EA200000400A1 - Галогензамещенные тетрациклические производные тетрагидрофурана - Google Patents
Галогензамещенные тетрациклические производные тетрагидрофуранаInfo
- Publication number
- EA200000400A1 EA200000400A1 EA200000400A EA200000400A EA200000400A1 EA 200000400 A1 EA200000400 A1 EA 200000400A1 EA 200000400 A EA200000400 A EA 200000400A EA 200000400 A EA200000400 A EA 200000400A EA 200000400 A1 EA200000400 A1 EA 200000400A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- halogen
- alkyl
- hydrogen
- tetrahydrofuran
- aryl
- Prior art date
Links
- 229910052736 halogen Inorganic materials 0.000 title abstract 5
- 125000005843 halogen group Chemical group 0.000 title abstract 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical class C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004970 halomethyl group Chemical group 0.000 abstract 1
- -1 halomethylcarbonyl Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Abstract
Данное изобретение относится к соединениям формулы (I), их N-оксидным формам, фармацевтически приемлемым солям присоединения и стереохимически изомерным формам, где n представляет собой ноль, 1, 2, 3, 4, 5 или 6; X представляет собой CHили O; Rи R, каждый независимо представляют собой водород, Cалкил, Cалкилкарбонил, галогенметилкарбонил, или Cалкил, замещенный гидрокси, Cалкилоксигруппой, карбоксилом, Cалкилкарбонилоксигруппой, Cалкилоксикарбонилом или арилом; или Rи R, взятые вместе с атомом азота, к которому они присоединены, могут образовывать морфолинильное кольцо, или необязательно замещенный гетероцикл; Rи Rоба являются галогеном; или Rявляется галогеном, а Rявляется водородом; или Rявляется водородом, а Rявляется галогеном; а арил представляет собой фенил или фенил, замещенный 1, 2 или 3 заместителями, выбранными из галогена, гидрокси, Cалкила и галогенметила. Соединения формулы (I) могут быть использованы в качестве терапевтических агентов.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97203154 | 1997-10-10 | ||
| PCT/EP1998/006352 WO1999019317A1 (en) | 1997-10-10 | 1998-10-06 | Halogen substituted tetracyclic tetrahydrofuran derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200000400A1 true EA200000400A1 (ru) | 2000-10-30 |
| EA003698B1 EA003698B1 (ru) | 2003-08-28 |
Family
ID=8228817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200000400A EA003698B1 (ru) | 1997-10-10 | 1998-10-06 | Галогензамещенные тетрациклические производные тетрагидрофурана |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US6511976B1 (ru) |
| EP (1) | EP1021432B1 (ru) |
| JP (1) | JP3248902B2 (ru) |
| KR (1) | KR100366014B1 (ru) |
| CN (1) | CN100340554C (ru) |
| AP (1) | AP1239A (ru) |
| AR (1) | AR017325A1 (ru) |
| AT (1) | ATE235479T1 (ru) |
| AU (1) | AU737334B2 (ru) |
| BG (1) | BG64387B1 (ru) |
| BR (1) | BR9812871A (ru) |
| CA (1) | CA2305612C (ru) |
| CZ (1) | CZ296928B6 (ru) |
| DE (1) | DE69812668T2 (ru) |
| DK (1) | DK1021432T3 (ru) |
| EA (1) | EA003698B1 (ru) |
| EE (1) | EE04526B1 (ru) |
| ES (1) | ES2195403T3 (ru) |
| HK (1) | HK1029106A1 (ru) |
| HR (1) | HRP20000189A2 (ru) |
| HU (1) | HU225161B1 (ru) |
| ID (1) | ID23903A (ru) |
| IL (1) | IL135538A (ru) |
| MY (1) | MY117783A (ru) |
| NO (1) | NO317159B1 (ru) |
| NZ (1) | NZ503294A (ru) |
| OA (1) | OA11898A (ru) |
| PL (1) | PL339833A1 (ru) |
| PT (1) | PT1021432E (ru) |
