CN107074904B - 信号约束测序(scs)和用于信号约束测序的核苷酸类似物 - Google Patents
信号约束测序(scs)和用于信号约束测序的核苷酸类似物 Download PDFInfo
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- CN107074904B CN107074904B CN201580057628.8A CN201580057628A CN107074904B CN 107074904 B CN107074904 B CN 107074904B CN 201580057628 A CN201580057628 A CN 201580057628A CN 107074904 B CN107074904 B CN 107074904B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Abstract
Description
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201462067952P | 2014-10-23 | 2014-10-23 | |
US62/067,952 | 2014-10-23 | ||
PCT/US2015/057094 WO2016065248A1 (en) | 2014-10-23 | 2015-10-23 | Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing |
Publications (2)
Publication Number | Publication Date |
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CN107074904A CN107074904A (zh) | 2017-08-18 |
CN107074904B true CN107074904B (zh) | 2022-12-23 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201580057628.8A Active CN107074904B (zh) | 2014-10-23 | 2015-10-23 | 信号约束测序(scs)和用于信号约束测序的核苷酸类似物 |
Country Status (3)
Country | Link |
---|---|
US (1) | US10190162B2 (zh) |
CN (1) | CN107074904B (zh) |
WO (1) | WO2016065248A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016065248A1 (en) | 2014-10-23 | 2016-04-28 | Complete Genomics, Inc. | Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing |
PT3565905T (pt) | 2017-01-04 | 2022-08-02 | Mgi Tech Co Ltd | Sequenciação de ácidos nucleicos utilizando reagentes de afinidade |
CA3144531A1 (en) * | 2019-12-23 | 2021-07-01 | Illumina, Inc. | Nanoparticle with single site for template polynucleotide attachment |
CN114574571A (zh) * | 2022-05-05 | 2022-06-03 | 深圳铭毅智造科技有限公司 | 一种核苷酸衍生物及基因测序方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002044326A2 (en) * | 2000-11-30 | 2002-06-06 | Stratagene | Methods for detection of a target nucleic acid by capture |
CN101384729A (zh) * | 2003-02-05 | 2009-03-11 | 通用电气医疗集团生物科学公司 | 固相测序 |
WO2009100382A1 (en) * | 2008-02-07 | 2009-08-13 | Pacific Biosciences Of California, Inc. | Cis reactive oxygen quenchers integrated into linkers |
WO2009114182A1 (en) * | 2008-03-13 | 2009-09-17 | Pacific Biosciences Of California, Inc. | Labeled reactants and their uses |
WO2010117420A2 (en) * | 2009-03-30 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Fret-labeled compounds and uses therefor |
WO2012027625A2 (en) * | 2010-08-25 | 2012-03-01 | Pacific Biosciences Of California, Inc. | Scaffold-based polymerase enzyme substrates |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0541168T3 (da) | 1991-11-08 | 1998-05-11 | Merck & Co Inc | HIV-proteaseinhibitorer, som er egnede til behandling af AIDS |
ES2182847T3 (es) | 1993-09-29 | 2003-03-16 | Nabi | Nucleosidos y nucleotidos de anillo expandido. |
US6613560B1 (en) | 1994-10-19 | 2003-09-02 | Agilent Technologies, Inc. | PCR microreactor for amplifying DNA using microquantities of sample fluid |
US6232075B1 (en) | 1998-12-14 | 2001-05-15 | Li-Cor, Inc. | Heterogeneous assay for pyrophosphate detection |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
GB0013276D0 (en) | 2000-06-01 | 2000-07-26 | Amersham Pharm Biotech Uk Ltd | Nucleotide analogues |
JP3638516B2 (ja) | 2000-09-28 | 2005-04-13 | 株式会社日立製作所 | 核酸検出方法および核酸検出キット |
AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
GB0129012D0 (en) | 2001-12-04 | 2002-01-23 | Solexa Ltd | Labelled nucleotides |
DK3147292T3 (en) | 2002-08-23 | 2018-12-03 | Illumina Cambridge Ltd | LABELED NUCLEOTIDES |
US7414116B2 (en) | 2002-08-23 | 2008-08-19 | Illumina Cambridge Limited | Labelled nucleotides |
ES2407681T3 (es) | 2002-08-23 | 2013-06-13 | Illumina Cambridge Limited | Nucleótidos modificados para la secuenciación de polinucleótidos. |
US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
EP1671109A4 (en) | 2003-06-20 | 2007-09-19 | Univ California | ANALYSIS BY FLUORESCENCE WITH MODULATED EXCITATION |
