BRPI0408561A - métodos para manufatura de 2'-desoxi-59-l-nucleosìeos - Google Patents

métodos para manufatura de 2'-desoxi-59-l-nucleosìeos

Info

Publication number
BRPI0408561A
BRPI0408561A BRPI0408561-2A BRPI0408561A BRPI0408561A BR PI0408561 A BRPI0408561 A BR PI0408561A BR PI0408561 A BRPI0408561 A BR PI0408561A BR PI0408561 A BRPI0408561 A BR PI0408561A
Authority
BR
Brazil
Prior art keywords
deoxy
manufacturing
methods
nucleosides
prodrugs
Prior art date
Application number
BRPI0408561-2A
Other languages
English (en)
Inventor
Jaime A Rabi
Original Assignee
Microbiol Quimica Farmaceutica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbiol Quimica Farmaceutica filed Critical Microbiol Quimica Farmaceutica
Publication of BRPI0408561A publication Critical patent/BRPI0408561A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides

Abstract

"MéTODOS PARA MANUFATURA DE 2<39>-DESOXI-<225>-L-NUCLEOSìDEOS". A presente invenção está relacionada à sintese de 2<39>1desoxi-<39>-L-timidina, 2<39>-desoxi-<225>-L-uridina e 2<39>-desoxi-<225>-Lcitidina, e seus derivados, como pró-medicamentos- de 3<39> -0acil ou 3<39>,5<39>-0-diacil, que incluem os pró-medicamentos 3<39>O-L-aminoacil e 3<39>,5<39>-0-L-diaminoacil, e particularmente os pró-medicamentos 3<39>-0-L-valinil e 3<39>,5<39>-0-L-divalinil.
BRPI0408561-2A 2003-03-20 2004-03-22 métodos para manufatura de 2'-desoxi-59-l-nucleosìeos BRPI0408561A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45646503P 2003-03-20 2003-03-20
PCT/IB2004/001308 WO2004084453A2 (en) 2003-03-20 2004-03-22 METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES

Publications (1)

Publication Number Publication Date
BRPI0408561A true BRPI0408561A (pt) 2006-03-21

Family

ID=33030097

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408561-2A BRPI0408561A (pt) 2003-03-20 2004-03-22 métodos para manufatura de 2'-desoxi-59-l-nucleosìeos

Country Status (6)

