ATE516026T1 - Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung - Google Patents
Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkungInfo
- Publication number
- ATE516026T1 ATE516026T1 AT06714066T AT06714066T ATE516026T1 AT E516026 T1 ATE516026 T1 AT E516026T1 AT 06714066 T AT06714066 T AT 06714066T AT 06714066 T AT06714066 T AT 06714066T AT E516026 T1 ATE516026 T1 AT E516026T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- hiv integrase
- bicyclic
- hydrogen
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005043310 | 2005-02-21 | ||
JP2005131161 | 2005-04-28 | ||
JP2005312076 | 2005-10-27 | ||
PCT/JP2006/302925 WO2006088173A1 (ja) | 2005-02-21 | 2006-02-20 | Hivインテグラーゼ阻害活性を有する2環性カルバモイルピリドン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE516026T1 true ATE516026T1 (de) | 2011-07-15 |
Family
ID=36916569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06714066T ATE516026T1 (de) | 2005-02-21 | 2006-02-20 | Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung |
Country Status (5)
Country | Link |
---|---|
US (1) | US7858788B2 (de) |
EP (1) | EP1852434B1 (de) |
JP (1) | JP5317257B2 (de) |
AT (1) | ATE516026T1 (de) |
WO (1) | WO2006088173A1 (de) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200510425A (en) * | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
US7550463B2 (en) * | 2004-09-15 | 2009-06-23 | Shionogi & Co., Ltd. | Carbamoylpyridone derivatives having inhibitory activity against HIV integrase |
MX302718B (es) | 2005-04-28 | 2012-08-27 | Smithkline Beecham Corp | Derivado de carbamoilpiridona policiclico que tiene actividad inhibidora de la integrasa de hiv. |
JP5131689B2 (ja) | 2005-10-27 | 2013-01-30 | 塩野義製薬株式会社 | Hivインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体 |
AU2007313293A1 (en) * | 2006-10-18 | 2008-04-24 | Merck & Co., Inc. | HIV integrase inhibitors |
RS52557B (en) | 2008-02-06 | 2013-04-30 | Pulmagen Therapeutics (Synergy) Limited | UNITS |
EP2320908B9 (de) * | 2008-07-25 | 2014-06-18 | VIIV Healthcare Company | Prodrugs von Dolutegravir |
ES2607403T3 (es) | 2008-07-25 | 2017-03-31 | Shionogi & Co., Ltd. | Compuestos químicos como intermedios sintéticos |
WO2010011815A1 (en) * | 2008-07-25 | 2010-01-28 | Smithkline Beecham Corporation | Chemical compounds |
SG171308A1 (en) | 2008-12-11 | 2011-07-28 | Shionogi & Co | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
SG171731A1 (en) | 2008-12-11 | 2011-07-28 | Glaxosmithkline Llc | Processes and intermediates for carbamoylpyridone hiv integrase inhibitors |
TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
US8835461B2 (en) | 2009-03-26 | 2014-09-16 | Shionogi & Co., Ltd. | Substituted 3-hydroxy-4-pyridone derivative |
RS57244B1 (sr) * | 2009-06-15 | 2018-07-31 | Shionogi & Co | Supstituisani policiklički derivati karbamoilpiridona |
GB0913342D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
WO2011105590A1 (ja) | 2010-02-26 | 2011-09-01 | 日本たばこ産業株式会社 | 1,3,4,8-テトラヒドロ-2H-ピリド[1,2-a]ピラジン誘導体及びそのHIVインテグラーゼ阻害剤としての利用 |
TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
JP5766690B2 (ja) | 2010-04-12 | 2015-08-19 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有するピリドン誘導体 |
JP5636054B2 (ja) | 2010-08-05 | 2014-12-03 | 塩野義製薬株式会社 | Hivインテグラーゼ阻害活性を有する化合物の製造方法 |
LT2620436T (lt) * | 2010-09-24 | 2018-08-10 | Shionogi & Co., Ltd. | Pakeistojo policiklinio karbamoilpiridono darinio provaistas |
EP2797597B1 (de) | 2011-12-28 | 2020-02-26 | Global Blood Therapeutics, Inc. | Substituierte heteroarylaldehydverbindungen und verfahren zu deren verwendung bei der erhöhung einer gewebeoxigenierung |
JP6242810B2 (ja) | 2011-12-28 | 2017-12-06 | グローバル・ブラッド・セラピューティクス・インコーポレイテッドGlobal Blood Therapeutics,Inc. | 置換ベンズアルデヒド化合物および組織酸素化の増加におけるそれらの使用方法 |
BR112014020416B1 (pt) | 2012-03-28 | 2022-03-29 | Fujifilm Corporation | Cristal de 1-(2-desoxi-2-flúor-4-tio-ß-darabinofuranosil)citosina e composição farmacêutica contendo o referido cristal |
SI2883866T1 (sl) | 2012-08-13 | 2019-07-31 | Fujifilm Corporation | INTERMEDIAT ZA SINTEZO 1-(2-DEOKSI-2-FLUORO-4-TIO-beta-D-ARABINOFURANOZIL) CITOZINA, INTERMEDIAT ZA SINTEZO TIONUKLEOZIDA, IN POSTOPKI ZA PROIZVODNJO TEH INTERMEDIATOV |
KR102040007B1 (ko) | 2012-12-21 | 2019-11-05 | 길리애드 사이언시즈, 인코포레이티드 | 폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도 |
JP6320039B2 (ja) | 2012-12-27 | 2018-05-09 | 日本たばこ産業株式会社 | 置換されたスピロピリド[1,2−a]ピラジン誘導体及びそのHIVインテグラーゼ阻害剤としての医薬用途 |
KR20190041548A (ko) | 2013-03-15 | 2019-04-22 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
US20160083343A1 (en) | 2013-03-15 | 2016-03-24 | Global Blood Therapeutics, Inc | Compounds and uses thereof for the modulation of hemoglobin |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
MX2015011769A (es) | 2013-03-15 | 2016-06-02 | Global Blood Therapeutics Inc | Compuestos y sus usos para modular la hemoglobina. |
NO2865735T3 (de) | 2013-07-12 | 2018-07-21 | ||
ES2645192T3 (es) | 2013-07-12 | 2017-12-04 | Gilead Sciences, Inc. | Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH |
MA38922A3 (fr) * | 2013-09-27 | 2018-11-30 | Merck Sharp & Dohme | Dérivés de quinolizine substitués utiles en tant qu'inhibiteurs de l'integrase du vih |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
WO2015089847A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrase inhibitors |
EA028529B1 (ru) | 2014-02-07 | 2017-11-30 | Глобал Блад Терапьютикс, Инк. | Кристаллические полиморфные формы свободного основания 2-гидрокси-6-((2-(1-изопропил-1н-пиразол-5-ил)пиридин-3-ил)метокси)бензальдегида |
EP3109245B1 (de) | 2014-02-18 | 2018-01-03 | FUJIFILM Corporation | Verfahren zur herstellung eines thiolanskelettartigen glycokonjugats und thiolanskelettartiges glycokonjugat |
TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
NO2717902T3 (de) | 2014-06-20 | 2018-06-23 | ||
TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
CN107074904B (zh) | 2014-10-23 | 2022-12-23 | 深圳华大智造科技股份有限公司 | 信号约束测序(scs)和用于信号约束测序的核苷酸类似物 |
TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
WO2016090545A1 (en) * | 2014-12-09 | 2016-06-16 | Merck Sharp & Dohme Corp. | Spirocyclic heterocycle compounds useful as hiv integrate inhibitors |
TWI738321B (zh) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
EP3253767A2 (de) * | 2015-02-06 | 2017-12-13 | Mylan Laboratories Ltd. | Verfahren zur herstellung von dolutegravir |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
EP3736274A1 (de) * | 2015-04-02 | 2020-11-11 | Gilead Sciences, Inc. | Polycyclische carbamoylpyridonverbindungen und deren pharmazeutische verwendung |
EP3377066B1 (de) | 2015-11-17 | 2021-04-07 | Merck Sharp & Dohme Corp. | Amidosubstituierte pyridotriazinderivate als hiv-integrase-hemmer |
EP3377065B1 (de) * | 2015-11-17 | 2022-05-18 | Merck Sharp & Dohme Corp. | Spirocyclische pyridotriazinderivate zur verwendung als hiv-integrase-inhibitoren |
TW201731509A (zh) | 2015-12-04 | 2017-09-16 | 全球血液治療公司 | 針對2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之劑量方案 |
TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
KR102198656B1 (ko) | 2016-08-31 | 2021-01-05 | 후지필름 가부시키가이샤 | 항종양제, 항종양 효과 증강제 및 항종양용 키트 |
WO2018057408A1 (en) * | 2016-09-21 | 2018-03-29 | Merck Sharp & Dohme Corp. | Drug delivery system for the delivery of integrase inhibitors |
TWI778983B (zh) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
