KR920702620A - 암치료에 유용하며 항히스타민성 특성을 갖는 약물 - Google Patents
암치료에 유용하며 항히스타민성 특성을 갖는 약물Info
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Abstract
내용 없음
Description
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Claims (18)
- 항종양성 제제의 치료 효과를 증가시킬수 있는 약물을 제조함에 있어서 하기 일반식(I)의 화합물 또는 그의 약학적 허용염을 사용하는 방법.상기식에서, A는또는로부터 선택된 기이며 X는-CH-또는-N-을 나타내고R1은 수소 또는 할로겐 원자, C1-4알콕시기, C1-4알킬기, 또는 1 내지 3개의 할로겐 원자로 치환된 C1-4알킬기를 나타내며; R2는 수소 또는 할로겐 원자, C1-4알콕시키, 벤질옥시, -R7COOR8(이때, R7은 단일결합 또는 C1-72가 지방족 탄화수소기를 나타내며 R8은 수소원자 또는 C1-4알킬기를 나타낸다) 또는 R7CONR8aR8b(이때, R8a및R8b각각은 수소원자 또는 알킬기를 나타내거나 또는 질소원자와 함께 4 내지 6원 포화 헤테로사이클릭 고리를 형성하기도 한다)를 나타내고; R3및R4각각 수소원자 또는 C1-4알킬기를 나타내는 것으로서 서로 같거나 다를수 있거나, 또는 R3및R4가 부착된 질소원자와 함께 4 내지 6원포화 헤테로사이클릭 고리를 형성할수 있는데 이때 시소원자 또는 추가의 질소원자를 임의로 함유할 수 있고 이들은C1-4알킬기에 의해 치환될 수도 있으며; R5및R6는 수소원자를 나타내거나 또는 -CH2CH2-,CH2O-, -OCH2-, -NHCH2- 또는 -CH2NH-로부터 선택된, 방향족 고리사이의 연결기를 함께 형성할 수도 있으며; n은 0 또는 1 내지 3의 정수이고; 그리고 p 및 q는 1 내지 4의 정수로 부터 각각 선택되며, 단, (a)R5와 R6가 연결기를 형성할 경우, A는-(CH2)n-일 수 없으며, (b) A가기이고 n은 1이며 R1은 메틸이고, NR3R4는 피롤리디노이며 R5및 R가 모두 수소인 경우 R2는 수소 또는 -CH=CHCO2H가 될 수 없다.
- 제 1항에 있어서, 상기 일반식 (I)의 화합물은 하기 일반식 (Ⅱ)의 화합물 또는 그것의 약학적 허용염으로 표시될수 있음을 특징으로 하는 방법:상기 식에서 R9는 할로겐이고;R10는 수소, 할로겐, C1-4알콕시 -OCH2C6H5, 또는 -CH=CHCO2R12이며 이때 R12는 C1-4알킬, 바람직하게는 에틸이며; 그리고 R11은 C1-4알킬, -CH2CH2=CH2또는 CH2C6H4CH3-이다.
- 제 1항에 있어서, 상기 일반식(I)의 화합물은 하기 일반식(Ⅲ)의 화합물 또는 그것의 약학적 허용염으로 표시될 수 있음을 특징으로 하는 방법.상기 식에서R13은 C1-72가 지방족 탄화수소기 또는 단일 결합을 나타내며;R14는 C1-4알킬이고;R15는 수소, 할로겐, C1-4알콕시, C1-4알킬 또는 1 내지 3 할로겐 원자로 치환된 C1-4알킬이며;R16및 R17은 각각 수소원자 또는 C1-4알킬기를 나타내는 것으로서 서로 같거나 다를 수 있으며 또는 질소원자와 함께 4 내지 6원 포화헤테로 사이클릭기를 형성할 수도 있고; 그리고 A'은 각각이 수소원자를 나타내거나, -A'C - CA'는 -C=C-를 나타낸다.
