PE20201414A1 - Derivado policiclico de piridona - Google Patents

Derivado policiclico de piridona

Info

Publication number
PE20201414A1
PE20201414A1 PE2020001864A PE2020001864A PE20201414A1 PE 20201414 A1 PE20201414 A1 PE 20201414A1 PE 2020001864 A PE2020001864 A PE 2020001864A PE 2020001864 A PE2020001864 A PE 2020001864A PE 20201414 A1 PE20201414 A1 PE 20201414A1
Authority
PE
Peru
Prior art keywords
substituted
ring
unsubstituted
alkyl
unsubstituted non
Prior art date
Application number
PE2020001864A
Other languages
English (en)
Inventor
Yoshiyuki Taoda
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of PE20201414A1 publication Critical patent/PE20201414A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Abstract

La presente invencion se refiere a un compuesto de formula I o una sal farmaceuticamente aceptable del mismo, caracterizado porque: el anillo A es un heterociclo no aromatico sustituido o no sustituido; el anillo C es un anillo de benceno o un anillo de piridina; Q es un heterociclo aromatico de 5 o 6 miembros opcionalmente sustituido con halogeno, alquilo, halolalquilo, entre otros; R1 es halogeno, alquilo, haloalquilo, entre otros; L es alquileno sustituido o no sustituido; R3 es alquilo sustituido o no sustituido, carbociclilo no aromatico sustituido o no sustituido o heterociclilo no aromatico sustituido o no sustituido; R4 es hidrogeno o alquilo sustituido o no sustituido; R4 y R4, o R3 y un sustituyente en el anillo A pueden tomarse junto con los atomos adyacentes para formar un heterociclo no aromatico sustituido o no sustituido; y n es un numero entero de 1 a 3. Tambien se refiere a una composicion farmaceutica que lo contiene. Dicho compuesto es un derivado policiclico de piridona, el cual inhibe la integrasa del virus de la inmunodeficiencia humana (VIH), siendo util en el tratamiento de una infeccion por VIH.
PE2020001864A 2018-05-31 2019-05-30 Derivado policiclico de piridona PE20201414A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018104160 2018-05-31
PCT/JP2019/021445 WO2019230857A1 (ja) 2018-05-31 2019-05-30 多環性ピリドン誘導体

Publications (1)

Publication Number Publication Date
PE20201414A1 true PE20201414A1 (es) 2020-12-07

Family

ID=68698906

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020001864A PE20201414A1 (es) 2018-05-31 2019-05-30 Derivado policiclico de piridona

Country Status (21)

Country Link
US (1) US11453669B2 (es)
EP (1) EP3805221A4 (es)
JP (1) JP7353707B2 (es)
KR (1) KR20210018324A (es)
CN (1) CN112533922B (es)
AU (1) AU2019277547A1 (es)
BR (1) BR112020024098A2 (es)
CA (1) CA3101950A1 (es)
CL (1) CL2020002987A1 (es)
CO (1) CO2020014296A2 (es)
CR (1) CR20200645A (es)
DO (1) DOP2020000222A (es)
EA (1) EA202092923A1 (es)
IL (1) IL279050A (es)
MA (1) MA52802A (es)
MX (1) MX2020012185A (es)
PE (1) PE20201414A1 (es)
PH (1) PH12020551999A1 (es)
SG (1) SG11202011386QA (es)
WO (1) WO2019230857A1 (es)
ZA (1) ZA202007568B (es)

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BR112020024077A2 (pt) 2018-05-31 2021-02-09 Shionogi & Co., Ltd. derivado de carbamoilpiridona policíclica
WO2020197991A1 (en) 2019-03-22 2020-10-01 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
JPWO2021107066A1 (es) * 2019-11-28 2021-06-03
JPWO2021107065A1 (es) * 2019-11-28 2021-06-03
CA3166480A1 (en) 2020-02-24 2021-09-02 Lan Jiang Tetracyclic compounds for treating hiv infection
CN115667270A (zh) * 2020-05-21 2023-01-31 辰欣药业股份有限公司 稠环衍生物及其在药学上的应用
PE20231297A1 (es) 2021-01-19 2023-08-22 Gilead Sciences Inc Compuestos de piridotriazina sustituidos y usos de estos
WO2023018913A1 (en) * 2021-08-11 2023-02-16 Merck Sharp & Dohme Llc Polycyclic cap-dependent endonuclease inhibitors for treating or preventing influenza

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WO2004058757A1 (en) 2002-12-27 2004-07-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
WO2006088173A1 (ja) 2005-02-21 2006-08-24 Shionogi & Co., Ltd. Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体
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Also Published As

Publication number Publication date
CO2020014296A2 (es) 2020-12-21
MX2020012185A (es) 2021-01-29
EA202092923A1 (ru) 2021-04-09
WO2019230857A1 (ja) 2019-12-05
EP3805221A4 (en) 2022-01-05
DOP2020000222A (es) 2021-03-15
US11453669B2 (en) 2022-09-27
CN112533922A (zh) 2021-03-19
KR20210018324A (ko) 2021-02-17
CN112533922B (zh) 2024-03-22
AU2019277547A1 (en) 2021-01-14
SG11202011386QA (en) 2020-12-30
US20210155622A1 (en) 2021-05-27
IL279050A (en) 2021-01-31
PH12020551999A1 (en) 2021-09-27
CL2020002987A1 (es) 2021-04-16
EP3805221A1 (en) 2021-04-14
BR112020024098A2 (pt) 2021-02-17
CA3101950A1 (en) 2019-12-05
ZA202007568B (en) 2022-04-28
MA52802A (fr) 2021-04-14
JPWO2019230857A1 (ja) 2021-06-24
CR20200645A (es) 2021-02-05
JP7353707B2 (ja) 2023-10-02

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