CL2009000133A1 - Compuestos derivados de ftalazinona, inhibidores de la actividad parp; composicion farmaceutica; uso en el tratamiento de enfermedades vasculares, shock septico, lesion isquemica, neurotoxicidad, shock hemorragico, como auxiliar en la terapia del cancer de mama, de ovario, de pancreas, entre otras. - Google Patents
Compuestos derivados de ftalazinona, inhibidores de la actividad parp; composicion farmaceutica; uso en el tratamiento de enfermedades vasculares, shock septico, lesion isquemica, neurotoxicidad, shock hemorragico, como auxiliar en la terapia del cancer de mama, de ovario, de pancreas, entre otras.Info
- Publication number
- CL2009000133A1 CL2009000133A1 CL2009000133A CL2009000133A CL2009000133A1 CL 2009000133 A1 CL2009000133 A1 CL 2009000133A1 CL 2009000133 A CL2009000133 A CL 2009000133A CL 2009000133 A CL2009000133 A CL 2009000133A CL 2009000133 A1 CL2009000133 A1 CL 2009000133A1
- Authority
- CL
- Chile
- Prior art keywords
- phthalazinone
- neurotoxicity
- ovarian
- breast
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos derivados de ftalazinona, inhibidores de la actividad parp; composición farmacológica; y su uso en enfermedades vasculares, shock séptico, lesión isquémica, neurotoxicidad, shock hemorrágico, infección viral, como auxiliar en la terapia del cáncer de mama, de ovario, de páncreas o de próstata, entre otras.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2290008P | 2008-01-23 | 2008-01-23 | |
US14241309P | 2009-01-05 | 2009-01-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009000133A1 true CL2009000133A1 (es) | 2010-10-15 |
Family
ID=40510546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009000133A CL2009000133A1 (es) | 2008-01-23 | 2009-01-23 | Compuestos derivados de ftalazinona, inhibidores de la actividad parp; composicion farmaceutica; uso en el tratamiento de enfermedades vasculares, shock septico, lesion isquemica, neurotoxicidad, shock hemorragico, como auxiliar en la terapia del cancer de mama, de ovario, de pancreas, entre otras. |
Country Status (24)
Country | Link |
---|---|
US (2) | US8129380B2 (es) |
EP (1) | EP2231638A1 (es) |
JP (1) | JP2011510056A (es) |
KR (1) | KR20100116187A (es) |
CN (1) | CN101925595A (es) |
AR (1) | AR070221A1 (es) |
AU (1) | AU2009207498A1 (es) |
BR (1) | BRPI0906436A2 (es) |
CA (1) | CA2708175A1 (es) |
CL (1) | CL2009000133A1 (es) |
CO (1) | CO6290715A2 (es) |
DO (1) | DOP2010000219A (es) |
EA (1) | EA201070523A1 (es) |
EC (1) | ECSP10010349A (es) |
IL (1) | IL206026A0 (es) |
MX (1) | MX2010006364A (es) |
NI (1) | NI201000120A (es) |
NZ (1) | NZ585982A (es) |
PE (1) | PE20091335A1 (es) |
SV (1) | SV2010003625A (es) |
TW (1) | TW200936577A (es) |
UY (1) | UY31603A1 (es) |
WO (1) | WO2009093032A1 (es) |
ZA (1) | ZA201003752B (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2007143049A (ru) * | 2005-04-21 | 2009-05-27 | Ниппон Синяку Ко., Лтд. (Jp) | Производное фталазинона и содержащая его фармацевтическая композиция |
GB0521373D0 (en) * | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
ES2383969T3 (es) * | 2006-01-16 | 2012-06-27 | Ube Industries, Ltd. | Compuesto de pirrolopiridazinona como inhibidor de PDE4 |
US20080280910A1 (en) * | 2007-03-22 | 2008-11-13 | Keith Allan Menear | Phthalazinone derivatives |
