ATE451365T1 - Als atm-inhibitoren geeignete pyranone - Google Patents

Als atm-inhibitoren geeignete pyranone

Info

Publication number
ATE451365T1
ATE451365T1 AT03742608T AT03742608T ATE451365T1 AT E451365 T1 ATE451365 T1 AT E451365T1 AT 03742608 T AT03742608 T AT 03742608T AT 03742608 T AT03742608 T AT 03742608T AT E451365 T1 ATE451365 T1 AT E451365T1
Authority
AT
Austria
Prior art keywords
pyranones
atm inhibitors
sulfonamino
acylamido
prodrugs
Prior art date
Application number
AT03742608T
Other languages
English (en)
Inventor
Graeme Smith
Niall Martin
Stephen Jackson
Mark O'connor
Alan Lau
Xiao-Ling Fan Cockcroft
Ian Matthews
Keith Menear
Laurent Rigoreau
Marc Hummersone
Roger Griffin
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0204350.3A external-priority patent/GB0204350D0/en
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Application granted granted Critical
Publication of ATE451365T1 publication Critical patent/ATE451365T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • AIDS & HIV (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03742608T 2002-02-25 2003-02-24 Als atm-inhibitoren geeignete pyranone ATE451365T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0204350.3A GB0204350D0 (en) 2002-02-25 2002-02-25 ATM inhibitors
US39588402P 2002-07-15 2002-07-15
PCT/GB2003/000770 WO2003070726A1 (en) 2002-02-25 2003-02-24 Pyranones useful as atm inhibitors

Publications (1)

Publication Number Publication Date
ATE451365T1 true ATE451365T1 (de) 2009-12-15

Family

ID=27758841

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03742608T ATE451365T1 (de) 2002-02-25 2003-02-24 Als atm-inhibitoren geeignete pyranone

Country Status (20)

Country Link
EP (2) EP2174939A1 (de)
JP (1) JP2005521689A (de)
CN (1) CN100358891C (de)
AT (1) ATE451365T1 (de)
AU (1) AU2003209990B8 (de)
BR (1) BR0307944A (de)
CA (1) CA2473100A1 (de)
CY (1) CY1109835T1 (de)
DE (1) DE60330442D1 (de)
DK (1) DK1485377T5 (de)
ES (1) ES2336206T3 (de)
GB (1) GB2401606B (de)
HK (1) HK1069827A1 (de)
MX (1) MXPA04007809A (de)
NO (1) NO329806B1 (de)
NZ (1) NZ534821A (de)
PL (1) PL370074A1 (de)
PT (1) PT1485377E (de)
SI (1) SI1485377T1 (de)
WO (1) WO2003070726A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7196085B2 (en) 2002-04-30 2007-03-27 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US7122189B2 (en) 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US7413738B2 (en) 2002-08-13 2008-08-19 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on biodegradable linkers
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
WO2004097426A2 (en) * 2003-05-01 2004-11-11 Kudos Pharmaceuticals Limited Methods and means for the treatment of disorders associated with cellular senescence
NZ545919A (en) * 2003-08-13 2009-07-31 Kudos Pharm Ltd Aminopyrones and their use as ATM inhibitors
JP5545690B2 (ja) 2003-12-01 2014-07-09 クドス ファーマシューティカルズ リミテッド 癌治療のためのｄｎａ損傷修復阻害剤
WO2005118543A1 (ja) * 2004-06-03 2005-12-15 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
AU2005286329A1 (en) 2004-09-20 2006-03-30 Cancer Research Technology Limited DNA-PK inhibitors
EP1848712A1 (de) * 2005-02-09 2007-10-31 Kudos Pharmaceuticals Ltd Atm-inhibitoren
AR054438A1 (es) 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
TW200745094A (en) * 2005-08-31 2007-12-16 Kudos Pharm Ltd ATM inhibitor
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
RU2010108008A (ru) 2007-09-14 2011-10-20 Астразенека Аб (Se) Фталазиноновые производные
CN102238945B (zh) 2008-10-07 2014-10-29 阿斯利康(英国)有限公司 药物制剂514
EP2486923B1 (de) * 2011-02-11 2015-09-09 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Histon-Deacetylase (HDAC) hemmende Verbindungen und Verfahren zu deren Herstellung
AU2012275841A1 (en) 2011-06-27 2014-01-16 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
WO2015030057A1 (ja) * 2013-08-29 2015-03-05 富士フイルム株式会社 新規なモルホリン誘導体またはその塩
JP2023539715A (ja) 2020-06-24 2023-09-19 アストラゼネカ ユーケー リミテッド 抗体－薬物コンジュゲートとａｔｍ阻害剤との組合わせ
CN112094210A (zh) * 2020-09-24 2020-12-18 江苏扬农化工股份有限公司 一种取代的亚磺酸盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0331250B1 (de) * 1988-03-02 1994-04-13 Merck & Co. Inc. Antihypercholesterolemisches Mittel
DK0489877T3 (da) * 1990-06-29 1996-02-05 Upjohn Co Antiatherosklerotiske og antithrombotiske 2-amino-6-phenyl-4H-pyran-4-oner
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
WO1997043434A1 (fr) * 1996-05-14 1997-11-20 Snow Brand Milk Products Co., Ltd. Nouvelle substance active sur le plan physiologique et son procede de preparation
FR2765579A1 (fr) * 1997-07-01 1999-01-08 Lipha Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides
WO1999016763A1 (fr) * 1997-09-26 1999-04-08 Toray Industries, Inc. Derive de cetone et son utilisation en medecine
DE69917237T2 (de) * 1998-03-12 2005-05-04 Teijin Ltd. Benzofurylpyron-derivate

Also Published As

Publication number Publication date
BR0307944A (pt) 2005-02-01
CY1109835T1 (el) 2014-09-10
WO2003070726A1 (en) 2003-08-28
PL370074A1 (en) 2005-05-16
SI1485377T1 (sl) 2010-04-30
MXPA04007809A (es) 2004-10-15
JP2005521689A (ja) 2005-07-21
PT1485377E (pt) 2010-03-12
CN1639154A (zh) 2005-07-13
GB2401606B (en) 2005-08-31
DK1485377T5 (da) 2010-12-06
NZ534821A (en) 2006-07-28
CA2473100A1 (en) 2003-08-28
HK1069827A1 (en) 2005-06-03
EP1485377B8 (de) 2010-02-24
EP1485377B9 (de) 2010-10-06
AU2003209990B8 (en) 2008-10-30
NO20044063L (no) 2004-09-24
AU2003209990B2 (en) 2008-10-09
DE60330442D1 (de) 2010-01-21
NO329806B1 (no) 2010-12-20
CN100358891C (zh) 2008-01-02
EP2174939A1 (de) 2010-04-14
EP1485377B1 (de) 2009-12-09
AU2003209990A1 (en) 2003-09-09
GB2401606A (en) 2004-11-17
DK1485377T3 (da) 2010-04-19
GB0419534D0 (en) 2004-10-06
EP1485377A1 (de) 2004-12-15
ES2336206T3 (es) 2010-04-09
ES2336206T9 (es) 2011-03-24

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