| SI (1) | SI1021432T1 (ru) |
| SK (1) | SK284028B6 (ru) |
| TR (1) | TR200000918T2 (ru) |
| TW (1) | TW567186B (ru) |
| UA (1) | UA52778C2 (ru) |
| WO (1) | WO1999019317A1 (ru) |
| ZA (1) | ZA989204B (ru) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA79248C2 (en) * | 2001-11-09 | 2007-06-11 | Janssen Pharmaceutica Nv | Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives |
| WO2003048146A1 (en) * | 2001-12-07 | 2003-06-12 | Janssen Pharmaceutica N.V. | PREPARATION OF TRANS-FUSED 3,3a,8,12b-TETRAHYDRO-2H-DIBENZO[3,4:6,7]CYCLOHEPTA[1,2-b]FURAN DERIVATIVES |
| EP1463722A2 (en) | 2001-12-07 | 2004-10-06 | Janssen Pharmaceutica N.V. | PREPARATION OF CIS-FUSED 3,3a,8,12b-TETRAHYDRO-2-H-DIBENZO[3,4:6,7]CYCLOHEPTA[1,2-b]FURAN DERIVATIVES |
| HRP20020305A8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| HRP20020441A2 (en) * | 2002-05-21 | 2003-12-31 | Pliva D D | 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
| HRP20030160A2 (en) * | 2003-03-06 | 2005-04-30 | Pliva-Istra�iva�ki institut d.o.o. | 1-thiadibenzoazulene derivatives and biological action thereof |
| HRP20030885A2 (en) * | 2003-11-03 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS |
| HRP20030953A2 (en) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030956A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU |
| HRP20030958A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030959A2 (ru) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | |
| HRP20030955A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030957A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030954A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva D.D. | USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20040104A2 (en) * | 2004-01-30 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders |
| CN1968942B (zh) * | 2004-06-14 | 2011-06-15 | 詹森药业有限公司 | 四环四氢呋喃衍生物 |
| CA2568752C (en) | 2004-06-23 | 2013-05-07 | Janssen Pharmaceutica N.V. | Novel unsaturated tetracyclic tetrahydrofuran derivatives |
| US7799785B2 (en) | 2004-12-07 | 2010-09-21 | Janssen Pharmaceutica Nv | Substituted tetracyclic tetahydrofuran, pyrrolidine and tetrahydrothiophene derivatives |
| AU2011202995B2 (en) * | 2004-12-07 | 2012-02-02 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives |
| MX2007009092A (es) * | 2005-01-27 | 2007-09-12 | Janssen Pharmaceutica Nv | Derivados de tetrahidrofurano tetraciclicos heterociclicos como inhibidores de 5ht2 en el tratamiento de trastornos del sistema nervioso central. |
| MX2007014431A (es) * | 2005-05-19 | 2008-02-11 | Janssen Pharmaceutica Nv | Derivados tetraciclicos de tetrahidrofurano seleccionados que contiene una cadena lateral de amina ciclica. |
| NZ562008A (en) * | 2005-05-26 | 2010-03-26 | Janssen Pharmaceutica Nv | Novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives and their use as a medicament |
| BRPI0613711A2 (pt) * | 2005-06-17 | 2011-02-01 | Janssen Pharmaceutica Nv | compostos derivados de tetra-hidrofurano tetracìclico, uso dos mesmos, composição farmacêutica e processo para a preparação destes |
| US9125866B1 (en) | 2015-01-28 | 2015-09-08 | King Saud University | Antidepressant compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2161159C2 (ru) * | 1994-11-02 | 2000-12-27 | Жансен Фармасетика Н.В. | Замещенные тетрациклические производные оксазепина и тиазепина, способ их получения, композиция, обладающая антипсихотической активностью, и способ ее получения |