- 제1항에 있어서, 상기 일반식(1)의 화합물은 하기 일반식(Ⅳ)의 화합물 또는 그것의 약학적 허용염으로 표시될 수 있음을 특징으로 하는 방법.상기 식에서 R19는 -CH2CH2-, -CH2O-, -OCH2-,-NHCH2-, 또는 -CH2NH-이고; Y는 1,2,3 또는 4위치에 결합된 수소 또는 할로겐이며; Y'은 7,8,9 또는 10 위치에 결합된 수소 또는 할로겐이며; n은 0 또는 3이고; p 및 q 각각은 1 내지 4이며; 그리고 R20및R21은 수소 또는 C1-4알킬로 부터 각각 선택되거나 또는 질소원자와 함께 4내지 6원으로 구성된 질소-함유 헤테로사이클릭고리를 형성할수도 있다.
- 제1항에 있어서, 상기 일반식(I)의 화합물은 하기 일반식(Ⅴ)의 화합물 또는 그것의 약학적 허용염으로 표시될 수 있음을 특징으로 하는 방법.상기 식에서 R22는 할로겐, -COOH-, -CH=CH-COOH-, -CH2COOH 또는 -(CH2)2COOH이고;R23은 수소, 할로겐, C1-4알콕시 또는 C1-4알킬이며; 그리고R24및R25는 같거나 상이하며 각각은 수소 또는C1-4이거나 또는 NR24R25는 피롤리디노일 수도 있다.
- 제1항에 있어서, 상기 일반식(I)의 화합물은 하기 일반식(Ⅵ)의 화합물 또는 그것의 약학적 허용염으로 표시될 수 있음을 특징으로 하는 방법.상기 식에서 R22는 할로겐, -COOH, -CH=CH-COOH, -CH2COOH 또는 -(CH2)2COOH이다.
- 제1항 내지 제6항중 어느 한 항에 있어서, 항종양성 제제에 대해 내성을 갖는 종양의 상기 항종양성 제제에 대한 감수성을 증가시키기 위한 약물을 제조함에 있어서 상기 일반식(I)의 화합물을 사용하는 방법.
- 제1항 내지 제6항중 어느 한 항에 있어서, 종양세포의 성장을 선택적으로 억제시킬 수 있는 약물을 제조함에 있어서 상기 일반식(I)의 화합물을 사용하는 방법.
- 제1항 내지 제6항중 어느 한 항에 있어서, 종양에 대한 다형 약물 내성을 억제할 수 있는 약물의 제조시 상기 일반식(I)의 화합물을 사용하는 방법.
- 제1항 내지 제7항중 어느 한 항에 있어서, 상기 항종양성 제제는 빈카 알카로이드, 에피포도필로톡신 안트라사이클린 항생제, 엑티노마이신 D, 플리카마이신, 퓨로마이신, 그라미시딘 D, 탁솔, 콜키신, 시토칼라신 B, 에메틴, 메이탄신 및 암사트린으로부터 선택된 것을 특징으로 하는 방법.
- 제1항 내지 제10항중 어느 한 항에 있어서, 상기 약물이 선암의 치료를 목적으로 하는 것을 특징으로 하는 방법.
- 항종양성 제제의 치료효과를 증가시키는 데에 사용될 수 있는 제1항 내지 제6항중 어느 한 항에 정의된 일반식(1)의 화합물.
- 제1항 내지 제6항중 어느 한 항에 있어서 정의된 일반식(I)의 화합물 및 항종양성 제제를 약학적 허용담체 또는 부형제와 함께 포함하는, 종양의 치료에 사용될 수 있는 약학적 조성물.
- 제12항에 있어서, 상기 항종양성 제제는 제10항에서 정의된 것임을 특징으로 하는 조성물.
- 하기 일반식(Ⅳa)의 화합물 또는 그것의 약학적 허용염;상기 식에서, R19는 -CH2CH2-,CH2O-, -OCH2-,-NHCH2- 또는-CH2NH-이고; Y는 1,2,3 또는 4위치에 부착된 수소 또는 할로겐이며; Y'은 7,8,9 또는 10 위치에 부착된 수소 또는 할로겐이며; n은 0 또는 3이고 p 및 q 각각은 1 내지 4이며; 그리고 R20및R21은 수소 또는 C1-4알킬로부터 각각 선택되거나 또는 질소원자와 함께 4내지 6원으로 구성된 질소-함유 헤테로사이클릭고리를 형성할수도 있으며, 단, a)R19가 -CH2CH2-,-CH2O 또는 -OCH2-이고 p와 q는 각각 1이며, Y와 Y'중 하나가 할로겐인 경우 나머지는 수소가 아니며, b)R19가 -CH2CH2또는 -CH2O-이고 p와 q는 둘 모두 1이며, Y와 Y'은 각각 수소 또는 할로겐인 경우 n은 2가 아니어야 한다.
- a) 하기 일반식(Ⅷ)의 화합물을 적절한 위티크 시약 또는 그리그나드 시약과 반응시킨후 탈수시키는 단계; b) 하기 일반식(Ⅸ)의 화합물을 할로겐화하는 단계; 및 c) 일반식(Ⅳ)의 화합물을 할로겐 교환에 의해 또 다른 일반식(Ⅳ)의 화합물로 전환시키는 단계를 포함하는, 제15항에서 정의된 일반식(Ⅳa)이 화합물의 제조방법.
- 치료제로 사용될 수 있는 하기 일반식(Ⅳb)의 화합물 또는 그것의 약학적 허용염:상기 식에서R19는 -CH2CH2-,CH2O-,-COH2-,-NHCH2- 또는 -CH2NH-이고: Y는 1,2,3 또는 4위치에 부착된 수소 또는 할로겐이며; Y'은 7,8,9 또는 10 위치에 부착된 수소 또는 할로겐이며; n은 0 또는 3이고 p 및 q 각각은 1 내지 4이며; 그리고 R20및 R21은 수소 또는 C1-4알킬로부터 각각 선택되거나 또는 질소원자와 함께 4내지 6원으로 구성된 질소-함유 헤테로사이클릭고리를 형성할수도 있으며, 단, R19가 -CH2CH2-, 또는-CH2O-이고, p와 q는 둘 모두 1이며 Y와 Y'은 각소 수소 또는 할로겐인 경우, n은 2가 아니어야한다.
- 일반식(Ⅳa) 또는 (Ⅳb)의 화합물 또는 그것의 약학적 허용염을 그것의 약학적 허용 담체와 함께 포함하는 약학적 제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898914060A GB8914060D0 (en) | 1989-06-19 | 1989-06-19 | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
GB8914040.4 | 1989-06-19 | ||
GB8914062.8 | 1989-06-19 | ||
GB8914061.2 | 1989-06-19 | ||
GB898914061A GB8914061D0 (en) | 1989-06-19 | 1989-06-19 | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
GB898914062A GB8914062D0 (en) | 1989-06-19 | 1989-06-19 | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
GB898914040A GB8914040D0 (en) | 1989-06-19 | 1989-06-19 | Agents for potentiating the effects of antitumour agents and combating multiple drug resistance |
GB8914060.2 | 1989-06-19 | ||
PCT/GB1990/000935 WO1990015599A1 (en) | 1989-06-19 | 1990-06-18 | Medicaments useful in cancer therapy and having antihistaminic properties |
Publications (1)
Publication Number | Publication Date |
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KR920702620A true KR920702620A (ko) | 1992-10-06 |
Family
ID=27450357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910701934A KR920702620A (ko) | 1989-06-19 | 1990-06-18 | 암치료에 유용하며 항히스타민성 특성을 갖는 약물 |
Country Status (18)
Country | Link |
---|---|
EP (2) | EP0487502A3 (ko) |
JP (1) | JPH04506072A (ko) |
KR (1) | KR920702620A (ko) |
AT (1) | ATE94061T1 (ko) |
AU (1) | AU650421B2 (ko) |
CA (1) | CA2059127A1 (ko) |
CZ (1) | CZ277925B6 (ko) |
DE (1) | DE69003200T2 (ko) |
DK (1) | DK0409406T3 (ko) |
FI (1) | FI915970A0 (ko) |
HU (1) | HUT59377A (ko) |
IE (1) | IE902182A1 (ko) |
IL (1) | IL94768A (ko) |
NO (1) | NO914960L (ko) |
NZ (1) | NZ234110A (ko) |
PL (1) | PL285683A1 (ko) |
PT (1) | PT94402A (ko) |
WO (1) | WO1990015599A1 (ko) |
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US5130139A (en) * | 1990-07-06 | 1992-07-14 | Alza Corporation | Reduction or prevention of skin irritation by drugs |
ES2104887T3 (es) * | 1991-01-11 | 1997-10-16 | Glaxo Lab Sa | Derivados de acridina. |
US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
AU662602B2 (en) * | 1992-02-06 | 1995-09-07 | Merrell Dow Pharmaceuticals Inc. | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
DE69309310T2 (de) * | 1993-01-21 | 1997-11-06 | Merrell Pharmaceuticals Inc., Cincinnati, Ohio | Als mittel gegen mehrfach resistente tumorenverwendbare diarylalkylpiperidine |
US5387685A (en) * | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
HU221726B1 (hu) * | 1993-07-30 | 2002-12-28 | Ardent Pharmaceuticals Inc. | Piperazinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására |
US5436243A (en) * | 1993-11-17 | 1995-07-25 | Research Triangle Institute Duke University | Aminoanthraquinone derivatives to combat multidrug resistance |
US5574173A (en) * | 1993-12-06 | 1996-11-12 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US5670521A (en) * | 1994-08-05 | 1997-09-23 | Merrell Pharmaceuticals Inc. | Reversal of multi-drug resistance by triphenyl-azacycloalkane derivatives |
US5767113A (en) * | 1995-05-10 | 1998-06-16 | The Salk Institute For Biological Studies | Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance |
US5756528A (en) * | 1995-06-06 | 1998-05-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5972984A (en) * | 1995-06-06 | 1999-10-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
IT1277597B1 (it) | 1995-09-15 | 1997-11-11 | Smithkline Beecham Spa | Derivati di diarilalchenilammina |
US6130217A (en) * | 1995-09-20 | 2000-10-10 | Pfizer Inc | Compounds enhancing antitumor activity of other cytotoxic agents |
DE19848200A1 (de) * | 1998-10-20 | 2000-04-27 | Basf Ag | Verfahren zur Trocknung von Phenoxymethylbenzoesäuren |
JP4665379B2 (ja) * | 2002-06-28 | 2011-04-06 | Dic株式会社 | ヘリカルツイスティングパワーの増大方法、光学活性化合物、それを含有した液晶組成物及び液晶表示素子 |
US20090012010A1 (en) * | 2007-05-18 | 2009-01-08 | Neuromed Phramaceuticals Ltd. | Amino acid derivatives as calcium channel blockers |
WO2010016549A1 (ja) | 2008-08-06 | 2010-02-11 | 協和発酵キリン株式会社 | 3環系化合物 |
JP5460620B2 (ja) * | 2010-01-29 | 2014-04-02 | 日本臓器製薬株式会社 | アミノプロピリデン誘導体を含有する医薬 |
WO2020063999A1 (en) * | 2018-09-30 | 2020-04-02 | National Institute Of Biological Sciences, Beijing | Mono halogen or methyl-substituted 5-ht2b antagonists with increased activity |
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DE1232161B (de) * | 1961-10-07 | 1967-01-12 | Boehringer & Soehne Gmbh | Verfahren zur Herstellung von basisch substituierten Dibenzo-oxepinen und deren Salzen |
NL284002A (ko) * | 1961-10-07 | |||
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US3497596A (en) * | 1967-08-16 | 1970-02-24 | Colgate Palmolive Co | Method of treating parkinsonism with morphanthridine derivatives |
CH540222A (de) * | 1968-03-20 | 1973-08-15 | Hoffmann La Roche | Verfahren zur Herstellung von tricyclischen Verbindungen |
US3996222A (en) * | 1972-02-01 | 1976-12-07 | Crc Compagnia De Ricerca Chimica | Piperazine derivatives |
US3993757A (en) * | 1975-06-06 | 1976-11-23 | Richardson-Merrell Inc. | Method of treating inflammation with morphanthridines |
