PE20221339A1 - Inhibidores de parp1 - Google Patents
Inhibidores de parp1Info
- Publication number
- PE20221339A1 PE20221339A1 PE2022000086A PE2022000086A PE20221339A1 PE 20221339 A1 PE20221339 A1 PE 20221339A1 PE 2022000086 A PE2022000086 A PE 2022000086A PE 2022000086 A PE2022000086 A PE 2022000086A PE 20221339 A1 PE20221339 A1 PE 20221339A1
- Authority
- PE
- Peru
- Prior art keywords
- oxo
- parp1 inhibitors
- naftiridin
- parp1
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE (2-OXO-1H-1,6-NAFTIRIDIN-7-IL; 6-OXO-5H-1,5-NAFTIRIDIN-3IL o 3-OXO-4H-QUINOXALIN-6-IL)-METIL-PIPERAZIN-1IL-N-PIRIDIN-2-CARBOXAMIDA DE FORMULA (I) DONDE X1, X2 y X3 SE SELECCIONAN DE N y C; R1, R2 y R3 SON ALQUILO C1-4, ENTRE OTROS O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, DONDE DICHOS COMPUESTOS SON INHIBIDORES DE PARP1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962876065P | 2019-07-19 | 2019-07-19 | |
| PCT/EP2020/070306 WO2021013735A1 (en) | 2019-07-19 | 2020-07-17 | Parp1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20221339A1 true PE20221339A1 (es) | 2022-09-13 |
Family
ID=71728735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2022000086A PE20221339A1 (es) | 2019-07-19 | 2020-07-17 | Inhibidores de parp1 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US11325906B2 (es) |
| EP (1) | EP3999506A1 (es) |
| JP (1) | JP2022541483A (es) |
| KR (1) | KR20220035941A (es) |
| CN (1) | CN114144413B (es) |
| AR (1) | AR119424A1 (es) |
| AU (1) | AU2020318599B2 (es) |
| BR (1) | BR112022000534A2 (es) |
| CA (1) | CA3145644A1 (es) |
| CL (1) | CL2022000110A1 (es) |
| CO (1) | CO2022001590A2 (es) |
| CR (1) | CR20220070A (es) |
| DO (1) | DOP2022000006A (es) |
| EC (1) | ECSP22012826A (es) |
| IL (1) | IL289534A (es) |
| JO (1) | JOP20220008A1 (es) |
| MX (1) | MX2022000711A (es) |
| PE (1) | PE20221339A1 (es) |
| TW (1) | TWI837403B (es) |
| UY (1) | UY38793A (es) |
| WO (1) | WO2021013735A1 (es) |
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| BR112023006337A2 (pt) | 2020-10-09 | 2023-05-09 | Astrazeneca Uk Ltd | Produto farmacêutico, uso de um conjugado anticorpo anti-her2-fármaco ou um inibidor seletivo de parp1, e, método de tratamento do câncer |
| JP2024510792A (ja) | 2021-03-23 | 2024-03-11 | ニューベイション・バイオ・インコーポレイテッド | 抗がん核内ホルモン受容体標的化化合物 |
| AU2022260495A1 (en) | 2021-04-19 | 2023-10-05 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| CA3213029A1 (en) * | 2021-04-22 | 2022-10-27 | Yuli Xie | Parp inhibitor containing piperazine structure, preparation method therefor and pharmaceutical use thereof |
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| WO2022222964A1 (zh) * | 2021-04-23 | 2022-10-27 | 成都百裕制药股份有限公司 | 吡啶衍生物及其在医药上的应用 |
| CN116710433A (zh) * | 2021-04-23 | 2023-09-05 | 成都百裕制药股份有限公司 | 一种选择性parp1抑制剂及其应用 |
| TW202304911A (zh) * | 2021-04-23 | 2023-02-01 | 大陸商南京明德新藥研發有限公司 | 吡啶醯胺類化合物 |
| CA3218577A1 (en) * | 2021-05-03 | 2022-11-10 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| JP2024518509A (ja) * | 2021-05-18 | 2024-05-01 | オンコニック セラピューティクス インコーポレイテッド | Ｐａｒｐ阻害剤抵抗性癌治療剤 |
