EA199801013A1 - Производные дистамицина, способ их получения и применение в качестве противоопухолевых и противовирусных агентов - Google Patents
Производные дистамицина, способ их получения и применение в качестве противоопухолевых и противовирусных агентовInfo
- Publication number
- EA199801013A1 EA199801013A1 EA199801013A EA199801013A EA199801013A1 EA 199801013 A1 EA199801013 A1 EA 199801013A1 EA 199801013 A EA199801013 A EA 199801013A EA 199801013 A EA199801013 A EA 199801013A EA 199801013 A1 EA199801013 A1 EA 199801013A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- distamicin
- tumor
- derivatives
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Предложено соединение, которое представляет производное дистамицина формулы (I):где n равно 2, 3 или 4, Rпредставляет С-С-алкил или C-С-галогеналкил; Rи R, которые могут быть одинаковыми или различными, представляют, каждый, водород, С-С-алкил, необязательно замещенный одним или несколькими атомами фтора, или С-С-алкокси, Х представляет атом галогена; В выбирают из (А, В, С, D, Е, F, G, H, I, J и K)где R, R, R, R, R, Rи R, которые могут быть одинаковыми или различными, представляют, каждый, водород или С-С-алкил и m равно 0, 1 или 2, или его фармацевтически приемлемая соль. Такие соединения можно использовать в качестве противоопухолевых и противовирусных агентов.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9610079.7A GB9610079D0 (en) | 1996-05-14 | 1996-05-14 | Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents |
PCT/EP1997/002158 WO1997043258A1 (en) | 1996-05-14 | 1997-04-24 | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199801013A1 true EA199801013A1 (ru) | 1999-06-24 |
EA002273B1 EA002273B1 (ru) | 2002-02-28 |
Family
ID=10793694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199801013A EA002273B1 (ru) | 1996-05-14 | 1997-04-24 | Производные дистамицина, способ их получения и применение в качестве противоопухолевых агентов |
Country Status (27)
Country | Link |
---|---|
US (1) | US6177408B1 (ru) |
EP (1) | EP0912509B1 (ru) |
JP (1) | JP2000510129A (ru) |
CN (1) | CN1089755C (ru) |
AR (1) | AR007108A1 (ru) |
AT (1) | ATE203011T1 (ru) |
AU (1) | AU721140B2 (ru) |
BR (1) | BR9709451A (ru) |
CA (1) | CA2253652A1 (ru) |
DE (1) | DE69705622T2 (ru) |
DK (1) | DK0912509T3 (ru) |
EA (1) | EA002273B1 (ru) |
ES (1) | ES2160951T3 (ru) |
GB (1) | GB9610079D0 (ru) |
GR (1) | GR3036824T3 (ru) |
HK (1) | HK1020734A1 (ru) |
HU (1) | HUP9901387A3 (ru) |
IL (1) | IL126840A (ru) |
MY (1) | MY118004A (ru) |
NO (1) | NO311886B1 (ru) |
NZ (1) | NZ332923A (ru) |
PL (1) | PL329878A1 (ru) |
PT (1) | PT912509E (ru) |
TW (1) | TW498066B (ru) |
UA (1) | UA45457C2 (ru) |
WO (1) | WO1997043258A1 (ru) |
ZA (1) | ZA973883B (ru) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9806692D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
GB9806689D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents |
GB9812211D0 (en) | 1998-06-05 | 1998-08-05 | Pharmacia & Upjohn Spa | Cinnamoyl distamycin analogous derivatives,process for their preparation,and their use as antitumor agents |
GB9816653D0 (en) * | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
GB9816652D0 (en) * | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
GB9928703D0 (en) * | 1999-12-03 | 2000-02-02 | Pharmacia & Upjohn Spa | Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents |
US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
GB0011059D0 (en) | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
GB0015447D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
GB0015446D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
GB0016447D0 (en) * | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
GB0017852D0 (en) * | 2000-07-20 | 2000-09-06 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