TW200900396A (en) * | 2007-04-10 | 2009-01-01 | Kudos Pharm Ltd | Phthalazinone derivatives |
AR079774A1 (es) | 2009-07-15 | 2012-02-22 | Astrazeneca Ab | Compuesto de ftalazinona como forma cristalina c , composicion farmaceutica y usos del mismo |
WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
WO2011058766A1 (en) * | 2009-11-16 | 2011-05-19 | Raqualia Pharma Inc. | Aryl carboxamide derivatives as ttx-s blockers |
JP2013532683A (ja) | 2010-07-27 | 2013-08-19 | カディラ ヘルスケア リミティド | ポリ(adpリボース)ポリメラーゼ−1阻害剤としての、置換4−(4−フルオロ−3−(ピペラジン−1−カルボニル)ベンジル)フタラジン−1(2h)−オン誘導体 |
CN102372706A (zh) * | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
CN102485721B (zh) * | 2010-12-03 | 2015-12-09 | 曹亚 | 取代的2,3-二氮杂萘酮化合物及其用途 |
WO2012166983A1 (en) | 2011-05-31 | 2012-12-06 | Newgen Therapeutics, Inc. | Tricyclic inhibitors of poly(adp-ribose)polymerase |
AR088352A1 (es) * | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
CN103130723B (zh) | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
CN102702108A (zh) * | 2012-06-27 | 2012-10-03 | 上海大学 | 1,2-二氢酞嗪类化合物及其合成方法 |
CN102863393A (zh) * | 2012-09-26 | 2013-01-09 | 上海大学 | 1,2-二氢酞嗪类化合物及其合成方法 |
WO2014085208A1 (en) * | 2012-11-27 | 2014-06-05 | Merck Sharp & Dohme Corp. | 2-pyridylamino-4-nitrile-piperidinyl orexin receptor antagonists |
BR112015012425A2 (pt) * | 2012-12-31 | 2017-07-11 | Cadila Healthcare Ltd | composto, composição farmacêutica, método e medicamento para o tratamento de doenças medicadas pela proteína parp-1 e uso do composto |
WO2014137883A1 (en) * | 2013-03-08 | 2014-09-12 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-4-ether orexin receptor antagonists |
EP3027598B1 (en) * | 2013-07-31 | 2017-04-12 | Merck Patent GmbH | Oxoquinazolinyl-butanamide derivatives |
KR101670126B1 (ko) * | 2013-09-13 | 2016-10-27 | 일동제약(주) | 신규 프탈라지논 유도체 및 그 제조방법 |
JP6957535B2 (ja) * | 2016-06-29 | 2021-11-02 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ピリダジノンベースの広域スペクトル抗インフルエンザ阻害剤 |
MX2018014032A (es) | 2017-03-20 | 2019-08-21 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de piruvato cinasa (pkr). |
WO2018197461A1 (en) | 2017-04-28 | 2018-11-01 | Akribes Biomedical Gmbh | A parp inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing |
JP2021516229A (ja) | 2018-02-28 | 2021-07-01 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 低親和性ポリ(ad−リボース)ポリメラーゼ1依存性細胞毒性剤 |
CN110577953B (zh) * | 2018-06-11 | 2024-02-20 | 深圳华大生命科学研究院 | 基因突变体及其应用 |
CN108727338B (zh) * | 2018-07-05 | 2020-12-15 | 福建医科大学 | 一种4-哌啶酮类化合物及其制备方法与应用 |
CN113226356A (zh) | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
EP3853206B1 (en) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Treating sickle cell disease with a pyruvate kinase r activating compound |
CN109748923A (zh) * | 2019-01-31 | 2019-05-14 | 中国药科大学 | 含苯并[4,5]咪唑[1,2-a]吡嗪酮类衍生物及其制备方法与用途 |
CA3138197A1 (en) * | 2019-05-14 | 2020-11-19 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
UY38793A (es) | 2019-07-19 | 2021-02-26 | Astrazeneca Ab | Compuestos químicos |
EP4058464A1 (en) | 2019-11-13 | 2022-09-21 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
EP4139297A4 (en) | 2020-04-21 | 2024-05-22 | Idience Co Ltd | CRYSTALLINE FORMS OF PHTHACAZ1NONF COMPOUND |
CN112624981B (zh) * | 2021-03-09 | 2021-05-25 | 南京桦冠生物技术有限公司 | 一种2-氟-5-[(4-氧代-3h-2,3-二氮杂萘基)甲基]苯甲酸的制备方法 |
