AR058124A1 - Derivados de ftalazinona como inhibidores de parp-1 - Google Patents
Derivados de ftalazinona como inhibidores de parp-1Info
- Publication number
- AR058124A1 AR058124A1 ARP060104580A ARP060104580A AR058124A1 AR 058124 A1 AR058124 A1 AR 058124A1 AR P060104580 A ARP060104580 A AR P060104580A AR P060104580 A ARP060104580 A AR P060104580A AR 058124 A1 AR058124 A1 AR 058124A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- compound
- formula
- substituted alkyl
- ring
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Un compuesto de formula (1): donde; A y B representan juntos un anillo aromático fusionado opcionalmente sustituido; D se selecciona entre: (i) un compuesto de formula (2), donde Y1 se selecciona enrte CH y N, Y2 se selecciona entre CH y N, Y3 se selecciona entre CH, CF y N; y (ii) un compuesto seleccionado del grupo de formulas (3), donde Q es O o S; RD es: un compuesto de formula (4), donde RN1 se selecciona entre H y C1-10alquilo opcionalmente sustituido; X se selecciona entre un enlace simple, NRN2, CRc3Rc4 y C=O; RN2 se selecciona entre H y C1-10alquilo opcionalmente sustituido; Rc3 y Rc4 se seleccionan independientemente entre H, R, C(=O)OR, donde R es C1-10 alquilo opcionalmente sustituido, C5-20 arilo opcionalmente sustituido o C3-20 heterociclilo opcionalmente sustituido; Y se selecciona ente NRN3 y CRc1Rc2; Rc1 y Rc2 se seleccionan independientemente entre H, R, C=(=O)OR, donde R es C1-10 alquilo opcionalmente sustituido, C5-20 arilo opcionalmente sustituido o C3-20 heterociclilo opcionalmente sustituido; Rc1 y Rc2, junto con el átomo de carbono al que están unidos, pueen formar un anillo C5-7 carbocíclico o heterocíclico fusionado a espiro opcionalmente sustituido; y cuando X es un enlace simple, RN1 y Rc2, junto con los átomos de N y C a los que están unidos, pueden formar un anillo C5-7 heterocíclico opcionalmente sustituido; y cuando X es CRc3Rc4, Rc2 y Rc4 pueden formar juntos un enlace adicional, de modo que haya un enlace doble entre los átomos sustituidos con Rc1y Rc3.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72805005P | 2005-10-19 | 2005-10-19 | |
GBGB0521373.1A GB0521373D0 (en) | 2005-10-20 | 2005-10-20 | Pthalazinone derivatives |
US82266306P | 2006-08-17 | 2006-08-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR058124A1 true AR058124A1 (es) | 2008-01-23 |
Family
ID=35458374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060104580A AR058124A1 (es) | 2005-10-19 | 2006-10-19 | Derivados de ftalazinona como inhibidores de parp-1 |
Country Status (12)
Country | Link |
---|---|
US (2) | US7470688B2 (es) |
EP (1) | EP1948642A1 (es) |
JP (1) | JP2009512671A (es) |
AR (1) | AR058124A1 (es) |
AU (1) | AU2006303038A1 (es) |
BR (1) | BRPI0617437A2 (es) |
CA (1) | CA2623703A1 (es) |
GB (1) | GB0521373D0 (es) |
NZ (1) | NZ567445A (es) |
TW (1) | TW200800964A (es) |
UY (1) | UY29870A1 (es) |
WO (1) | WO2007045877A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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US7151102B2 (en) * | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
GB0419072D0 (en) * | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
GB0428111D0 (en) * | 2004-12-22 | 2005-01-26 | Kudos Pharm Ltd | Pthalazinone derivatives |
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
LT3100727T (lt) | 2006-03-27 | 2018-12-10 | The Regents Of The University Of California | Androgeno receptoriaus moduliatorius, skirtas prostatos vėžio ir su androgeno receptoriumi susijusių ligų gydymui |
AU2013205325B2 (en) * | 2006-03-27 | 2016-03-24 | The Regents Of The University Of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
AU2016201061B2 (en) * | 2006-03-27 | 2017-03-02 | The Regents Of The University Of California | Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases |
WO2007127010A2 (en) | 2006-03-29 | 2007-11-08 | The Regents Of The University Of California | Diarylthiohydantoin compounds |
US20070238853A1 (en) * | 2006-04-07 | 2007-10-11 | Ht Materials Corporation | High temperature poly(aryl ether)s containing a phthalazinone moiety |
UY30639A1 (es) * | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
US8466150B2 (en) | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
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US20090023727A1 (en) * | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
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EP2220050A2 (en) | 2007-10-26 | 2010-08-25 | The Regents Of The University Of California | Diarylhydantoin compounds as androgen receptor modulators |
WO2009059243A1 (en) | 2007-11-01 | 2009-05-07 | The Uab Research Foundation | Treating and preventing viral infections |
UY31603A1 (es) | 2008-01-23 | 2009-08-31 | Derivados de ftalazinona | |
ME02640B (me) * | 2008-10-07 | 2017-06-20 | Kudos Pharm Ltd | Farmaceutske formulacije 514 |
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EA201792046A1 (ru) | 2010-02-16 | 2018-05-31 | Арагон Фармасьютикалс, Инк. | Модуляторы рецептора андрогенов и их применение |
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-
2005
- 2005-10-20 GB GBGB0521373.1A patent/GB0521373D0/en not_active Ceased
-
2006
- 2006-10-17 US US11/550,004 patent/US7470688B2/en not_active Expired - Fee Related
- 2006-10-18 UY UY29870A patent/UY29870A1/es not_active Application Discontinuation
- 2006-10-19 EP EP06794830A patent/EP1948642A1/en not_active Withdrawn
- 2006-10-19 CA CA002623703A patent/CA2623703A1/en not_active Abandoned
- 2006-10-19 JP JP2008536123A patent/JP2009512671A/ja active Pending
- 2006-10-19 WO PCT/GB2006/003889 patent/WO2007045877A1/en active Application Filing
- 2006-10-19 BR BRPI0617437-0A patent/BRPI0617437A2/pt not_active IP Right Cessation
- 2006-10-19 TW TW095138562A patent/TW200800964A/zh unknown
- 2006-10-19 AU AU2006303038A patent/AU2006303038A1/en not_active Abandoned
- 2006-10-19 NZ NZ567445A patent/NZ567445A/en unknown
- 2006-10-19 AR ARP060104580A patent/AR058124A1/es not_active Application Discontinuation
-
2008
- 2008-11-14 US US12/271,308 patent/US7902193B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1948642A1 (en) | 2008-07-30 |
BRPI0617437A2 (pt) | 2011-07-26 |
JP2009512671A (ja) | 2009-03-26 |
UY29870A1 (es) | 2007-09-28 |
US20090069303A1 (en) | 2009-03-12 |
US7902193B2 (en) | 2011-03-08 |
WO2007045877A1 (en) | 2007-04-26 |
US7470688B2 (en) | 2008-12-30 |
US20070093489A1 (en) | 2007-04-26 |
TW200800964A (en) | 2008-01-01 |
CA2623703A1 (en) | 2007-04-26 |
NZ567445A (en) | 2011-03-31 |
AU2006303038A1 (en) | 2007-04-26 |
GB0521373D0 (en) | 2005-11-30 |
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