BR0307944A - Piranonas úteis como inibidores de atm - Google Patents

Piranonas úteis como inibidores de atm

Info

Publication number
BR0307944A
BR0307944A BR0307944-9A BR0307944A BR0307944A BR 0307944 A BR0307944 A BR 0307944A BR 0307944 A BR0307944 A BR 0307944A BR 0307944 A BR0307944 A BR 0307944A
Authority
BR
Brazil
Prior art keywords
atm inhibitors
pyranones
useful
pyranones useful
sulfonamino
Prior art date
Application number
BR0307944-9A
Other languages
English (en)
Inventor
Graeme Cameron Murray Smith
Niall Morrison Barr Martin
Stephen Phlip Jackson
Mark James O'connor
Alan Yin Kai Lau
Xiao-Ling Fan Cockcroft
Ian Timothy Williams Matthews
Keith Allan Menear
Laurent Jean Martin Rigoreau
Marc Geoffrey Hummersone
Roger John Griffin
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0204350.3A external-priority patent/GB0204350D0/en
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of BR0307944A publication Critical patent/BR0307944A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PIRANONAS úTEIS COMO INIBIDORES DE ATM". O pedido se refere a um composto da fórmula I: (I) em que um entre P e Q é O, e o outro entre P e Q é H, onde há uma ligação dupla entre aquele entre Q e P que for CH e o átomo de carbono contendo o grupo R^ 3^;Y é O ou S; R^ 1^ e R^ 2^ são independentemente hidrogênio, um grupo alquila C~ 1-7~ opcionalmente substituído, grupo heterociclila C~ 3-20~, ou grupo arila C^ 5-20^, ou podem juntos formar um anel heterocíclico opcionalmente substituído tendo de 4 a 8 átomos de anel; R^ 3^ é um grupo de fenila ou piridila, ligado por um primeiro grupo de ligação selecionado entre -S-, -S(=0)-, -S(=0)2-, -0-, -NR^ N^- e CR^ C1^R^ C2^ - a um grupo carboarila C~ 5-20~ opcionalmente substituído, o grupo fenila ou piridila e grupo carboarila C~ 5-20~ opcionalmente substituído sendo opcionalmente ligado adicionalmente por um segundo grupo de ligação, de modo a formar um anel C~ 5-7~ opcionalmente substituído, o grupo de fenila ou piridila sendo adicionalmente opcionalmente substituído.
BR0307944-9A 2002-02-25 2003-02-24 Piranonas úteis como inibidores de atm BR0307944A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0204350.3A GB0204350D0 (en) 2002-02-25 2002-02-25 ATM inhibitors
US39588402P 2002-07-15 2002-07-15
PCT/GB2003/000770 WO2003070726A1 (en) 2002-02-25 2003-02-24 Pyranones useful as atm inhibitors

Publications (1)

Publication Number Publication Date
BR0307944A true BR0307944A (pt) 2005-02-01

Family

ID=27758841

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307944-9A BR0307944A (pt) 2002-02-25 2003-02-24 Piranonas úteis como inibidores de atm

Country Status (20)

Country Link
EP (2) EP2174939A1 (pt)
JP (1) JP2005521689A (pt)
CN (1) CN100358891C (pt)
AT (1) ATE451365T1 (pt)
AU (1) AU2003209990B8 (pt)
BR (1) BR0307944A (pt)
CA (1) CA2473100A1 (pt)
CY (1) CY1109835T1 (pt)
DE (1) DE60330442D1 (pt)
DK (1) DK1485377T5 (pt)
ES (1) ES2336206T3 (pt)
GB (1) GB2401606B (pt)
HK (1) HK1069827A1 (pt)
MX (1) MXPA04007809A (pt)
NO (1) NO329806B1 (pt)
NZ (1) NZ534821A (pt)
PL (1) PL370074A1 (pt)
PT (1) PT1485377E (pt)
SI (1) SI1485377T1 (pt)
WO (1) WO2003070726A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
CA2482806A1 (en) 2002-04-30 2003-11-13 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US7413738B2 (en) 2002-08-13 2008-08-19 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on biodegradable linkers
US7122189B2 (en) 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
EP1618386A2 (en) * 2003-05-01 2006-01-25 Kudos Pharmaceuticals Limited Methods and means for the treatment of disorders associated with cellular senescence
US7429660B2 (en) * 2003-08-13 2008-09-30 Kudos Pharmaceuticals Limited ATM inhibitors
SG150548A1 (en) 2003-12-01 2009-03-30 Kudos Pharm Ltd Dna damage repair inhibitors for treatment of cancer
WO2005118543A1 (ja) * 2004-06-03 2005-12-15 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
US20070238731A1 (en) 2004-09-20 2007-10-11 Kudos Pharmaceuticals Limited Dna-Pk Inhibitors
TW200638938A (en) * 2005-02-09 2006-11-16 Kudos Pharm Ltd ATM inhibitors
AR053358A1 (es) 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
US20070049588A1 (en) * 2005-08-31 2007-03-01 Kudos Pharmaceuticals Limited Atm inhibitor
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
MX2010002749A (es) 2007-09-14 2010-06-25 Astrazeneca Ab Derivados de ftalazinona.
EA020783B1 (ru) 2008-10-07 2015-01-30 Астразенека Юк Лимитед Фармацевтическая композиция, содержащая 4-[3-(4-циклопропанкарбонилпиперазин-1-карбонил)-4-фторбензил]-2н-фталазин-1-он и коповидон
EP2486923B1 (en) * 2011-02-11 2015-09-09 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Histone deacetylase (HDAC) inhibiting compounds and method of making same
AU2012275841A1 (en) 2011-06-27 2014-01-16 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
JP6074043B2 (ja) * 2013-08-29 2017-02-01 富士フイルム株式会社 新規なモルホリン誘導体またはその塩
JP2023539715A (ja) 2020-06-24 2023-09-19 アストラゼネカ ユーケー リミテッド 抗体－薬物コンジュゲートとａｔｍ阻害剤との組合わせ
CN112094210A (zh) * 2020-09-24 2020-12-18 江苏扬农化工股份有限公司 一种取代的亚磺酸盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
DE68914495T2 (de) * 1988-03-02 1994-10-27 Merck & Co Inc Antihypercholesterolemisches Mittel.
KR920702353A (ko) * 1990-06-29 1992-09-03 로버트 에이. 아미테이지 아테롬성 동맥경화증 및 혈전등 치료제인 2-아미노-6-페닐-4h-피란-4-온
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
JP3851661B2 (ja) * 1996-05-14 2006-11-29 第一製薬株式会社 新規生理活性物質及びその製造方法
FR2765579A1 (fr) * 1997-07-01 1999-01-08 Lipha Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides
ATE321035T1 (de) * 1997-09-26 2006-04-15 Toray Industries Zyklische ketonderivate und ihre pharmazeutische verwendung
BR9908706A (pt) * 1998-03-12 2000-11-21 Teijin Ltd Derivado de benzofuril-alfa-pirona, composição farmacêutica, acentuador de metabolismo de lipìdeos, inibidor de biossìntese de triglicerìdeos, agente redutor de triglicerìdeos do sangue, agente elevador de hdl do sangue, agente profilático para a arteriosclerose, e, agente de tratamento para a arteriosclerose

Also Published As

Publication number Publication date
WO2003070726A1 (en) 2003-08-28
PT1485377E (pt) 2010-03-12
AU2003209990B2 (en) 2008-10-09
EP1485377B8 (en) 2010-02-24
DE60330442D1 (de) 2010-01-21
ATE451365T1 (de) 2009-12-15
CN1639154A (zh) 2005-07-13
AU2003209990A1 (en) 2003-09-09
EP2174939A1 (en) 2010-04-14
GB0419534D0 (en) 2004-10-06
GB2401606B (en) 2005-08-31
ES2336206T3 (es) 2010-04-09
JP2005521689A (ja) 2005-07-21
CY1109835T1 (el) 2014-09-10
NO20044063L (no) 2004-09-24
EP1485377B9 (en) 2010-10-06
MXPA04007809A (es) 2004-10-15
SI1485377T1 (sl) 2010-04-30
NO329806B1 (no) 2010-12-20
PL370074A1 (en) 2005-05-16
ES2336206T9 (es) 2011-03-24
NZ534821A (en) 2006-07-28
DK1485377T5 (da) 2010-12-06
HK1069827A1 (en) 2005-06-03
EP1485377B1 (en) 2009-12-09
EP1485377A1 (en) 2004-12-15
AU2003209990B8 (en) 2008-10-30
CN100358891C (zh) 2008-01-02
CA2473100A1 (en) 2003-08-28
DK1485377T3 (da) 2010-04-19
GB2401606A (en) 2004-11-17

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 9A ANUIDADE.