EA201290576A1 - Ингибиторы вирусов flaviviridae - Google Patents

Ингибиторы вирусов flaviviridae

Info

Publication number
EA201290576A1
EA201290576A1 EA201290576A EA201290576A EA201290576A1 EA 201290576 A1 EA201290576 A1 EA 201290576A1 EA 201290576 A EA201290576 A EA 201290576A EA 201290576 A EA201290576 A EA 201290576A EA 201290576 A1 EA201290576 A1 EA 201290576A1
Authority
EA
Eurasian Patent Office
Prior art keywords
flaviviridae virus
virus inhibitors
flaviviridae
compounds
inhibitors
Prior art date
Application number
EA201290576A
Other languages
English (en)
Other versions
EA021196B1 (ru
Inventor
Эда Каналес
Майкл О'Нил Ханрахан Кларк
Скотт Е. Лазервит
Уиллард Лью
Филип Энтони Морганелли
Уильям Дж. Уоткинс
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43538203&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201290576(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201290576A1 publication Critical patent/EA201290576A1/ru
Publication of EA021196B1 publication Critical patent/EA021196B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Предложены соединения формулы (I) и их фармацевтически приемлемые соли и сложные эфиры. Предложенные соединения, композиции и способы подходят для лечения вирусных инфекций Flaviviridae, в частности инфекции гепатита С.
EA201290576A 2010-01-15 2011-01-14 Ингибиторы вирусов flaviviridae EA021196B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29557610P 2010-01-15 2010-01-15
US35348110P 2010-06-10 2010-06-10
PCT/US2011/021335 WO2011088345A1 (en) 2010-01-15 2011-01-14 Inhibitors of flaviviridae viruses

Publications (2)

Publication Number Publication Date
EA201290576A1 true EA201290576A1 (ru) 2013-01-30
EA021196B1 EA021196B1 (ru) 2015-04-30

Family

ID=43538203

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290576A EA021196B1 (ru) 2010-01-15 2011-01-14 Ингибиторы вирусов flaviviridae

Country Status (27)

Country Link
US (2) US8513298B2 (ru)
EP (2) EP2523950B1 (ru)
JP (2) JP5868872B2 (ru)
KR (1) KR101727776B1 (ru)
CN (1) CN102712633B (ru)
AP (1) AP3576A (ru)
AR (1) AR080001A1 (ru)
AU (1) AU2011205744B2 (ru)
BR (1) BR112012017382A2 (ru)
CA (1) CA2785567C (ru)
CL (1) CL2012001960A1 (ru)
CR (1) CR20120417A (ru)
EA (1) EA021196B1 (ru)
EC (1) ECSP12012104A (ru)
ES (1) ES2626150T3 (ru)
IL (1) IL220545B (ru)
MX (1) MX2012008211A (ru)
NZ (1) NZ600817A (ru)
PE (1) PE20130281A1 (ru)
PL (1) PL2523950T3 (ru)
PT (1) PT2523950T (ru)
SG (2) SG10201500298PA (ru)
SI (1) SI2523950T1 (ru)
TW (1) TWI491609B (ru)
UY (1) UY33183A (ru)
WO (1) WO2011088345A1 (ru)
ZA (1) ZA201205248B (ru)

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Also Published As

Publication number Publication date
CN102712633B (zh) 2015-07-29
US20130315861A1 (en) 2013-11-28
KR101727776B1 (ko) 2017-04-17
EA021196B1 (ru) 2015-04-30
AP2012006414A0 (en) 2012-08-31
ECSP12012104A (es) 2012-09-28
IL220545B (en) 2018-02-28
UY33183A (es) 2011-08-31
CL2012001960A1 (es) 2012-10-26
US20110178129A1 (en) 2011-07-21
ZA201205248B (en) 2013-03-27
IL220545A0 (en) 2012-08-30
PE20130281A1 (es) 2013-03-08
AU2011205744B2 (en) 2015-06-25
WO2011088345A1 (en) 2011-07-21
US9321753B2 (en) 2016-04-26
MX2012008211A (es) 2012-08-08
PT2523950T (pt) 2017-06-01
ES2626150T3 (es) 2017-07-24
EP3219713A1 (en) 2017-09-20
EP2523950B1 (en) 2017-03-15
KR20120101733A (ko) 2012-09-14
CA2785567C (en) 2018-03-27
BR112012017382A2 (pt) 2017-12-05
TWI491609B (zh) 2015-07-11
CA2785567A1 (en) 2011-07-21
CN102712633A (zh) 2012-10-03
CR20120417A (es) 2012-11-30
JP2013517291A (ja) 2013-05-16
TW201134822A (en) 2011-10-16
JP2016041732A (ja) 2016-03-31
PL2523950T3 (pl) 2017-09-29
JP5868872B2 (ja) 2016-02-24
AU2011205744A1 (en) 2012-07-26
SI2523950T1 (sl) 2017-06-30
EP2523950A1 (en) 2012-11-21
AR080001A1 (es) 2012-03-07
SG10201500298PA (en) 2015-03-30
SG182475A1 (en) 2012-08-30
US8513298B2 (en) 2013-08-20
AP3576A (en) 2016-02-08
NZ600817A (en) 2014-08-29

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