PE20220808A1 - Derivados de benzisoxazol sulfonamida - Google Patents

Derivados de benzisoxazol sulfonamida

Info

Publication number
PE20220808A1
PE20220808A1 PE2021002180A PE2021002180A PE20220808A1 PE 20220808 A1 PE20220808 A1 PE 20220808A1 PE 2021002180 A PE2021002180 A PE 2021002180A PE 2021002180 A PE2021002180 A PE 2021002180A PE 20220808 A1 PE20220808 A1 PE 20220808A1
Authority
PE
Peru
Prior art keywords
alkyl
halogen
membered heteroaryl
sulfonamide derivatives
methoxy
Prior art date
Application number
PE2021002180A
Other languages
English (en)
Inventor
Ylva Elisabet Bergman Bozikis
Oleg Brodsky
Michelle Ang Camerino
Samantha Elizabeth Greasley
Robert Louis Hoffman
Robert Arnold Kumpf
Pei-Pei Kung
Paul Francis Richardson
Paul Anthony Stupple
Scott Channing Sutton
Original Assignee
Pfizer
Ctxt Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Ctxt Pty Ltd filed Critical Pfizer
Publication of PE20220808A1 publication Critical patent/PE20220808A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Referido a un compuesto de la Formula I, o una sal farmaceuticamente aceptable del mismo, en donde R1 es un H o heteroarilo de 5-6 miembros opcionalmente sustituido por metilo; R2 es un H o -(CHR8)n-(heteroarilo de 5-9 miembros) opcionalmente sustituido por halogeno, alquilo de C1-C3, entre otros; R3 es H, halogeno, alquilo de C1-C3, entre otros; R4 es H, halogeno, alquilo de C1-C3, ciclopropilo, entre otros; Anillo A es arilo de C6-C10 o heteroarilo de 9-10 miembros; R5 es H, fluor, ciano, alquilo de C1-C3, entre otros; R6 es H, fluor, metilo, -OH, o metoxi; R7 es H, bromo, cloro, fluor, o metoxi; R8 es un H o -OH; y n es 0 o 1. Estos compuestos son derivados de benzisoxazol sulfonamida actuan como inhibidores de Lisina Acetil Transferasa (KAT) y son utiles para el tratamiento de crecimiento celular anormal, tal como cancer. Tambien se refiere a una composicion farmaceutica que comprende dicho compuesto, y un portador farmaceuticamente aceptable o diluyente.
PE2021002180A 2019-06-18 2020-06-16 Derivados de benzisoxazol sulfonamida PE20220808A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962863199P 2019-06-18 2019-06-18
US201962953223P 2019-12-24 2019-12-24
US202063025278P 2020-05-15 2020-05-15
PCT/IB2020/055589 WO2020254946A1 (en) 2019-06-18 2020-06-16 Benzisoxazole sulfonamide derivatives

Publications (1)

Publication Number Publication Date
PE20220808A1 true PE20220808A1 (es) 2022-05-20

Family

ID=71738189

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2021002180A PE20220808A1 (es) 2019-06-18 2020-06-16 Derivados de benzisoxazol sulfonamida

Country Status (29)

Country Link
US (2) US11492346B2 (es)
EP (2) EP3986890B1 (es)
JP (2) JP7352662B2 (es)
KR (1) KR20220024671A (es)
CN (1) CN114364672A (es)
AU (2) AU2020296361A1 (es)
BR (1) BR112021025528A2 (es)
CA (1) CA3143666A1 (es)
CL (1) CL2021003372A1 (es)
CO (1) CO2021017504A2 (es)
CR (1) CR20210627A (es)
DK (1) DK3986890T3 (es)
EC (1) ECSP21091615A (es)
ES (1) ES2969616T3 (es)
FI (1) FI3986890T3 (es)
HR (1) HRP20231501T1 (es)
HU (1) HUE064683T2 (es)
IL (1) IL288802A (es)
LT (1) LT3986890T (es)
MD (1) MD3986890T2 (es)
MX (1) MX2021016085A (es)
PE (1) PE20220808A1 (es)
PL (1) PL3986890T3 (es)
PT (1) PT3986890T (es)
RS (1) RS64931B1 (es)
SI (1) SI3986890T1 (es)
TW (1) TWI787620B (es)
UY (1) UY38752A (es)
WO (1) WO2020254946A1 (es)