ATE516026T1 (de) | 2005-02-21 | 2011-07-15 | Shionogi & Co | Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung |
US20070048773A1 (en) | 2005-07-29 | 2007-03-01 | Applera Corporation | Detection of polyphosphate using fluorescently labeled polyphosphate acceptor substrates |
GB0517097D0 (en) | 2005-08-19 | 2005-09-28 | Solexa Ltd | Modified nucleosides and nucleotides and uses thereof |
WO2007042407A1 (en) | 2005-10-13 | 2007-04-19 | Huntsman International Llc | Process for preparing a polyisocyanurate polyurethane material |
US8178360B2 (en) | 2006-05-18 | 2012-05-15 | Illumina Cambridge Limited | Dye compounds and the use of their labelled conjugates |
US8481259B2 (en) | 2007-02-05 | 2013-07-09 | Intelligent Bio-Systems, Inc. | Methods and devices for sequencing nucleic acids in smaller batches |
US7678894B2 (en) | 2007-05-18 | 2010-03-16 | Helicos Biosciences Corporation | Nucleotide analogs |
EP4310194A2 (en) | 2007-10-19 | 2024-01-24 | The Trustees of Columbia University in the City of New York | Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis |
US9115163B2 (en) | 2007-10-19 | 2015-08-25 | The Trustees Of Columbia University In The City Of New York | DNA sequence with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators |
US8623598B2 (en) | 2008-03-19 | 2014-01-07 | Intelligent Bio Systems, Inc. | Methods and compositions for inhibiting undesired cleaving of labels |
US9017973B2 (en) | 2008-03-19 | 2015-04-28 | Intelligent Biosystems, Inc. | Methods and compositions for incorporating nucleotides |
US20100035252A1 (en) | 2008-08-08 | 2010-02-11 | Ion Torrent Systems Incorporated | Methods for sequencing individual nucleic acids under tension |
WO2011038241A1 (en) | 2009-09-25 | 2011-03-31 | President And Fellows Of Harvard College | Nucleic acid amplification and sequencing by synthesis with fluorogenic nucleotides |
EP2523950B1 (en) | 2010-01-15 | 2017-03-15 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
CA2785563C (en) | 2010-01-15 | 2019-05-14 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
US9309569B2 (en) | 2010-08-26 | 2016-04-12 | Intelligent Bio-Systems, Inc. | Methods and compositions for sequencing nucleic acid using charge |
ES2641871T3 (es) | 2010-12-17 | 2017-11-14 | The Trustees Of Columbia University In The City Of New York | Secuenciación de ADN mediante síntesis usando nucleótidos modificados y detección con nanoporos |
US9624539B2 (en) | 2011-05-23 | 2017-04-18 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by synthesis using Raman and infrared spectroscopy detection |
SI3623481T1 (sl) | 2011-09-23 | 2022-01-31 | Illumina, Inc. | Sestavki za sekvenciranje nukleinske kisline |
WO2013154999A2 (en) | 2012-04-09 | 2013-10-17 | The Trustees Of Columbia University In The City Of New York | Method of preparation of nanopore and uses thereof |
US9551682B2 (en) | 2012-06-29 | 2017-01-24 | Intel Corporation | High throughput biochemical detection using single molecule fingerprinting arrays |
DK2964612T3 (en) | 2013-03-08 | 2017-04-03 | Illumina Cambridge Ltd | POLYMETHIN COMPOUNDS AND USE THEREOF AS FLUORESCING LABELS |
US8809551B1 (en) | 2013-03-08 | 2014-08-19 | Illumina Cambridge Limited | Polymethine compounds and their use as fluorescent labels |
US8754244B1 (en) | 2013-03-08 | 2014-06-17 | Illumina Cambridge Limited | Rhodamine compounds and their use as fluorescent labels |
EP2964624B1 (en) | 2013-03-08 | 2017-01-04 | Illumina Cambridge Limited | Rhodamine compounds and their use as fluorescent labels |
US20150152122A1 (en) | 2013-03-13 | 2015-06-04 | Avon Products, Inc. | Tyrosinase inhibitors |
DK2970356T3 (en) | 2013-03-15 | 2018-08-27 | Illumina Cambridge Ltd | Modified nucleosides or nucleotides |
WO2014144883A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Raman cluster tagged molecules for biological imaging |
