ATE94061T1 - Arylsubstituierte aminderivate verwendbar in der krebstherapie. - Google Patents
Arylsubstituierte aminderivate verwendbar in der krebstherapie.Info
- Publication number
- ATE94061T1 ATE94061T1 AT90306612T AT90306612T ATE94061T1 AT E94061 T1 ATE94061 T1 AT E94061T1 AT 90306612 T AT90306612 T AT 90306612T AT 90306612 T AT90306612 T AT 90306612T AT E94061 T1 ATE94061 T1 AT E94061T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen
- atom
- alkyl group
- represent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898914040A GB8914040D0 (en) | 1989-06-19 | 1989-06-19 | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
GB898914061A GB8914061D0 (en) | 1989-06-19 | 1989-06-19 | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
GB898914060A GB8914060D0 (en) | 1989-06-19 | 1989-06-19 | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
GB898914062A GB8914062D0 (en) | 1989-06-19 | 1989-06-19 | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
EP90306612A EP0409406B1 (de) | 1989-06-19 | 1990-06-18 | Arylsubstituierte Aminderivate verwendbar in der Krebstherapie |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE94061T1 true ATE94061T1 (de) | 1993-09-15 |
Family
ID=27450357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90306612T ATE94061T1 (de) | 1989-06-19 | 1990-06-18 | Arylsubstituierte aminderivate verwendbar in der krebstherapie. |
Country Status (18)
Country | Link |
---|---|
EP (2) | EP0487502A3 (de) |
JP (1) | JPH04506072A (de) |
KR (1) | KR920702620A (de) |
AT (1) | ATE94061T1 (de) |
AU (1) | AU650421B2 (de) |
CA (1) | CA2059127A1 (de) |
CZ (1) | CZ277925B6 (de) |
DE (1) | DE69003200T2 (de) |
DK (1) | DK0409406T3 (de) |
FI (1) | FI915970A0 (de) |
HU (1) | HUT59377A (de) |
IE (1) | IE902182A1 (de) |
IL (1) | IL94768A (de) |
NO (1) | NO914960D0 (de) |
NZ (1) | NZ234110A (de) |
PL (1) | PL285683A1 (de) |
PT (1) | PT94402A (de) |
WO (1) | WO1990015599A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5130139A (en) * | 1990-07-06 | 1992-07-14 | Alza Corporation | Reduction or prevention of skin irritation by drugs |
KR100220538B1 (ko) * | 1991-01-11 | 1999-09-15 | 뮈쉘 쥐르밀 | 아크리딘 유도체 |
GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
WO1993016044A1 (en) * | 1992-02-06 | 1993-08-19 | Merrell Dow Pharmaceuticals Inc. | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
JP3398748B2 (ja) * | 1993-01-21 | 2003-04-21 | メレルダウファーマスーティカルズ インコーポレイテッド | 多剤耐性腫瘍剤として有用なジアリールアルキルピペリジン類 |
US5387685A (en) * | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
HU221726B1 (hu) * | 1993-07-30 | 2002-12-28 | Ardent Pharmaceuticals Inc. | Piperazinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
US5436243A (en) * | 1993-11-17 | 1995-07-25 | Research Triangle Institute Duke University | Aminoanthraquinone derivatives to combat multidrug resistance |
US5574173A (en) * | 1993-12-06 | 1996-11-12 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US5670521A (en) * | 1994-08-05 | 1997-09-23 | Merrell Pharmaceuticals Inc. | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
US5767113A (en) * | 1995-05-10 | 1998-06-16 | The Salk Institute For Biological Studies | Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance |
US5756528A (en) * | 1995-06-06 | 1998-05-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5972984A (en) * | 1995-06-06 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
IT1277597B1 (it) | 1995-09-15 | 1997-11-11 | Smithkline Beecham Spa | Derivati di diarilalchenilammina |
US6130217A (en) * | 1995-09-20 | 2000-10-10 | Pfizer Inc | Compounds enhancing antitumor activity of other cytotoxic agents |
DE19848200A1 (de) * | 1998-10-20 | 2000-04-27 | Basf Ag | Verfahren zur Trocknung von Phenoxymethylbenzoesäuren |
JP4665379B2 (ja) * | 2002-06-28 | 2011-04-06 | Dic株式会社 | ヘリカルツイスティングパワーの増大方法、光学活性化合物、それを含有した液晶組成物及び液晶表示素子 |
US20090012010A1 (en) * | 2007-05-18 | 2009-01-08 | Neuromed Phramaceuticals Ltd. | Amino acid derivatives as calcium channel blockers |
US8486980B2 (en) | 2008-08-06 | 2013-07-16 | Kyowa Hakko Kirin Co., Ltd. | Tricyclic compound |
JP5460620B2 (ja) * | 2010-01-29 | 2014-04-02 | 日本臓器製薬株式会社 | アミノプロピリデン誘導体を含有する医薬 |
CN113227037A (zh) * | 2018-09-30 | 2021-08-06 | 北京生命科学研究所 | 活性增加的单卤素或甲基取代的5-ht2b拮抗剂 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL284002A (de) * | 1961-10-07 | |||
