BR9812871A - Derivados tetracìclicos de tetrahidrofurano substituìdos com halogênio - Google Patents

Derivados tetracìclicos de tetrahidrofurano substituìdos com halogênio

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Publication number
BR9812871A
BR9812871A BR9812871-0A BR9812871A BR9812871A BR 9812871 A BR9812871 A BR 9812871A BR 9812871 A BR9812871 A BR 9812871A BR 9812871 A BR9812871 A BR 9812871A
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BR
Brazil
Prior art keywords
halogen
tetrahydrofuran
hydrogen
compounds
alkyl
Prior art date
Application number
BR9812871-0A
Other languages
English (en)
Inventor
Jose Ignacio Andres-Gil
Francisco Javi Fernandez-Gadea
Pilar Gil-Lopetegui
Adolfo Dias-Martinez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR9812871A publication Critical patent/BR9812871A/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS TETRACìCLICOS DE TETRAHIDROFURANO SUBSTITUìDOS COM HALOGêNIO"<D>. A presente invenção refere-se a compostos de fórmula (I), a formas N-óxido, aos sais de adição farmaceuticamente aceitáveis e às formas estereoquimicamente isoméricas dos compostos, nos quais n é zero 1, 2, 3, 4, 5 ou 6; X é CH~ 2~ ou O; R^ 1^ e R^ 2^, cada um independentemente, são hidrogênio, C~ 1-6~alquila, C~ 1-6~alquilcarbonila, halometilcarbonila ou C~ 1-6~alquila substituída com hidróxi, C~ 1-6~alquilóxi, carboxila, C~ 1-6~alquilcarbonilóxi, C~ 1-6~alquiloxicarbonila ou arila; ou R^ 1^ e R^ 2^ tomados juntamente com o átomo de nitrogênio ao qual se ligam poderão formar um anel morfolinila ou um heterociclo opcionalmente substituído; R^ 3^ e R^ 4^ são ambos halogênio; ou R^ 3^ é halogênio e R^ 4^ é hidrogênio; ou R^ 3^ é hidrogênio e R^ 4^ é halogênio; e arila é fenila ou fenila substituída com 1, 2, ou 3 substituintes selecionados de halo, hidróxi, C~ 1-6~alquila e halometila. Os compostos de fórmula (I) poderão ser usados como agentes terapêuticos.
BR9812871-0A 1997-10-10 1998-10-06 Derivados tetracìclicos de tetrahidrofurano substituìdos com halogênio BR9812871A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97203154 1997-10-10
PCT/EP1998/006352 WO1999019317A1 (en) 1997-10-10 1998-10-06 Halogen substituted tetracyclic tetrahydrofuran derivatives

Publications (1)

Publication Number Publication Date
BR9812871A true BR9812871A (pt) 2000-08-08

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ID=8228817

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Application Number Title Priority Date Filing Date
BR9812871-0A BR9812871A (pt) 1997-10-10 1998-10-06 Derivados tetracìclicos de tetrahidrofurano substituìdos com halogênio