US11834458B2 (en) | 2021-03-23 | 2023-12-05 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
TW202304431A (zh) | 2021-04-01 | 2023-02-01 | 大陸商藥捷安康(南京)科技股份有限公司 | 磷酸二酯酶抑制劑的製備方法 |
CN117897380A (zh) * | 2021-08-17 | 2024-04-16 | 益方生物科技(上海)股份有限公司 | 哒嗪酮或吡啶酮化合物、其制备方法和用途 |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB721286A (en) | 1951-02-16 | 1955-01-05 | Smith Kline & French Internat | Improvements in or relating to the preparation of tetrahydroisoquinolone derivatives |
DE2143745A1 (de) | 1971-09-01 | 1973-03-08 | Hoechst Ag | 3,4-dihydro-2h-isochinolin-1-thione und verfahren zu ihrer herstellung |
US3813384A (en) | 1972-01-17 | 1974-05-28 | Asta Werke Ag Chem Fab | Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof |
FR2262513A1 (en) | 1974-03-01 | 1975-09-26 | Delalande Sa | 3,4,5-Triphenyl-delta-1,2,4-oxadiazolines - with bronchodilator, anti-cholinergic, hypertensive, analgesic and sedative activity |
JPS54156526A (en) | 1978-05-31 | 1979-12-10 | Asahi Chemical Ind | Dry picture forming material |
US4283539A (en) | 1979-12-18 | 1981-08-11 | Pfizer Inc. | Isoquinoline acetic acids |
JPS58164577A (ja) | 1982-03-24 | 1983-09-29 | Taiho Yakuhin Kogyo Kk | 4―ベンジル―1―(2h)イソキノロン誘導体 |
US4665181A (en) | 1984-05-17 | 1987-05-12 | Pennwalt Corporation | Anti-inflammatory phthalazinones |
US5041653A (en) | 1985-05-03 | 1991-08-20 | Sri International | Substituted benzamide radiosensitizers |
US5032617A (en) | 1985-05-03 | 1991-07-16 | Sri International | Substituted benzamide radiosensitizers |
US5215738A (en) | 1985-05-03 | 1993-06-01 | Sri International | Benzamide and nicotinamide radiosensitizers |
DE3677322D1 (de) | 1985-11-11 | 1991-03-07 | Asta Pharma Ag | 4-benzyl-1-(2h)-phthalazinon-derivate. |
GB8610018D0 (en) | 1986-04-24 | 1986-05-29 | Fujisawa Pharmaceutical Co | Phthalazine derivatives |
DE3640641A1 (de) | 1986-11-28 | 1988-07-14 | Thomae Gmbh Dr K | Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE3813531A1 (de) | 1987-05-02 | 1988-11-10 | Asta Pharma Ag | Neue 2-aminoalkyl-4-benzyl-1-(2h)-phthalazinon-derivate |
JP2786896B2 (ja) | 1988-08-19 | 1998-08-13 | ワーナー―ランバート・コンパニー | 置換されたジヒドロイソキノリノンおよび関連化合物 |
ES2075082T3 (es) | 1989-03-28 | 1995-10-01 | Nisshin Flour Milling Co | Derivados de isoquinolina para el tratamiento del glaucoma o hipertension ocular. |
DD287032A5 (de) | 1989-07-28 | 1991-02-14 | Karl-Marx-Universitaet Leipzig,De | Verfahren zur herstellung von 3-carbamoyl-4-aryl-1,2-di-hydro-isochinolin-1h-onen |
GB9011833D0 (en) | 1990-05-25 | 1990-07-18 | Collins Mary K L | Inhibition of viral infection |
EP0502575A1 (en) | 1991-03-06 | 1992-09-09 | Merck & Co. Inc. | Substituted 1-(2H)-isoquinolinones |
WO1993014086A1 (en) | 1992-01-17 | 1993-07-22 | Syntex (U.S.A.) Inc. | Substituted 1-isoquinolone derivatives as angiotensin ii antagonists |
CZ199593A3 (en) | 1992-10-02 | 1994-04-13 | Asta Medica Ag | Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr) |
US5668279A (en) | 1992-11-02 | 1997-09-16 | Merck & Co., Inc. | Substituted phthalazinones as neurotensin antagonists |
EP0634404A1 (en) | 1993-07-13 | 1995-01-18 | Rhone Poulenc Agriculture Ltd. | Phtalazin derivatives and their use as pesticides |
US5587384A (en) | 1994-02-04 | 1996-12-24 | The Johns Hopkins University | Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity |
US5648355A (en) | 1994-02-09 | 1997-07-15 | Kos Pharmaceutical, Inc. | Method of treatment of endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin |
GB9404485D0 (en) | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
EP0699754B2 (en) | 1994-08-12 | 2009-08-12 | The University of Utah Research Foundation | Method for diagnosing a predisposition for breast and ovarian cancer |
CN1172502A (zh) | 1994-08-12 | 1998-02-04 | 亿万遗传股份有限公司 | 17q连锁的乳房癌和卵巢癌易患性基因的体内突变和多态性 |
US5589483A (en) | 1994-12-21 | 1996-12-31 | Geron Corporation | Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence |
US5834466A (en) | 1994-12-22 | 1998-11-10 | The Regents Of The University Of California | Method for protecting of heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia or resulting from ischemia |
IL120264A0 (en) | 1996-02-29 | 1997-06-10 | Pfizer | Method of reducing tissue damage associated with non-cardiac ischemia |
CA2205757C (en) | 1996-05-30 | 2006-01-24 | F. Hoffmann-La Roche Ag | Pyridazinone derivatives and their use as inhibitors of prostaglandin g/h synthase i and ii(cox i and ii) |
US5888529A (en) | 1997-03-28 | 1999-03-30 | The Regents Of The University Of California | Ileus treatment method |
BR9809115A (pt) | 1997-05-13 | 2002-01-02 | Octamer Inc | Métodos para tratar inflamação e doenças inflamatórias usando inibidores de padprt |
WO1999008680A1 (en) | 1997-08-15 | 1999-02-25 | The Johns Hopkins University | Method of using selective parp inhibitors to prevent or treat neurotoxicity |
US20020022636A1 (en) | 1997-09-03 | 2002-02-21 | Jia-He Li | Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity |
US6426415B1 (en) | 1997-09-03 | 2002-07-30 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity |
US6291425B1 (en) | 1999-09-01 | 2001-09-18 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage |
US6635642B1 (en) | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
US6197785B1 (en) | 1997-09-03 | 2001-03-06 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity |
US6514983B1 (en) | 1997-09-03 | 2003-02-04 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage |
WO1999025340A1 (en) | 1997-11-14 | 1999-05-27 | Eli Lilly And Company | Treatment for alzheimer's disease |
WO1999044612A1 (en) | 1998-03-02 | 1999-09-10 | Cocensys, Inc. | Substituted quinazolines and analogs and the use thereof |
FR2776291B1 (fr) | 1998-03-18 | 2000-06-16 | Pf Medicament | Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament |
ITMI981671A1 (it) | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
PL210415B1 (pl) | 1999-01-11 | 2012-01-31 | Agouron Pharma | Pochodne indolu, środek farmaceutyczny i zastosowanie pochodnych indolu |
KR20010101675A (ko) | 1999-01-26 | 2001-11-14 | 우에노 도시오 | 2h-프탈라진-1-온 유도체 및 그 유도체를 유효 성분으로하는 약제 |
DE19921567A1 (de) | 1999-05-11 | 2000-11-16 | Basf Ag | Verwendung von Phthalazine-Derivaten |
US6465448B1 (en) | 1999-08-13 | 2002-10-15 | Case Western Reserve University | Methoxyamine potentiation of temozolomide anti-cancer activity |
ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
AU7314200A (en) | 1999-09-17 | 2001-04-24 | Yamanouchi Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
IL143349A0 (en) | 1999-09-28 | 2002-04-21 | Basf Ag | Azepinoindole derivatives, the production and use thereof |
