IT1277597B1 - Derivati di diarilalchenilammina - Google Patents

Derivati di diarilalchenilammina

Info

Publication number
IT1277597B1
IT1277597B1 IT95MI001930A ITMI951930A IT1277597B1 IT 1277597 B1 IT1277597 B1 IT 1277597B1 IT 95MI001930 A IT95MI001930 A IT 95MI001930A IT MI951930 A ITMI951930 A IT MI951930A IT 1277597 B1 IT1277597 B1 IT 1277597B1
Authority
IT
Italy
Prior art keywords
diarylalkenylamine
derivatives
diarylalkenylamine derivatives
Prior art date
Application number
IT95MI001930A
Other languages
English (en)
Inventor
Giulio Dondio
Silvano Ronzoni
Original Assignee
Smithkline Beecham Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Spa filed Critical Smithkline Beecham Spa
Publication of ITMI951930A0 publication Critical patent/ITMI951930A0/it
Priority to IT95MI001930A priority Critical patent/IT1277597B1/it
Priority to AT96931791T priority patent/ATE240307T1/de
Priority to TR1998/00478T priority patent/TR199800478T1/xx
Priority to EP96931791A priority patent/EP0873330B1/en
Priority to IL12362196A priority patent/IL123621A0/xx
Priority to ES96931791T priority patent/ES2195010T3/es
Priority to CA002232161A priority patent/CA2232161A1/en
Priority to NZ318774A priority patent/NZ318774A/en
Priority to PCT/EP1996/003988 priority patent/WO1997010230A1/en
Priority to CZ98785A priority patent/CZ78598A3/cs
Priority to BR9610597A priority patent/BR9610597A/pt
Priority to AU70847/96A priority patent/AU706980B2/en
Priority to DE69628200T priority patent/DE69628200T2/de
Priority to KR1019980701930A priority patent/KR19990044675A/ko
Priority to HU9900374A priority patent/HUP9900374A3/hu
Priority to US09/029,892 priority patent/US6262104B1/en
Priority to JP9511657A priority patent/JPH11512413A/ja
Priority to CN96198240A priority patent/CN1202164A/zh
Priority to PL96325552A priority patent/PL325552A1/xx
Priority to ARP960104332A priority patent/AR004205A1/es
Priority to ZA9607741A priority patent/ZA967741B/xx
Publication of ITMI951930A1 publication Critical patent/ITMI951930A1/it
Application granted granted Critical
Publication of IT1277597B1 publication Critical patent/IT1277597B1/it
Priority to NO981131A priority patent/NO981131L/no
Priority to MXPA/A/1998/002024A priority patent/MXPA98002024A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
IT95MI001930A 1995-09-15 1995-09-15 Derivati di diarilalchenilammina IT1277597B1 (it)

Priority Applications (23)

Application Number Priority Date Filing Date Title
IT95MI001930A IT1277597B1 (it) 1995-09-15 1995-09-15 Derivati di diarilalchenilammina
DE69628200T DE69628200T2 (de) 1995-09-15 1996-09-09 Diarylalkenylamin-derivate
HU9900374A HUP9900374A3 (en) 1995-09-15 1996-09-09 Diarylalkenylamine derivatives and pharmaceutical compns. contg. them
EP96931791A EP0873330B1 (en) 1995-09-15 1996-09-09 Diarylalkenylamine derivatives
IL12362196A IL123621A0 (en) 1995-09-15 1996-09-09 Diarylalkenylamine derivatives
ES96931791T ES2195010T3 (es) 1995-09-15 1996-09-09 Derivados de di-arilalquenilaminas.
CA002232161A CA2232161A1 (en) 1995-09-15 1996-09-09 Diarylalkenylamine derivatives
NZ318774A NZ318774A (en) 1995-09-15 1996-09-09 Dialkyl-substituted benzamides
PCT/EP1996/003988 WO1997010230A1 (en) 1995-09-15 1996-09-09 Diarylalkenylamine derivatives
CZ98785A CZ78598A3 (cs) 1995-09-15 1996-09-09 Diarylalkenylaminové deriváty, farmaceutické prostředky s jejich obsahem, použití a způsob
BR9610597A BR9610597A (pt) 1995-09-15 1996-09-09 Derivados de diarilalcenilamina
AU70847/96A AU706980B2 (en) 1995-09-15 1996-09-09 Diarylalkenylamine derivatives
AT96931791T ATE240307T1 (de) 1995-09-15 1996-09-09 Diarylalkenylamin-derivate
KR1019980701930A KR19990044675A (ko) 1995-09-15 1996-09-09 디아릴알케닐아민 유도체
TR1998/00478T TR199800478T1 (xx) 1995-09-15 1996-09-09 Diarilalkenilamin t�revleri
US09/029,892 US6262104B1 (en) 1995-09-15 1996-09-09 Diarylalkenylamine derivatives
JP9511657A JPH11512413A (ja) 1995-09-15 1996-09-09 ジアリールアルケニルアミン誘導体
CN96198240A CN1202164A (zh) 1995-09-15 1996-09-09 二芳基链烯基胺衍生物
PL96325552A PL325552A1 (en) 1995-09-15 1996-09-09 Derivatives of diaryl alkenylamine
ARP960104332A AR004205A1 (es) 1995-09-15 1996-09-12 Derivados de diarilalquenilaminas, composiciones farmaceuticas que las contienen y el uso de dichos derivados en la preparacion de medicamentos.
ZA9607741A ZA967741B (en) 1995-09-15 1996-09-13 Diarylalkenylamine derivatives.
NO981131A NO981131L (no) 1995-09-15 1998-03-13 Diarylalkenylamin-derivater
MXPA/A/1998/002024A MXPA98002024A (en) 1995-09-15 1998-03-13 Derivatives of diarilalquenilam

