UY31603A1 - Derivados de ftalazinona - Google Patents
Derivados de ftalazinonaInfo
- Publication number
- UY31603A1 UY31603A1 UY031603A UY31603A UY31603A1 UY 31603 A1 UY31603 A1 UY 31603A1 UY 031603 A UY031603 A UY 031603A UY 31603 A UY31603 A UY 31603A UY 31603 A1 UY31603 A1 UY 31603A1
- Authority
- UY
- Uruguay
- Prior art keywords
- optionally substituted
- alkyl
- ftalazinona
- derivatives
- aromatic ring
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Abstract
Un compuesto de la fórmula (I): donde A y B juntos representan un anillo aromático fusionado opcionalmente sustituido; X e Y se seleccionan entre CH y CH, CF y CH, CH y CF y N y CH respectivamente; Rc se selecciona entre H, C1-4 alquilo; y R1 se selecciona entre C1-7 alquilo, C3-20 heterociclilo y C5-20 arilo, estando dichos grupos opcionalmente sustituidos; o Rc y R1 junto con los átomos de carbono y oxígeno a los cuales están unidos forman un grupo espiro-C5-7 heterocíclico que contiene oxígeno, que es un anillo aromático C5-7 opcionalmente sustituido.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2290008P | 2008-01-23 | 2008-01-23 | |
US14241309P | 2009-01-05 | 2009-01-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31603A1 true UY31603A1 (es) | 2009-08-31 |
Family
ID=40510546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY031603A UY31603A1 (es) | 2008-01-23 | 2009-01-21 | Derivados de ftalazinona |
Country Status (24)
Country | Link |
---|---|
US (2) | US8129380B2 (es) |
EP (1) | EP2231638A1 (es) |
JP (1) | JP2011510056A (es) |
KR (1) | KR20100116187A (es) |
CN (1) | CN101925595A (es) |
AR (1) | AR070221A1 (es) |
AU (1) | AU2009207498A1 (es) |
BR (1) | BRPI0906436A2 (es) |
CA (1) | CA2708175A1 (es) |
CL (1) | CL2009000133A1 (es) |
CO (1) | CO6290715A2 (es) |
DO (1) | DOP2010000219A (es) |
EA (1) | EA201070523A1 (es) |
EC (1) | ECSP10010349A (es) |
IL (1) | IL206026A0 (es) |
MX (1) | MX2010006364A (es) |
NI (1) | NI201000120A (es) |
NZ (1) | NZ585982A (es) |
PE (1) | PE20091335A1 (es) |
SV (1) | SV2010003625A (es) |
TW (1) | TW200936577A (es) |
UY (1) | UY31603A1 (es) |
WO (1) | WO2009093032A1 (es) |
ZA (1) | ZA201003752B (es) |
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CN101163681A (zh) * | 2005-04-21 | 2008-04-16 | 日本新药株式会社 | 2,3-二氮杂萘酮衍生物及其医药品 |
GB0521373D0 (en) * | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
ATE548369T1 (de) * | 2006-01-16 | 2012-03-15 | Ube Industries | Pyrrolopyridazinonverbindung als pde4 inhibitor |
US20080280910A1 (en) * | 2007-03-22 | 2008-11-13 | Keith Allan Menear | Phthalazinone derivatives |
TW200900396A (en) * | 2007-04-10 | 2009-01-01 | Kudos Pharm Ltd | Phthalazinone derivatives |
TW201114756A (en) | 2009-07-15 | 2011-05-01 | Astrazeneca Ab | Phthalazinone compound |
WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
US9051296B2 (en) | 2009-11-16 | 2015-06-09 | Raqualia Pharma Inc. | Aryl carboxamide derivatives as TTX-S blockers |
US8871765B2 (en) | 2010-07-27 | 2014-10-28 | Cadila Healthcare Limited | Substituted 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one derivatives as poly (ADP-ribose) polymerase-1 inhibitors |
CN102372706A (zh) * | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
CN102485721B (zh) * | 2010-12-03 | 2015-12-09 | 曹亚 | 取代的2,3-二氮杂萘酮化合物及其用途 |
US20140221314A1 (en) | 2011-05-31 | 2014-08-07 | Newgen Therapeutics, Inc. | Tricyclic inhibitors of poly(adp-ribose)polymerase |
AR088352A1 (es) * | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
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CN102863393A (zh) * | 2012-09-26 | 2013-01-09 | 上海大学 | 1,2-二氢酞嗪类化合物及其合成方法 |
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KR101670126B1 (ko) | 2013-09-13 | 2016-10-27 | 일동제약(주) | 신규 프탈라지논 유도체 및 그 제조방법 |
CN109415345B (zh) * | 2016-06-29 | 2022-01-11 | 豪夫迈·罗氏有限公司 | 基于哒嗪酮的广谱抗流感抑制剂 |
EA201992215A1 (ru) | 2017-03-20 | 2020-02-06 | Форма Терапьютикс, Инк. | Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr) |