US6476048B1 (en) | 1999-12-07 | 2002-11-05 | Inotek Pharamaceuticals Corporation | Substituted phenanthridinones and methods of use thereof |
ATE372337T1 (de) | 2000-02-01 | 2007-09-15 | Abbott Gmbh & Co Kg | Heterozyklische verbindungen und deren anwendung als parp-inhibitoren |
AU2001248748A1 (en) | 2000-04-18 | 2001-10-30 | Sumitomo Pharmaceuticals Company, Limited | Substituted piperazine compounds |
US7122679B2 (en) | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
DE10022925A1 (de) | 2000-05-11 | 2001-11-15 | Basf Ag | Substituierte Indole als PARP-Inhibitoren |
US20030176454A1 (en) | 2000-05-15 | 2003-09-18 | Akira Yamada | N-coating heterocyclic compounds |
AU2001264595A1 (en) | 2000-05-19 | 2001-12-03 | Guilford Pharmaceuticals Inc. | Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses |
AU9578901A (en) | 2000-10-30 | 2002-05-15 | Kudos Pharm Ltd | Phthalazinone derivatives |
US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
WO2002044157A2 (en) | 2000-12-01 | 2002-06-06 | Iconix Pharmaceuticals, Inc. | Parb inhibitors |
WO2002068407A1 (fr) | 2001-02-28 | 2002-09-06 | Yamanouchi Pharmaceutical Co., Ltd. | Compose benzimidazole |
JP2004528376A (ja) | 2001-05-08 | 2004-09-16 | クドス ファーマシューティカルズ リミテッド | Parp阻害薬としてのイソキノリノン誘導体 |
US20040176361A1 (en) | 2001-05-23 | 2004-09-09 | Masakazu Fujio | Fused heterocyclic compound and medicinal use thereof |
WO2003007959A1 (en) | 2001-07-16 | 2003-01-30 | Fujisawa Pharmaceutical Co., Ltd. | Quinoxaline derivatives which have parp inhibitory action |
AU2002358650A1 (en) | 2001-12-14 | 2003-06-30 | Altana Pharma Ag | Known and novel 4,5-dihydro-imidazo(4,5,1-ij)quinolin-6-ones useful as poly(adp-ribose)polymerase inhibitors |
AUPR975601A0 (en) | 2001-12-24 | 2002-01-31 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivatives |
US7157452B2 (en) | 2001-12-31 | 2007-01-02 | Mgi Gp, Inc. | Substituted 4,9-dihydrocyclopenta{imn}phenanthridine-5-ones derivatives thereof and their uses |
AUPS019702A0 (en) | 2002-01-29 | 2002-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
CA2476406A1 (en) | 2002-02-19 | 2003-08-28 | Ono Pharmaceutical Co., Ltd. | Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient |
DE60335359D1 (de) * | 2002-04-30 | 2011-01-27 | Kudos Pharm Ltd | Phthalazinonderivate |
EA009469B1 (ru) * | 2003-03-12 | 2007-12-28 | Кудос Фармасеутикалс Лимитед | Производные фталазинона |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
DK2305221T3 (en) | 2003-12-01 | 2015-08-24 | Kudos Pharm Ltd | DNA damage repair inhibitors for the treatment of cancer |
GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
KR20070057859A (ko) * | 2004-08-26 | 2007-06-07 | 쿠도스 파마슈티칼스 리미티드 | 4-헤테로아릴메틸 치환된 프탈라지논 유도체 |
EP1908481A1 (en) | 2005-06-24 | 2008-04-09 | Ono Pharmaceutical Co., Ltd. | Agent for reduction of bleeding in cerebrovascular disorder |
GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
WO2007138355A1 (en) * | 2006-05-31 | 2007-12-06 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Pyrrolo[1,2-a]pyrazin-1(2h)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2h)-one derivatives as inhibitors of poly(adp-ribose)polymerase(parp) |
BRPI0722070A2 (pt) | 2006-12-28 | 2014-04-08 | Abbott Lab | Inibidores de poli(adp-ribose)polimerase |
