BRPI0408284B8 - compostos derivados de ftalazinona, seu uso e composição farmacêutica compreendendo os mesmos - Google Patents

compostos derivados de ftalazinona, seu uso e composição farmacêutica compreendendo os mesmos

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Publication number
BRPI0408284B8
BRPI0408284B8 BRPI0408284A BRPI0408284A BRPI0408284B8 BR PI0408284 B8 BRPI0408284 B8 BR PI0408284B8 BR PI0408284 A BRPI0408284 A BR PI0408284A BR PI0408284 A BRPI0408284 A BR PI0408284A BR PI0408284 B8 BRPI0408284 B8 BR PI0408284B8
Authority
BR
Brazil
Prior art keywords
crxry
optionally substituted
pharmaceutical composition
phthalazinone derivatives
nrx
Prior art date
Application number
BRPI0408284A
Other languages
English (en)
Inventor
Ashworth Alan
Kerrigan Frank
Cameron Murray Smith Graeme
Timothy Williams Matthews Ian
Allan Menear Keith
Morrison Barr Martin Niall
Philip Jackson Stephen
M Loh Junior Vincent
Fan Cockcroft Xiao-Ling
Original Assignee
Kudos Pharm Ltd
Maybridge Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32996122&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0408284(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB0305681.9A external-priority patent/GB0305681D0/en
Application filed by Kudos Pharm Ltd, Maybridge Ltd filed Critical Kudos Pharm Ltd
Publication of BRPI0408284A publication Critical patent/BRPI0408284A/pt
Publication of BRPI0408284B1 publication Critical patent/BRPI0408284B1/pt
Publication of BRPI0408284B8 publication Critical patent/BRPI0408284B8/pt

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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/502Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
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    • A61P31/12Antivirals
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
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    • A61P35/00Antineoplastic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30Phthalazines
    • C07D237/32Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
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  • Endocrinology (AREA)
  • Reproductive Health (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

derivados de ftalazinona compostos apresentando fórmula (i): onde a e b jutomados em conjunto representam um anel aromático fundido, opcionalmente substituído; x pode ser nrx ou crxry; se x = nrx então n é 1 ou 2 e se x = crxry então n é 1; rx é selecionado a partir do grupo que consiste em grupos h, alquila c1-20, arila c5-20, heterociclila c3-20, opcionalmente substituídas, amido, tioamido, éster, acila, e sulfonila; ry é selecionado a partir de h, hidróxi, amino; ou rx e ry podem juntos formar um grupo espiro-cicloalquila c3-7 ou heterociclila; rc1 ou rc2 são ambos hidrogênio, ou quando x é crxry, rc1, rc2, rx e ry, em conjunto com os átomos de carbono ao qual são fixados, podem formar um anel aromático fundido opcionalmente substituído; e r1 é selecionado a partir de h e halo.
BRPI0408284A 2003-03-12 2004-03-12 compostos derivados de ftalazinona, seu uso e composição farmacêutica compreendendo os mesmos BRPI0408284B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0305681.9A GB0305681D0 (en) 2003-03-12 2003-03-12 Phthalazinone derivatives
US45499503P 2003-03-14 2003-03-14
US49339903P 2003-08-06 2003-08-06
US52624403P 2003-12-01 2003-12-01
PCT/GB2004/001059 WO2004080976A1 (en) 2003-03-12 2004-03-12 Phthalazinone derivatives

Publications (3)

Publication Number Publication Date
BRPI0408284A BRPI0408284A (pt) 2006-03-07
BRPI0408284B1 BRPI0408284B1 (pt) 2018-12-26
BRPI0408284B8 true BRPI0408284B8 (pt) 2021-05-25

Family

ID=32996122

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408284A BRPI0408284B8 (pt) 2003-03-12 2004-03-12 compostos derivados de ftalazinona, seu uso e composição farmacêutica compreendendo os mesmos

Country Status (22)

Country Link
EP (1) EP1633724B1 (pt)
JP (3) JP4027406B2 (pt)
KR (1) KR101146806B1 (pt)
AU (1) AU2004220321B2 (pt)
BR (1) BRPI0408284B8 (pt)
CA (1) CA2517629C (pt)
CO (1) CO5650256A2 (pt)
CY (1) CY1111597T1 (pt)
EA (1) EA009469B1 (pt)
EC (1) ECSP056094A (pt)
GB (1) GB2415430B (pt)
HK (1) HK1079530A1 (pt)
HR (1) HRP20050895B1 (pt)
IS (1) IS2813B (pt)
LT (1) LTC1633724I2 (pt)
MA (1) MA27758A1 (pt)
MX (1) MXPA05009661A (pt)
NO (2) NO331807B1 (pt)
NZ (1) NZ542680A (pt)
PL (1) PL1633724T3 (pt)
TN (1) TNSN05212A1 (pt)
WO (1) WO2004080976A1 (pt)

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WO2005041684A2 (en) 2003-08-06 2005-05-12 Senomyx Inc. Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
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RU2413515C2 (ru) * 2003-12-01 2011-03-10 Кудос Фармасьютикалс Лимитед Ингибиторы репарации повреждения днк для лечения рака
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JP5271897B2 (ja) * 2006-05-31 2013-08-21 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ ポリ(ADP−リボース)ポリメラーゼ(PARP)の阻害剤としての、ピロロ[1,2−a]ピラジン−1(2H)−オン及びピロロ[1,2−d][1,2,4]トリアジン−1(2H)−オン誘導体
GB0610680D0 (en) 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
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