CA2820501C (en) | 2013-06-27 | 2021-01-26 | Nova Chemicals Corporation | Synthesis of phosphinimide coordination compounds |
JP2015023123A (ja) | 2013-07-18 | 2015-02-02 | カーリットホールディングス株式会社 | 固体電解コンデンサの製造方法 |
GB2516303A (en) | 2013-07-18 | 2015-01-21 | Redx Pharma Ltd | Compounds |
EP2830125B9 (de) | 2013-07-22 | 2016-12-21 | Sihl GmbH | Separator für elektrochemische Zelle und Verfahren zu seiner Herstellung |
FR3008709B1 (fr) | 2013-07-22 | 2016-07-01 | Inst Nat De Rech En Sciences Et Tech Pour L'environnement Et L'agriculture (Irstea) | Hydrate semi-clathrate mixte, son procede de preparation et dispositif de stockage d'energie thermique |
WO2015013715A2 (en) | 2013-07-26 | 2015-01-29 | Thr Regents Of The University Of California | C-h fluorination of heterocycles with silver (ii) fluoride |
JP6437187B2 (ja) | 2013-07-26 | 2018-12-12 | 関東化學株式会社 | 光学活性2級アルコールの製造方法 |
DE202013010956U1 (de) | 2013-09-13 | 2014-12-17 | Ewh Industrieanlagen Gmbh & Co. Kg | Behandlungslösung für ein Verfahren zum Erzeugen einer korrosionsschützenden Überzugsschicht und Konzentrat einer solchen Behandlungslösung |
RU2540089C1 (ru) | 2013-10-15 | 2015-01-27 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | Способ получения 1-этил-3-[(оксифенил)метил]алюминациклопентанов |
CN103866010B (zh) | 2014-02-28 | 2016-04-20 | 郭诚 | 一种基因测序的方法 |
WO2016065248A1 (en) | 2014-10-23 | 2016-04-28 | Complete Genomics, Inc. | Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing |
-
2015
- 2015-10-23 WO PCT/US2015/057094 patent/WO2016065248A1/en active Application Filing
- 2015-10-23 US US14/921,466 patent/US10190162B2/en active Active
- 2015-10-23 CN CN201580057628.8A patent/CN107074904B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002044326A2 (en) * | 2000-11-30 | 2002-06-06 | Stratagene | Methods for detection of a target nucleic acid by capture |
CN101384729A (zh) * | 2003-02-05 | 2009-03-11 | 通用电气医疗集团生物科学公司 | 固相测序 |
WO2009100382A1 (en) * | 2008-02-07 | 2009-08-13 | Pacific Biosciences Of California, Inc. | Cis reactive oxygen quenchers integrated into linkers |
WO2009114182A1 (en) * | 2008-03-13 | 2009-09-17 | Pacific Biosciences Of California, Inc. | Labeled reactants and their uses |
WO2010117420A2 (en) * | 2009-03-30 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Fret-labeled compounds and uses therefor |
WO2012027625A2 (en) * | 2010-08-25 | 2012-03-01 | Pacific Biosciences Of California, Inc. | Scaffold-based polymerase enzyme substrates |
Also Published As
Publication number | Publication date |
---|---|
CN107074904A (zh) | 2017-08-18 |
US10190162B2 (en) | 2019-01-29 |
US20160130647A1 (en) | 2016-05-12 |
WO2016065248A1 (en) | 2016-04-28 |
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Effective date of registration: 20191024 Address after: 2 Floor, 11 Building, Beishan Industrial Zone, 146 Beishan Road, Yantian District, Shenzhen City, Guangdong Province Applicant after: BGI SHENZHEN Co.,Ltd. Address before: California, USA Applicant before: COMPLETE GENOMICS, Inc. Effective date of registration: 20191024 Address after: 518083 comprehensive building of Beishan industrial zone and 11 Building 2, Yantian District, Guangdong, Shenzhen Applicant after: MGI TECH Co.,Ltd. Address before: 518083 2 building, Beishan Industrial Zone, 146 Beishan Road, Yantian District, Shenzhen, Guangdong, China, 11 Applicant before: BGI SHENZHEN Co.,Ltd. |
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Address after: 518083 the comprehensive building of Beishan industrial zone and 11 2 buildings in Yantian District, Shenzhen, Guangdong. Applicant after: Shenzhen Huada Zhizao Technology Co.,Ltd. Address before: 518083 the comprehensive building of Beishan industrial zone and 11 2 buildings in Yantian District, Shenzhen, Guangdong. Applicant before: MGI TECH Co.,Ltd. |
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