US8466150B2 (en) | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
US20090023727A1 (en) | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
CN101809017A (zh) | 2007-09-14 | 2010-08-18 | 阿斯利康(瑞典)有限公司 | 酞嗪酮衍生物 |
-
2009
- 2009-01-21 AR ARP090100183A patent/AR070221A1/es not_active Application Discontinuation
- 2009-01-21 UY UY031603A patent/UY31603A1/es not_active Application Discontinuation
- 2009-01-22 US US12/357,957 patent/US8129380B2/en not_active Expired - Fee Related
- 2009-01-23 EP EP09703506A patent/EP2231638A1/en not_active Withdrawn
- 2009-01-23 MX MX2010006364A patent/MX2010006364A/es not_active Application Discontinuation
- 2009-01-23 TW TW098103128A patent/TW200936577A/zh unknown
- 2009-01-23 CL CL2009000133A patent/CL2009000133A1/es unknown
- 2009-01-23 CN CN2009801027174A patent/CN101925595A/zh active Pending
- 2009-01-23 PE PE2009000100A patent/PE20091335A1/es not_active Application Discontinuation
- 2009-01-23 KR KR1020107017727A patent/KR20100116187A/ko not_active Application Discontinuation
- 2009-01-23 JP JP2010543563A patent/JP2011510056A/ja active Pending
- 2009-01-23 NZ NZ585982A patent/NZ585982A/en not_active IP Right Cessation
- 2009-01-23 WO PCT/GB2009/000181 patent/WO2009093032A1/en active Application Filing
- 2009-01-23 AU AU2009207498A patent/AU2009207498A1/en not_active Abandoned
- 2009-01-23 CA CA2708175A patent/CA2708175A1/en not_active Abandoned
- 2009-01-23 EA EA201070523A patent/EA201070523A1/ru unknown
- 2009-01-23 BR BRPI0906436-2A patent/BRPI0906436A2/pt not_active IP Right Cessation
-
2010
- 2010-05-26 ZA ZA2010/03752A patent/ZA201003752B/en unknown
- 2010-05-27 IL IL206026A patent/IL206026A0/en unknown
- 2010-07-16 CO CO10087223A patent/CO6290715A2/es not_active Application Discontinuation
- 2010-07-16 NI NI201000120A patent/NI201000120A/es unknown
- 2010-07-16 DO DO2010000219A patent/DOP2010000219A/es unknown
- 2010-07-16 EC EC2010010349A patent/ECSP10010349A/es unknown
- 2010-07-19 SV SV2010003625A patent/SV2010003625A/es not_active Application Discontinuation
-
2012
- 2012-01-30 US US13/361,911 patent/US20120129855A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20100116187A (ko) | 2010-10-29 |
US8129380B2 (en) | 2012-03-06 |
NI201000120A (es) | 2011-03-23 |
CA2708175A1 (en) | 2009-07-30 |
JP2011510056A (ja) | 2011-03-31 |
AR070221A1 (es) | 2010-03-25 |
CN101925595A (zh) | 2010-12-22 |
MX2010006364A (es) | 2010-07-05 |
US20120129855A1 (en) | 2012-05-24 |
UY31603A1 (es) | 2009-08-31 |
ZA201003752B (en) | 2011-03-30 |
WO2009093032A1 (en) | 2009-07-30 |
NZ585982A (en) | 2011-12-22 |
ECSP10010349A (es) | 2010-08-31 |
SV2010003625A (es) | 2011-05-20 |
CO6290715A2 (es) | 2011-06-20 |
IL206026A0 (en) | 2010-11-30 |
TW200936577A (en) | 2009-09-01 |
BRPI0906436A2 (pt) | 2015-07-14 |
US20090192156A1 (en) | 2009-07-30 |
AU2009207498A1 (en) | 2009-07-30 |
DOP2010000219A (es) | 2010-08-15 |
EP2231638A1 (en) | 2010-09-29 |
EA201070523A1 (ru) | 2011-02-28 |
PE20091335A1 (es) | 2009-10-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2009000133A1 (es) | Compuestos derivados de ftalazinona, inhibidores de la actividad parp; composicion farmaceutica; uso en el tratamiento de enfermedades vasculares, shock septico, lesion isquemica, neurotoxicidad, shock hemorragico, como auxiliar en la terapia del cancer de mama, de ovario, de pancreas, entre otras. | |