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GB201810092D0 (en) * 2018-06-20 2018-08-08 Ctxt Pty Ltd Compounds
MX2021014441A (es) 2019-05-31 2022-01-06 Ikena Oncology Inc Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
LT3986890T (lt) * 2019-06-18 2023-12-11 Pfizer Inc. Benzizoksazolo sulfonamido dariniai
JP2022019654A (ja) * 2020-07-15 2022-01-27 ファイザー・インク がん処置のためのｋａｔ６阻害剤方法および組合せ
WO2022187688A1 (en) * 2021-03-05 2022-09-09 Umbra Therapeutics Inc. Covalent kras-binding compounds for therapeutic purposes
WO2022187693A1 (en) * 2021-03-05 2022-09-09 Umbra Therapeutics Inc. Covalent cdk2-binding compounds for therapeutic purposes
CN117881677A (zh) * 2021-05-21 2024-04-12 奥瑞基尼肿瘤有限公司 作为KAT6Aw抑制剂的稠合异噁唑基化合物
EP4368620A1 (en) * 2021-07-05 2024-05-15 Hangzhou Innogate Pharma Co., Ltd. Compound serving as kat6 inhibitor
CA3228411A1 (en) 2021-08-10 2023-02-16 Xiaomin Zhang Sulfonamide derivative, preparation method therefor and medical use thereof
CA3237830A1 (en) * 2021-11-16 2023-05-25 Insilico Medicine Ip Limited Lysine acetyltransferase 6a (kat6a) inhibitors and uses thereof
WO2023114710A1 (en) * 2021-12-13 2023-06-22 Aurigene Oncology Limited Fused benzoisoxazolyl compounds as kat6a inhibitors
TW202400593A (zh) * 2022-03-28 2024-01-01 美商艾索司特瑞克斯公司 Ｍｙｓｔ家族離胺酸乙醯轉移酶之抑制劑
WO2023245150A1 (en) * 2022-06-16 2023-12-21 Prelude Therapeutics Incorporated Kat6 targeting compounds with ubiquitin ligase binding moiety
WO2024023703A1 (en) 2022-07-29 2024-02-01 Pfizer Inc. Dosing regimens comprising a kat6 inhibitor for the treatment of cancer

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Publication number Publication date
EP4299135A2 (en) 2024-01-03
TW202115048A (zh) 2021-04-16
AU2023274178A1 (en) 2024-02-15
CL2021003372A1 (es) 2022-10-07
CO2021017504A2 (es) 2022-01-17
JP2023175821A (ja) 2023-12-12
US11492346B2 (en) 2022-11-08
WO2020254946A1 (en) 2020-12-24
UY38752A (es) 2021-01-29
CN114364672A (zh) 2022-04-15
ECSP21091615A (es) 2022-01-31
JP2022537285A (ja) 2022-08-25
PL3986890T3 (pl) 2024-03-11
FI3986890T3 (fi) 2024-01-15
MX2021016085A (es) 2022-04-20
JP7352662B2 (ja) 2023-09-28
LT3986890T (lt) 2023-12-11
US20200399258A1 (en) 2020-12-24
CA3143666A1 (en) 2020-12-24
EP4299135A3 (en) 2024-02-28
PT3986890T (pt) 2024-01-17
BR112021025528A2 (pt) 2022-04-19
KR20220024671A (ko) 2022-03-03
EP3986890B1 (en) 2023-11-15
CR20210627A (es) 2022-02-08
AU2020296361A1 (en) 2022-01-06
RS64931B1 (sr) 2023-12-29
EP3986890A1 (en) 2022-04-27
IL288802A (en) 2022-02-01
US20230174522A1 (en) 2023-06-08
SI3986890T1 (sl) 2024-03-29
DK3986890T3 (da) 2023-12-18
MD3986890T2 (ro) 2024-04-30
HUE064683T2 (hu) 2024-04-28
ES2969616T3 (es) 2024-05-21
HRP20231501T1 (hr) 2024-03-01
TWI787620B (zh) 2022-12-21

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