RU95108759A - Фармацевтические соединения - Google Patents

Фармацевтические соединения

Info

Publication number
RU95108759A
RU95108759A RU95108759/04A RU95108759A RU95108759A RU 95108759 A RU95108759 A RU 95108759A RU 95108759/04 A RU95108759/04 A RU 95108759/04A RU 95108759 A RU95108759 A RU 95108759A RU 95108759 A RU95108759 A RU 95108759A
Authority
RU
Russia
Prior art keywords
alkyl
atom
hydrogen atom
independently selected
group
Prior art date
Application number
RU95108759/04A
Other languages
English (en)
Inventor
Энтони Дэвид Коллинз Марк
Gb]
Инес Чикарелли-Робинсон Мария
Стивен Брайанс Джастин
Br]
Джеймс Брочини Стивен
Джон Лэтам Кристофер
Us]
Original Assignee
Ксенова Лимитед (Gb)
Ксенова Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ксенова Лимитед (Gb), Ксенова Лимитед filed Critical Ксенова Лимитед (Gb)
Publication of RU95108759A publication Critical patent/RU95108759A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Дикетопиперазин или его фармацевтически приемлемая соль или эфир являются модуляторами множественной устойчивости к лекарственным средствам. Формула соединения и значения радикалов приведены в описании изобретения.

Claims (1)

  1. Дикетопиперазин или его фармацевтически приемлемая соль или эфир являются модуляторами множественной устойчивости к лекарственным средствам. Формула соединения и значения радикалов приведены в описании изобретения.
RU95108759/04A 1992-08-14 1993-08-16 Фармацевтические соединения RU95108759A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929217331A GB9217331D0 (en) 1992-08-14 1992-08-14 Pharmaceutical compounds
GB9217331.9 1992-08-14

Publications (1)

Publication Number Publication Date
RU95108759A true RU95108759A (ru) 1996-12-10

Family

ID=10720385

Family Applications (2)

Application Number Title Priority Date Filing Date
RU95108387/04A RU95108387A (ru) 1992-08-14 1993-08-16 Дикетопиперазин, способ его получения, фармацевтическая композиция, применение дикетопиперазина
RU95108759/04A RU95108759A (ru) 1992-08-14 1993-08-16 Фармацевтические соединения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU95108387/04A RU95108387A (ru) 1992-08-14 1993-08-16 Дикетопиперазин, способ его получения, фармацевтическая композиция, применение дикетопиперазина

Country Status (24)

Country Link
US (1) US5700804A (ru)
EP (2) EP0655060B1 (ru)
JP (2) JPH08504175A (ru)
KR (2) KR950702967A (ru)
AT (1) ATE162186T1 (ru)
AU (2) AU693420B2 (ru)
BG (2) BG99496A (ru)
BR (2) BR9306905A (ru)
CA (2) CA2141938A1 (ru)
CZ (2) CZ38395A3 (ru)
DE (1) DE69316370T2 (ru)
DK (1) DK0655060T3 (ru)
ES (1) ES2111169T3 (ru)
FI (2) FI950617A (ru)
GB (2) GB9217331D0 (ru)
GR (1) GR3026272T3 (ru)
HU (2) HUT71593A (ru)
IL (2) IL106695A0 (ru)
PL (2) PL307437A1 (ru)
RU (2) RU95108387A (ru)
SK (2) SK19595A3 (ru)
TW (1) TW334427B (ru)
WO (2) WO1994004513A1 (ru)
ZA (2) ZA935969B (ru)

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DK85193D0 (da) 1993-07-16 1993-07-16 Cancerforskningsfondet Af 1989 Suppression of inhibitors
GB9402809D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9402807D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9402805D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
IL112627A0 (en) * 1994-02-14 1995-05-26 Xenova Ltd Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them
GB9410387D0 (en) * 1994-05-24 1994-07-13 Xenova Ltd Pharmaceutical compounds
GB2311781B (en) * 1994-12-23 1998-09-16 Xenova Ltd Piperazine 2,5 dione derivatives as modulators of multi-drug resistance
GB9426071D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB9426090D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB2310854B (en) * 1994-12-23 1998-09-09 Xenova Ltd Piperazine-2,5-dione derivatives as modulators of multi-drug resistance
GB9426224D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
US5891877A (en) * 1995-02-14 1999-04-06 Xenova Limited Pharmaceutical compounds
CA2393440A1 (en) * 1999-12-03 2001-06-07 Emory University Curcumin analogs with anti-tumor and anti-angiogenic properties
US7288545B2 (en) 2000-05-09 2007-10-30 Angiorx Corporation Piperazinedione compounds
ATE417614T1 (de) * 2000-05-09 2009-01-15 Angiorx Corp Piperazindion-verbindungen
US6555543B2 (en) 2000-08-04 2003-04-29 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
DE60131177T2 (de) 2000-09-06 2008-08-07 AP Pharma, Inc., Redwood Abbaubare polyacetal-polymere
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
WO2002062797A2 (en) * 2000-12-29 2002-08-15 Celltech R & D, Inc. Pharmaceutical uses and synthesis of diketopiperazines
GB2372740A (en) * 2001-01-17 2002-09-04 Xenova Ltd Diketopiperazines
US20060229239A9 (en) * 2002-03-08 2006-10-12 Mamoru Shoji Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis
US7935704B2 (en) 2003-08-01 2011-05-03 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
KR101184374B1 (ko) 2002-08-02 2012-09-20 니리어스 파마슈티컬즈, 인코퍼레이션 데하이드로페닐아히스틴 및 그의 동족체, 및 이들의 합성 방법
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
DE10238144A1 (de) * 2002-08-15 2004-02-26 Basf Ag Verwendung von Diketopiperazin-Derivaten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
JP4674317B2 (ja) 2002-10-02 2011-04-20 ディエムアイ アクイジション コーポレイション 疾病の判定および監視
KR20150080004A (ko) 2003-05-15 2015-07-08 앰피오 파마슈티컬스 인코퍼레이티드 Ｔ-세포 매개성 질환의 치료 방법
GB0314738D0 (en) 2003-06-24 2003-07-30 Glaxo Group Ltd Novel compounds
WO2006105051A2 (en) * 2005-03-29 2006-10-05 Nereus Pharmaceuticals, Inc. Synthesis of diketopiperazines
WO2007098504A1 (en) * 2006-02-24 2007-08-30 Emory University Prodrugs of curcumin analogs
US8129527B2 (en) 2006-11-03 2012-03-06 Nereus Pharmacuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
CA2810844C (en) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions
RU2606624C2 (ru) * 2011-02-10 2017-01-10 Маннкайнд, Корп Получение n-защищенного бис-3,6-(4-аминоалкил)-2,5-дикетопиперазина
WO2013055734A1 (en) 2011-10-10 2013-04-18 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
MY172699A (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
MX355446B (es) 2011-10-28 2018-04-18 Ampio Pharmaceuticals Inc Tratamiento de rinitis.
EP2968315B1 (en) 2013-03-15 2020-06-03 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
CN103396372B (zh) * 2013-08-09 2015-05-20 中国科学院南海海洋研究所 一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用
CN105272968B (zh) * 2014-06-10 2018-03-13 首都医科大学 (3s,6r)‑3,6二取代哌嗪‑2,5‑二酮,其制备及应用
WO2016028790A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
CN104610170B (zh) * 2015-01-14 2017-02-01 中国科学院南海海洋研究所 2,5‑二酮哌嗪衍生物及其制备方法和应用
US10238650B2 (en) 2015-03-06 2019-03-26 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
US10076518B2 (en) 2015-03-06 2018-09-18 Beyondspring Pharmaceuticals, Inc. Method of treating a brain tumor
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
AU2016291708B2 (en) 2015-07-13 2020-12-24 Beyondspring Pharmaceuticals, Inc Plinabulin compositions
SG11201806583XA (en) 2016-02-08 2018-09-27 Beyondspring Pharmaceuticals Inc Compositions containing tucaresol or its analogs
CN109475524A (zh) 2016-06-06 2019-03-15 万春药业公司 用于减少中性粒细胞减少症的组合物和方法
CN110431135A (zh) 2017-01-06 2019-11-08 大连万春布林医药有限公司 微管蛋白结合化合物及其治疗用途
KR20190109479A (ko) 2017-02-01 2019-09-25 비욘드스프링 파마수티컬스, 인코포레이티드. 호중구감소증의 감소 방법
CN110054619A (zh) * 2018-01-18 2019-07-26 西北农林科技大学 新型二酮哌嗪类组蛋白去乙酰化酶抑制剂
US11786523B2 (en) 2018-01-24 2023-10-17 Beyondspring Pharmaceuticals, Inc. Composition and method for reducing thrombocytopenia
WO2021195265A1 (en) 2020-03-24 2021-09-30 Ampio Pharmaceuticals, Inc. Methods for treating diseases associated with respiratory viruses