CL2011001863A1 (es) | Compuestos derivados de fenilaminopirimidinas, inhibidores de quinasa del linfoma anaplastico; composicion farmaceutica; combinacion farmacologica; y su uso en el tratamiento de trastornos proliferativos tales como linfoma, osteosarcoma, melanoma o tumor de mama, renal y de prostata, entre otros (divisional solicitud 3552-07). | |
DOP2012000063A (es) | (heteroarilmetil) tiohidantoinas sustituidas como drogas anticancer | |
UY29186A1 (es) | Nuevas piridinureas de antranilamida como inhibidores de la quinasa receptora del factor de crecimiento vascular endotelial (vegf) | |
CL2016001629A1 (es) | Compuestos tricíclicos como agentes anticancerígenos | |
UA108618C2 (uk) | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
NI201500067A (es) | Compuestos de pirrolopirimidina como inhibidores de quinasa | |
CL2012000772A1 (es) | Compuestos derivados de hetorociclos carboxamidicos sustituidos, antagonista ar; composición farmacéutica que los comprende; y uso en el tratamiento del cáncer de próstata. | |
EA201201464A1 (ru) | Новая комбинированная терапия для лечения онкологических и фиброзных заболеваний | |
HN2008001532A (es) | Derivados de dihidropirazolopirimidina | |
BR112015006524A2 (pt) | derivados de quinazolinona como inibidores de parp | |
EA200970953A1 (ru) | СПЕЦИФИЧНЫЕ ИНГИБИТОРЫ PDGFRβ | |
GB2471588A (en) | Therapeutic peptidomimetic macrocycles | |
CL2007002994A1 (es) | Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros. | |
CL2012002250A1 (es) | Compuestos heterociclicos fusionados derivados de pirimidinonas, inhibidores potentes de cdc7; composicion farmaceutica; y su uso en la prevencion o el tratamiento del cancer. | |
CR20110477A (es) | Inhibidores de enzimas de proteina cinasa activadas por mitogeno p38 | |
BRPI0808775A2 (pt) | compostos e composições como moduladores de atividade de gpr119 | |
CL2011003350A1 (es) | Compuestos derivados de heterociclo nitrogenados, moduladores pkm2; composicion farmaceutica que los comprende; y su uso en el tratamiento del cancer. | |
CL2008001234A1 (es) | Compuestos derivados de heterociclos nitrogenados, inhibidores de las proteinas de apoptosis; y uso en el tratamiento del cancer. | |
CR20110230A (es) | Inhibidores de las enzimas de proteina cinasa activadas por mitogeno p38 | |
CL2011001445A1 (es) | Compuesto 3-(4-cloro-2-fluorobencil)-2-metil-n-(5-metil-1h-pirazol-3-il)-8-(morfolinometil)imidazo[1,2-b]piridazin-6-amina; composicion farmaceutica; y uso en el tratamiento de trastornos mieloproliferantes cronicos y en el tratamiento de glioblastoma, cancer de amama, mieloma multiple, cancer de prostata y leucemias | |
CL2009000727A1 (es) | Compuestos derivados de n-hidroxi-3-fenilprop-2-enemida y n-hidroxi-3-fenilpropanamida sustituidos; inhibidores de la enzima desacetilasa; su composicion farmaceutica; utiles en el tratamiento del cancer, tumores, psoriasis, alzheimer, entre otras. | |
CL2008003200A1 (es) | Compuestos derivados de tiazol, inhibidores de la proteina quinasas; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de vejiga, de mama y de rinon. | |
BRPI0908635A8 (pt) | composto, composição farmacêutica e método de tratamento de câncer | |
CL2015003595A1 (es) | Inhibidores/antiandrógenos novedosos de cyp17 |