WO2018197461A1 (en) | 2017-04-28 | 2018-11-01 | Akribes Biomedical Gmbh | A parp inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing |
CA3129516A1 (en) * | 2018-02-28 | 2019-09-06 | The Trustees Of The University Of Pennsylvania | Low affinity poly(ad-ribose) polymerase 1 dependent cytotoxic agents |
CN110577953B (zh) * | 2018-06-11 | 2024-02-20 | 深圳华大生命科学研究院 | 基因突变体及其应用 |
CN108727338B (zh) * | 2018-07-05 | 2020-12-15 | 福建医科大学 | 一种4-哌啶酮类化合物及其制备方法与应用 |
EP3852791A4 (en) | 2018-09-19 | 2022-06-15 | Forma Therapeutics, Inc. | ACTIVATION OF PYRUVATE KINASE R |
US20220031671A1 (en) | 2018-09-19 | 2022-02-03 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
CN109748923A (zh) * | 2019-01-31 | 2019-05-14 | 中国药科大学 | 含苯并[4,5]咪唑[1,2-a]吡嗪酮类衍生物及其制备方法与用途 |
JP2022532342A (ja) * | 2019-05-14 | 2022-07-14 | ニューベイション・バイオ・インコーポレイテッド | 抗がん核内ホルモン受容体標的化化合物 |
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CN112624981B (zh) * | 2021-03-09 | 2021-05-25 | 南京桦冠生物技术有限公司 | 一种2-氟-5-[(4-氧代-3h-2,3-二氮杂萘基)甲基]苯甲酸的制备方法 |
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-
2009
- 2009-01-21 UY UY031603A patent/UY31603A1/es not_active Application Discontinuation
- 2009-01-21 AR ARP090100183A patent/AR070221A1/es not_active Application Discontinuation
- 2009-01-22 US US12/357,957 patent/US8129380B2/en not_active Expired - Fee Related
- 2009-01-23 CA CA2708175A patent/CA2708175A1/en not_active Abandoned
- 2009-01-23 WO PCT/GB2009/000181 patent/WO2009093032A1/en active Application Filing
- 2009-01-23 NZ NZ585982A patent/NZ585982A/en not_active IP Right Cessation
- 2009-01-23 JP JP2010543563A patent/JP2011510056A/ja active Pending
- 2009-01-23 CN CN2009801027174A patent/CN101925595A/zh active Pending
- 2009-01-23 MX MX2010006364A patent/MX2010006364A/es not_active Application Discontinuation
- 2009-01-23 KR KR1020107017727A patent/KR20100116187A/ko not_active Application Discontinuation
- 2009-01-23 AU AU2009207498A patent/AU2009207498A1/en not_active Abandoned
- 2009-01-23 BR BRPI0906436-2A patent/BRPI0906436A2/pt not_active IP Right Cessation
- 2009-01-23 CL CL2009000133A patent/CL2009000133A1/es unknown
- 2009-01-23 EA EA201070523A patent/EA201070523A1/ru unknown
- 2009-01-23 EP EP09703506A patent/EP2231638A1/en not_active Withdrawn
- 2009-01-23 PE PE2009000100A patent/PE20091335A1/es not_active Application Discontinuation
- 2009-01-23 TW TW098103128A patent/TW200936577A/zh unknown
-
2010
- 2010-05-26 ZA ZA2010/03752A patent/ZA201003752B/en unknown
- 2010-05-27 IL IL206026A patent/IL206026A0/en unknown
- 2010-07-16 NI NI201000120A patent/NI201000120A/es unknown
- 2010-07-16 CO CO10087223A patent/CO6290715A2/es not_active Application Discontinuation
- 2010-07-16 EC EC2010010349A patent/ECSP10010349A/es unknown
- 2010-07-16 DO DO2010000219A patent/DOP2010000219A/es unknown
- 2010-07-19 SV SV2010003625A patent/SV2010003625A/es not_active Application Discontinuation
-
2012
- 2012-01-30 US US13/361,911 patent/US20120129855A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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CO6290715A2 (es) | 2011-06-20 |
PE20091335A1 (es) | 2009-10-04 |
CA2708175A1 (en) | 2009-07-30 |
AU2009207498A1 (en) | 2009-07-30 |
US20090192156A1 (en) | 2009-07-30 |
US8129380B2 (en) | 2012-03-06 |
EP2231638A1 (en) | 2010-09-29 |
WO2009093032A1 (en) | 2009-07-30 |
MX2010006364A (es) | 2010-07-05 |
JP2011510056A (ja) | 2011-03-31 |
BRPI0906436A2 (pt) | 2015-07-14 |
EA201070523A1 (ru) | 2011-02-28 |
SV2010003625A (es) | 2011-05-20 |
DOP2010000219A (es) | 2010-08-15 |
ZA201003752B (en) | 2011-03-30 |
US20120129855A1 (en) | 2012-05-24 |
NZ585982A (en) | 2011-12-22 |
KR20100116187A (ko) | 2010-10-29 |
CL2009000133A1 (es) | 2010-10-15 |
NI201000120A (es) | 2011-03-23 |
TW200936577A (en) | 2009-09-01 |
IL206026A0 (en) | 2010-11-30 |
CN101925595A (zh) | 2010-12-22 |
AR070221A1 (es) | 2010-03-25 |
ECSP10010349A (es) | 2010-08-31 |
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