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IT1170342B (it) * | 1983-03-24 | 1987-06-03 | Polifarma Spa | Agente farmaceutico per il trattamento di tumori in fase di metastatizzazione e di anemie da labilita' della membrana eritrocitaria |
GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
GB8320699D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Ethylenediamines |
GB8500615D0 (en) * | 1985-01-10 | 1985-02-13 | Lundbeck & Co As H | Organic compounds |
GB8520662D0 (en) * | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
ATE128623T1 (de) * | 1988-08-02 | 1995-10-15 | Nissan Chemical Ind Ltd | Mittel zur verbesserung von arzneimitteleffekten für antitumormittel. |
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-
1990
- 1990-06-18 WO PCT/GB1990/000935 patent/WO1990015599A1/en active Application Filing
- 1990-06-18 HU HU904785A patent/HUT59377A/hu unknown
- 1990-06-18 EP EP19920100224 patent/EP0487502A3/en not_active Withdrawn
- 1990-06-18 PT PT94402A patent/PT94402A/pt not_active Application Discontinuation
- 1990-06-18 AU AU58281/90A patent/AU650421B2/en not_active Ceased
- 1990-06-18 EP EP90306612A patent/EP0409406B1/en not_active Expired - Lifetime
- 1990-06-18 IE IE218290A patent/IE902182A1/en unknown
- 1990-06-18 JP JP2508659A patent/JPH04506072A/ja active Pending
- 1990-06-18 AT AT90306612T patent/ATE94061T1/de not_active IP Right Cessation
- 1990-06-18 IL IL9476890A patent/IL94768A/en not_active IP Right Cessation
- 1990-06-18 CA CA002059127A patent/CA2059127A1/en not_active Abandoned
- 1990-06-18 KR KR1019910701934A patent/KR920702620A/ko not_active Application Discontinuation
- 1990-06-18 DE DE90306612T patent/DE69003200T2/de not_active Expired - Fee Related
- 1990-06-18 NZ NZ234110A patent/NZ234110A/xx unknown
- 1990-06-18 DK DK90306612.4T patent/DK0409406T3/da active
- 1990-06-19 CZ CS903037A patent/CZ277925B6/cs unknown
- 1990-06-19 PL PL28568390A patent/PL285683A1/xx unknown
-
1991
- 1991-12-16 NO NO91914960A patent/NO914960L/no unknown
- 1991-12-18 FI FI915970A patent/FI915970A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JPH04506072A (ja) | 1992-10-22 |
PT94402A (pt) | 1991-03-20 |
AU650421B2 (en) | 1994-06-23 |
EP0409406A3 (en) | 1991-04-03 |
FI915970A0 (fi) | 1991-12-18 |
NO914960D0 (no) | 1991-12-16 |
NO914960L (no) | 1991-12-16 |
HUT59377A (en) | 1992-05-28 |
AU5828190A (en) | 1991-01-08 |
DE69003200D1 (de) | 1993-10-14 |
EP0487502A3 (en) | 1992-06-24 |
CZ277925B6 (en) | 1993-06-16 |
HU904785D0 (en) | 1992-03-30 |
IE902182L (en) | 1990-12-19 |
IL94768A (en) | 1995-08-31 |
CA2059127A1 (en) | 1990-12-20 |
PL285683A1 (en) | 1991-05-20 |
EP0409406A2 (en) | 1991-01-23 |
WO1990015599A1 (en) | 1990-12-27 |
EP0487502A2 (en) | 1992-05-27 |
IL94768A0 (en) | 1991-04-15 |
CS9003037A2 (en) | 1991-11-12 |
ATE94061T1 (de) | 1993-09-15 |
IE902182A1 (en) | 1991-01-02 |
NZ234110A (en) | 1993-01-27 |
EP0409406B1 (en) | 1993-09-08 |
DK0409406T3 (da) | 1994-02-07 |
DE69003200T2 (de) | 1994-01-20 |
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