru)
HU (1) HUP0301442A3 (ru)
IL (1) IL154912A0 (ru)
IS (1) IS6747A (ru)
MA (1) MA26953A1 (ru)
MX (1) MXPA03003475A (ru)
NO (1) NO20031572L (ru)
NZ (1) NZ524742A (ru)
OA (1) OA12519A (ru)
PA (1) PA8530901A1 (ru)
PE (1) PE20020587A1 (ru)
PL (1) PL362077A1 (ru)
SK (1) SK4642003A3 (ru)
SV (1) SV2002000694A (ru)
TN (1) TNSN01144A1 (ru)
WO (1) WO2002032901A2 (ru)
YU (1) YU30603A (ru)
ZA (1) ZA200302157B (ru)

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KR20040012956A (ko) 2001-06-20 2004-02-11 화이자 프로덕츠 인코포레이티드 설폰산 유도체
ATE456559T1 (de) 2001-10-22 2010-02-15 Pfizer Prod Inc Piperazinderivate mit ccr1-rezeptor- antagonistischer wirkung
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
JP4723242B2 (ja) 2002-06-12 2011-07-13 ケモセントリックス インコーポレーティッド 炎症および免疫障害治療用ｃｃｒ１アンタゴニストとして使用するための１−アリール−４−置換ピペラジン誘導体
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) * 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
CA2558211C (en) * 2004-03-03 2013-09-03 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
GB0409236D0 (en) * 2004-04-26 2004-05-26 Novartis Ag Organic compounds
ES2439969T3 (es) * 2008-07-16 2014-01-27 F. Hoffmann-La Roche Ag Nuevos compuestos heterocíclicos para el tratamiento de enfermedades cardiovasculares
WO2011104307A2 (en) * 2010-02-25 2011-09-01 Graffinity Pharmaceuticals Gmbh Ligands for antibody purification by affinity chromatography
CN101874798B (zh) * 2010-06-29 2012-08-29 北京大学 白三烯a4水解酶与环氧合酶的双功能抑制剂及其用途
CN105294700B (zh) * 2014-07-01 2019-01-08 上海合全药业股份有限公司 一种2-氧代-3,8-二氮杂二环[3.2.1]辛烷-8-羧酸叔丁酯的制备方法
US10231970B2 (en) 2014-09-30 2019-03-19 NV Heterocycles Methods of producing heteropolycycles via bis-epoxidation
TW202108559A (zh) 2019-05-31 2021-03-01 美商醫肯納腫瘤學公司 Tead抑制劑及其用途
US11274082B2 (en) 2019-05-31 2022-03-15 Ikena Oncology, Inc. Tead inhibitors and uses thereof

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NO20031572D0 (no) 2003-04-08
IS6747A (is) 2003-03-17
OA12519A (en) 2006-05-30
YU30603A (sh) 2006-05-25
CA2423789A1 (en) 2002-04-25
HRP20030298A2 (en) 2005-02-28
GEP20053617B (en) 2005-09-26
GT200100209A (es) 2002-06-04
AR035354A1 (es) 2004-05-12
EE200300189A (et) 2003-10-15
KR20030040548A (ko) 2003-05-22
BG107655A (bg) 2004-01-30
AU2001292160A1 (en) 2002-04-29
NZ524742A (en) 2004-12-24
CZ20031013A3 (en) 2004-03-17
CN1471534A (zh) 2004-01-28
SK4642003A3 (en) 2004-05-04
ZA200302157B (en) 2004-04-22
PE20020587A1 (es) 2002-07-08
EP1326867A2 (en) 2003-07-16
PL362077A1 (en) 2004-10-18
HUP0301442A2 (hu) 2003-12-29
TNSN01144A1 (fr) 2005-11-10
JP2004511558A (ja) 2004-04-15
AP2001002306A0 (en) 2001-12-31
ECSP034561A (es) 2003-06-25
HUP0301442A3 (en) 2007-03-28
MXPA03003475A (es) 2003-07-14
MA26953A1 (fr) 2004-12-20
BR0114697A (pt) 2003-11-18
SV2002000694A (es) 2002-12-02
PA8530901A1 (es) 2003-11-12
NO20031572L (no) 2003-06-10
WO2002032901A3 (en) 2002-07-25
US20020119961A1 (en) 2002-08-29
WO2002032901A2 (en) 2002-04-25
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IL154912A0 (en) 2003-10-31
DOP2001000268A (es) 2002-05-30

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