EA201390822A1 - Макроциклические ингибиторы вирусов flaviviridae - Google Patents

Макроциклические ингибиторы вирусов flaviviridae

Info

Publication number
EA201390822A1
EA201390822A1 EA201390822A EA201390822A EA201390822A1 EA 201390822 A1 EA201390822 A1 EA 201390822A1 EA 201390822 A EA201390822 A EA 201390822A EA 201390822 A EA201390822 A EA 201390822A EA 201390822 A1 EA201390822 A1 EA 201390822A1
Authority
EA
Eurasian Patent Office
Prior art keywords
flaviviridae viruses
macrocyclic inhibitors
flaviviridae
macrocyclic
inhibitors
Prior art date
Application number
EA201390822A
Other languages
English (en)
Other versions
EA026114B1 (ru
Inventor
Тодд Эплбай
Ганс Г. Флири
Эндрю Дж. Китс
Линос Лазаридс
Ричард Л. Макман
Саймон Н. Петтит
Карин Г. Пулленнек
Джонатан Санвуасин
Виктория А. Стедман
Грегори М. Ватт
Original Assignee
Джилид Сайэнс, Инк.
Селсиа Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джилид Сайэнс, Инк., Селсиа Лимитед filed Critical Джилид Сайэнс, Инк.
Publication of EA201390822A1 publication Critical patent/EA201390822A1/ru
Publication of EA026114B1 publication Critical patent/EA026114B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid

Abstract

Предложены соединения формулы (I)и их фармацевтически приемлемые соли и сложные эфиры. Предложенные соединения, композиции и способы подходят для лечения вирусных инфекций Flaviviridaeв частности инфекций гепатита С.
EA201390822A 2010-12-10 2011-12-08 Макроциклические ингибиторы вирусов flaviviridae EA026114B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42207110P 2010-12-10 2010-12-10
PCT/US2011/064009 WO2012078915A1 (en) 2010-12-10 2011-12-08 Macrocyclic inhibitors of flaviviridae viruses

Publications (2)

Publication Number Publication Date
EA201390822A1 true EA201390822A1 (ru) 2013-12-30
EA026114B1 EA026114B1 (ru) 2017-03-31

Family

ID=45464097

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390822A EA026114B1 (ru) 2010-12-10 2011-12-08 Макроциклические ингибиторы вирусов flaviviridae

Country Status (21)

Country Link
US (2) US8513184B2 (ru)
EP (1) EP2649076B1 (ru)
JP (1) JP5847193B2 (ru)
KR (1) KR20140031841A (ru)
CN (1) CN103403009B (ru)
AR (1) AR084217A1 (ru)
AU (1) AU2011338262B2 (ru)
BR (1) BR112013014063A2 (ru)
CA (1) CA2819824A1 (ru)
EA (1) EA026114B1 (ru)
ES (1) ES2536321T3 (ru)
HK (1) HK1191000A1 (ru)
IL (1) IL226739A (ru)
MX (1) MX2013006475A (ru)
NZ (1) NZ612159A (ru)
PL (1) PL2649076T3 (ru)
PT (1) PT2649076E (ru)
SI (1) SI2649076T1 (ru)
TW (1) TWI520966B (ru)
UY (1) UY33775A (ru)
WO (1) WO2012078915A1 (ru)

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CA2819824A1 (en) 2012-06-14
WO2012078915A1 (en) 2012-06-14
SI2649076T1 (sl) 2015-07-31
PL2649076T3 (pl) 2015-08-31
CN103403009A (zh) 2013-11-20
ES2536321T3 (es) 2015-05-22
US8933015B2 (en) 2015-01-13
AU2011338262B2 (en) 2016-12-15
TWI520966B (zh) 2016-02-11
NZ612159A (en) 2015-07-31
KR20140031841A (ko) 2014-03-13
AU2011338262A1 (en) 2013-07-11
JP2014503516A (ja) 2014-02-13
BR112013014063A2 (pt) 2016-09-13
CN103403009B (zh) 2016-01-13
US20140023616A1 (en) 2014-01-23
US8513184B2 (en) 2013-08-20
MX2013006475A (es) 2013-11-01
EP2649076A1 (en) 2013-10-16
JP5847193B2 (ja) 2016-01-20
TW201307355A (zh) 2013-02-16
HK1191000A1 (en) 2014-07-18
EA026114B1 (ru) 2017-03-31
IL226739A (en) 2017-05-29
PT2649076E (pt) 2015-06-02
EP2649076B1 (en) 2015-03-04
US20130022573A1 (en) 2013-01-24
AR084217A1 (es) 2013-05-02
UY33775A (es) 2012-07-31

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