MX9703250A - Derivados tetraciclicos de oxazepina y tiazepina sustituidos con afinidad al receptor de 5-ht2. - Google Patents

Derivados tetraciclicos de oxazepina y tiazepina sustituidos con afinidad al receptor de 5-ht2.

Info

Publication number
MX9703250A
MX9703250A MX9703250A MX9703250A MX9703250A MX 9703250 A MX9703250 A MX 9703250A MX 9703250 A MX9703250 A MX 9703250A MX 9703250 A MX9703250 A MX 9703250A MX 9703250 A MX9703250 A MX 9703250A
Authority
MX
Mexico
Prior art keywords
hydrogen
alkyl
6alkyl
formula
oxazepine
Prior art date
Application number
MX9703250A
Other languages
English (en)
Other versions
MXPA97003250A (es
Inventor
Francisco Javier Fernand Gadea
Victor Karel Sipido
Jose Ignacio Andres Gil
Theo Frans Meert
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority claimed from PCT/EP1995/004197 external-priority patent/WO1996014321A1/en
Publication of MX9703250A publication Critical patent/MX9703250A/es
Publication of MXPA97003250A publication Critical patent/MXPA97003250A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Esta invencion se refiere a los compuestos de formula (I), las sales farmacéuticamente aceptables y las formas estereoisoméricas de las mismas, y también las formas de N-oxido de las mismas. En dicha formula, R1 y R2 son cada uno independientemente hidrogeno; C1-6 alquilo; C1-6 alquilcarbonilo; trihalometilcarbonilo; C1-6 alquilo sustituido con hidroxi, C1-6 alquiloxi, carboxilo, C1-6 alquilcarboniloxi, C1-6 alquiloxicarbonilo o arilo; o R1 y R2 considerados juntos con el átomo de nitrogeno al cual están unidos pueden formar un anillo de morfolinilo o un heterociclo sustituido opcionalmente; R3 y R10 son cada uno independientemente hidrogeno, halogeno, ciano, hidroxi, trifluorometilo, trifluorometoxi, carboxilo, nitro, amino, mono- o di(C1-6alquil)amino, C1-6 alquilcarbonilamino, aminosulfonilo, mono- o di(C1-6 alquil)-aminosulfonilo, C1-6 alquilo, C1-6 alquiloxi, C1-6 alquilcarbonilo, C1-6 alquiloxicarbonilo; R11 es hidrogeno, C1-6 alquilo o trifluorometilo; R12 es hidrogeno, C1-6 alquilo, ciano o trifluorometilo; n es 0 a 6; y X es 0,S,S(-O) o S(=O)2. Los compuestos de formula (I) pueden utilizarse como agentes terapéuticos en el tratamiento o la prevencion de trastornos del SNC, trastornos cardiovasculares o trastornos gastrointestinales.
MXPA/A/1997/003250A 1994-11-02 1995-10-25 Derivados tetraciclicos de oxazepina y tiazepinasustituidos con afinidad al receptor de 5-ht2 MXPA97003250A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP94203177 1994-11-02
EP94203177.4 1994-11-02
US45499395A 1995-05-31 1995-05-31
US454,993 1995-05-31
US454993 1995-05-31
PCT/EP1995/004197 WO1996014321A1 (en) 1994-11-02 1995-10-25 Substituted tetracyclic oxazepine and thiazepine derivatives with 5-ht2 receptor affinity

Publications (2)

Publication Number Publication Date
MX9703250A true MX9703250A (es) 1997-07-31
MXPA97003250A MXPA97003250A (es) 1997-12-01

Family

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Also Published As

Publication number Publication date
NO308036B1 (no) 2000-07-10
FI971855A0 (fi) 1997-04-30
CN1065245C (zh) 2001-05-02
IL115820A (en) 1999-06-20
NO972018D0 (no) 1997-04-30
IL115820A0 (en) 1996-01-19
CN1162314A (zh) 1997-10-15
FI971855A (fi) 1997-04-30
TW449601B (en) 2001-08-11
FI113270B (fi) 2004-03-31
NO972018L (no) 1997-04-30

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