ATE199088T1 - Substituierte tetracyclische oxazepine- und thiazepinederivate mit 5-ht2 rezeptoraffinität - Google Patents
Substituierte tetracyclische oxazepine- und thiazepinederivate mit 5-ht2 rezeptoraffinitätInfo
- Publication number
- ATE199088T1 ATE199088T1 AT95937007T AT95937007T ATE199088T1 AT E199088 T1 ATE199088 T1 AT E199088T1 AT 95937007 T AT95937007 T AT 95937007T AT 95937007 T AT95937007 T AT 95937007T AT E199088 T1 ATE199088 T1 AT E199088T1
- Authority
- AT
- Austria
- Prior art keywords
- 6alkyl
- hydrogen
- pct
- trifluoromethyl
- oxazepine
- Prior art date
Links
- 108091005479 5-HT2 receptors Proteins 0.000 title 1
- SFJGCXYXEFWEBK-UHFFFAOYSA-N oxazepine Chemical compound O1C=CC=CC=N1 SFJGCXYXEFWEBK-UHFFFAOYSA-N 0.000 title 1
- 150000004912 thiazepines Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- -1 C1-6alkyloxy Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94203177 | 1994-11-02 | ||
| PCT/EP1995/004197 WO1996014321A1 (en) | 1994-11-02 | 1995-10-25 | Substituted tetracyclic oxazepine and thiazepine derivatives with 5-ht2 receptor affinity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199088T1 true ATE199088T1 (de) | 2001-02-15 |
Family
ID=8217336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95937007T ATE199088T1 (de) | 1994-11-02 | 1995-10-25 | Substituierte tetracyclische oxazepine- und thiazepinederivate mit 5-ht2 rezeptoraffinität |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5773433A (de) |
| EP (1) | EP0789702B1 (de) |
| JP (1) | JP3887785B2 (de) |
| AT (1) | ATE199088T1 (de) |
| AU (1) | AU699545B2 (de) |
| CA (1) | CA2203664A1 (de) |
| DE (1) | DE69520071T2 (de) |
| DK (1) | DK0789702T3 (de) |
| ES (1) | ES2155899T3 (de) |
| GR (1) | GR3035666T3 (de) |
| MY (1) | MY114106A (de) |
| NZ (1) | NZ295657A (de) |
| PL (1) | PL183618B1 (de) |
| PT (1) | PT789702E (de) |
| RU (1) | RU2161159C2 (de) |
| WO (1) | WO1996014321A1 (de) |
| ZA (1) | ZA959216B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0892804B1 (de) * | 1996-04-12 | 2002-08-28 | Janssen Pharmaceutica N.V. | Isoxazolidine derivate |
| UA52778C2 (uk) | 1997-10-10 | 2003-01-15 | Янссен Фармацевтика Н.В. | Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі |
| KR100864267B1 (ko) * | 2001-06-14 | 2008-10-20 | 엔.브이.오가논 | ＡＭＰＡ 수용체의 양성 조절제로서의(피리도/티에노)-[ｆ]-옥사제핀-5-온 유도체 |
| HRP20020305A8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| HRP20020304B1 (en) * | 2002-04-10 | 2008-04-30 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof |
| US20050143350A1 (en) * | 2003-11-19 | 2005-06-30 | Seed John C. | Combination drug therapy to treat obesity |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU39062B (en) * | 1968-10-24 | 1984-04-30 | Sankyo Co | Process for the production of benzodizazepine compaounds |
| NL7414038A (nl) * | 1974-10-28 | 1976-05-03 | Akzo Nv | Nieuwe tetracyclische pyrrolidino derivaten. |
| JPS5572177A (en) * | 1978-11-27 | 1980-05-30 | Shionogi & Co Ltd | 4,1-benzoxazepine or 4,1-benzothiazepine |
| JPS60500176A (ja) * | 1982-12-30 | 1985-02-07 | ビ−チヤム グル−プ ピ−エルシ− | 四環式化合物 |
| US4723007A (en) * | 1983-05-18 | 1988-02-02 | Hoechst-Roussel Pharmaceuticals Inc. | Benzopyrrolobenzodiazepines and quinobenzodiazepines |
| CA2026925A1 (en) * | 1989-10-05 | 1991-04-06 | Hiroshi Fukumi | Tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use |
-
1995
- 1995-10-25 US US08/817,989 patent/US5773433A/en not_active Expired - Fee Related
- 1995-10-25 DE DE69520071T patent/DE69520071T2/de not_active Expired - Fee Related
- 1995-10-25 DK DK95937007T patent/DK0789702T3/da active
- 1995-10-25 EP EP95937007A patent/EP0789702B1/de not_active Expired - Lifetime
- 1995-10-25 NZ NZ295657A patent/NZ295657A/en unknown
- 1995-10-25 RU RU97108688/04A patent/RU2161159C2/ru not_active IP Right Cessation
- 1995-10-25 AU AU39250/95A patent/AU699545B2/en not_active Ceased
- 1995-10-25 JP JP51501096A patent/JP3887785B2/ja not_active Expired - Fee Related
- 1995-10-25 PT PT95937007T patent/PT789702E/pt unknown
- 1995-10-25 WO PCT/EP1995/004197 patent/WO1996014321A1/en not_active Ceased
- 1995-10-25 CA CA002203664A patent/CA2203664A1/en not_active Abandoned
- 1995-10-25 PL PL95319870A patent/PL183618B1/pl not_active IP Right Cessation
- 1995-10-25 ES ES95937007T patent/ES2155899T3/es not_active Expired - Lifetime
- 1995-10-25 AT AT95937007T patent/ATE199088T1/de not_active IP Right Cessation
- 1995-10-31 ZA ZA959216A patent/ZA959216B/xx unknown
- 1995-11-02 MY MYPI95003314A patent/MY114106A/en unknown
-
2001
- 2001-03-29 GR GR20010400516T patent/GR3035666T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2155899T3 (es) | 2001-06-01 |
| AU699545B2 (en) | 1998-12-03 |
| RU2161159C2 (ru) | 2000-12-27 |
| DK0789702T3 (da) | 2001-06-11 |
| WO1996014321A1 (en) | 1996-05-17 |
| GR3035666T3 (en) | 2001-06-29 |
| ZA959216B (en) | 1997-04-30 |
| JP3887785B2 (ja) | 2007-02-28 |
| EP0789702A1 (de) | 1997-08-20 |
| PT789702E (pt) | 2001-07-31 |
| US5773433A (en) | 1998-06-30 |
| PL319870A1 (en) | 1997-09-01 |
| CA2203664A1 (en) | 1996-05-17 |
| AU3925095A (en) | 1996-05-31 |
| EP0789702B1 (de) | 2001-02-07 |
| NZ295657A (en) | 1998-08-26 |
| PL183618B1 (pl) | 2002-06-28 |
| DE69520071T2 (de) | 2001-09-13 |
| JPH10508309A (ja) | 1998-08-18 |
| DE69520071D1 (de) | 2001-03-15 |
| MY114106A (en) | 2002-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |