WO2008146914A1 - 複素環化合物 - Google Patents

複素環化合物 Download PDF

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Publication number
WO2008146914A1
WO2008146914A1 PCT/JP2008/060028 JP2008060028W WO2008146914A1 WO 2008146914 A1 WO2008146914 A1 WO 2008146914A1 JP 2008060028 W JP2008060028 W JP 2008060028W WO 2008146914 A1 WO2008146914 A1 WO 2008146914A1
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WO
WIPO (PCT)
Prior art keywords
substituted
ring
alkoxy
useful
heterocyclic group
Prior art date
Application number
PCT/JP2008/060028
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English (en)
French (fr)
Inventor
Shigeru Furukubo
Hiroshi Miyazaki
Tatsuo Nakajima
Yousuke Ikeda
Kenji Morokuma
Chihiro Nakamaki
Original Assignee
Mitsubishi Tanabe Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corporation filed Critical Mitsubishi Tanabe Pharma Corporation
Publication of WO2008146914A1 publication Critical patent/WO2008146914A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

　式 （式中、環Ａはピリミジン等を示し、環Ｂは置換されていてもよい炭素環、置換されていてもよい芳香族複素環または置換されていてもよい脂環式複素環を示し、環Ｃは置換されていてもよい芳香族炭素環を示し、Ｘは単結合またはアルキレンを示し、Ｒ１は置換されていてもよい複素環式基または複素環式基置換アルコキシ等を示し、Ｒ２は水素、アルキル、ハロアルキル、アルコキシ、アルカノイル、シアノ、カルバモイル、アルコキシカルボニル、ハロゲン等を示し、ｍは１、２を示す。） で表される化合物またはその製薬上許容しうる塩は、気管支喘息、アトピー性皮膚炎等の疾患の予防・治療に有用なＣＣＲ４機能調節剤として有用である。
PCT/JP2008/060028 2007-06-01 2008-05-30 複素環化合物 WO2008146914A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007147090A JP2010208945A (ja) 2007-06-01 2007-06-01 複素環化合物
JP2007-147090 2007-06-01

Publications (1)

Publication Number Publication Date
WO2008146914A1 true WO2008146914A1 (ja) 2008-12-04

Family

ID=40075144

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060028 WO2008146914A1 (ja) 2007-06-01 2008-05-30 複素環化合物

Country Status (2)

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JP (1) JP2010208945A (ja)
WO (1) WO2008146914A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011079114A1 (en) * 2009-12-23 2011-06-30 Elan Pharmaceuticals, Inc. Pteridinones as inhibitors of polo - like kinase
JP2013508328A (ja) * 2009-10-21 2013-03-07 エフ．ホフマン−ラ ロシュ アーゲー ケモカイン受容体のモジュレーターとしてのジアゼパン誘導体
JP2015500240A (ja) * 2011-12-01 2015-01-05 ケモセントリックス，インコーポレイティド Ｃｃｒ（４）アンタゴニストとしての置換ベンズイミダゾール及びベンゾピラゾール
US9045445B2 (en) 2010-06-04 2015-06-02 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
CN104672147A (zh) * 2015-02-17 2015-06-03 衢州学院 一种2,4-二羟基-5-嘧啶甲酸甲酯的制备方法
EP2473486B1 (de) 2009-09-02 2015-10-28 Vifor (International) Ag Pyrimidine als hepcidin-antagonisten
WO2019147862A1 (en) * 2018-01-26 2019-08-01 Flx Bio, Inc. Chemokine receptor modulators and uses thereof
JP2019525962A (ja) * 2016-07-29 2019-09-12 ラプト・セラピューティクス・インコーポレイテッド ケモカイン受容体調節剤及びそれの使用
CN115043780A (zh) * 2022-07-11 2022-09-13 上海飞琰化工科技有限公司 一种4-羟基-5-氟-6-乙基嘧啶的合成方法及其应用
EP3929198A4 (en) * 2019-02-19 2022-11-16 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING IT, METHOD FOR PREPARING IT AND ITS USE
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA029054B1 (ru) 2012-10-11 2018-02-28 Саузерн Рисерч Инститьют Мочевинные и амидные производные аминоалкилпиперазинов и их применение
CA2896731A1 (en) * 2012-12-28 2014-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibitors of the usp1/uaf1 deubiquitinase complex and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011442A1 (ja) * 2002-07-29 2004-02-05 Shizuoka Coffein Co., Ltd. ピリミジン誘導体
WO2004074260A1 (ja) * 2003-02-21 2004-09-02 Kyowa Hakko Kogyo Co., Ltd. ピリミジン誘導体
WO2005082865A1 (ja) * 2004-02-27 2005-09-09 Astellas Pharma Inc. 縮合二環性ピリミジン誘導体
WO2005085212A1 (ja) * 2004-03-04 2005-09-15 Astellas Pharma Inc. 置換ピリミジン誘導体
WO2006004776A1 (en) * 2004-06-29 2006-01-12 Rigel Pharmaceuticals, Inc. 4-pyrimidineamine compounds and their uses as anti-proliferative agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011442A1 (ja) * 2002-07-29 2004-02-05 Shizuoka Coffein Co., Ltd. ピリミジン誘導体
WO2004074260A1 (ja) * 2003-02-21 2004-09-02 Kyowa Hakko Kogyo Co., Ltd. ピリミジン誘導体
WO2005082865A1 (ja) * 2004-02-27 2005-09-09 Astellas Pharma Inc. 縮合二環性ピリミジン誘導体
WO2005085212A1 (ja) * 2004-03-04 2005-09-15 Astellas Pharma Inc. 置換ピリミジン誘導体
WO2006004776A1 (en) * 2004-06-29 2006-01-12 Rigel Pharmaceuticals, Inc. 4-pyrimidineamine compounds and their uses as anti-proliferative agents

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2473486B1 (de) 2009-09-02 2015-10-28 Vifor (International) Ag Pyrimidine als hepcidin-antagonisten
JP2013508328A (ja) * 2009-10-21 2013-03-07 エフ．ホフマン−ラ ロシュ アーゲー ケモカイン受容体のモジュレーターとしてのジアゼパン誘導体
WO2011079114A1 (en) * 2009-12-23 2011-06-30 Elan Pharmaceuticals, Inc. Pteridinones as inhibitors of polo - like kinase
WO2011079118A1 (en) * 2009-12-23 2011-06-30 Elan Pharmaceuticals, Inc Pteridinones as inhibitors of polo-like kinase
CN102762568A (zh) * 2009-12-23 2012-10-31 伊兰药品公司 作为polo样激酶的抑制剂的蝶啶酮
JP2013515734A (ja) * 2009-12-23 2013-05-09 エラン ファーマシューティカルズ，インコーポレイテッド ポロ様キナーゼの阻害薬としてのプテリジノン
US8445503B2 (en) 2009-12-23 2013-05-21 Elan Pharmaceuticals, Inc. Inhibitors of polo-like kinase
US8541418B2 (en) 2009-12-23 2013-09-24 Elan Pharmaceutical, Inc. Inhibitors of polo-like kinase
US9045445B2 (en) 2010-06-04 2015-06-02 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
JP2015500240A (ja) * 2011-12-01 2015-01-05 ケモセントリックス，インコーポレイティド Ｃｃｒ（４）アンタゴニストとしての置換ベンズイミダゾール及びベンゾピラゾール
CN104672147A (zh) * 2015-02-17 2015-06-03 衢州学院 一种2,4-二羟基-5-嘧啶甲酸甲酯的制备方法
JP2019525962A (ja) * 2016-07-29 2019-09-12 ラプト・セラピューティクス・インコーポレイテッド ケモカイン受容体調節剤及びそれの使用
WO2019147862A1 (en) * 2018-01-26 2019-08-01 Flx Bio, Inc. Chemokine receptor modulators and uses thereof
US10683280B2 (en) 2018-01-26 2020-06-16 Rapt Therapeutics, Inc. Chemokine receptor modulators and uses thereof
CN111971279A (zh) * 2018-01-26 2020-11-20 拉普特医疗公司 趋化因子受体调节剂及其用途
US11192879B2 (en) 2018-01-26 2021-12-07 Rapt Therapeutics, Inc. Chemokine receptor modulators and uses thereof
US11384064B2 (en) 2018-01-26 2022-07-12 Rapt Therapeutics, Inc. Chemokine receptor modulators and uses thereof
AU2019212478B2 (en) * 2018-01-26 2023-02-23 Rapt Therapeutics, Inc. Chemokine receptor modulators and uses thereof
AU2019212478C1 (en) * 2018-01-26 2023-11-16 Rapt Therapeutics, Inc. Chemokine receptor modulators and uses thereof
TWI826416B (zh) * 2018-01-26 2023-12-21 美商瑞佩特治療公司 趨化介素受體調節劑及其用途
EP3929198A4 (en) * 2019-02-19 2022-11-16 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING IT, METHOD FOR PREPARING IT AND ITS USE
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途
CN115043780A (zh) * 2022-07-11 2022-09-13 上海飞琰化工科技有限公司 一种4-羟基-5-氟-6-乙基嘧啶的合成方法及其应用
CN115043780B (zh) * 2022-07-11 2024-01-16 上海飞琰化工科技有限公司 一种4-羟基-5-氟-6-乙基嘧啶的合成方法及其应用

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