PE20071131A1 - Nucleosidos antivirales (2r)2'-deoxi-2-metil-2-fluoro-citidina - Google Patents
Nucleosidos antivirales (2r)2'-deoxi-2-metil-2-fluoro-citidinaInfo
- Publication number
- PE20071131A1 PE20071131A1 PE2006001586A PE2006001586A PE20071131A1 PE 20071131 A1 PE20071131 A1 PE 20071131A1 PE 2006001586 A PE2006001586 A PE 2006001586A PE 2006001586 A PE2006001586 A PE 2006001586A PE 20071131 A1 PE20071131 A1 PE 20071131A1
- Authority
- PE
- Peru
- Prior art keywords
- fluoro
- methyl
- 2r3r4r5r
- furan
- amino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DI ACILO DE LA 4-AMINO-((2R3R4R5R)-3-FLUORO-4-HIDROXI-5-HIDROXIMETIL-3-METIL-TETRAHIDRO-FURAN-2-IL)-1H-PIRIMIDIN-2-ONA (LLAMADA TAMBIEN (2R)2'-DEOXI-2-METIL-2-FLUORO-CITIDINA) DE FORMULA (I), EN DONDE R1 ES ALQUILO(C2-C5), ALQUENILO(C2-C5), O ALQUINILO(C2-C5) LINEALES O RAMIFICADOS, HALOALQUILO INFERIOR, CICLOALQUILO(C3-C6) Y ALCOXILO(C2-C4). SON SELECCIONADOS: ESTER DEL ACIDO (2R3R4R5R)-5-(4-AMINO-2-OXO-2H-PIRIMIDIN-1-IL)-4-FLUORO-4-METIL-3-PROPIONILOXI-TETRAHIDRO-FURAN-2-ILMETIL ESTER PROPIONICO, ESTER DEL ACIDO (2R3R4R5R)-5-(4-AMINO-2-OXO-2H-PIRIMIDIN-1-IL)-4-FLUORO-3-ISOBUTIRILOXI-4-METIL-TETRAHIDRO-FURAN-2-ILMETIL ESTER ISOBUTIRICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE LA POLIMERASA NS5b DEL VIRUS DE LA HEPATITIS C, POR LO QUE SON UTILES EN EL TRATAMIENTO DE UNA ENFERMEDAD MEDIADA POR EL VIRUS DE HEPATITIS C (HCV)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74931905P | 2005-12-09 | 2005-12-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20071131A1 true PE20071131A1 (es) | 2007-11-30 |
Family
ID=37608355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006001586A PE20071131A1 (es) | 2005-12-09 | 2006-12-11 | Nucleosidos antivirales (2r)2'-deoxi-2-metil-2-fluoro-citidina |
Country Status (25)
Country | Link |
---|---|
US (1) | US7754699B2 (es) |
EP (1) | EP1957510A1 (es) |
JP (2) | JP4979710B2 (es) |
KR (1) | KR101238461B1 (es) |
CN (1) | CN101336247B (es) |
AR (1) | AR056850A1 (es) |
AU (1) | AU2006324098C1 (es) |
BR (1) | BRPI0619563A2 (es) |
CA (1) | CA2632626C (es) |
CR (1) | CR10136A (es) |
EC (1) | ECSP088518A (es) |
GT (1) | GT200800095A (es) |
HN (1) | HN2006041184A (es) |
IL (1) | IL192002A0 (es) |
MA (1) | MA30057B1 (es) |
MY (1) | MY150667A (es) |
NO (1) | NO20082934L (es) |
NZ (1) | NZ568909A (es) |
PE (1) | PE20071131A1 (es) |
RU (1) | RU2422454C2 (es) |
TW (1) | TWI394759B (es) |
UA (1) | UA91255C2 (es) |
UY (1) | UY30004A1 (es) |
WO (1) | WO2007065829A1 (es) |
ZA (1) | ZA200804958B (es) |
Families Citing this family (74)
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SI1576138T1 (sl) | 2002-11-15 | 2017-07-31 | Idenix Pharmaceuticals Llc | 2'-metil nukleozidi v kombinaciji z interferon in flaviviridae mutacijo |
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EA201100851A1 (ru) | 2008-12-23 | 2012-04-30 | Фармассет, Инк. | Аналоги нуклеозидов |
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EA019295B1 (ru) | 2008-12-23 | 2014-02-28 | Джилид Фармассет, Ллс. | Соединения пуриновых нуклеозидов и способ их получения |
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RU2489153C2 (ru) | 2009-01-21 | 2013-08-10 | Ф.Хоффманн-Ля Рош Аг | Фармацевтические композиции, включающие пролекарство ингибитора полимеразы hcv |
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BR112012006180A2 (pt) | 2009-09-21 | 2015-09-08 | Gilead Sciences Inc | processos e intermediários para a preparação de análogos de 1'-substituido carba-nucleosídeo |
PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
UA122959C2 (uk) | 2010-03-31 | 2021-01-27 | Гайлід Фармассет Елелсі | Нуклеозидфосфорамідати |
EP2609923B1 (en) | 2010-03-31 | 2017-05-24 | Gilead Pharmasset LLC | Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate |
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2006
- 2006-11-29 NZ NZ568909A patent/NZ568909A/en unknown
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