ATE548369T1 - Pyrrolopyridazinonverbindung als pde4 inhibitor - Google Patents

Pyrrolopyridazinonverbindung als pde4 inhibitor

Info

Publication number
ATE548369T1
ATE548369T1 AT07706860T AT07706860T ATE548369T1 AT E548369 T1 ATE548369 T1 AT E548369T1 AT 07706860 T AT07706860 T AT 07706860T AT 07706860 T AT07706860 T AT 07706860T AT E548369 T1 ATE548369 T1 AT E548369T1
Authority
AT
Austria
Prior art keywords
group
substituent
substituted
alkyl
hydroxy
Prior art date
Application number
AT07706860T
Other languages
English (en)
Inventor
Masahiko Hagihara
Masayuki Tanaka
Tetsushi Katsube
Makoto Okudo
Noriaki Iwase
Manabu Shigetomi
Tomoko Kanda
Takayuki Nakanishi
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Application granted granted Critical
Publication of ATE548369T1 publication Critical patent/ATE548369T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT07706860T 2006-01-16 2007-01-16 Pyrrolopyridazinonverbindung als pde4 inhibitor ATE548369T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006006981 2006-01-16
PCT/JP2007/050533 WO2007081030A1 (ja) 2006-01-16 2007-01-16 ピロロピリダジノン化合物

Publications (1)

Publication Number Publication Date
ATE548369T1 true ATE548369T1 (de) 2012-03-15

Family

ID=38256432

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07706860T ATE548369T1 (de) 2006-01-16 2007-01-16 Pyrrolopyridazinonverbindung als pde4 inhibitor

Country Status (10)

Country Link
US (1) US8450319B2 (de)
EP (1) EP1982986B1 (de)
JP (1) JP5067165B2 (de)
KR (1) KR20080094921A (de)
CN (1) CN101374844B (de)
AT (1) ATE548369T1 (de)
AU (1) AU2007205452B2 (de)
CA (1) CA2637388C (de)
ES (1) ES2383969T3 (de)
WO (1) WO2007081030A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703778B2 (en) 2008-09-26 2014-04-22 Intellikine Llc Heterocyclic kinase inhibitors
WO2014081756A1 (en) * 2012-11-20 2014-05-30 Biogen Idec Ma Inc. S1p and/or atx modulating agents
CN104177209B (zh) * 2014-08-05 2015-12-02 太原理工大学 一种芳基末端炔的制备方法
CN110563673A (zh) * 2019-07-23 2019-12-13 武汉药明康德新药开发有限公司 一种(5-(4-(二氟甲氧基)-3-异丙氧基苯基)呋喃-3-基)甲醇的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2185693T3 (es) * 1994-01-19 2003-05-01 Sankyo Co Derivado de pirrolopiridacina.
JP2004503553A (ja) 2000-06-14 2004-02-05 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ６，５−縮合二環式複素環
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
AR070221A1 (es) * 2008-01-23 2010-03-25 Astrazeneca Ab Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas.

Also Published As

Publication number Publication date
AU2007205452A1 (en) 2007-07-19
WO2007081030A1 (ja) 2007-07-19
US20090036453A1 (en) 2009-02-05
AU2007205452B2 (en) 2012-04-12
AU2007205452A2 (en) 2008-10-30
US8450319B2 (en) 2013-05-28
ES2383969T3 (es) 2012-06-27
EP1982986B1 (de) 2012-03-07
KR20080094921A (ko) 2008-10-27
JP5067165B2 (ja) 2012-11-07
CN101374844B (zh) 2012-10-24
CN101374844A (zh) 2009-02-25
EP1982986A1 (de) 2008-10-22
CA2637388A1 (en) 2007-07-19
EP1982986A4 (de) 2010-11-03
JPWO2007081030A1 (ja) 2009-06-11
CA2637388C (en) 2013-12-17

Similar Documents

Publication Publication Date Title
EP1591120A4 (de) Rezeptor-agonisten
WO2008083252A3 (en) Methods of use for cyclopamine analogs
EP1889842A4 (de) Heterozyklische verbindung
MX2011008305A (es) Compuestos de piridazinona.
WO2005116028A3 (en) Bicyclic heterocycles as kinase inhibitors
WO2008146914A1 (ja) 複素環化合物
TW200710086A (en) Diaryl-substituted hetero 5-membered ring derivatives
CR9710A (es) Proceso para la preparacion de ciertos derivados de fenilpropargileter
EA201200891A1 (ru) Производные 3,4,4a,10d-тетрагидро-1h-тиопирано[4,3-c]изохинолина
WO2006034093A3 (en) 3- (2-acylamino-1-hydroxyethyl)- morpholine derivatives and their use as bace inhibitors
EP1790636A4 (de) Piperidinderivate und deren anwendung
GB0423405D0 (en) Organic compounds
WO2008033299A3 (en) Use of n-containing spirocompounds for the enhancement of cognitive function
ATE548369T1 (de) Pyrrolopyridazinonverbindung als pde4 inhibitor
WO2005035537A3 (en) Substituted tricyclic heterocycles and their uses
WO2006030977A3 (en) Imidazole derivatives as large conductance calcium-activated k channel openers
NO20061317L (no) Imidazopyridinderivater som induserbare NO-syntaseinhibatorer
WO2007062308A3 (en) Homo- and heterocyclic compounds suitable as cetp inhibitors
EP1726584A4 (de) 2-aminochinazolinderivat
WO2005115984A3 (en) Large conductance calcium-activitated k channel opener
GB0412314D0 (en) Compounds
ATE486071T1 (de) Azabicycloä3.1.0ühexan-derivate als modulatoren des dopamin-d3-rezeptors
WO2006026034A3 (en) Processes for the preparation of isothiazole derivatives
DE602004014630D1 (de) Imidazopyridinderivate als inhibitoren der induzierbaren no-synthase
WO2007027878A3 (en) 4-substituted 2-aryloxyphenol derivatives as antibacterial agents