DE1232161B (de) * | 1961-10-07 | 1967-01-12 | Boehringer & Soehne Gmbh | Verfahren zur Herstellung von basisch substituierten Dibenzo-oxepinen und deren Salzen |
CH407990A (de) * | 1962-02-01 | 1966-02-28 | Hoffmann La Roche | Verfahren zur Herstellung von tricyclischen sekundären Aminen |
BE641498A (de) * | 1962-03-13 | |||
US3122551A (en) * | 1962-11-05 | 1964-02-25 | Abbott Lab | N-alkyl and n-aralkyl benzoxacycloalkaneamides |
FR88751E (de) * | 1963-07-09 | 1967-06-07 | ||
DE1470350B1 (de) * | 1963-09-13 | 1970-04-02 | Thomae Gmbh Dr K | 5,6-Dihydro-morphanthridine und Verfahren zu ihrer Herstellung |
US3497596A (en) * | 1967-08-16 | 1970-02-24 | Colgate Palmolive Co | Method of treating parkinsonism with morphanthridine derivatives |
CH540222A (de) * | 1968-03-20 | 1973-08-15 | Hoffmann La Roche | Verfahren zur Herstellung von tricyclischen Verbindungen |
US3996222A (en) * | 1972-02-01 | 1976-12-07 | Crc Compagnia De Ricerca Chimica | Piperazine derivatives |
US3993757A (en) * | 1975-06-06 | 1976-11-23 | Richardson-Merrell Inc. | Method of treating inflammation with morphanthridines |
SI8310221A8 (en) * | 1982-02-04 | 1995-10-31 | Wellcome Found | Process for obtaining new pyridil compounds |
JPS58208222A (ja) * | 1982-05-28 | 1983-12-03 | Japan Found Cancer | 抗腫瘍剤効果増強剤 |
IT1170342B (it) * | 1983-03-24 | 1987-06-03 | Polifarma Spa | Agente farmaceutico per il trattamento di tumori in fase di metastatizzazione e di anemie da labilita' della membrana eritrocitaria |
GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
GB8320699D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Ethylenediamines |
GB8500615D0 (en) * | 1985-01-10 | 1985-02-13 | Lundbeck & Co As H | Organic compounds |
GB8520662D0 (en) * | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
EP0353692B1 (de) * | 1988-08-02 | 1995-10-04 | Nissan Chemical Industries Ltd. | Mittel zur Verbesserung von Arzneimitteleffekten für Antitumormittel |
US5104858A (en) * | 1988-09-29 | 1992-04-14 | Yale University | Sensitizing multidrug resistant cells to antitumor agents |
-
1990
- 1990-06-18 JP JP2508659A patent/JPH04506072A/ja active Pending
- 1990-06-18 NZ NZ234110A patent/NZ234110A/xx unknown
- 1990-06-18 HU HU904785A patent/HUT59377A/hu unknown
- 1990-06-18 EP EP19920100224 patent/EP0487502A3/en not_active Withdrawn
- 1990-06-18 IL IL9476890A patent/IL94768A/en not_active IP Right Cessation
- 1990-06-18 PT PT94402A patent/PT94402A/pt not_active Application Discontinuation
- 1990-06-18 IE IE218290A patent/IE902182A1/en unknown
- 1990-06-18 CA CA002059127A patent/CA2059127A1/en not_active Abandoned
- 1990-06-18 DE DE90306612T patent/DE69003200T2/de not_active Expired - Fee Related
- 1990-06-18 AU AU58281/90A patent/AU650421B2/en not_active Ceased
- 1990-06-18 KR KR1019910701934A patent/KR920702620A/ko not_active Application Discontinuation
- 1990-06-18 AT AT90306612T patent/ATE94061T1/de not_active IP Right Cessation
- 1990-06-18 WO PCT/GB1990/000935 patent/WO1990015599A1/en active Application Filing
- 1990-06-18 EP EP90306612A patent/EP0409406B1/de not_active Expired - Lifetime
- 1990-06-18 DK DK90306612.4T patent/DK0409406T3/da active
- 1990-06-19 CZ CS903037A patent/CZ277925B6/cs unknown
- 1990-06-19 PL PL28568390A patent/PL285683A1/xx unknown
-
1991
- 1991-12-16 NO NO914960A patent/NO914960D0/no unknown
- 1991-12-18 FI FI915970A patent/FI915970A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0409406B1 (de) | 1993-09-08 |
CS9003037A2 (en) | 1991-11-12 |
DK0409406T3 (da) | 1994-02-07 |
WO1990015599A1 (en) | 1990-12-27 |
HU904785D0 (en) | 1992-03-30 |
AU5828190A (en) | 1991-01-08 |
DE69003200D1 (de) | 1993-10-14 |
IE902182A1 (en) | 1991-01-02 |
PL285683A1 (en) | 1991-05-20 |
FI915970A0 (fi) | 1991-12-18 |
DE69003200T2 (de) | 1994-01-20 |
HUT59377A (en) | 1992-05-28 |
CZ277925B6 (en) | 1993-06-16 |
AU650421B2 (en) | 1994-06-23 |
EP0409406A3 (en) | 1991-04-03 |
NZ234110A (en) | 1993-01-27 |
EP0409406A2 (de) | 1991-01-23 |
PT94402A (pt) | 1991-03-20 |
IL94768A0 (en) | 1991-04-15 |
IL94768A (en) | 1995-08-31 |
EP0487502A3 (en) | 1992-06-24 |
CA2059127A1 (en) | 1990-12-20 |
NO914960L (no) | 1991-12-16 |
NO914960D0 (no) | 1991-12-16 |
EP0487502A2 (de) | 1992-05-27 |
KR920702620A (ko) | 1992-10-06 |
JPH04506072A (ja) | 1992-10-22 |
IE902182L (en) | 1990-12-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |