PE20231297A1 - Compuestos de piridotriazina sustituidos y usos de estos - Google Patents
Compuestos de piridotriazina sustituidos y usos de estosInfo
- Publication number
- PE20231297A1 PE20231297A1 PE2023002101A PE2023002101A PE20231297A1 PE 20231297 A1 PE20231297 A1 PE 20231297A1 PE 2023002101 A PE2023002101 A PE 2023002101A PE 2023002101 A PE2023002101 A PE 2023002101A PE 20231297 A1 PE20231297 A1 PE 20231297A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- alkyloxy
- compounds
- haloalkyl
- Prior art date
Links
- HHQDNOXLJMIISM-UHFFFAOYSA-N pyrido[3,2-d]triazine Chemical class C1=NN=NC2=CC=CN=C21 HHQDNOXLJMIISM-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 3
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 102220632799 Immunoglobulin heavy variable 1-69_R11A_mutation Human genes 0.000 abstract 1
- 102220495208 NAD(P)H pyrophosphatase NUDT13, mitochondrial_R12A_mutation Human genes 0.000 abstract 1
- 102220495705 NAD(P)H pyrophosphatase NUDT13, mitochondrial_R13A_mutation Human genes 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente descripcion se refiere a compuestos triciclicos de Formula I, donde Ar es arilo C6-C10 o heteroarilo de seis a diez miembros que contiene uno, dos o tres heteroatomos seleccionados de N, O, y S; en donde el arilo C6-C10 o heteroarilo de seis a diez miembros esta opcionalmente sustituido con 1-4 sustituyentes seleccionados independientemente del grupo que consiste en halogeno, alquilo C1-C6, haloalquilo C1-C6, y alquiloxi C1-C6; R1 es H, alquilo C1-C3 o fenilo; R2 es H o alquilo C1-C3; R3 es H o alquilo C1-C3; R4 y R5 son H, halogeno, ciano, alquilo C1-C6, alquiloxi C1-C6, arilo C6-C10, entre otros; R6 es H, halogeno, alquilo C1-C6, alquiloxi C1-C6 o haloalquilo C1-C6; R7 es H, halogeno, alquilo C1-C6, alquiloxi C1-C6, o haloalquilo C1-C6; R8A y R8B son H, alquilo C1-C3 o bencilo; y -X-Y- es -(CR13AR13B)p-CR9=CR10-, - o -(CR13AR13B)q-CR11AR11BCR12AR12B-; en donde R9 es H, halogeno, alquilo C1-C6, haloalquilo C1-C6 o alquiloxi C1-C6; R10 es H, halogeno, alquilo C1-C6, entre otros; R11A, R11B, R12A, R12B, R13A, y R13B son H, halogeno, alquilo C1-C6, alquiloxi C1-C6, entre otros; p es 0 o 1; q es 0 o 1. Tambien esta referida composiciones farmaceuticas que comprenden dichos compuestos y metodos para preparar dichos compuestos y composiciones farmaceuticas. Los compuestos de la descripcion son utiles para tratar o prevenir la infeccion por el virus de inmunodeficiencia humana (VIH).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163139237P | 2021-01-19 | 2021-01-19 | |
| US202163190461P | 2021-05-19 | 2021-05-19 | |
| PCT/US2022/012773 WO2022159387A1 (en) | 2021-01-19 | 2022-01-18 | Substituted pyridotriazine compounds and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20231297A1 true PE20231297A1 (es) | 2023-08-22 |
Family
ID=80514578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023002101A PE20231297A1 (es) | 2021-01-19 | 2022-01-18 | Compuestos de piridotriazina sustituidos y usos de estos |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11613546B2 (es) |
| EP (2) | EP4196479B1 (es) |
| JP (1) | JP2024503116A (es) |
| KR (1) | KR20230134529A (es) |
| AU (1) | AU2022210247A1 (es) |
| CA (1) | CA3202957A1 (es) |
| CL (1) | CL2023002074A1 (es) |
| CO (1) | CO2023009518A2 (es) |
| CR (1) | CR20230315A (es) |
| DK (1) | DK4196479T3 (es) |
| DO (1) | DOP2023000139A (es) |
| ES (1) | ES2968058T3 (es) |
| FI (1) | FI4196479T3 (es) |
| HR (1) | HRP20231654T1 (es) |
| HU (1) | HUE064467T2 (es) |
| IL (1) | IL304222A (es) |
| LT (1) | LT4196479T (es) |
| MX (1) | MX2023008137A (es) |
| PE (1) | PE20231297A1 (es) |
| PL (1) | PL4196479T3 (es) |
| PT (1) | PT4196479T (es) |
| SI (1) | SI4196479T1 (es) |
| TW (1) | TWI824384B (es) |
| WO (1) | WO2022159387A1 (es) |
| ZA (1) | ZA202306360B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2023008137A (es) | 2021-01-19 | 2023-07-21 | Gilead Sciences Inc | Compuestos de piridotriazina sustituidos y usos de estos. |
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| JP2024503116A (ja) | 2024-01-24 |
| EP4196479B1 (en) | 2023-11-01 |
| ES2968058T3 (es) | 2024-05-07 |
| CA3202957A1 (en) | 2022-07-28 |
| PL4196479T3 (pl) | 2024-03-18 |
| HUE064467T2 (hu) | 2024-03-28 |
| FI4196479T3 (fi) | 2024-01-17 |
| HRP20231654T1 (hr) | 2024-03-15 |
| IL304222A (en) | 2023-09-01 |
| EP4196479A1 (en) | 2023-06-21 |
| WO2022159387A1 (en) | 2022-07-28 |
| CL2023002074A1 (es) | 2024-01-12 |
| PT4196479T (pt) | 2024-01-03 |
| TWI824384B (zh) | 2023-12-01 |
| CR20230315A (es) | 2023-09-01 |
| KR20230134529A (ko) | 2023-09-21 |
| MX2023008137A (es) | 2023-07-21 |
| LT4196479T (lt) | 2023-12-11 |
| DOP2023000139A (es) | 2023-08-15 |
| AU2022210247A1 (en) | 2023-08-17 |
| EP4321217A3 (en) | 2024-04-10 |
| DK4196479T3 (da) | 2024-01-22 |
| US11613546B2 (en) | 2023-03-28 |
| US11897892B2 (en) | 2024-02-13 |
| TW202237128A (zh) | 2022-10-01 |
| SI4196479T1 (sl) | 2024-01-31 |
| AU2022210247A9 (en) | 2024-05-09 |
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| US20220267343A1 (en) | 2022-08-25 |
| US20230257389A1 (en) | 2023-08-17 |
| ZA202306360B (en) | 2024-04-24 |
| EP4321217A2 (en) | 2024-02-14 |
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