Country Link
US (1) US7582748B2 (pt)
EP (1) EP1745573A4 (pt)
KR (1) KR20060008297A (pt)
CN (1) CN101415719A (pt)
BR (1) BRPI0408561A (pt)
WO (1) WO2004084453A2 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR20080021797A (ko) 2000-05-26 2008-03-07 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
PL374781A1 (en) 2002-06-28 2005-10-31 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
EP1576138B1 (en) 2002-11-15 2017-02-01 Idenix Pharmaceuticals LLC. 2'-methyl nucleosides in combination with interferon and flaviviridae mutation
WO2004096149A2 (en) * 2003-04-28 2004-11-11 Idenix (Cayman) Limited Industrially scalable nucleoside synthesis
BR122018015050B1 (pt) 2003-05-30 2021-07-13 Gilead Pharmasset Llc Derivados fosfatados de nucleosídeo e composição farmacêutica dos mesmos
KR20060035652A (ko) * 2003-06-30 2006-04-26 이데닉스 (케이만) 리미티드 β-Ｌ-2-데옥시 뉴클레오시드의 합성
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
ES2725457T3 (es) 2004-09-14 2019-09-24 Gilead Pharmasset Llc Preparación de ribofuranosil pirimidinas y purinas 2'fluoro-2'-alquil-sustituidas u otras opcionalmente sustituidas y sus derivados
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
GB0609178D0 (en) 2006-05-09 2006-06-21 Univ Cardiff Novel compounds
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CN102209467B (zh) * 2008-10-03 2014-03-12 台湾神隆股份有限公司 地西他滨(Decitabine)的合成
US8586729B2 (en) * 2008-10-03 2013-11-19 Scinopharm Taiwan Ltd. Synthesis of decitabine
KR20110104074A (ko) 2008-12-23 2011-09-21 파마셋 인코포레이티드 퓨린 뉴클레오시드의 합성
AU2009329867B2 (en) 2008-12-23 2015-01-29 Gilead Pharmasset Llc Nucleoside phosphoramidates
CN102753563A (zh) 2008-12-23 2012-10-24 吉利德制药有限责任公司 核苷类似物
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
EP2752422B1 (en) 2010-03-31 2017-08-16 Gilead Pharmasset LLC Stereoselective synthesis of phosphorus containing actives
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
KR101241321B1 (ko) * 2010-08-05 2013-03-11 케이피엑스 라이프사이언스 주식회사 수율 및 순도가 개선된 데시타빈의 제조방법
EP2646453A1 (en) 2010-11-30 2013-10-09 Gilead Pharmasset LLC Compounds
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
EP3038601B1 (en) 2013-08-27 2020-04-08 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
CN104744538A (zh) * 2013-12-26 2015-07-01 康普药业股份有限公司 一种替比夫定的制备方法
CN104059057A (zh) * 2014-01-03 2014-09-24 石家庄龙泽制药有限公司 拉米夫定杂质3-tu的制备方法
CN104356186B (zh) * 2014-10-24 2017-03-15 济南尚博生物科技有限公司 一种3’，5’‑二‑氧‑(4‑对甲基苯甲酰基)‑β‑L‑胸腺嘧啶的制备方法
CN106478752B (zh) * 2015-09-01 2019-10-25 四川科伦药物研究院有限公司 一种替比夫定的制备方法
MX2018002707A (es) * 2015-09-02 2018-08-01 Abbvie Inc Derivados de tetrahidrofurano antivirales.
CN108299518A (zh) * 2018-02-02 2018-07-20 王成宇 一种2`-脱氧-β-尿苷的合成方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2122991C2 (de) * 1971-05-04 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden
DD140254A1 (de) 1978-12-04 1980-02-20 Dieter Baerwolff Verfahren zur herstellung von 4-substituierten pyrimidin-nucleosiden
US4754026A (en) * 1985-06-04 1988-06-28 Takeda Chemical Industries, Ltd. Conversion of uracil derivatives to cytosine derivatives
EP0311694B1 (en) * 1987-04-23 1995-12-13 Rikagaku Kenkyusho Nucleoside derivatives and process for their preparation
GB8719367D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
SE8802687D0 (sv) 1988-07-20 1988-07-20 Astra Ab Nucleoside derivatives
US5358936A (en) * 1990-08-03 1994-10-25 Paul Gordon Anionic furanose derivatives, methods of making and using the same
DE4224737A1 (de) 1992-07-27 1994-02-03 Herbert Prof Dr Schott Neue Cytosinnucleosidanaloga, Verfahren zu ihrer Herstellung und ihre Verwendung
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
JP3693357B2 (ja) 1993-04-09 2005-09-07 峯郎 実吉 逆転写酵素阻害剤
FR2709754B1 (fr) 1993-09-10 1995-12-01 Centre Nat Rech Scient Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale.
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
JPH07224081A (ja) 1994-02-10 1995-08-22 Kobayashi Koryo Kk デオキシリボフラノシルハライド誘導体の製造方法
WO1996011204A1 (de) 1994-10-07 1996-04-18 Max-Delbrück-Centrum für Molekulare Medizin NEUE β-L-NUCLEOSIDE UND IHRE VERWENDUNG
US5559101A (en) 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
PT831852E (pt) 1995-06-07 2007-02-28 Uab Research Foundation Nucleósidos com actividade anti-vírus da hepatite b
AU709345B2 (en) * 1995-09-07 1999-08-26 Emory University Therapeutic azide compounds
US6248878B1 (en) * 1996-12-24 2001-06-19 Ribozyme Pharmaceuticals, Inc. Nucleoside analogs
US6444652B1 (en) * 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
AU5475799A (en) * 1998-08-10 2000-03-06 Centre National De La Recherche Scientifique Beta-l-2'-deoxy-nucleosides for the treatment of hepatitis
JP4067226B2 (ja) 1999-04-01 2008-03-26 三井化学株式会社 １―ハロゲノ−２−デオキシリボフラノース誘導体の製造方法
WO2001058917A1 (fr) * 2000-02-10 2001-08-16 Mitsui Chemicals, Inc. Procede de preparation de derives de trifluorothymidine
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
US6875751B2 (en) * 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
MY141594A (en) 2000-06-15 2010-05-14 Novirio Pharmaceuticals Ltd 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES
JP2005536440A (ja) * 2001-09-28 2005-12-02 イデニクス（ケイマン）リミテツド ４’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
JP5116972B2 (ja) * 2002-12-12 2013-01-09 イデニクス（ケイマン）リミテツド ２’−分枝ヌクレオシドの製造方法