| WO2022247816A1 (zh) | 2021-05-24 | 2022-12-01 | 江苏恒瑞医药股份有限公司 | 含氮杂环类化合物、其制备方法及其在医药上的应用 |
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| WO2023046034A1 (zh) * | 2021-09-22 | 2023-03-30 | 明慧医药（杭州）有限公司 | 一种含氮杂环化合物、其制备方法、其中间体及其应用 |
| WO2023046158A1 (zh) * | 2021-09-26 | 2023-03-30 | 张文燕 | 氮杂喹啉酮类化合物及其医药用途 |
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| EP4421074A1 (en) | 2021-10-22 | 2024-08-28 | Xizang Haisco Pharmaceutical Co., Ltd. | Parp-1 degradation agent and use thereof |
| WO2023089527A1 (en) | 2021-11-18 | 2023-05-25 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and parp1 selective inhibitor |
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| WO2024041643A1 (zh) * | 2022-08-25 | 2024-02-29 | 江苏恒瑞医药股份有限公司 | 稠合三环类化合物、其制备方法及其在医药上的应用 |
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| WO2024083218A1 (zh) * | 2022-10-20 | 2024-04-25 | 成都赜灵生物医药科技有限公司 | 取代四氢吡啶类化合物及其用途 |
| CN117917407A (zh) * | 2022-10-20 | 2024-04-23 | 成都赜灵生物医药科技有限公司 | 并杂环类化合物及其用途 |
| WO2024083211A1 (zh) * | 2022-10-20 | 2024-04-25 | 成都赜灵生物医药科技有限公司 | 并杂环类氘代化合物及其用途 |
| WO2024083204A1 (zh) * | 2022-10-21 | 2024-04-25 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂的盐、晶型及其制备方法和应用 |
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2020
- 2020-07-17 CA CA3145644A patent/CA3145644A1/en active Pending
- 2020-07-17 CN CN202080051330.7A patent/CN114144413B/zh active Active
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- 2020-07-17 WO PCT/EP2020/070306 patent/WO2021013735A1/en active Application Filing
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- 2020-07-17 KR KR1020227005427A patent/KR20220035941A/ko unknown
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- 2020-07-17 AU AU2020318599A patent/AU2020318599B2/en active Active
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- 2020-07-17 JP JP2022502556A patent/JP2022541483A/ja active Pending
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- 2020-07-17 EP EP20743121.4A patent/EP3999506A1/en active Pending
- 2020-07-17 TW TW109124347A patent/TWI837403B/zh active
- 2020-07-17 US US16/931,792 patent/US11325906B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| CN114144413B (zh) | 2024-08-16 |
| TW202116750A (zh) | 2021-05-01 |
| US20210040084A1 (en) | 2021-02-11 |
| AU2020318599A1 (en) | 2022-03-10 |
| WO2021013735A1 (en) | 2021-01-28 |
| AU2020318599B2 (en) | 2023-09-07 |
| UY38793A (es) | 2021-02-26 |
| AR119424A1 (es) | 2021-12-15 |
| TWI837403B (zh) | 2024-04-01 |
| IL289534A (en) | 2022-03-01 |
| JOP20220008A1 (ar) | 2023-01-30 |
| CL2022000110A1 (es) | 2022-09-20 |
| US20220227768A1 (en) | 2022-07-21 |
| DOP2022000006A (es) | 2022-03-15 |
| CR20220070A (es) | 2022-03-21 |
| ECSP22012826A (es) | 2022-03-31 |
| CO2022001590A2 (es) | 2022-03-18 |
| MX2022000711A (es) | 2022-02-23 |
| KR20220035941A (ko) | 2022-03-22 |
| JP2022541483A (ja) | 2022-09-26 |
| EP3999506A1 (en) | 2022-05-25 |
| CA3145644A1 (en) | 2021-01-28 |
| US11325906B2 (en) | 2022-05-10 |
| BR112022000534A2 (pt) | 2022-05-10 |
| CN114144413A (zh) | 2022-03-04 |
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