CY1109835T1 - Πυρανονες χρησιμες ως αναστολεις της atm - Google Patents
Πυρανονες χρησιμες ως αναστολεις της atmInfo
- Publication number
- CY1109835T1 CY1109835T1 CY20101100162T CY101100162T CY1109835T1 CY 1109835 T1 CY1109835 T1 CY 1109835T1 CY 20101100162 T CY20101100162 T CY 20101100162T CY 101100162 T CY101100162 T CY 101100162T CY 1109835 T1 CY1109835 T1 CY 1109835T1
- Authority
- CY
- Cyprus
- Prior art keywords
- atm
- suspensions
- keywords used
- sulfonamino
- acylamido
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η αίτηση αφορά μια ένωση του τύπου I: (I) όπου ένα από τα Ρ και Q είναι Ο, και το άλλο από τα Ρ και Q είναι Η, όπου υπάρχει ένας διπλός δεσμός μεταξύ οποιουδήποτε από τα Q και Ρ είναι CH και του ατόμου άνθρακα που φέρει την ομάδα R3· το Υ είναι είτε Ο είτε S· τα R1 και R2 είναι ανεξαρτήτως υδρογόνο, μια προαιρετικώς υποκατεστημένη C1-7 αλκυλο ομάδα, C3-20 ετεροκυκλυλο ομάδα, ή C5-20 αρυλο ομάδα, ή μαζί μπορούν να σχηματίσουν έναν προαιρετικώς υποκατεστημένο ετεροκυκλικό δακτύλιο που έχει από 4 έως 8 άτομα δακτυλίου· το R3 είναι μια φαινυλο ή πυριδυλο ομάδα, που συνδέεται με μια πρώτη ομάδα γέφυρας που επιλέγεται από -S-, -S(=O)-, -S(=O)2-, -Ο-, -NRN- και CRC1RC2- σε μια προαιρετικώς υποκατεστημένη C5-20 καρβοαρυλο ομάδα, όπου η φαινυλο ή πυριδυλο ομάδα και η προαιρετικώς υποκατεστημένη C5-20 καρβοαρυλο ομάδα προαιρετικώς συνδέονται περαιτέρω με μια δεύτερη ομάδα γέφυρας, έτσι ώστε να σχηματίσουν έναν προαιρετικώς υποκατεστημένο C5-7 δακτύλιο, όπου η φαινυλο ή πυριδυλο ομάδα είναι προαιρετικώς περαιτέρω υποκατεστημένη.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0204350.3A GB0204350D0 (en) | 2002-02-25 | 2002-02-25 | ATM inhibitors |
| US39588402P | 2002-07-15 | 2002-07-15 | |
| EP03742608A EP1485377B9 (en) | 2002-02-25 | 2003-02-24 | Pyranones useful as atm inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109835T1 true CY1109835T1 (el) | 2014-09-10 |
Family
ID=27758841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100162T CY1109835T1 (el) | 2002-02-25 | 2010-02-18 | Πυρανονες χρησιμες ως αναστολεις της atm |
Country Status (20)
| Country | Link |
|---|---|
| EP (2) | EP1485377B9 (el) |
| JP (1) | JP2005521689A (el) |
| CN (1) | CN100358891C (el) |
| AT (1) | ATE451365T1 (el) |
| AU (1) | AU2003209990B8 (el) |
| BR (1) | BR0307944A (el) |
| CA (1) | CA2473100A1 (el) |
| CY (1) | CY1109835T1 (el) |
| DE (1) | DE60330442D1 (el) |
| DK (1) | DK1485377T5 (el) |
| ES (1) | ES2336206T3 (el) |
| GB (1) | GB2401606B (el) |
| HK (1) | HK1069827A1 (el) |
| MX (1) | MXPA04007809A (el) |
| NO (1) | NO329806B1 (el) |
| NZ (1) | NZ534821A (el) |
| PL (1) | PL370074A1 (el) |
| PT (1) | PT1485377E (el) |
| SI (1) | SI1485377T1 (el) |
| WO (1) | WO2003070726A1 (el) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| GB0119863D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| US7196085B2 (en) | 2002-04-30 | 2007-03-27 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US7413738B2 (en) | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| US7122189B2 (en) | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
| EP1618386A2 (en) * | 2003-05-01 | 2006-01-25 | Kudos Pharmaceuticals Limited | Methods and means for the treatment of disorders associated with cellular senescence |
| KR20060066722A (ko) * | 2003-08-13 | 2006-06-16 | 쿠도스 파마슈티칼스 리미티드 | 아미노피론 및 ａｔｍ억제제로서의 이의 용도 |
| ATE521341T1 (de) | 2003-12-01 | 2011-09-15 | Kudos Pharm Ltd | Dna-schäden-reparatur-hemmer zur behandlung von krebs |
| WO2005118543A1 (ja) * | 2004-06-03 | 2005-12-15 | Ono Pharmaceutical Co., Ltd. | キナーゼ阻害薬およびその用途 |
| TW200616986A (en) | 2004-09-20 | 2006-06-01 | Kudos Pharm Ltd | DNA-pk inhibitors |
| EP1848712A1 (en) * | 2005-02-09 | 2007-10-31 | Kudos Pharmaceuticals Ltd | Atm inhibitors |
| AR054438A1 (es) | 2005-04-15 | 2007-06-27 | Kudos Pharm Ltd | Inhibidores de adn -pk |
| TW200745094A (en) * | 2005-08-31 | 2007-12-16 | Kudos Pharm Ltd | ATM inhibitor |
| GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
| US7981890B2 (en) | 2007-09-14 | 2011-07-19 | Astrazeneca Ab | Phthalazinone derivatives |
| HRP20161154T4 (hr) | 2008-10-07 | 2023-09-29 | Kudos Pharmaceuticals Limited | Farmaceutska formulacija 514 |
| EP2486923B1 (en) * | 2011-02-11 | 2015-09-09 | Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG | Histone deacetylase (HDAC) inhibiting compounds and method of making same |
| EP2724156B1 (en) | 2011-06-27 | 2017-08-16 | The Jackson Laboratory | Methods and compositions for treatment of cancer and autoimmune disease |
| WO2015030057A1 (ja) * | 2013-08-29 | 2015-03-05 | 富士フイルム株式会社 | 新規なモルホリン誘導体またはその塩 |
| EP4171651A1 (en) | 2020-06-24 | 2023-05-03 | AstraZeneca UK Limited | Combination of antibody-drug conjugate and atm inhibitor |
| CN112094210A (zh) * | 2020-09-24 | 2020-12-18 | 江苏扬农化工股份有限公司 | 一种取代的亚磺酸盐的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4282155A (en) * | 1980-02-04 | 1981-08-04 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| DE68914495T2 (de) * | 1988-03-02 | 1994-10-27 | Merck & Co Inc | Antihypercholesterolemisches Mittel. |
| AU630822B2 (en) * | 1990-06-29 | 1992-11-05 | Upjohn Company, The | Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4h-pyran-4-ones |
| IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
| WO1997043434A1 (fr) * | 1996-05-14 | 1997-11-20 | Snow Brand Milk Products Co., Ltd. | Nouvelle substance active sur le plan physiologique et son procede de preparation |
| FR2765579A1 (fr) * | 1997-07-01 | 1999-01-08 | Lipha | Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides |
| EP0962456B1 (en) * | 1997-09-26 | 2006-03-22 | Toray Industries, Inc. | Cyclic ketone derivative and pharmaceutical use thereof |
