HK1029106A1 - Halogen substituted tetracyclic tetrahydrofuran derivatives - Google Patents

Halogen substituted tetracyclic tetrahydrofuran derivatives

Info

Publication number
HK1029106A1
HK1029106A1 HK00107164A HK00107164A HK1029106A1 HK 1029106 A1 HK1029106 A1 HK 1029106A1 HK 00107164 A HK00107164 A HK 00107164A HK 00107164 A HK00107164 A HK 00107164A HK 1029106 A1 HK1029106 A1 HK 1029106A1
Authority
HK
Hong Kong
Prior art keywords
halogen substituted
tetrahydrofuran derivatives
substituted tetracyclic
tetracyclic tetrahydrofuran
derivatives
Prior art date
Application number
HK00107164A
Other languages
English (en)
Inventor
Jose Ignacio Andres-Gil
Francisco Javi Fernandez-Gadea
Pilar Gil-Lopetegui
Adolfo Diaz-Martinez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1029106A1 publication Critical patent/HK1029106A1/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
HK00107164A 1997-10-10 2000-11-10 Halogen substituted tetracyclic tetrahydrofuran derivatives HK1029106A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97203154 1997-10-10
PCT/EP1998/006352 WO1999019317A1 (en) 1997-10-10 1998-10-06 Halogen substituted tetracyclic tetrahydrofuran derivatives

Publications (1)

Publication Number Publication Date
HK1029106A1 true HK1029106A1 (en) 2001-03-23

Family

ID=8228817

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00107164A HK1029106A1 (en) 1997-10-10 2000-11-10 Halogen substituted tetracyclic tetrahydrofuran derivatives

Country Status (36)

Country Link
US (2) US6511976B1 (xx)
EP (1) EP1021432B1 (xx)
JP (1) JP3248902B2 (xx)
KR (1) KR100366014B1 (xx)
CN (1) CN100340554C (xx)
AP (1) AP1239A (xx)
AR (1) AR017325A1 (xx)
AT (1) ATE235479T1 (xx)
AU (1) AU737334B2 (xx)
BG (1) BG64387B1 (xx)
BR (1) BR9812871A (xx)
CA (1) CA2305612C (xx)
CZ (1) CZ296928B6 (xx)
DE (1) DE69812668T2 (xx)
DK (1) DK1021432T3 (xx)
EA (1) EA003698B1 (xx)
EE (1) EE04526B1 (xx)
ES (1) ES2195403T3 (xx)
HK (1) HK1029106A1 (xx)
HR (1) HRP20000189A2 (xx)
HU (1) HU225161B1 (xx)
ID (1) ID23903A (xx)
IL (1) IL135538A (xx)
MY (1) MY117783A (xx)
NO (1) NO317159B1 (xx)
NZ (1) NZ503294A (xx)
OA (1) OA11898A (xx)
PL (1) PL339833A1 (xx)
PT (1) PT1021432E (xx)
SI (1) SI1021432T1 (xx)
SK (1) SK284028B6 (xx)
TR (1) TR200000918T2 (xx)
TW (1) TW567186B (xx)
UA (1) UA52778C2 (xx)
WO (1) WO1999019317A1 (xx)
ZA (1) ZA989204B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA79248C2 (en) * 2001-11-09 2007-06-11 Janssen Pharmaceutica Nv Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
ES2242076T3 (es) * 2001-12-07 2005-11-01 Janssen Pharmaceutica N.V. Preparacion de derivados de 3,3a,8,12b-tetrahidro-2h-dibenzo(3,4:6,7)ciclohepta(1,2-b)furano condensados en trans.
CA2468040A1 (en) 2001-12-07 2003-06-12 Janssen Pharmaceutica N.V. Preparation of cis-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
HRP20020305A8 (en) 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030959A2 (xx) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o.
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
PL1761514T3 (pl) * 2004-06-14 2009-01-30 Janssen Pharmaceutica Nv Nowe tetracykliczne pochodne tetrahydrofuranu
EP1761545A2 (en) 2004-06-23 2007-03-14 Janssen Pharmaceutica N.V. Novel unsaturated tetracyclic tetrahydrofuran derivatives
US7799785B2 (en) 2004-12-07 2010-09-21 Janssen Pharmaceutica Nv Substituted tetracyclic tetahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
AU2011202995B2 (en) * 2004-12-07 2012-02-02 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
WO2006079637A1 (en) 2005-01-27 2006-08-03 Janssen Pharmaceutica N.V. Heterocyclic tetracyclic tetrahydrofuran derivatives as 5ht2 inhibitors in the treatment of cns disorders
CA2606774A1 (en) * 2005-05-19 2006-11-23 Janssen Pharmaceutica N.V. Selected tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain
JP2008542241A (ja) * 2005-05-26 2008-11-27 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 新規な置換四環式テトラヒドロフラン、ピロリジンおよびテトラヒドロチオフェン誘導体および医薬としてのそれらの使用
MX2007016247A (es) * 2005-06-17 2008-03-10 Janssen Pharmaceutica Nv Derivados de tetrahidrofurano tetraciclicos novedosos que contienen una cadena lateral de amida ciclica.
US9125866B1 (en) 2015-01-28 2015-09-08 King Saud University Antidepressant compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE199088T1 (de) 1994-11-02 2001-02-15 Janssen Pharmaceutica Nv Substituierte tetracyclische oxazepine- und thiazepinederivate mit 5-ht2 rezeptoraffinität
US5552399A (en) * 1994-11-02 1996-09-03 Janssen Pharmaceutica N.V. Substituted tetracyclic azepine derivatives
ES2196328T3 (es) 1996-04-12 2003-12-16 Janssen Pharmaceutica Nv Derivados de tetrahidrofurano tetraciclicos sustituidos.
BR9711273A (pt) 1996-08-28 1999-08-17 Lilly Co Eli 1,2,3,4- Tetraidro-2-dibenzofuranaminas substituidas e 2- aminociclohepta b benzofuranos

Also Published As

Publication number Publication date
NO317159B1 (no) 2004-08-30
US6511976B1 (en) 2003-01-28
WO1999019317A1 (en) 1999-04-22
ATE235479T1 (de) 2003-04-15
EE04526B1 (et) 2005-08-15
AP1239A (en) 2004-01-15
EE200000161A (et) 2001-04-16
EP1021432A1 (en) 2000-07-26
EA003698B1 (ru) 2003-08-28
ES2195403T3 (es) 2003-12-01
DE69812668D1 (de) 2003-04-30
UA52778C2 (uk) 2003-01-15
SK4712000A3 (en) 2000-10-09
NZ503294A (en) 2001-08-31
PT1021432E (pt) 2003-08-29
AP2000001784A0 (en) 2000-06-30
BR9812871A (pt) 2000-08-08
SI1021432T1 (en) 2003-08-31
US20030134852A1 (en) 2003-07-17
AR017325A1 (es) 2001-09-05
HRP20000189A2 (en) 2001-02-28
EP1021432B1 (en) 2003-03-26
US6699858B2 (en) 2004-03-02
NO20001792L (no) 2000-04-06
IL135538A0 (en) 2001-05-20
AU737334B2 (en) 2001-08-16
HUP0003748A3 (en) 2002-02-28
TR200000918T2 (tr) 2000-07-21
BG64387B1 (bg) 2004-12-30
CN1274353A (zh) 2000-11-22
DK1021432T3 (da) 2003-07-14
TW567186B (en) 2003-12-21
HU225161B1 (en) 2006-07-28
ID23903A (id) 2000-05-25
MY117783A (en) 2004-08-30
ZA989204B (en) 2000-04-10
IL135538A (en) 2005-07-25
JP3248902B2 (ja) 2002-01-21
EA200000400A1 (ru) 2000-10-30
KR20010023292A (ko) 2001-03-26
KR100366014B1 (ko) 2002-12-26
SK284028B6 (sk) 2004-08-03
CA2305612A1 (en) 1999-04-22
OA11898A (en) 2006-04-10
PL339833A1 (en) 2001-01-02
CN100340554C (zh) 2007-10-03
CZ296928B6 (cs) 2006-07-12
BG104287A (en) 2000-11-30
NO20001792D0 (no) 2000-04-06
CA2305612C (en) 2007-07-31
AU9629698A (en) 1999-05-03
CZ20001136A3 (cs) 2000-08-16
HUP0003748A2 (hu) 2002-01-28
JP2001519425A (ja) 2001-10-23
DE69812668T2 (de) 2004-01-29

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PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20071006