AR054438A1 - Inhibidores de adn -pk - Google Patents
Inhibidores de adn -pkInfo
- Publication number
- AR054438A1 AR054438A1 ARP060101479A ARP060101479A AR054438A1 AR 054438 A1 AR054438 A1 AR 054438A1 AR P060101479 A ARP060101479 A AR P060101479A AR P060101479 A ARP060101479 A AR P060101479A AR 054438 A1 AR054438 A1 AR 054438A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- group
- alkyl
- attached
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Reivindicacion 1: Un compuesto caracterizado porque es de formula (1) e isomeros, sales, solvatos, formas químicamente protegidas y prodrogas del mismo, donde: A, B y D se seleccionan respectivamente entre el grupo que consiste en (i) CH, NH, C; (ii) CH, N, N; y (ii) CH, O, C; la líneas punteadas representan dos doble enlaces en las ubicaciones apropiadas; RN1 y RN2 se seleccionan en forma independiente entre hidrogeno, un grupo C1-7 alquilo, C3-20 heterociclilo, o C5-20 arilo opcionalmente sustituido, o pueden formar juntos, junto con el átomo de nitrogeno al cual están unidos, un anillo heterocíclico opcionalmente sustituido con entre 4 y 8 átomos del anillo; Z2,Z3, Z4, Z5 y Z6, junto con el átomo de carbono al cual están unidos, forman un anillo aromático; Z2 se selecciona entre el grupo que consiste en CR2, N, NH, S, y O; Z3 es CR3; Z4 se selecciona entre el grupo que consiste en CR4, N, NH, S y O; Z5 es un enlace directo, o se selecciona entre el grupo que consiste en O, N, NH, S y CH; R2 es H; R3 se selecciona entre halo o C5-20 arilo opcionalmente sustituido; R4 se selecciona ente el grupo que consiste en H, OH, NO2 y Q-Y-X, donde Q es -NH-C(=O)- o -O-; Y es un grupo C1-5 alquileno opcionalmente sustituido; X se selecciona entre SRS1 o NRN3RN4, donde, RS1, o RN3 y RN4 se seleccionan en forma independiente entre hidrogeno, grupos C1-7 alquilo, C5-20arilo, o C3-20 heterociclilo opcionalmente sustituidos, o RN3 y RN4 pueden formar juntos, junto con el átomo de nitrogeno al cual están unidos, un anillo heterocíclico opcionalmente sustituido con entre 4 y 8 átomos del anillo; si Q es -O-, X puede seleccionarse además ente -C(=O)-NRN5RN6, donde RN5 y RN6 se seleccionan en forma independiente entre hidrogeno, grupos C1-7 alquilo, C5-20arilo, o C3-20 heterociclilo opcionalmente sustituidos, o RN5 y RN6 pueden formar juntos, junto con el átomo de nitrogeno al cual están unidos, un anillo heterocíclico opcionalmente sustituido con entre 4 y 8 átomos del anillo y si Q es -NH-C(=O)-, -Y-X puede seleccionarse adicionalmente entre C1-7 alquilo. Composiciones farmacéuticas que los contienen y usos como agentes potenciadores de la quimioterapia y de la radioterapia, en el tratamiento del cáncer.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67188605P | 2005-04-15 | 2005-04-15 | |
US67183005P | 2005-04-15 | 2005-04-15 | |
GB0507831A GB0507831D0 (en) | 2005-04-18 | 2005-04-18 | DNA-PK inhibitors |
US69606405P | 2005-07-01 | 2005-07-01 | |
US71890405P | 2005-09-20 | 2005-09-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR054438A1 true AR054438A1 (es) | 2007-06-27 |
Family
ID=36579227
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060101480A AR053358A1 (es) | 2005-04-15 | 2006-04-12 | Inhibidores de adn - pk |
ARP060101479A AR054438A1 (es) | 2005-04-15 | 2006-04-12 | Inhibidores de adn -pk |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060101480A AR053358A1 (es) | 2005-04-15 | 2006-04-12 | Inhibidores de adn - pk |
