EE04526B1 - Halogeenasendatud tetratsklilise tetrahdrofuraani derivaadid, nende valmistamismeetod, kasutamineja farmatseutiline kompositsioon - Google Patents
Halogeenasendatud tetratsklilise tetrahdrofuraani derivaadid, nende valmistamismeetod, kasutamineja farmatseutiline kompositsioonInfo
- Publication number
- EE04526B1 EE04526B1 EEP200000161A EEP200000161A EE04526B1 EE 04526 B1 EE04526 B1 EE 04526B1 EE P200000161 A EEP200000161 A EE P200000161A EE P200000161 A EEP200000161 A EE P200000161A EE 04526 B1 EE04526 B1 EE 04526B1
- Authority
- EE
- Estonia
- Prior art keywords
- halogen
- preparation
- methods
- pharmaceutical composition
- tetrahydrofuran derivatives
- Prior art date
Links
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical class C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97203154 | 1997-10-10 | ||
| PCT/EP1998/006352 WO1999019317A1 (en) | 1997-10-10 | 1998-10-06 | Halogen substituted tetracyclic tetrahydrofuran derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200000161A EE200000161A (et) | 2001-04-16 |
| EE04526B1 true EE04526B1 (et) | 2005-08-15 |
Family
ID=8228817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000161A EE04526B1 (et) | 1997-10-10 | 1998-10-06 | Halogeenasendatud tetratsklilise tetrahdrofuraani derivaadid, nende valmistamismeetod, kasutamineja farmatseutiline kompositsioon |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US6511976B1 (et) |
| EP (1) | EP1021432B1 (et) |
| JP (1) | JP3248902B2 (et) |
| KR (1) | KR100366014B1 (et) |
| CN (1) | CN100340554C (et) |
| AP (1) | AP1239A (et) |
| AR (1) | AR017325A1 (et) |
| AT (1) | ATE235479T1 (et) |
| AU (1) | AU737334B2 (et) |
| BG (1) | BG64387B1 (et) |
| BR (1) | BR9812871A (et) |
| CA (1) | CA2305612C (et) |
| CZ (1) | CZ296928B6 (et) |
| DE (1) | DE69812668T2 (et) |
| DK (1) | DK1021432T3 (et) |
| EA (1) | EA003698B1 (et) |
| EE (1) | EE04526B1 (et) |
| ES (1) | ES2195403T3 (et) |
| HK (1) | HK1029106A1 (et) |
| HR (1) | HRP20000189A2 (et) |
| HU (1) | HU225161B1 (et) |
| ID (1) | ID23903A (et) |
| IL (1) | IL135538A (et) |
| MY (1) | MY117783A (et) |
| NO (1) | NO317159B1 (et) |
| NZ (1) | NZ503294A (et) |
| OA (1) | OA11898A (et) |
| PL (1) | PL339833A1 (et) |
| PT (1) | PT1021432E (et) |
| SI (1) | SI1021432T1 (et) |
| SK (1) | SK284028B6 (et) |
| TR (1) | TR200000918T2 (et) |
| TW (1) | TW567186B (et) |
| UA (1) | UA52778C2 (et) |
| WO (1) | WO1999019317A1 (et) |
| ZA (1) | ZA989204B (et) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA79248C2 (en) * | 2001-11-09 | 2007-06-11 | Janssen Pharmaceutica Nv | Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives |
| PL370440A1 (en) | 2001-12-07 | 2005-05-30 | Janssen Pharmaceutica N.V. | Preparation of cis-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives |
| NZ532806A (en) * | 2001-12-07 | 2006-01-27 | Janssen Pharmaceutica Nv | Preparation of trans-fused 3,3a,8,12b-tetrahydro-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives |
| HRP20020305A8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| HRP20020441A2 (en) * | 2002-05-21 | 2003-12-31 | Pliva D D | 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
| HRP20030160A2 (en) * | 2003-03-06 | 2005-04-30 | Pliva-Istra�iva�ki institut d.o.o. | 1-thiadibenzoazulene derivatives and biological action thereof |
| HRP20030885A2 (en) * | 2003-11-03 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS |
| HRP20030958A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030955A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030954A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva D.D. | USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030953A2 (en) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030956A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU |
| HRP20030959A2 (et) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | |
| HRP20030957A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20040104A2 (en) * | 2004-01-30 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders |
| AR049512A1 (es) * | 2004-06-14 | 2006-08-09 | Janssen Pharmaceutica Nv | Derivados de tetrahidrofurano tetraciclicos. composiciones farmaceuticas |
| WO2006000555A2 (en) | 2004-06-23 | 2006-01-05 | Janssen Pharmaceutica N.V. | Novel unsaturated tetracyclic tetrahydrofuran derivatives |
| AU2011202995B2 (en) * | 2004-12-07 | 2012-02-02 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives |
| WO2006061392A2 (en) | 2004-12-07 | 2006-06-15 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives |
| CN101107254B (zh) | 2005-01-27 | 2010-12-08 | 詹森药业有限公司 | 在中枢神经系统病症的治疗中作为5ht2抑制剂的杂环四环四氢呋喃衍生物 |
| CA2606774A1 (en) * | 2005-05-19 | 2006-11-23 | Janssen Pharmaceutica N.V. | Selected tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain |
| NZ562008A (en) * | 2005-05-26 | 2010-03-26 | Janssen Pharmaceutica Nv | Novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives and their use as a medicament |
| NZ564181A (en) * | 2005-06-17 | 2010-02-26 | Janssen Pharmaceutica Nv | Novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain |
| US9125866B1 (en) | 2015-01-28 | 2015-09-08 | King Saud University | Antidepressant compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5773433A (en) * | 1994-11-02 | 1998-06-30 | Janssen Pharmaceutica, N.V. | Substituted tetracyclic oxazepine and thiazepine derivatives |
| US5552399A (en) * | 1994-11-02 | 1996-09-03 | Janssen Pharmaceutica N.V. | Substituted tetracyclic azepine derivatives |
| TR199801164T2 (xx) * | 1996-04-12 | 1998-10-21 | Janssen Pharmaceutica N.V. | S�bstit�e edilmi� tetrasiklik tetrahidrofuran t�revleri. |
| UA48245C2 (uk) | 1996-08-28 | 2002-08-15 | Елі Ліллі Енд Компані | ЗАМІЩЕНІ 1,2,3,4-ТЕТРАГІДРО-2-ДИБЕНЗОФУРАНАМІНИ ТА 2-АМІНОЦИКЛОГЕПТА[B]БЕНЗОФУРАНИ, ФАРМАЦЕВТИЧНА ЛІКАРСЬКА ФОРМА ТА СПОСІБ ПІДВИЩЕННЯ АКТИВАЦІЇ 5-НТ<sub>1F</sub> РЕЦЕПТОРА У ССАВЦЯ |
-
1998
- 1998-06-10 UA UA2000041945A patent/UA52778C2/uk unknown
- 1998-10-06 ID IDW20000646A patent/ID23903A/id unknown
- 1998-10-06 US US09/529,252 patent/US6511976B1/en not_active Expired - Fee Related
- 1998-10-06 KR KR1020007001926A patent/KR100366014B1/ko not_active IP Right Cessation
- 1998-10-06 ES ES98950107T patent/ES2195403T3/es not_active Expired - Lifetime
- 1998-10-06 BR BR9812871-0A patent/BR9812871A/pt not_active Application Discontinuation
- 1998-10-06 JP JP2000515890A patent/JP3248902B2/ja not_active Expired - Fee Related
- 1998-10-06 EP EP98950107A patent/EP1021432B1/en not_active Expired - Lifetime
- 1998-10-06 PT PT98950107T patent/PT1021432E/pt unknown
- 1998-10-06 NZ NZ503294A patent/NZ503294A/en not_active IP Right Cessation
- 1998-10-06 PL PL98339833A patent/PL339833A1/xx not_active IP Right Cessation
- 1998-10-06 CZ CZ20001136A patent/CZ296928B6/cs not_active IP Right Cessation
- 1998-10-06 DK DK98950107T patent/DK1021432T3/da active
- 1998-10-06 OA OA00000105A patent/OA11898A/en unknown
- 1998-10-06 SK SK471-2000A patent/SK284028B6/sk unknown
- 1998-10-06 WO PCT/EP1998/006352 patent/WO1999019317A1/en active IP Right Grant
- 1998-10-06 AT AT98950107T patent/ATE235479T1/de active
- 1998-10-06 CN CNB98809956XA patent/CN100340554C/zh not_active Expired - Fee Related
- 1998-10-06 IL IL13553898A patent/IL135538A/xx not_active IP Right Cessation
- 1998-10-06 EA EA200000400A patent/EA003698B1/ru not_active IP Right Cessation
- 1998-10-06 MY MYPI98004563A patent/MY117783A/en unknown
- 1998-10-06 SI SI9830430T patent/SI1021432T1/xx unknown
- 1998-10-06 CA CA002305612A patent/CA2305612C/en not_active Expired - Fee Related
- 1998-10-06 TR TR2000/00918T patent/TR200000918T2/xx unknown
- 1998-10-06 AU AU96296/98A patent/AU737334B2/en not_active Ceased