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001930A IT1277597B1 (it) 1995-09-15 1995-09-15 Derivati di diarilalchenilammina

Publications (3)

Publication Number Publication Date
ITMI951930A0 ITMI951930A0 (it) 1995-09-15
ITMI951930A1 ITMI951930A1 (it) 1997-03-15
IT1277597B1 true IT1277597B1 (it) 1997-11-11

Family

ID=11372254

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI001930A IT1277597B1 (it) 1995-09-15 1995-09-15 Derivati di diarilalchenilammina

Country Status (22)

Country Link
US (1) US6262104B1 (it)
EP (1) EP0873330B1 (it)
JP (1) JPH11512413A (it)
KR (1) KR19990044675A (it)
CN (1) CN1202164A (it)
AR (1) AR004205A1 (it)
AT (1) ATE240307T1 (it)
AU (1) AU706980B2 (it)
BR (1) BR9610597A (it)
CA (1) CA2232161A1 (it)
CZ (1) CZ78598A3 (it)
DE (1) DE69628200T2 (it)
ES (1) ES2195010T3 (it)
HU (1) HUP9900374A3 (it)
IL (1) IL123621A0 (it)
IT (1) IT1277597B1 (it)
NO (1) NO981131L (it)
NZ (1) NZ318774A (it)
PL (1) PL325552A1 (it)
TR (1) TR199800478T1 (it)
WO (1) WO1997010230A1 (it)
ZA (1) ZA967741B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985880A (en) 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
US6103722A (en) * 1997-07-23 2000-08-15 The Medical College Of Wisconsin Research Foundation Inc. Ischemic preconditioning
ES2251121T3 (es) * 1997-12-24 2006-04-16 Ortho-Mcneil Pharmaceutical, Inc. (4)-aril(piperidin-4-il) aminobenzamidas que se unen al receptor opioide delta.
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
WO2001060796A1 (en) * 2000-02-18 2001-08-23 Meiji Seika Kaisha, Ltd. PHENOXYALKYLAMINE DERIVATIVES USEFUL AS OPIOID δ RECEPTOR AGONISTS
EP1277737A4 (en) * 2000-03-24 2003-05-07 Meiji Seika Kaisha DIPHENYLALKYLAMINE DERIVATIVES AS AGONISTS OF THE OPIOID -g (d) RECEPTOR
EP1680109A4 (en) 2003-10-07 2009-05-06 Renovis Inc AMIDE DERIVATIVES AS ION CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE DERIVATIVES
WO2006023757A2 (en) * 2004-08-19 2006-03-02 University Of Virginia Patent Foundation Novel tricyclic, bicyclic, monocyclic, and acyclic amines as potent sodium channel blocking agents
AU2005286733B2 (en) * 2004-09-23 2009-11-05 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
BRPI0606365A2 (pt) * 2005-02-28 2017-06-27 Renovis Inc composto ou um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo e estereoisômeros e tautômeros do mesmo, composição farmacêutica, métodos para prevenir, tratar, melhorar ou controlar uma doença ou condição e para preparar um composto, uso de um composto ou um sal, solvato ou composição farmaceuticamente aceitável do mesmo, método de tratamento de um mamífero, e, combinação

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47628B1 (en) * 1977-07-04 1984-05-16 Astra Laekemedel Ab Substituted aralkyl amines and amino-aryl alkenes having therapeutic activity
SI8310221A8 (en) 1982-02-04 1995-10-31 Wellcome Found Process for obtaining new pyridil compounds
US4514414A (en) * 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
US4564685A (en) * 1983-03-10 1986-01-14 Findlay John W A Diphenylmethane compounds
EP0219756B1 (de) 1985-10-09 1994-01-05 Shell Internationale Researchmaatschappij B.V. Neue Acrylsäureamide
WO1990015599A1 (en) 1989-06-19 1990-12-27 The Wellcome Foundation Limited Medicaments useful in cancer therapy and having antihistaminic properties

Also Published As

Publication number Publication date
CN1202164A (zh) 1998-12-16
DE69628200T2 (de) 2003-11-27
WO1997010230A1 (en) 1997-03-20
CA2232161A1 (en) 1997-03-20
IL123621A0 (en) 1998-10-30
NZ318774A (en) 1998-08-26
HUP9900374A3 (en) 1999-11-29
BR9610597A (pt) 1999-07-06
JPH11512413A (ja) 1999-10-26
AU706980B2 (en) 1999-07-01
US6262104B1 (en) 2001-07-17
KR19990044675A (ko) 1999-06-25
TR199800478T1 (xx) 1998-06-22
ATE240307T1 (de) 2003-05-15
EP0873330A1 (en) 1998-10-28
ZA967741B (en) 1998-03-13
PL325552A1 (en) 1998-08-03
AR004205A1 (es) 1998-11-04
EP0873330B1 (en) 2003-05-14
AU7084796A (en) 1997-04-01
CZ78598A3 (cs) 1998-08-12
NO981131L (no) 1998-03-16
NO981131D0 (no) 1998-03-13
ITMI951930A1 (it) 1997-03-15
DE69628200D1 (de) 2003-06-18
ES2195010T3 (es) 2003-12-01
MX9802024A (es) 1998-08-30
ITMI951930A0 (it) 1995-09-15
HUP9900374A2 (hu) 1999-06-28

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Legal Events

Date Code Title Description
0001 Granted