GB0029004D0 (en) | 2000-11-28 | 2001-01-10 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
EP1470119A4 (en) * | 2001-06-13 | 2005-10-19 | Genesoft Pharmaceuticals Inc | BENZOTHIOPHENE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY |
US20030236198A1 (en) * | 2001-06-13 | 2003-12-25 | Genesoft, Inc. | Antipathogenic benzamide compounds |
US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
KR102573190B1 (ko) | 2015-10-16 | 2023-09-01 | 삼성전자주식회사 | 전자장치 및 전자장치 제조방법 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8612218D0 (en) * | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
GB9416005D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
-
1996
- 1996-05-14 GB GBGB9610079.7A patent/GB9610079D0/en active Pending
-
1997
- 1997-04-24 PT PT97920753T patent/PT912509E/pt unknown
- 1997-04-24 BR BR9709451A patent/BR9709451A/pt not_active Application Discontinuation
- 1997-04-24 HU HU9901387A patent/HUP9901387A3/hu unknown
- 1997-04-24 JP JP09540439A patent/JP2000510129A/ja not_active Withdrawn
- 1997-04-24 AT AT97920753T patent/ATE203011T1/de not_active IP Right Cessation
- 1997-04-24 UA UA98126575A patent/UA45457C2/uk unknown
- 1997-04-24 AU AU27016/97A patent/AU721140B2/en not_active Ceased
- 1997-04-24 DE DE69705622T patent/DE69705622T2/de not_active Expired - Fee Related
- 1997-04-24 ES ES97920753T patent/ES2160951T3/es not_active Expired - Lifetime
- 1997-04-24 CA CA002253652A patent/CA2253652A1/en not_active Abandoned
- 1997-04-24 NZ NZ332923A patent/NZ332923A/xx unknown
- 1997-04-24 CN CN97195530A patent/CN1089755C/zh not_active Expired - Fee Related
- 1997-04-24 US US09/147,264 patent/US6177408B1/en not_active Expired - Fee Related
- 1997-04-24 WO PCT/EP1997/002158 patent/WO1997043258A1/en active IP Right Grant
- 1997-04-24 PL PL97329878A patent/PL329878A1/xx unknown
- 1997-04-24 EP EP97920753A patent/EP0912509B1/en not_active Expired - Lifetime
- 1997-04-24 DK DK97920753T patent/DK0912509T3/da active
- 1997-04-24 IL IL12684097A patent/IL126840A/en not_active IP Right Cessation
- 1997-04-24 EA EA199801013A patent/EA002273B1/ru not_active IP Right Cessation
- 1997-05-05 TW TW086106038A patent/TW498066B/zh not_active IP Right Cessation
- 1997-05-06 ZA ZA9703883A patent/ZA973883B/xx unknown
- 1997-05-13 AR ARP970101989A patent/AR007108A1/es unknown
- 1997-05-13 MY MYPI97002075A patent/MY118004A/en unknown
-
1998
- 1998-11-13 NO NO19985307A patent/NO311886B1/no unknown
-
1999
- 1999-12-21 HK HK99105996A patent/HK1020734A1/xx not_active IP Right Cessation
-
2001
- 2001-10-08 GR GR20010401685T patent/GR3036824T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE203011T1 (de) | 2001-07-15 |
HUP9901387A2 (hu) | 2000-04-28 |
HK1020734A1 (en) | 2000-05-19 |
NO311886B1 (no) | 2002-02-11 |
US6177408B1 (en) | 2001-01-23 |
HUP9901387A3 (en) | 2002-10-28 |
ES2160951T3 (es) | 2001-11-16 |
NZ332923A (en) | 2000-03-27 |
PL329878A1 (en) | 1999-04-12 |
BR9709451A (pt) | 1999-08-10 |
TW498066B (en) | 2002-08-11 |
EA002273B1 (ru) | 2002-02-28 |
CN1089755C (zh) | 2002-08-28 |
CA2253652A1 (en) | 1997-11-20 |
WO1997043258A1 (en) | 1997-11-20 |
UA45457C2 (uk) | 2002-04-15 |
GB9610079D0 (en) | 1996-07-17 |
IL126840A0 (en) | 1999-09-22 |
AR007108A1 (es) | 1999-10-13 |
AU721140B2 (en) | 2000-06-22 |
EP0912509A1 (en) | 1999-05-06 |
DE69705622T2 (de) | 2002-05-08 |
PT912509E (pt) | 2001-12-28 |
EP0912509B1 (en) | 2001-07-11 |
NO985307L (no) | 1999-01-12 |
AU2701697A (en) | 1997-12-05 |
ZA973883B (en) | 1997-12-08 |
NO985307D0 (no) | 1998-11-13 |
MY118004A (en) | 2004-08-30 |
CN1222144A (zh) | 1999-07-07 |
IL126840A (en) | 2002-03-10 |
DE69705622D1 (de) | 2001-08-16 |
DK0912509T3 (da) | 2001-10-22 |
GR3036824T3 (en) | 2002-01-31 |
JP2000510129A (ja) | 2000-08-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY KZ RU |