AU2018404329B2 (en) | 2018-01-29 | 2021-09-09 | Fujifilm Corporation | Antitumor agent for biliary tract cancer and method for treating biliary tract cancer |
TWI820141B (zh) * | 2018-05-31 | 2023-11-01 | 日商鹽野義製藥股份有限公司 | 衍生物 |
CA3102063A1 (en) | 2018-05-31 | 2019-12-05 | Shionogi & Co., Ltd. | Polycyclic carbamoylpyridone derivative |
CR20200645A (es) | 2018-05-31 | 2021-02-05 | Shionogi & Co | Derivado policiclíco de piridona |
EP3860975B1 (de) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulatoren von hämoglobin zur behandlung von sichelzellenanämie |
TW202204356A (zh) * | 2019-03-22 | 2022-02-01 | 美商基利科學股份有限公司 | 橋鍵聯三環胺甲醯吡啶酮化合物及其醫藥用途 |
TW202133858A (zh) | 2019-11-28 | 2021-09-16 | 日商鹽野義製藥股份有限公司 | 以組合整合酶阻礙劑及抗hiv藥為特徵之hiv感染症的預防及治療用醫藥 |
WO2021173522A1 (en) | 2020-02-24 | 2021-09-02 | Gilead Sciences, Inc. | Tetracyclic compounds for treating hiv infection |
WO2022079739A1 (en) | 2020-10-14 | 2022-04-21 | Cipla Limited | Fixed dose compositions of cabotegravir and rilpivirine |
EP4321217A3 (de) | 2021-01-19 | 2024-04-10 | Gilead Sciences, Inc. | Substituierte pyridotriazinverbindungen und verwendungen davon |
WO2023006087A1 (zh) * | 2021-07-30 | 2023-02-02 | 南京明德新药研发有限公司 | 大环吡啶酮类化合物及其应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0296506A (ja) | 1988-09-30 | 1990-04-09 | Daicel Chem Ind Ltd | 除草剤組成物 |
JP2533796B2 (ja) | 1988-10-18 | 1996-09-11 | ダイセル化学工業株式会社 | 5−アルコキシピリジン−3−カルボキサミド誘導体とその製造方法及び植物成長抑制剤 |
JP2551472B2 (ja) | 1988-10-18 | 1996-11-06 | ダイセル化学工業株式会社 | 5−アルコキシ−γ−ピロン−3−カルボキサミド誘導体とその製造方法及び植物成長抑制剤 |
PL360944A1 (en) * | 2000-10-12 | 2004-09-20 | Merck & Co, Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
DE60128936T2 (de) * | 2000-10-12 | 2008-04-10 | Merck & Co, Inc. | Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer |
JP2003032772A (ja) | 2001-07-12 | 2003-01-31 | Foster Electric Co Ltd | 耳掛け式イヤホン |
KR100907852B1 (ko) | 2001-07-31 | 2009-07-14 | 카오카부시키가이샤 | 중공 섬유 성형체의 제조방법, 중공 섬유 성형체 및 그제조장치 |
KR100977701B1 (ko) * | 2001-08-10 | 2010-08-24 | 시오노기세이야쿠가부시키가이샤 | 항바이러스제 |
ATE355064T1 (de) | 2001-10-26 | 2006-03-15 | Angeletti P Ist Richerche Bio | Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase |
US7109186B2 (en) * | 2002-07-09 | 2006-09-19 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
DE60322920D1 (de) * | 2002-08-13 | 2008-09-25 | Shionogi & Co | Heterocyclische verbindungen mit hiv-integrase-hemmender wirkung |
WO2004024078A2 (en) * | 2002-09-11 | 2004-03-25 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors |
AU2003292436B2 (en) * | 2002-12-27 | 2009-07-30 | Msd Italia S.R.L. | Tetrahydro-4H-pyrido[1,2-A]pyrimidines and related compounds useful as HIV integrase inhibitors |
JP2004244320A (ja) | 2003-02-10 | 2004-09-02 | Shionogi & Co Ltd | 含窒素複素環抗ウイルス剤 |
TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
EP1973906A1 (de) * | 2004-12-23 | 2008-10-01 | Virochem Pharma Inc. | Hydroxydihydropyridopyrazin-1,8-dione und verfahren zur inhibierung von hiv-integrase |
-
2006
- 2006-02-20 JP JP2007503763A patent/JP5317257B2/ja not_active Expired - Fee Related
- 2006-02-20 AT AT06714066T patent/ATE516026T1/de not_active IP Right Cessation
- 2006-02-20 WO PCT/JP2006/302925 patent/WO2006088173A1/ja active Application Filing
- 2006-02-20 US US11/884,686 patent/US7858788B2/en not_active Expired - Fee Related
- 2006-02-20 EP EP06714066A patent/EP1852434B1/de not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
EP1852434B1 (de) | 2011-07-13 |
JP5317257B2 (ja) | 2013-10-16 |
US7858788B2 (en) | 2010-12-28 |
JPWO2006088173A1 (ja) | 2008-07-03 |
EP1852434A1 (de) | 2007-11-07 |
EP1852434A4 (de) | 2010-01-13 |
US20080161271A1 (en) | 2008-07-03 |
WO2006088173A1 (ja) | 2006-08-24 |
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