AR004205A1 - Derivados de diarilalquenilaminas, composiciones farmaceuticas que las contienen y el uso de dichos derivados en la preparacion de medicamentos. - Google Patents
Derivados de diarilalquenilaminas, composiciones farmaceuticas que las contienen y el uso de dichos derivados en la preparacion de medicamentos.Info
- Publication number
- AR004205A1 AR004205A1 ARP960104332A AR10433296A AR004205A1 AR 004205 A1 AR004205 A1 AR 004205A1 AR P960104332 A ARP960104332 A AR P960104332A AR 10433296 A AR10433296 A AR 10433296A AR 004205 A1 AR004205 A1 AR 004205A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- derivatives
- hydrogen
- branched
- same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Abstract
Derivados de diarialquenilaminas son agonistas y antagonistas delta potentes y selectivos de los opioides y tienen utilidad terapéutica potencialcomo analgésicos, entre otras cosas. Estos compuestos tienen la fórmula (I), en la cual, R1 yR2, que pueden ser iguales o diferentes, son cada uno hidrógeno,alquilo C1-6 lineal o ramificado, cicloalquilo C3-7, cicloalquenilo C3-7, cicloalquilalquilo C4-6, alquenilo C3-6, alquinilo C3-5, arilo, aralquilo ofuran-2 ó 3-il-alquilo, ópueden f ormar juntos un anillo de cicloalquilo C3-7 que puede estar interrumpido por oxígeno; R3 y R4, que pueden ser iguales odiferentes, son cada uno hidrógeno, alquilo C1-6 lineal o ramificado; R5 es hidroxi, alcoxi C1-6, tiol o alquiltio;R6 es un grupo -C(Z)-R8, en el cualZ es oxígeno o azufre, R8 es alquilo C1-8, alcoxi C1-8 ó NR9R10, en el cual R9 y R10, que puede ser iguales o diferentes, son hidrógeno, alquilo C1-6 linealo ramificado, cicloalquilo C3-7, cicloalquilalquilo C4-6,alquenilo C3-6, arilo o aralquilo, o R6 es un grupo (II), en el cual R11 y R12 tienen el mismosignificado que R9 y R10 o forman juntos un anillo heterocíclico opcionalmente sustituido y Z es como se ha definido anteriormente, y R7 eshidrógeno, alquilo C1-8 lineal o ramificado o halógeno. Asimismo, la presente invención describe composiciones farmacéuticas y el uso de dichos compuestos para la preparaciónde medicamentos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95MI001930A IT1277597B1 (it) | 1995-09-15 | 1995-09-15 | Derivati di diarilalchenilammina |
Publications (1)
Publication Number | Publication Date |
---|---|
AR004205A1 true AR004205A1 (es) | 1998-11-04 |
Family
ID=11372254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960104332A AR004205A1 (es) | 1995-09-15 | 1996-09-12 | Derivados de diarilalquenilaminas, composiciones farmaceuticas que las contienen y el uso de dichos derivados en la preparacion de medicamentos. |
Country Status (22)
Country | Link |
---|---|
US (1) | US6262104B1 (es) |
EP (1) | EP0873330B1 (es) |
JP (1) | JPH11512413A (es) |
KR (1) | KR19990044675A (es) |
CN (1) | CN1202164A (es) |
AR (1) | AR004205A1 (es) |
AT (1) | ATE240307T1 (es) |
AU (1) | AU706980B2 (es) |
BR (1) | BR9610597A (es) |
CA (1) | CA2232161A1 (es) |
CZ (1) | CZ78598A3 (es) |
DE (1) | DE69628200T2 (es) |
ES (1) | ES2195010T3 (es) |
HU (1) | HUP9900374A3 (es) |
IL (1) | IL123621A0 (es) |
IT (1) | IT1277597B1 (es) |
NO (1) | NO981131L (es) |
NZ (1) | NZ318774A (es) |
PL (1) | PL325552A1 (es) |
TR (1) | TR199800478T1 (es) |
WO (1) | WO1997010230A1 (es) |
ZA (1) | ZA967741B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985880A (en) * | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
US6103722A (en) * | 1997-07-23 | 2000-08-15 | The Medical College Of Wisconsin Research Foundation Inc. | Ischemic preconditioning |
ZA9811842B (en) * | 1997-12-24 | 2000-06-23 | Ortho Mcneil Pharm Inc | 4-[aryl(piperidin-4-yl)]aminobenzamides. |
US6436959B1 (en) | 1998-12-23 | 2002-08-20 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)]aminobenzamides |
ES2248281T3 (es) | 2000-02-18 | 2006-03-16 | Meiji Seika Kaisha, Ltd. | Derivados de fenoxialquilamina utiles como agonistas del receptor opioide delta. |
AU4274401A (en) * | 2000-03-24 | 2001-10-03 | Meiji Seika Kaisha | Diphenylalkylamine derivatives useful as opioid delta receptor agonists |
TW200526631A (en) | 2003-10-07 | 2005-08-16 | Renovis Inc | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
WO2006023757A2 (en) * | 2004-08-19 | 2006-03-02 | University Of Virginia Patent Foundation | Novel tricyclic, bicyclic, monocyclic, and acyclic amines as potent sodium channel blocking agents |
CA2580694A1 (en) * | 2004-09-23 | 2006-03-30 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
US20080300243A1 (en) * | 2005-02-28 | 2008-12-04 | Kelly Michael G | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same |
US7576099B2 (en) | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE47628B1 (en) * | 1977-07-04 | 1984-05-16 | Astra Laekemedel Ab | Substituted aralkyl amines and amino-aryl alkenes having therapeutic activity |
YU44821B (en) | 1982-02-04 | 1991-02-28 | Wellcome Found | Process for obtaiing new pyridyl derivatives |
US4514414A (en) * | 1982-10-25 | 1985-04-30 | Smithkline Beckman Corporation | N-Substituted pyrrolidineacetic acids and their esters |
US4564685A (en) * | 1983-03-10 | 1986-01-14 | Findlay John W A | Diphenylmethane compounds |
DE3689506D1 (de) * | 1985-10-09 | 1994-02-17 | Shell Int Research | Neue Acrylsäureamide. |
KR920702620A (ko) | 1989-06-19 | 1992-10-06 | 엠. 피. 잭슨 | 암치료에 유용하며 항히스타민성 특성을 갖는 약물 |
-
1995
- 1995-09-15 IT IT95MI001930A patent/IT1277597B1/it active IP Right Grant
-
1996
- 1996-09-09 EP EP96931791A patent/EP0873330B1/en not_active Expired - Lifetime
- 1996-09-09 PL PL96325552A patent/PL325552A1/xx unknown
- 1996-09-09 TR TR1998/00478T patent/TR199800478T1/xx unknown
- 1996-09-09 US US09/029,892 patent/US6262104B1/en not_active Expired - Fee Related
- 1996-09-09 AU AU70847/96A patent/AU706980B2/en not_active Ceased
- 1996-09-09 AT AT96931791T patent/ATE240307T1/de not_active IP Right Cessation
- 1996-09-09 IL IL12362196A patent/IL123621A0/xx unknown
- 1996-09-09 KR KR1019980701930A patent/KR19990044675A/ko not_active Application Discontinuation
- 1996-09-09 CN CN96198240A patent/CN1202164A/zh active Pending
- 1996-09-09 CZ CZ98785A patent/CZ78598A3/cs unknown
- 1996-09-09 DE DE69628200T patent/DE69628200T2/de not_active Expired - Fee Related
- 1996-09-09 JP JP9511657A patent/JPH11512413A/ja not_active Withdrawn
- 1996-09-09 ES ES96931791T patent/ES2195010T3/es not_active Expired - Lifetime
- 1996-09-09 BR BR9610597A patent/BR9610597A/pt unknown
- 1996-09-09 NZ NZ318774A patent/NZ318774A/en unknown
- 1996-09-09 CA CA002232161A patent/CA2232161A1/en not_active Abandoned
- 1996-09-09 WO PCT/EP1996/003988 patent/WO1997010230A1/en not_active Application Discontinuation
- 1996-09-09 HU HU9900374A patent/HUP9900374A3/hu unknown
- 1996-09-12 AR ARP960104332A patent/AR004205A1/es unknown
- 1996-09-13 ZA ZA9607741A patent/ZA967741B/xx unknown
-
1998
- 1998-03-13 NO NO981131A patent/NO981131L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ITMI951930A0 (it) | 1995-09-15 |
MX9802024A (es) | 1998-08-30 |
NO981131L (no) | 1998-03-16 |
ZA967741B (en) | 1998-03-13 |
TR199800478T1 (xx) | 1998-06-22 |
DE69628200D1 (de) | 2003-06-18 |
ES2195010T3 (es) | 2003-12-01 |
HUP9900374A3 (en) | 1999-11-29 |
JPH11512413A (ja) | 1999-10-26 |
BR9610597A (pt) | 1999-07-06 |
EP0873330B1 (en) | 2003-05-14 |
AU7084796A (en) | 1997-04-01 |
IT1277597B1 (it) | 1997-11-11 |
US6262104B1 (en) | 2001-07-17 |
CA2232161A1 (en) | 1997-03-20 |
NO981131D0 (no) | 1998-03-13 |
CN1202164A (zh) | 1998-12-16 |
PL325552A1 (en) | 1998-08-03 |
EP0873330A1 (en) | 1998-10-28 |
IL123621A0 (en) | 1998-10-30 |
ATE240307T1 (de) | 2003-05-15 |
DE69628200T2 (de) | 2003-11-27 |
CZ78598A3 (cs) | 1998-08-12 |
NZ318774A (en) | 1998-08-26 |
KR19990044675A (ko) | 1999-06-25 |
ITMI951930A1 (it) | 1997-03-15 |
AU706980B2 (en) | 1999-07-01 |
HUP9900374A2 (hu) | 1999-06-28 |
WO1997010230A1 (en) | 1997-03-20 |
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