ATE548369T1 - Pyrrolopyridazinonverbindung als pde4 inhibitor - Google Patents
Pyrrolopyridazinonverbindung als pde4 inhibitorInfo
- Publication number
- ATE548369T1 ATE548369T1 AT07706860T AT07706860T ATE548369T1 AT E548369 T1 ATE548369 T1 AT E548369T1 AT 07706860 T AT07706860 T AT 07706860T AT 07706860 T AT07706860 T AT 07706860T AT E548369 T1 ATE548369 T1 AT E548369T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- substituent
- substituted
- alkyl
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006006981 | 2006-01-16 | ||
PCT/JP2007/050533 WO2007081030A1 (ja) | 2006-01-16 | 2007-01-16 | ピロロピリダジノン化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE548369T1 true ATE548369T1 (de) | 2012-03-15 |
Family
ID=38256432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07706860T ATE548369T1 (de) | 2006-01-16 | 2007-01-16 | Pyrrolopyridazinonverbindung als pde4 inhibitor |
Country Status (10)
Country | Link |
---|---|
US (1) | US8450319B2 (de) |
EP (1) | EP1982986B1 (de) |
JP (1) | JP5067165B2 (de) |
KR (1) | KR20080094921A (de) |
CN (1) | CN101374844B (de) |
AT (1) | ATE548369T1 (de) |
AU (1) | AU2007205452B2 (de) |
CA (1) | CA2637388C (de) |
ES (1) | ES2383969T3 (de) |
WO (1) | WO2007081030A1 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8703778B2 (en) * | 2008-09-26 | 2014-04-22 | Intellikine Llc | Heterocyclic kinase inhibitors |
US9771326B2 (en) | 2012-11-20 | 2017-09-26 | Biogen Ma Inc. | S1P and/or ATX modulating agents |
CN104177209B (zh) * | 2014-08-05 | 2015-12-02 | 太原理工大学 | 一种芳基末端炔的制备方法 |
CN110563673A (zh) * | 2019-07-23 | 2019-12-13 | 武汉药明康德新药开发有限公司 | 一种(5-(4-(二氟甲氧基)-3-异丙氧基苯基)呋喃-3-基)甲醇的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0742218B1 (de) * | 1994-01-19 | 2002-12-04 | Sankyo Company Limited | Pyrrolopyridazin-derivate |
JP2004503553A (ja) | 2000-06-14 | 2004-02-05 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 6,5−縮合二環式複素環 |
ES2211344B1 (es) * | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
AR070221A1 (es) * | 2008-01-23 | 2010-03-25 | Astrazeneca Ab | Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas. |
-
2007
- 2007-01-16 KR KR1020087020087A patent/KR20080094921A/ko active IP Right Grant
- 2007-01-16 CN CN2007800024201A patent/CN101374844B/zh not_active Expired - Fee Related
- 2007-01-16 AT AT07706860T patent/ATE548369T1/de active
- 2007-01-16 WO PCT/JP2007/050533 patent/WO2007081030A1/ja active Application Filing
- 2007-01-16 ES ES07706860T patent/ES2383969T3/es active Active
- 2007-01-16 AU AU2007205452A patent/AU2007205452B2/en not_active Ceased
- 2007-01-16 JP JP2007553988A patent/JP5067165B2/ja not_active Expired - Fee Related
- 2007-01-16 CA CA2637388A patent/CA2637388C/en not_active Expired - Fee Related
- 2007-01-16 EP EP07706860A patent/EP1982986B1/de not_active Not-in-force
- 2007-01-16 US US12/087,864 patent/US8450319B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP5067165B2 (ja) | 2012-11-07 |
AU2007205452B2 (en) | 2012-04-12 |
EP1982986A1 (de) | 2008-10-22 |
WO2007081030A1 (ja) | 2007-07-19 |
CN101374844B (zh) | 2012-10-24 |
EP1982986B1 (de) | 2012-03-07 |
CN101374844A (zh) | 2009-02-25 |
EP1982986A4 (de) | 2010-11-03 |
JPWO2007081030A1 (ja) | 2009-06-11 |
CA2637388C (en) | 2013-12-17 |
CA2637388A1 (en) | 2007-07-19 |
AU2007205452A1 (en) | 2007-07-19 |
US8450319B2 (en) | 2013-05-28 |
KR20080094921A (ko) | 2008-10-27 |
US20090036453A1 (en) | 2009-02-05 |
AU2007205452A2 (en) | 2008-10-30 |
ES2383969T3 (es) | 2012-06-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1889842A4 (de) | Heterozyklische verbindung | |
TW200710086A (en) | Diaryl-substituted hetero 5-membered ring derivatives | |
WO2005116028A3 (en) | Bicyclic heterocycles as kinase inhibitors | |
MX2011008305A (es) | Compuestos de piridazinona. | |
WO2006034093A3 (en) | 3- (2-acylamino-1-hydroxyethyl)- morpholine derivatives and their use as bace inhibitors | |
WO2006030977A3 (en) | Imidazole derivatives as large conductance calcium-activated k channel openers | |
EP1726584A4 (de) | 2-aminochinazolinderivat | |
WO2005115984A3 (en) | Large conductance calcium-activitated k channel opener | |
RS51654B (en) | DERIVATIVES OF THE SUBSTITUTED BICYCLIC PIRIMIDONE | |
ATE516291T1 (de) | Thenopyrimidin-verbindungen mit fungizider aktivität | |
PL1805170T3 (pl) | Inhibitory MIF | |
WO2008146914A1 (ja) | 複素環化合物 | |
CR9710A (es) | Proceso para la preparacion de ciertos derivados de fenilpropargileter | |
WO2008140066A3 (en) | Pyridone derivatives as p38a mapk inhibitors | |
ATE486071T1 (de) | Azabicycloä3.1.0ühexan-derivate als modulatoren des dopamin-d3-rezeptors | |
WO2007062308A3 (en) | Homo- and heterocyclic compounds suitable as cetp inhibitors | |
EA201200891A1 (ru) | Производные 3,4,4a,10d-тетрагидро-1h-тиопирано[4,3-c]изохинолина | |
WO2008033299A3 (en) | Use of n-containing spirocompounds for the enhancement of cognitive function | |
ATE548369T1 (de) | Pyrrolopyridazinonverbindung als pde4 inhibitor | |
WO2005035537A3 (en) | Substituted tricyclic heterocycles and their uses | |
NO20061344L (no) | Imidazopyridinderivater som induserbare NO-syntaseoinhibitorer | |
WO2006026034A3 (en) | Processes for the preparation of isothiazole derivatives | |
WO2007027878A3 (en) | 4-substituted 2-aryloxyphenol derivatives as antibacterial agents | |
TW200716604A (en) | Carboxamide compound and use thereof | |
NO20060603L (no) | Fremgangsmate for fremstillingen av fenyltetrazolderivater |