| AU756965B2 (en) * | 1998-03-12 | 2003-01-30 | Microbial Chemistry Research Foundation | Benzofurylpyrone derivatives |
-
2003
- 2003-02-24 PT PT03742608T patent/PT1485377E/pt unknown
- 2003-02-24 DE DE60330442T patent/DE60330442D1/de not_active Expired - Lifetime
- 2003-02-24 AT AT03742608T patent/ATE451365T1/de not_active IP Right Cessation
- 2003-02-24 CN CNB038045478A patent/CN100358891C/zh not_active Expired - Fee Related
- 2003-02-24 GB GB0419534A patent/GB2401606B/en not_active Expired - Fee Related
- 2003-02-24 PL PL03370074A patent/PL370074A1/xx not_active Application Discontinuation
- 2003-02-24 WO PCT/GB2003/000770 patent/WO2003070726A1/en active Application Filing
- 2003-02-24 EP EP03742608A patent/EP1485377B9/en not_active Expired - Lifetime
- 2003-02-24 BR BR0307944-9A patent/BR0307944A/pt not_active IP Right Cessation
- 2003-02-24 DK DK03742608.7T patent/DK1485377T5/da active
- 2003-02-24 CA CA002473100A patent/CA2473100A1/en not_active Abandoned
- 2003-02-24 SI SI200331759T patent/SI1485377T1/sl unknown
- 2003-02-24 MX MXPA04007809A patent/MXPA04007809A/es active IP Right Grant
- 2003-02-24 JP JP2003569633A patent/JP2005521689A/ja active Pending
- 2003-02-24 ES ES03742608T patent/ES2336206T3/es not_active Expired - Lifetime
- 2003-02-24 AU AU2003209990A patent/AU2003209990B8/en not_active Ceased
- 2003-02-24 EP EP09014921A patent/EP2174939A1/en not_active Withdrawn
- 2003-02-24 NZ NZ534821A patent/NZ534821A/en not_active IP Right Cessation
-
2004
- 2004-09-24 NO NO20044063A patent/NO329806B1/no not_active IP Right Cessation
-
2005
- 2005-04-19 HK HK05103310A patent/HK1069827A1/xx not_active IP Right Cessation
-
2010
- 2010-02-18 CY CY20101100162T patent/CY1109835T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60330442D1 (de) | 2010-01-21 |
| CA2473100A1 (en) | 2003-08-28 |
| SI1485377T1 (sl) | 2010-04-30 |
| PT1485377E (pt) | 2010-03-12 |
| HK1069827A1 (en) | 2005-06-03 |
| BR0307944A (pt) | 2005-02-01 |
| EP1485377A1 (en) | 2004-12-15 |
| GB2401606A (en) | 2004-11-17 |
| ES2336206T3 (es) | 2010-04-09 |
| ATE451365T1 (de) | 2009-12-15 |
| GB2401606B (en) | 2005-08-31 |
| WO2003070726A1 (en) | 2003-08-28 |
| CN1639154A (zh) | 2005-07-13 |
| NZ534821A (en) | 2006-07-28 |
| JP2005521689A (ja) | 2005-07-21 |
| DK1485377T3 (da) | 2010-04-19 |
| MXPA04007809A (es) | 2004-10-15 |
| AU2003209990B2 (en) | 2008-10-09 |
| CN100358891C (zh) | 2008-01-02 |
| GB0419534D0 (en) | 2004-10-06 |
| AU2003209990A1 (en) | 2003-09-09 |
| PL370074A1 (en) | 2005-05-16 |
| EP2174939A1 (en) | 2010-04-14 |
| EP1485377B1 (en) | 2009-12-09 |
| EP1485377B9 (en) | 2010-10-06 |
| NO20044063L (no) | 2004-09-24 |
| EP1485377B8 (en) | 2010-02-24 |
| DK1485377T5 (da) | 2010-12-06 |
| ES2336206T9 (es) | 2011-03-24 |
| AU2003209990B8 (en) | 2008-10-30 |
| NO329806B1 (no) | 2010-12-20 |
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