Country Status (13)
Country | Link |
---|---|
US (2) | US7696203B2 (es) |
EP (2) | EP1869021A1 (es) |
JP (2) | JP2008535903A (es) |
KR (1) | KR20080002963A (es) |
AR (2) | AR053358A1 (es) |
AU (1) | AU2006235731A1 (es) |
CA (1) | CA2603637A1 (es) |
IL (1) | IL186445A0 (es) |
MX (1) | MX2007012696A (es) |
NO (1) | NO20075809L (es) |
TW (2) | TW200720274A (es) |
UY (1) | UY29479A1 (es) |
WO (2) | WO2006109081A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0119865D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
MXPA06001599A (es) * | 2003-08-13 | 2006-05-19 | Kudos Pharm Ltd | Aminopironas y su uso como inhibidores de atm. |
CA2580229A1 (en) | 2004-09-20 | 2006-03-30 | Kudos Pharmaceuticals Limited | Dna-pk inhibitors |
TW200638938A (en) * | 2005-02-09 | 2006-11-16 | Kudos Pharm Ltd | ATM inhibitors |
AR053358A1 (es) * | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones | |
EP2198710A1 (de) | 2008-12-19 | 2010-06-23 | Bayer CropScience AG | Verwendung von 5-Pyridin-4yl-(1,3)Thiazole zur Bekämpfung phytopathogener Pilze |
WO2010136778A1 (en) * | 2009-05-29 | 2010-12-02 | Kudos Pharmaceuticals Limited | Dibenzothiophene derivatives as dna- pk inhibitors |
FR2947548B1 (fr) * | 2009-07-02 | 2012-05-18 | Sanofi Aventis | Nouveaux derives de 1h-pyrimidin-2-one, leur preparation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
FR2947551B1 (fr) * | 2009-07-02 | 2012-05-18 | Sanofi Aventis | Nouveaux derives de 1,2,3,4-tetrahydro-pyrimido{1,2-a)pyrimidin-6-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt (pkb) |
RS53317B (en) | 2009-07-02 | 2014-10-31 | Sanofi | NEW DERIVATIVES (6-OXO-1,6-DIHYDROPYRIMIDIN-2-IL) AMIDES, THEIR PRODUCTION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORILATION INHIBITOR |
FR2947550B1 (fr) * | 2009-07-02 | 2012-05-18 | Sanofi Aventis | Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt (pkb) |
FR2951170B1 (fr) * | 2009-10-09 | 2011-12-02 | Sanofi Aventis | Nouveaux derives de 1h-pyrimidin-2-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
EP2448939B1 (fr) * | 2009-07-02 | 2017-03-01 | Sanofi | Derives de 2,3-dihydro-1h-imidazo {1,2-a} pyrimidin-5-one, leur preparation et leur utilisation pharmaceutique |
BRPI1015943A8 (pt) * | 2009-07-02 | 2018-01-09 | Sanofi Sa | derivados de 1,2,3,4-tetra - hidro - pirimido {1,2-a} pirimidin-6-ona, o respectivo preparo e a respectiva utilização farmacêutica. |
WO2011001115A1 (fr) | 2009-07-02 | 2011-01-06 | Sanofi-Aventis | Nouveaux derives de 6-morpholin-4-yl-pyrimidin-4- ( 3h ) -one, leur preparation pharmaceutique comme inhibiteurs de phos phorylat i on d ' akt ( pkb ) |
US8399460B2 (en) * | 2009-10-27 | 2013-03-19 | Astrazeneca Ab | Chromenone derivatives |
US9618663B2 (en) | 2010-04-15 | 2017-04-11 | 3M Innovative Properties Company | Retroreflective articles including optically active areas and optically inactive areas |
US20130109687A1 (en) * | 2010-04-30 | 2013-05-02 | Gary J. Nabel | Methods of treating hiv infection: inhibition of dna dependent protein kinase |
DE102010035744A1 (de) | 2010-08-28 | 2012-03-01 | Merck Patent Gmbh | Imidazolonylchinoline |
HUE024504T2 (en) | 2010-12-23 | 2016-01-28 | Sanofi Sa | Pyrimidine derivatives, a process for their preparation and their use in medicine |
HUE030393T2 (en) | 2010-12-28 | 2017-05-29 | Sanofi Sa | New pyrimidine derivatives, a process for their preparation, and their pharmaceutical use as inhibitors of AKT (PKB) phosphorylation |
UY34013A (es) * | 2011-04-13 | 2012-11-30 | Astrazeneca Ab | ?compuestos de cromenona con actividad anti-tumoral?. |
CN106986863B (zh) | 2012-04-24 | 2019-12-31 | 沃泰克斯药物股份有限公司 | Dna-pk抑制剂 |
BR112014031292A2 (pt) * | 2012-06-15 | 2017-06-27 | Basf Se | sistema cristalino de múltiplos componentes, processo para obter a composição cristalina, e, composição farmacêutica |
FR2992314B1 (fr) | 2012-06-22 | 2015-10-16 | Sanofi Sa | Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique |
FR2992316A1 (fr) | 2012-06-22 | 2013-12-27 | Sanofi Sa | Derives de pyrimidinones, leur preparation et leur application en therapeutique |
CN105246883B (zh) | 2013-03-12 | 2017-07-21 | 沃泰克斯药物股份有限公司 | Dna‑pk抑制剂 |
WO2016086261A1 (en) | 2014-12-02 | 2016-06-09 | Prana Biotechnology Limited | 4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE COMPOUNDS |
US11110108B2 (en) | 2016-09-27 | 2021-09-07 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors |
CN109232476B (zh) * | 2018-11-06 | 2020-06-26 | 常州大学 | 一种制备n-苯基-3-吗啡啉丙酰胺的方法 |
US20230111712A1 (en) * | 2020-03-13 | 2023-04-13 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Stable reactive compositions for bioconjugation, probes, and protein labeling |
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GB1303724A (es) | 1969-05-14 | 1973-01-17 | ||
JPH0753725B2 (ja) * | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
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JPH04502322A (ja) | 1988-12-21 | 1992-04-23 | ジ・アップジョン・カンパニー | 抗アテローム性動脈硬化症性および抗血栓性1―ベンゾピラン―4―オン類および2―アミノ―1,3―ベンゾオキサジン―4―オン類 |
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JPH03215423A (ja) | 1990-01-18 | 1991-09-20 | Kyowa Hakko Kogyo Co Ltd | 血管拡張剤 |
CA2081577A1 (en) | 1990-06-20 | 1991-12-21 | Ronald B. Gammill | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1, 3-benzoxazine-4-ones |
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US5378725A (en) | 1993-07-19 | 1995-01-03 | The Arizona Board Of Regents | Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof |
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US6632789B1 (en) | 1994-04-29 | 2003-10-14 | The United States Of America As Represented By The Secretary Of The Navy | Methods for modulating T cell responses by manipulating intracellular signal transduction |
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US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
AU1461197A (en) | 1995-11-16 | 1997-06-05 | Icos Corporation | Cell cycle checkpoint pik-related kinase materials and methods |
GB2302021A (en) | 1996-10-16 | 1997-01-08 | Lilly Co Eli | Inhibiting bone loss or resorption |
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AU8068198A (en) | 1997-06-13 | 1998-12-30 | President And Fellows Of Harvard College | Methods for treating human cancers |
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US6348311B1 (en) * | 1999-02-10 | 2002-02-19 | St. Jude Childre's Research Hospital | ATM kinase modulation for screening and therapies |
US6333180B1 (en) * | 1999-12-21 | 2001-12-25 | International Flavors & Fragrances Inc. | Bioprocess for the high-yield production of food flavor-acceptable jasmonic acid and methyl jasmonate |
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KR20080015888A (ko) | 2000-06-28 | 2008-02-20 | 테바 파마슈티컬 인더스트리즈 리미티드 | 카르베딜올 |
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EP1353693B1 (en) | 2001-01-16 | 2005-03-16 | Glaxo Group Limited | Pharmaceutical combination containing a 4-quinazolineamine and paclitaxel, carboplatin or vinorelbine for the treatment of cancer |
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US7049313B2 (en) * | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
JP4500161B2 (ja) | 2002-04-30 | 2010-07-14 | クドス ファーマシューティカルズ リミテッド | フタラジノン誘導体 |
MXPA06001599A (es) | 2003-08-13 | 2006-05-19 | Kudos Pharm Ltd | Aminopironas y su uso como inhibidores de atm. |
CA2580229A1 (en) | 2004-09-20 | 2006-03-30 | Kudos Pharmaceuticals Limited | Dna-pk inhibitors |
TW200638938A (en) | 2005-02-09 | 2006-11-16 | Kudos Pharm Ltd | ATM inhibitors |
AR053358A1 (es) * | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
UY31232A1 (es) | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones |
-
2006
- 2006-04-12 AR ARP060101480A patent/AR053358A1/es not_active Application Discontinuation
- 2006-04-12 AR ARP060101479A patent/AR054438A1/es not_active Application Discontinuation
- 2006-04-13 JP JP2008505966A patent/JP2008535903A/ja active Pending
- 2006-04-13 KR KR1020077026502A patent/KR20080002963A/ko not_active Application Discontinuation
- 2006-04-13 AU AU2006235731A patent/AU2006235731A1/en not_active Abandoned
- 2006-04-13 EP EP06726768A patent/EP1869021A1/en not_active Withdrawn
- 2006-04-13 WO PCT/GB2006/001369 patent/WO2006109081A1/en active Application Filing
- 2006-04-13 JP JP2008505964A patent/JP2008535902A/ja active Pending
- 2006-04-13 WO PCT/GB2006/001379 patent/WO2006109084A1/en not_active Application Discontinuation
- 2006-04-13 EP EP06726777A patent/EP1869040A1/en not_active Withdrawn
- 2006-04-13 CA CA002603637A patent/CA2603637A1/en not_active Abandoned
- 2006-04-13 US US11/403,606 patent/US7696203B2/en not_active Expired - Fee Related
- 2006-04-13 US US11/403,763 patent/US20060264623A1/en not_active Abandoned
- 2006-04-13 MX MX2007012696A patent/MX2007012696A/es not_active Application Discontinuation
- 2006-04-14 TW TW095113561A patent/TW200720274A/zh unknown
- 2006-04-14 TW TW095113560A patent/TW200720271A/zh unknown
- 2006-04-18 UY UY29479A patent/UY29479A1/es not_active Application Discontinuation
-
2007
- 2007-10-07 IL IL186445A patent/IL186445A0/en unknown
- 2007-11-12 NO NO20075809A patent/NO20075809L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1869021A1 (en) | 2007-12-26 |
US7696203B2 (en) | 2010-04-13 |
KR20080002963A (ko) | 2008-01-04 |
WO2006109084A1 (en) | 2006-10-19 |
JP2008535902A (ja) | 2008-09-04 |
WO2006109081A1 (en) | 2006-10-19 |
TW200720274A (en) | 2007-06-01 |
AR053358A1 (es) | 2007-05-02 |
US20060264427A1 (en) | 2006-11-23 |
IL186445A0 (en) | 2008-01-20 |
TW200720271A (en) | 2007-06-01 |
EP1869040A1 (en) | 2007-12-26 |
NO20075809L (no) | 2007-12-27 |
JP2008535903A (ja) | 2008-09-04 |
MX2007012696A (es) | 2008-03-14 |
CA2603637A1 (en) | 2006-10-19 |
AU2006235731A1 (en) | 2006-10-19 |
UY29479A1 (es) | 2006-11-30 |
US20060264623A1 (en) | 2006-11-23 |
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Legal Events
Date | Code | Title | Description |
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FA | Abandonment or withdrawal |