| US5552399A (en) * | 1994-11-02 | 1996-09-03 | Janssen Pharmaceutica N.V. | Substituted tetracyclic azepine derivatives |
| EE03612B1 (et) * | 1996-04-12 | 2002-02-15 | Janssen Pharmaceutica N.V. | Asendatud tetratsüklilised tetrahüdrofuraanderivaadid |
| IL128500A (en) | 1996-08-28 | 2003-06-24 | Lilly Co Eli | SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA[b] BENZOFURANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
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1998
- 1998-06-10 UA UA2000041945A patent/UA52778C2/ru unknown
- 1998-10-06 SI SI9830430T patent/SI1021432T1/xx unknown
- 1998-10-06 JP JP2000515890A patent/JP3248902B2/ja not_active Expired - Fee Related
- 1998-10-06 AP APAP/P/2000/001784A patent/AP1239A/en active
- 1998-10-06 KR KR1020007001926A patent/KR100366014B1/ko not_active IP Right Cessation
- 1998-10-06 CZ CZ20001136A patent/CZ296928B6/cs not_active IP Right Cessation
- 1998-10-06 MY MYPI98004563A patent/MY117783A/en unknown
- 1998-10-06 EA EA200000400A patent/EA003698B1/ru not_active IP Right Cessation
- 1998-10-06 US US09/529,252 patent/US6511976B1/en not_active Expired - Fee Related
- 1998-10-06 CA CA002305612A patent/CA2305612C/en not_active Expired - Fee Related
- 1998-10-06 SK SK471-2000A patent/SK284028B6/sk unknown
- 1998-10-06 ID IDW20000646A patent/ID23903A/id unknown
- 1998-10-06 AT AT98950107T patent/ATE235479T1/de active
- 1998-10-06 DE DE69812668T patent/DE69812668T2/de not_active Expired - Lifetime
- 1998-10-06 BR BR9812871-0A patent/BR9812871A/pt not_active Application Discontinuation
- 1998-10-06 PT PT98950107T patent/PT1021432E/pt unknown
- 1998-10-06 DK DK98950107T patent/DK1021432T3/da active
- 1998-10-06 WO PCT/EP1998/006352 patent/WO1999019317A1/en active IP Right Grant
- 1998-10-06 IL IL13553898A patent/IL135538A/xx not_active IP Right Cessation
- 1998-10-06 AU AU96296/98A patent/AU737334B2/en not_active Ceased
- 1998-10-06 PL PL98339833A patent/PL339833A1/xx not_active IP Right Cessation
- 1998-10-06 TR TR2000/00918T patent/TR200000918T2/xx unknown
- 1998-10-06 EE EEP200000161A patent/EE04526B1/xx not_active IP Right Cessation
- 1998-10-06 NZ NZ503294A patent/NZ503294A/en not_active IP Right Cessation
- 1998-10-06 OA OA00000105A patent/OA11898A/en unknown
- 1998-10-06 CN CNB98809956XA patent/CN100340554C/zh not_active Expired - Fee Related
- 1998-10-06 HU HU0003748A patent/HU225161B1/hu not_active IP Right Cessation
- 1998-10-06 EP EP98950107A patent/EP1021432B1/en not_active Expired - Lifetime
- 1998-10-06 ES ES98950107T patent/ES2195403T3/es not_active Expired - Lifetime
- 1998-10-08 ZA ZA9809204A patent/ZA989204B/xx unknown
- 1998-10-09 TW TW087116681A patent/TW567186B/zh not_active IP Right Cessation
- 1998-10-09 AR ARP980105055A patent/AR017325A1/es unknown
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2000
- 2000-03-30 BG BG104287A patent/BG64387B1/bg unknown
- 2000-04-05 HR HR20000189A patent/HRP20000189A2/hr not_active Application Discontinuation
- 2000-04-06 NO NO20001792A patent/NO317159B1/no not_active IP Right Cessation
- 2000-11-10 HK HK00107164A patent/HK1029106A1/xx not_active IP Right Cessation
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2002
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