MX2012008211A - Inhibidores de virus flaviviridae. - Google Patents

Inhibidores de virus flaviviridae.

Info

Publication number
MX2012008211A
MX2012008211A MX2012008211A MX2012008211A MX2012008211A MX 2012008211 A MX2012008211 A MX 2012008211A MX 2012008211 A MX2012008211 A MX 2012008211A MX 2012008211 A MX2012008211 A MX 2012008211A MX 2012008211 A MX2012008211 A MX 2012008211A
Authority
MX
Mexico
Prior art keywords
inhibitors
flaviviridae viruses
compounds
infections
flaviviridae
Prior art date
Application number
MX2012008211A
Other languages
English (en)
Inventor
Eda Canales
Michael O'neil Hanrahan Clarke
Scott E Lazerwith
Willard Lew
Philip Anthony Morganelli
William J Watkins
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43538203&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012008211(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2012008211A publication Critical patent/MX2012008211A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Se proporcionan los compuestos de fórmula (I): y sales y ésteres farmacéuticamente aceptables de los mismos. Los compuestos, composiciones, y métodos proporcionados son útiles para el tratamiento de infecciones del virus Flaviviridae, particularmente infecciones causadas por la hepatitis C.
MX2012008211A 2010-01-15 2011-01-14 Inhibidores de virus flaviviridae. MX2012008211A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29557610P 2010-01-15 2010-01-15
US35348110P 2010-06-10 2010-06-10
PCT/US2011/021335 WO2011088345A1 (en) 2010-01-15 2011-01-14 Inhibitors of flaviviridae viruses

Publications (1)

Publication Number Publication Date
MX2012008211A true MX2012008211A (es) 2012-08-08

Family

ID=43538203

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012008211A MX2012008211A (es) 2010-01-15 2011-01-14 Inhibidores de virus flaviviridae.

Country Status (27)

Country Link
US (2) US8513298B2 (es)
EP (2) EP2523950B1 (es)
JP (2) JP5868872B2 (es)
KR (1) KR101727776B1 (es)
CN (1) CN102712633B (es)
AP (1) AP3576A (es)
AR (1) AR080001A1 (es)
AU (1) AU2011205744B2 (es)
BR (1) BR112012017382A2 (es)
CA (1) CA2785567C (es)
CL (1) CL2012001960A1 (es)
CR (1) CR20120417A (es)
EA (1) EA021196B1 (es)
EC (1) ECSP12012104A (es)
ES (1) ES2626150T3 (es)
IL (1) IL220545B (es)
MX (1) MX2012008211A (es)
NZ (1) NZ600817A (es)
PE (1) PE20130281A1 (es)
PL (1) PL2523950T3 (es)
PT (1) PT2523950T (es)
SG (2) SG10201500298PA (es)
SI (1) SI2523950T1 (es)
TW (1) TWI491609B (es)
UY (1) UY33183A (es)
WO (1) WO2011088345A1 (es)
ZA (1) ZA201205248B (es)

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EP2507249B1 (en) 2009-09-09 2015-11-11 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
CA2785563C (en) 2010-01-15 2019-05-14 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
EP2523950B1 (en) * 2010-01-15 2017-03-15 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
CA2822037A1 (en) 2010-12-20 2012-06-28 Gilead Sciences, Inc. Methods for treating hcv
DE102011003295A1 (de) * 2011-01-28 2012-08-02 Kiekert Ag Kraftfahrzeugschloss
WO2013010112A1 (en) * 2011-07-13 2013-01-17 Gilead Sciences, Inc. Thiophen-2-carboxylic acid derivatives useful as inhibitors of flaviviridae viruses
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CN103087052A (zh) * 2011-10-31 2013-05-08 上海壹志医药科技有限公司 噻吩衍生物及其药物用途
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
WO2013185090A1 (en) 2012-06-08 2013-12-12 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses
PT2861604T (pt) 2012-06-08 2017-05-05 Gilead Sciences Inc Inibidores macrocíclicos de vírus flaviridae
US8927741B2 (en) * 2012-08-17 2015-01-06 Gilead Sciences, Inc. Synthesis of an antiviral compound
US8841340B2 (en) 2012-08-17 2014-09-23 Gilead Sciences, Inc. Solid forms of an antiviral compound
US8759544B2 (en) * 2012-08-17 2014-06-24 Gilead Sciences, Inc. Synthesis of an antiviral compound
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WO2017192599A1 (en) * 2016-05-02 2017-11-09 Florida State University Research Foundation, Inc. Treatment of zika virus infections using alpha-glucosidase inhibitors
CN109562113A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的螺环降解决定子体
WO2017197055A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
CA3026074A1 (en) 2016-06-01 2017-12-07 M3 Biotechnology, Inc. N-hexanoic-l-tyrosine-l-isoleucine-(6)-aminohexanoic amide compounds and their use to treat neurodegenerative diseases
SG11202004403QA (en) 2017-12-07 2020-06-29 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN108096562B (zh) * 2017-12-25 2021-05-11 武汉百药联科科技有限公司 20s蛋白酶体抑制剂在制备治疗日本乙型脑炎病毒感染的药物中的用途
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Also Published As

Publication number Publication date
CN102712633B (zh) 2015-07-29
US20130315861A1 (en) 2013-11-28
EA201290576A1 (ru) 2013-01-30
KR101727776B1 (ko) 2017-04-17
EA021196B1 (ru) 2015-04-30
AP2012006414A0 (en) 2012-08-31
ECSP12012104A (es) 2012-09-28
IL220545B (en) 2018-02-28
UY33183A (es) 2011-08-31
CL2012001960A1 (es) 2012-10-26
US20110178129A1 (en) 2011-07-21
ZA201205248B (en) 2013-03-27
IL220545A0 (en) 2012-08-30
PE20130281A1 (es) 2013-03-08
AU2011205744B2 (en) 2015-06-25
WO2011088345A1 (en) 2011-07-21
US9321753B2 (en) 2016-04-26
PT2523950T (pt) 2017-06-01
ES2626150T3 (es) 2017-07-24
EP3219713A1 (en) 2017-09-20
EP2523950B1 (en) 2017-03-15
KR20120101733A (ko) 2012-09-14
CA2785567C (en) 2018-03-27
BR112012017382A2 (pt) 2017-12-05
TWI491609B (zh) 2015-07-11
CA2785567A1 (en) 2011-07-21
CN102712633A (zh) 2012-10-03
CR20120417A (es) 2012-11-30
JP2013517291A (ja) 2013-05-16
TW201134822A (en) 2011-10-16
JP2016041732A (ja) 2016-03-31
PL2523950T3 (pl) 2017-09-29
JP5868872B2 (ja) 2016-02-24
AU2011205744A1 (en) 2012-07-26
SI2523950T1 (sl) 2017-06-30
EP2523950A1 (en) 2012-11-21
AR080001A1 (es) 2012-03-07
SG10201500298PA (en) 2015-03-30
SG182475A1 (en) 2012-08-30
US8513298B2 (en) 2013-08-20
AP3576A (en) 2016-02-08
NZ600817A (en) 2014-08-29

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