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DE621862C (de) * 1932-07-01 1935-11-14 Guenther Schiemann Dr Verfahren zur Darstellung von Kondensationsprodukten kernfluorierter Arylaldehyde
BE584914A (ru) * 1958-11-24
JPS5747357A (en) * 1980-09-04 1982-03-18 Ricoh Co Ltd Novel disazo compound and its preparation
GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
GB2284420A (en) 1995-06-07
AU4726593A (en) 1994-03-15
EP0655060A1 (en) 1995-05-31
BG99495A (en) 1995-12-29
WO1994004513A1 (en) 1994-03-03
AU693420B2 (en) 1998-07-02
SK19495A3 (en) 1995-11-08
PL307438A1 (en) 1995-05-29
RU95108387A (ru) 1996-12-10
HUT71593A (en) 1996-01-29
FI950616A (fi) 1995-04-13
SK19595A3 (en) 1995-09-13
GB9217331D0 (en) 1992-09-30
EP0672036A1 (en) 1995-09-20
JPH08504175A (ja) 1996-05-07
TW334427B (en) 1998-06-21
HU9500436D0 (en) 1995-04-28
DE69316370T2 (de) 1998-07-16
IL106696A0 (en) 1993-12-08
FI950617A (fi) 1995-04-13
DE69316370D1 (de) 1998-02-19
CA2141939A1 (en) 1994-03-03
BG99496A (en) 1995-12-29
AU678172B2 (en) 1997-05-22
ZA935969B (en) 1995-02-16
PL307437A1 (en) 1995-05-29
GR3026272T3 (en) 1998-06-30
BR9306904A (pt) 1998-12-08
GB9502859D0 (en) 1995-04-05
ATE162186T1 (de) 1998-01-15
BR9306905A (pt) 1998-12-08
KR950702967A (ko) 1995-08-23
WO1994004512A1 (en) 1994-03-03
CZ38195A3 (en) 1995-09-13
FI950617A0 (fi) 1995-02-13
ZA935968B (en) 1995-02-16
IL106695A0 (en) 1993-12-08
HUT71592A (en) 1996-01-29
CA2141938A1 (en) 1994-03-03
JPH08504176A (ja) 1996-05-07
GB2284420B (en) 1996-09-25
EP0655060B1 (en) 1998-01-14
DK0655060T3 (da) 1998-02-09
FI950616A0 (fi) 1995-02-13
US5700804A (en) 1997-12-23
KR950702968A (ko) 1995-08-23
AU4726493A (en) 1994-03-15
ES2111169T3 (es) 1998-03-01
HU9500437D0 (en) 1995-04-28
CZ38395A3 (en) 1995-10-18

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