MX2013006475A - Inhibidores macrociclicos de virus flaviviridae. - Google Patents

Inhibidores macrociclicos de virus flaviviridae.

Info

Publication number
MX2013006475A
MX2013006475A MX2013006475A MX2013006475A MX2013006475A MX 2013006475 A MX2013006475 A MX 2013006475A MX 2013006475 A MX2013006475 A MX 2013006475A MX 2013006475 A MX2013006475 A MX 2013006475A MX 2013006475 A MX2013006475 A MX 2013006475A
Authority
MX
Mexico
Prior art keywords
flaviviridae viruses
macrocyclic inhibitors
compounds
macrocyclic
inhibitors
Prior art date
Application number
MX2013006475A
Other languages
English (en)
Inventor
Richard L Mackman
Todd Appleby
Hans G Fliri
Andrew J Keats
Karine Poullennec
Jonathan Sanvoisin
Linos Lazarides
Simon N Pettit
Victoria A Steadman
Gregory M Watt
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2013006475A publication Critical patent/MX2013006475A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona compuestos de la Fórmula I: (ver Fórmula) y sales farmacéuticamente aceptables y ésteres de ellos. Los compuestos, composicione,s y métodos proporcionados son útiles para el tratamiento de infecciones por virus de Flaviviridae, particularmente infecciones por hepatitis C.
MX2013006475A 2010-12-10 2011-12-08 Inhibidores macrociclicos de virus flaviviridae. MX2013006475A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42207110P 2010-12-10 2010-12-10
PCT/US2011/064009 WO2012078915A1 (en) 2010-12-10 2011-12-08 Macrocyclic inhibitors of flaviviridae viruses

Publications (1)

Publication Number Publication Date
MX2013006475A true MX2013006475A (es) 2013-11-01

Family

ID=45464097

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006475A MX2013006475A (es) 2010-12-10 2011-12-08 Inhibidores macrociclicos de virus flaviviridae.

Country Status (21)

Country Link
US (2) US8513184B2 (es)
EP (1) EP2649076B1 (es)
JP (1) JP5847193B2 (es)
KR (1) KR20140031841A (es)
CN (1) CN103403009B (es)
AR (1) AR084217A1 (es)
AU (1) AU2011338262B2 (es)
BR (1) BR112013014063A2 (es)
CA (1) CA2819824A1 (es)
EA (1) EA026114B1 (es)
ES (1) ES2536321T3 (es)
HK (1) HK1191000A1 (es)
IL (1) IL226739A (es)
MX (1) MX2013006475A (es)
NZ (1) NZ612159A (es)
PL (1) PL2649076T3 (es)
PT (1) PT2649076E (es)
SI (1) SI2649076T1 (es)
TW (1) TWI520966B (es)
UY (1) UY33775A (es)
WO (1) WO2012078915A1 (es)

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Also Published As

Publication number Publication date
CN103403009A (zh) 2013-11-20
PL2649076T3 (pl) 2015-08-31
EP2649076A1 (en) 2013-10-16
CA2819824A1 (en) 2012-06-14
US20140023616A1 (en) 2014-01-23
UY33775A (es) 2012-07-31
TW201307355A (zh) 2013-02-16
EP2649076B1 (en) 2015-03-04
EA201390822A1 (ru) 2013-12-30
US8933015B2 (en) 2015-01-13
US8513184B2 (en) 2013-08-20
CN103403009B (zh) 2016-01-13
WO2012078915A1 (en) 2012-06-14
AU2011338262B2 (en) 2016-12-15
US20130022573A1 (en) 2013-01-24
IL226739A (en) 2017-05-29
JP5847193B2 (ja) 2016-01-20
EA026114B1 (ru) 2017-03-31
HK1191000A1 (en) 2014-07-18
JP2014503516A (ja) 2014-02-13
NZ612159A (en) 2015-07-31
BR112013014063A2 (pt) 2016-09-13
AU2011338262A1 (en) 2013-07-11
SI2649076T1 (sl) 2015-07-31
ES2536321T3 (es) 2015-05-22
PT2649076E (pt) 2015-06-02
AR084217A1 (es) 2013-05-02
TWI520966B (zh) 2016-02-11
KR20140031841A (ko) 2014-03-13

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