Also Published As

Publication number Publication date
KR20060008297A (ko) 2006-01-26
EP1745573A2 (en) 2007-01-24
US20040266996A1 (en) 2004-12-30
CN101415719A (zh) 2009-04-22
EP1745573A4 (en) 2010-05-26
US7582748B2 (en) 2009-09-01
WO2004084453A2 (en) 2004-09-30
WO2004084453A3 (en) 2009-04-02

Similar Documents

Publication Publication Date Title
BRPI0408561A (pt) métodos para manufatura de 2&#39;-desoxi-59-l-nucleosìeos
BR0315296A (pt) Derivados do ciclohexanol espirocìclicos
BR0312729A (pt) Novos derivados de indol-3-enxofre
UY29927A1 (es) Derivados sustituidos de la 5-fenil-2-tioxo-imidazolin-4-ona y de la 5-fenil-2-amino-imidazolidin-4-ona y sus sales, composiciones y aplicaciones
UY29919A1 (es) Derivados sustituidos de 3,4-dihidroisoquinolin-1-amino-trifluoroacetato, sus composiciones farmacéuticas y aplicaciones
PA8595901A1 (es) &#34;n-arilheterociclos sustituidos, procedimientos para su preparacion, y su empleo como medicamentos
ECSP067043A (es) Derivados de pirrolotriazina útiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogénesis
HN2006019068A (es) &#34;sintesis de (r)-n-metilnaltrexona&#34;
BRPI0408347B8 (pt) derivados de pirimidina, seu uso, e composição e combinação farmacêuticas
CR9223A (es) 18-metil-19-nor-17-pregn-4-en-21, 17-carbolactonas,asi como preparaciones farmaceuticas que las contienen
BRPI0519710A2 (pt) aminoÁlcoois tricÍclicos, processo para sua preparaÇço e seu emprego como anti-inflamatàrio
PA8667201A1 (es) Nuevos compuestos farmaceuticos
CY1111206T1 (el) Βενζοθειοφαινια υποκατεστημενα με πιπεραζινη για την αγωγη διανοητικων διαταραχων
BRPI0418031A (pt) inibidores de quinase fosfonato-substituìdos
BRPI0411528A (pt) uso de isomalte como prebiótico
UY30025A1 (es) Derivados sustituidos de las 2-amino-5,6-dihidro pirimidin-4(3h)-onas y sus sales farmacéuticamente aceptables, composiciones farmacéuticas conteniéndolos y aplicaciones.
BR0211521A (pt) Derivados de retinóide com atividades antiangiogênicas, antitumorais e pró-apoptóticas
CR9182A (es) Derivado de quinolina, su uso, preparacion y medicamento que lo contiene
ECSP066291A (es) Sistemas emulsionantes que contienen derivados de azetidina
BRPI0518841A2 (pt) derivados de indenila e uso destes para o tratamento de transtornos neurolàgicos
BRPI0415203A (pt) pentanóis reestruturados, um processo para sua produção e seu uso como agentes antiinflamatórios
BRPI0406824A (pt) Indolonaoxazoldinonas antiibacterianas, intermediários para seu preparo e composições farmacêuticas que as contêm
BR0317284A (pt) Inibidores aminocianopiridina de proteìna quinase-2 ativada com proteìna quinase ativada com mitógeno
UY29417A1 (es) Agentes endoparasiticidas
PA8589801A1 (es) Aminoalcoxiindoles

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.