PE20130281A1 - Derivados de acido 5-alquinil-3-amida-2-tiofeno-carboxilico como inhibidores del virus flaviviridae - Google Patents
Derivados de acido 5-alquinil-3-amida-2-tiofeno-carboxilico como inhibidores del virus flaviviridaeInfo
- Publication number
- PE20130281A1 PE20130281A1 PE2012000999A PE2012000999A PE20130281A1 PE 20130281 A1 PE20130281 A1 PE 20130281A1 PE 2012000999 A PE2012000999 A PE 2012000999A PE 2012000999 A PE2012000999 A PE 2012000999A PE 20130281 A1 PE20130281 A1 PE 20130281A1
- Authority
- PE
- Peru
- Prior art keywords
- substituted
- alkinyl
- thiophene
- inhibitors
- amide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (a) ; DONDE R1 ES UN GRUPO ALQUILO C1-C12 SUSTITUIDO O NO, ALQUENILO C2-C12 SUSTITUIDO O NO, ALQUINILO C2-C12 SUSTITUIDO O NO, ENTRE OTROS, R2 ES UN GRUPO C1-C12 SUSTITUIDO O NO, ALQUENILO C2-C12 SUSTITUIDO O NO, ALQUINILO C2-C12 SUSTITUIDO O NO, ENTRE OTROS; R3 ES CICLOALQUILALQUILENO C4-C12 O CICLOALQUILALQUILENO C4-C12 SUSTITUIDO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES ACIDO 5-(3,3-DIMETILBUT-1-INIL)-3-(N-(4-HIDROXI-4-((PIRIDIN-3-ILOXI)METIL)CICLOHEXIL)-4-METILCICLOHEXANOCARBOXAMIDO)TIOFEN-2-CARBOXILICO. REFERIDA ADEMAS A UN TRATAMIENTO QUE DA COMO RESULTADO LA REDUCCION DE UNO O MAS DE LAS CARGAS VIRALES O EL ACLARAMIENTO DE ARN EN EL PACIENTE. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE PACIENTES CON INFECCIONES VIRALES POR FLAVIVIRIDAE, PARTICULARMENTE INFECCIONES DE HAPATITIS C.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29557610P | 2010-01-15 | 2010-01-15 | |
US35348110P | 2010-06-10 | 2010-06-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20130281A1 true PE20130281A1 (es) | 2013-03-08 |
Family
ID=43538203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2012000999A PE20130281A1 (es) | 2010-01-15 | 2011-01-14 | Derivados de acido 5-alquinil-3-amida-2-tiofeno-carboxilico como inhibidores del virus flaviviridae |
Country Status (27)
Country | Link |
---|---|
US (2) | US8513298B2 (es) |
EP (2) | EP2523950B1 (es) |
JP (2) | JP5868872B2 (es) |
KR (1) | KR101727776B1 (es) |
CN (1) | CN102712633B (es) |
AP (1) | AP3576A (es) |
AR (1) | AR080001A1 (es) |
AU (1) | AU2011205744B2 (es) |
BR (1) | BR112012017382A2 (es) |
CA (1) | CA2785567C (es) |
CL (1) | CL2012001960A1 (es) |
CR (1) | CR20120417A (es) |
EA (1) | EA021196B1 (es) |
EC (1) | ECSP12012104A (es) |
ES (1) | ES2626150T3 (es) |
IL (1) | IL220545B (es) |
MX (1) | MX2012008211A (es) |
NZ (1) | NZ600817A (es) |
PE (1) | PE20130281A1 (es) |
PL (1) | PL2523950T3 (es) |
PT (1) | PT2523950T (es) |
SG (2) | SG182475A1 (es) |
SI (1) | SI2523950T1 (es) |
TW (1) | TWI491609B (es) |
UY (1) | UY33183A (es) |
WO (1) | WO2011088345A1 (es) |
ZA (1) | ZA201205248B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102471327A (zh) * | 2009-07-21 | 2012-05-23 | 吉里德科学公司 | 黄病毒科病毒的抑制剂 |
EP2507249B1 (en) | 2009-09-09 | 2015-11-11 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
PE20121522A1 (es) * | 2010-01-15 | 2012-11-26 | Gilead Sciences Inc | Derivados de acido 5-alquinil-3-amida-2-tiofeno-carboxilico como inhibidores del virus flaviviridae |
PL2523950T3 (pl) * | 2010-01-15 | 2017-09-29 | Gilead Sciences, Inc. | Inhibitory wirusów flaviviridae |
JP5891241B2 (ja) * | 2010-12-20 | 2016-03-22 | ギリアード サイエンシーズ, インコーポレイテッド | Hcvを処置するための組合せ |
DE102011003295A1 (de) * | 2011-01-28 | 2012-08-02 | Kiekert Ag | Kraftfahrzeugschloss |
AU2012280959B2 (en) * | 2011-07-13 | 2015-08-06 | Gilead Sciences, Inc. | Thiophen-2-carboxylic acid derivatives useful as inhibitors of Flaviviridae viruses |
DE202012013074U1 (de) * | 2011-09-16 | 2014-10-29 | Gilead Pharmasset Lcc | Zusammensetzungen zur Behandlung von HCV |
CN103087052A (zh) * | 2011-10-31 | 2013-05-08 | 上海壹志医药科技有限公司 | 噻吩衍生物及其药物用途 |
AU2013270672B2 (en) * | 2012-06-08 | 2017-10-19 | Gilead Sciences, Inc. | Macrocyclic inhibitors of flaviviridae viruses |
KR20150040266A (ko) | 2012-06-08 | 2015-04-14 | 길리애드 사이언시즈, 인코포레이티드 | 플라비바이러스과 바이러스의 마크로시클릭 저해인자 |
AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
US8927741B2 (en) * | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
US8759544B2 (en) | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
SG10201706949VA (en) | 2013-01-31 | 2017-09-28 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
CN107074904B (zh) | 2014-10-23 | 2022-12-23 | 深圳华大智造科技股份有限公司 | 信号约束测序(scs)和用于信号约束测序的核苷酸类似物 |
HUE056470T2 (hu) | 2014-12-26 | 2022-02-28 | Univ Emory | Vírusellenes N4-Hidroxicitidin származékok |
BR112018072298A2 (pt) | 2016-05-02 | 2019-02-12 | Florida State University Research Foundation, Inc. | tratamento de infecções pelo vírus da zika usando inibidores da alfa-glicosidase |
EP3454862A4 (en) | 2016-05-10 | 2020-02-12 | C4 Therapeutics, Inc. | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
JP2019525947A (ja) | 2016-06-01 | 2019-09-12 | エムスリー・バイオテクノロジー・インコーポレイテッドM3 Biotechnology, Inc. | 化合物 |
GB2590198B (en) | 2017-12-07 | 2022-02-23 | Univ Emory | N4-hydroxycytidine derivatives and anti-viral uses related thereto |
CN108096562B (zh) * | 2017-12-25 | 2021-05-11 | 武汉百药联科科技有限公司 | 20s蛋白酶体抑制剂在制备治疗日本乙型脑炎病毒感染的药物中的用途 |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
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PL2523950T3 (pl) | 2010-01-15 | 2017-09-29 | Gilead Sciences, Inc. | Inhibitory wirusów flaviviridae |
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AU2012280959B2 (en) | 2011-07-13 | 2015-08-06 | Gilead Sciences, Inc. | Thiophen-2-carboxylic acid derivatives useful as inhibitors of Flaviviridae viruses |
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2011
- 2011-01-14 PL PL11700988T patent/PL2523950T3/pl unknown
- 2011-01-14 AU AU2011205744A patent/AU2011205744B2/en active Active
- 2011-01-14 TW TW100101437A patent/TWI491609B/zh active
- 2011-01-14 NZ NZ600817A patent/NZ600817A/en not_active IP Right Cessation
- 2011-01-14 MX MX2012008211A patent/MX2012008211A/es active IP Right Grant
- 2011-01-14 SG SG2012051181A patent/SG182475A1/en unknown
- 2011-01-14 EP EP11700988.6A patent/EP2523950B1/en active Active
- 2011-01-14 UY UY0001033183A patent/UY33183A/es not_active Application Discontinuation
- 2011-01-14 EA EA201290576A patent/EA021196B1/ru not_active IP Right Cessation
- 2011-01-14 AR ARP110100126A patent/AR080001A1/es unknown
- 2011-01-14 CN CN201180005975.8A patent/CN102712633B/zh active Active
- 2011-01-14 JP JP2012549122A patent/JP5868872B2/ja active Active
- 2011-01-14 ES ES11700988.6T patent/ES2626150T3/es active Active
- 2011-01-14 BR BR112012017382A patent/BR112012017382A2/pt not_active Application Discontinuation
- 2011-01-14 KR KR1020127021314A patent/KR101727776B1/ko active IP Right Grant
- 2011-01-14 WO PCT/US2011/021335 patent/WO2011088345A1/en active Application Filing
- 2011-01-14 CA CA2785567A patent/CA2785567C/en active Active
- 2011-01-14 SI SI201131169A patent/SI2523950T1/sl unknown
- 2011-01-14 PT PT117009886T patent/PT2523950T/pt unknown
- 2011-01-14 SG SG10201500298PA patent/SG10201500298PA/en unknown
- 2011-01-14 AP AP2012006414A patent/AP3576A/xx active
- 2011-01-14 PE PE2012000999A patent/PE20130281A1/es not_active Application Discontinuation
- 2011-01-14 EP EP17160365.7A patent/EP3219713A1/en not_active Withdrawn
- 2011-01-14 US US13/007,150 patent/US8513298B2/en active Active
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2012
- 2012-06-21 IL IL220545A patent/IL220545B/en not_active IP Right Cessation
- 2012-07-13 CL CL2012001960A patent/CL2012001960A1/es unknown
- 2012-07-13 ZA ZA2012/05248A patent/ZA201205248B/en unknown
- 2012-08-10 CR CR20120417A patent/CR20120417A/es unknown
- 2012-08-13 EC ECSP12012104 patent/ECSP12012104A/es unknown
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2013
- 2013-07-11 US US13/939,695 patent/US9321753B2/en active Active
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2015
- 2015-11-02 JP JP2015215450A patent/JP2016041732A/ja not_active Withdrawn
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