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US (2) US6511976B1 (pt)
EP (1) EP1021432B1 (pt)
JP (1) JP3248902B2 (pt)
KR (1) KR100366014B1 (pt)
CN (1) CN100340554C (pt)
AP (1) AP1239A (pt)
AR (1) AR017325A1 (pt)
AT (1) ATE235479T1 (pt)
AU (1) AU737334B2 (pt)
BG (1) BG64387B1 (pt)
BR (1) BR9812871A (pt)
CA (1) CA2305612C (pt)
CZ (1) CZ296928B6 (pt)
DE (1) DE69812668T2 (pt)
DK (1) DK1021432T3 (pt)
EA (1) EA003698B1 (pt)
EE (1) EE04526B1 (pt)
ES (1) ES2195403T3 (pt)
HK (1) HK1029106A1 (pt)
HR (1) HRP20000189A2 (pt)
HU (1) HU225161B1 (pt)
ID (1) ID23903A (pt)
IL (1) IL135538A (pt)
MY (1) MY117783A (pt)
NO (1) NO317159B1 (pt)
NZ (1) NZ503294A (pt)
OA (1) OA11898A (pt)
PL (1) PL339833A1 (pt)
PT (1) PT1021432E (pt)
SI (1) SI1021432T1 (pt)
SK (1) SK284028B6 (pt)
TR (1) TR200000918T2 (pt)
TW (1) TW567186B (pt)
UA (1) UA52778C2 (pt)
WO (1) WO1999019317A1 (pt)
ZA (1) ZA989204B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA79248C2 (en) * 2001-11-09 2007-06-11 Janssen Pharmaceutica Nv Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
JP4516752B2 (ja) * 2001-12-07 2010-08-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ トランス−縮合3,3a,8,12b−テトラヒドロ−2H−ジベンゾ[3,4:6,7]シクロヘプタ[1,2−b]フラン誘導体の製造法
IL162350A0 (en) * 2001-12-07 2005-11-20 Janssen Pharmaceutica Nv Preparation of cis-fused 3,3a,8,12b-tetrahydro-2h-dibenzo Ä3,4:6.7ÜcycloheptaÄ1,2-bÜfuran derivatives
HRP20020305A8 (en) * 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030959A2 (pt) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o.
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
ATE402932T1 (de) * 2004-06-14 2008-08-15 Janssen Pharmaceutica Nv Neue tetracyclische tetrahydrofuranderivate
CA2568752C (en) * 2004-06-23 2013-05-07 Janssen Pharmaceutica N.V. Novel unsaturated tetracyclic tetrahydrofuran derivatives
WO2006061392A2 (en) 2004-12-07 2006-06-15 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
AU2011202995B2 (en) * 2004-12-07 2012-02-02 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
CA2595170C (en) 2005-01-27 2014-08-05 Janssen Pharmaceutica N.V. Heterocyclic tetracyclic tetrahydrofuran derivatives as 5ht2 inhibitors in the treatment of cns disorders
NZ562724A (en) 2005-05-19 2010-07-30 Janssen Pharmaceutica Nv Selected tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain
WO2006125812A1 (en) * 2005-05-26 2006-11-30 Janssen Pharmaceutica N.V. Novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives and their use as a medicament
ES2342110T3 (es) * 2005-06-17 2010-07-01 Janssen Pharmaceutica Nv Nuevos derivados tetraciclicos de tetrahidrofurano que contienen una cadena lateral de amina ciclica.
US9125866B1 (en) 2015-01-28 2015-09-08 King Saud University Antidepressant compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552399A (en) 1994-11-02 1996-09-03 Janssen Pharmaceutica N.V. Substituted tetracyclic azepine derivatives
US5773433A (en) * 1994-11-02 1998-06-30 Janssen Pharmaceutica, N.V. Substituted tetracyclic oxazepine and thiazepine derivatives
US6057441A (en) * 1996-04-12 2000-05-02 Janssen Pharmaceutica, N.V. Substituted tetracyclic tetrahydrofuran derivatives
CA2264267A1 (en) 1996-08-28 1998-03-05 Michael Edward Flaugh Substituted 1,2,3,4-tetrahydro-2-dibenzofuranamines and 2-aminocyclohepta¬b|benzofurans

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OA11898A (en) 2006-04-10
CA2305612C (en) 2007-07-31
EE200000161A (et) 2001-04-16
KR20010023292A (ko) 2001-03-26
KR100366014B1 (ko) 2002-12-26
TW567186B (en) 2003-12-21
PL339833A1 (en) 2001-01-02
UA52778C2 (uk) 2003-01-15
AR017325A1 (es) 2001-09-05
CN1274353A (zh) 2000-11-22
MY117783A (en) 2004-08-30
IL135538A (en) 2005-07-25
NO20001792L (no) 2000-04-06
WO1999019317A1 (en) 1999-04-22
HRP20000189A2 (en) 2001-02-28
NO317159B1 (no) 2004-08-30
CN100340554C (zh) 2007-10-03
HK1029106A1 (en) 2001-03-23
US6511976B1 (en) 2003-01-28
BG104287A (en) 2000-11-30
EA200000400A1 (ru) 2000-10-30
NZ503294A (en) 2001-08-31
ATE235479T1 (de) 2003-04-15
JP3248902B2 (ja) 2002-01-21
US20030134852A1 (en) 2003-07-17
HUP0003748A3 (en) 2002-02-28
ID23903A (id) 2000-05-25
SI1021432T1 (en) 2003-08-31
ZA989204B (en) 2000-04-10
EP1021432B1 (en) 2003-03-26
DE69812668D1 (de) 2003-04-30
EE04526B1 (et) 2005-08-15
PT1021432E (pt) 2003-08-29
AU737334B2 (en) 2001-08-16
BG64387B1 (bg) 2004-12-30
IL135538A0 (en) 2001-05-20
CA2305612A1 (en) 1999-04-22
CZ296928B6 (cs) 2006-07-12
ES2195403T3 (es) 2003-12-01
JP2001519425A (ja) 2001-10-23
US6699858B2 (en) 2004-03-02
CZ20001136A3 (cs) 2000-08-16
SK284028B6 (sk) 2004-08-03
DE69812668T2 (de) 2004-01-29
NO20001792D0 (no) 2000-04-06
HUP0003748A2 (hu) 2002-01-28
AU9629698A (en) 1999-05-03
SK4712000A3 (en) 2000-10-09
HU225161B1 (en) 2006-07-28
TR200000918T2 (tr) 2000-07-21
AP1239A (en) 2004-01-15
AP2000001784A0 (en) 2000-06-30
DK1021432T3 (da) 2003-07-14
EP1021432A1 (en) 2000-07-26
EA003698B1 (ru) 2003-08-28

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