MX2009003795A - Preparacion de pirimidinas ribofuranosil nucleosidos. - Google Patents

Preparacion de pirimidinas ribofuranosil nucleosidos.

Info

Publication number
MX2009003795A
MX2009003795A MX2009003795A MX2009003795A MX2009003795A MX 2009003795 A MX2009003795 A MX 2009003795A MX 2009003795 A MX2009003795 A MX 2009003795A MX 2009003795 A MX2009003795 A MX 2009003795A MX 2009003795 A MX2009003795 A MX 2009003795A
Authority
MX
Mexico
Prior art keywords
preparation
nucleosides
ribofuranosyl
pyrimidines
ribofuranosyl pyrimidines
Prior art date
Application number
MX2009003795A
Other languages
English (en)
Inventor
Qingwu Jin
Byoung-Kwon Chun
Suguna Rachakonda
Keshab Sarma
Steven D Axt
Justin Vitale
Jiang Zhu
Bruce Ross
Original Assignee
Pharmasset Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmasset Inc filed Critical Pharmasset Inc
Publication of MX2009003795A publication Critical patent/MX2009003795A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Abstract

El presente proceso proporciona un método mejorado para la preparación de 4-amino-1-( (2R, 3R, 4R, 5R)-3-fluoro-4-hidroxi-5-h idroximetil-3-metil-tetrahidro-furan-2-il)-III-pirimidin-2-ona de la formula (IV) el cual es un potente inhibidor de la polimerasa NS5B del Virus de la Hepatitis C (IICV).
MX2009003795A 2006-10-10 2007-10-05 Preparacion de pirimidinas ribofuranosil nucleosidos. MX2009003795A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85096206P 2006-10-10 2006-10-10
PCT/US2007/021548 WO2008045419A1 (en) 2006-10-10 2007-10-05 Preparation of nucleosides ribofuranosyl pyrimidines

Publications (1)

Publication Number Publication Date
MX2009003795A true MX2009003795A (es) 2009-06-18

Family

ID=39111500

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003795A MX2009003795A (es) 2006-10-10 2007-10-05 Preparacion de pirimidinas ribofuranosil nucleosidos.

Country Status (19)

Country Link
US (2) US8912321B2 (es)
EP (1) EP2084174B1 (es)
JP (1) JP5252459B2 (es)
KR (1) KR101057239B1 (es)
CN (1) CN101600725B (es)
AU (1) AU2007307057B2 (es)
BR (1) BRPI0719174A2 (es)
CA (1) CA2666098C (es)
DK (1) DK2084174T3 (es)
ES (1) ES2429290T3 (es)
GT (1) GT200900080A (es)
HK (1) HK1133889A1 (es)
IL (1) IL198086A (es)
MX (1) MX2009003795A (es)
PL (1) PL2084174T3 (es)
PT (1) PT2084174E (es)
RU (1) RU2421461C2 (es)
SI (1) SI2084174T1 (es)
WO (1) WO2008045419A1 (es)

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Also Published As

Publication number Publication date
JP2010505954A (ja) 2010-02-25
KR101057239B1 (ko) 2011-08-16
IL198086A0 (en) 2009-12-24
GT200900080A (es) 2012-04-10
IL198086A (en) 2012-03-29
PT2084174E (pt) 2013-10-08
CN101600725B (zh) 2014-11-26
CN101600725A (zh) 2009-12-09
PL2084174T3 (pl) 2013-12-31
EP2084174A1 (en) 2009-08-05
US20100056770A1 (en) 2010-03-04
RU2009117396A (ru) 2010-11-20
RU2421461C2 (ru) 2011-06-20
JP5252459B2 (ja) 2013-07-31
US8912321B2 (en) 2014-12-16
SI2084174T1 (sl) 2013-10-30
ES2429290T3 (es) 2013-11-14
CA2666098C (en) 2012-09-25
US20080139802A1 (en) 2008-06-12
AU2007307057B2 (en) 2011-09-15
HK1133889A1 (en) 2010-04-09
WO2008045419A1 (en) 2008-04-17
DK2084174T3 (da) 2013-11-04
CA2666098A1 (en) 2008-04-17
EP2084174B1 (en) 2013-07-31
KR20090060460A (ko) 2009-06-12
BRPI0719174A2 (pt) 2017-06-13
AU2007307057A1 (en) 2008-04-17

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