- 1998-10-06 HU HU0003748A patent/HU225161B1/hu not_active IP Right Cessation
- 1998-10-06 AP APAP/P/2000/001784A patent/AP1239A/en active
- 1998-10-06 EE EEP200000161A patent/EE04526B1/et not_active IP Right Cessation
- 1998-10-06 DE DE69812668T patent/DE69812668T2/de not_active Expired - Lifetime
- 1998-10-08 ZA ZA9809204A patent/ZA989204B/xx unknown
- 1998-10-09 AR ARP980105055A patent/AR017325A1/es unknown
- 1998-10-09 TW TW087116681A patent/TW567186B/zh not_active IP Right Cessation
-
2000
- 2000-03-30 BG BG104287A patent/BG64387B1/bg unknown
- 2000-04-05 HR HR20000189A patent/HRP20000189A2/hr not_active Application Discontinuation
- 2000-04-06 NO NO20001792A patent/NO317159B1/no not_active IP Right Cessation
- 2000-11-10 HK HK00107164A patent/HK1029106A1/xx not_active IP Right Cessation
-
2002
- 2002-11-12 US US10/292,270 patent/US6699858B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EE04526B1 (et) | Halogeenasendatud tetratsklilise tetrahdrofuraani derivaadid, nende valmistamismeetod, kasutamineja farmatseutiline kompositsioon | |
| FR2786770B1 (fr) | Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique | |
| FR2786769B1 (fr) | Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique | |
| FR2790474B1 (fr) | Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique | |
| FR2769915B1 (fr) | Derives d'indazole tricycliques, leur preparation et leur application en therapeutique | |
| FR2728900B1 (fr) | Derives de 3-phenylisoquinolein-1(2h)-one, leur preparation et leur application en therapeutique | |
| FR2766823B1 (fr) | Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique | |
| BR9911178B1 (pt) | Derivados de 3-(2-oxo-[1,3']bipirrolidinil-3-ilidenometil)-cefems, bem como preparação farmacêutica e uso dos mesmos | |
| FR2761072B1 (fr) | Derives de 2,3-dihydrofuro[3,2-b]pyridine, leur preparation et leur application en therapeutique | |
| EE200000207A (et) | 8-asabitsüklo[3.2.1]oktaan-3-metaanamiini derivaadid, nende valmistamine ja terapeutiline kasutamine | |
| FR2761068B1 (fr) | Derives de piperazin-4-ylthieno[3,2-c]pyridin-4-yl-2- carboxamide, leur preparation et leur application en therapeutique | |
| FR2765582B1 (fr) | Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique | |
| FR2772377B1 (fr) | Derives de 1-(1-h-imidazol-2-yl)pyrrolidines et 1-(1-h-imidazol-2-ylpiperidines), leur preparation et leur application en therapeutique | |
| FR2765874B1 (fr) | Derives de 6-pyrrolidin-2-ylpyrindines, leur preparation et leur application en therapeutique | |
| FR2761070B1 (fr) | Derives de dihydropyrazino[1,2-a]indole-1-one, leur preparation et leur application en therapeutique | |
| BR9611895A (pt) | Derivados de 5-naftalen-1,3-dioxano preparação e uso terapêutico dos mesmos | |
| FR2752839B1 (fr) | Derives de benzofurane, leur preparation et leur application en therapeutique | |
| FR2753196B1 (fr) | Derives d'indazole tricyclique, leur preparation et leur application en therapeutique | |
| FR2724382B1 (fr) | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique | |
| FR2769914B1 (fr) | Derives d'indazole tricycliques leur preparation et leur application en therapeutique | |
| FR2785903B1 (fr) | Derives de 1-aminoethylquinoleine, leur preparation et leur application en therapeutique | |
| FR2777566B1 (fr) | Derives d'azacycloalcanes, leur preparation et leur application en therapeutique | |
| FR2765580B1 (fr) | Derives de (1h-imidazol-4-yl)piperidine, leur preparation et leur application en therapeutique | |
| FR2759698B1 (fr) | Derives de 1,4-diphenylimidazole-5-acetamide, leur preparation et leur application en therapeutique | |
| FR2772760B1 (fr) | Derives de 3-oxazol-5-yl-1-oxo-1,2-dihydroisoquinoleine-4- propanamide, leur preparation et leur application en therapeutique |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20071006 |