DE69316370D1 - Pharmazeutisch wiksame diketopiperazinen - Google Patents

Pharmazeutisch wiksame diketopiperazinen

Info

Publication number
DE69316370D1
DE69316370D1 DE69316370T DE69316370T DE69316370D1 DE 69316370 D1 DE69316370 D1 DE 69316370D1 DE 69316370 T DE69316370 T DE 69316370T DE 69316370 T DE69316370 T DE 69316370T DE 69316370 D1 DE69316370 D1 DE 69316370D1
Authority
DE
Germany
Prior art keywords
pct
nco2r11
nhco
alkyl
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69316370T
Other languages
English (en)
Other versions
DE69316370T2 (de
Inventor
Mark Collins
Maria Chicarelli-Robinson
Justin Bryans
Stephen Brocchini
Christopher Latham
John Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenova Ltd
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Ltd filed Critical Xenova Ltd
Publication of DE69316370D1 publication Critical patent/DE69316370D1/de
Application granted granted Critical
Publication of DE69316370T2 publication Critical patent/DE69316370T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69316370T 1992-08-14 1993-08-16 Pharmazeutisch wiksame diketopiperazinen Expired - Fee Related DE69316370T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929217331A GB9217331D0 (en) 1992-08-14 1992-08-14 Pharmaceutical compounds
PCT/GB1993/001734 WO1994004512A1 (en) 1992-08-14 1993-08-16 Pharmaceutically active diketopiperazines

Publications (2)

Publication Number Publication Date
DE69316370D1 true DE69316370D1 (de) 1998-02-19
DE69316370T2 DE69316370T2 (de) 1998-07-16

Family

ID=10720385

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69316370T Expired - Fee Related DE69316370T2 (de) 1992-08-14 1993-08-16 Pharmazeutisch wiksame diketopiperazinen

Country Status (24)

Country Link
US (1) US5700804A (de)
EP (2) EP0655060B1 (de)
JP (2) JPH08504175A (de)
KR (2) KR950702967A (de)
AT (1) ATE162186T1 (de)
AU (2) AU678172B2 (de)
BG (2) BG99495A (de)
BR (2) BR9306905A (de)
CA (2) CA2141938A1 (de)
CZ (2) CZ38195A3 (de)
DE (1) DE69316370T2 (de)
DK (1) DK0655060T3 (de)
ES (1) ES2111169T3 (de)
FI (2) FI950617A (de)
GB (2) GB9217331D0 (de)
GR (1) GR3026272T3 (de)
HU (2) HUT71592A (de)
IL (2) IL106695A0 (de)
PL (2) PL307438A1 (de)
RU (2) RU95108759A (de)
SK (2) SK19495A3 (de)
TW (1) TW334427B (de)
WO (2) WO1994004512A1 (de)
ZA (2) ZA935968B (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds
DK85193D0 (da) 1993-07-16 1993-07-16 Cancerforskningsfondet Af 1989 Suppression of inhibitors
GB9402805D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
IL112627A0 (en) * 1994-02-14 1995-05-26 Xenova Ltd Diketopiperazines, their preparation and pharmaceutical or veterinary compositions containing them
GB9402809D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9402807D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9410387D0 (en) * 1994-05-24 1994-07-13 Xenova Ltd Pharmaceutical compounds
GB9426224D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB2310854B (en) * 1994-12-23 1998-09-09 Xenova Ltd Piperazine-2,5-dione derivatives as modulators of multi-drug resistance
GB9426071D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB9426090D0 (en) * 1994-12-23 1995-02-22 Xenova Ltd Pharmaceutical compounds
GB2311781B (en) * 1994-12-23 1998-09-16 Xenova Ltd Piperazine 2,5 dione derivatives as modulators of multi-drug resistance
US5891877A (en) * 1995-02-14 1999-04-06 Xenova Limited Pharmaceutical compounds
JP2003515590A (ja) * 1999-12-03 2003-05-07 エモリー ユニバーシティ 癌を処置するためのクルクミンアナログ
KR100852965B1 (ko) * 2000-05-09 2008-08-19 애드파르마 인코포레이티드 피페라진디온 화합물
US7288545B2 (en) 2000-05-09 2007-10-30 Angiorx Corporation Piperazinedione compounds
ES2381775T3 (es) 2000-08-04 2012-05-31 Dmi Biosciences, Inc. Procedimiento del uso de dicetopiperazinas y composición que las contiene
WO2002020663A2 (en) 2000-09-06 2002-03-14 Ap Pharma, Inc. Degradable polyacetal polymers
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6815214B2 (en) 2000-12-29 2004-11-09 Celltech R & D, Inc. Pharmaceutical uses and synthesis of diketopiperazines
GB2372740A (en) * 2001-01-17 2002-09-04 Xenova Ltd Diketopiperazines
AU2003220091B2 (en) * 2002-03-08 2006-02-16 Emory University Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis
KR101049100B1 (ko) 2002-08-02 2011-07-15 니리어스 파마슈티컬즈, 인코퍼레이션 데하이드로페닐아히스틴 및 그의 동족체, 및 이들의 합성방법
US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
US7935704B2 (en) 2003-08-01 2011-05-03 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
DE10238144A1 (de) * 2002-08-15 2004-02-26 Basf Ag Verwendung von Diketopiperazin-Derivaten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
WO2004030522A2 (en) * 2002-10-02 2004-04-15 Dmi Biosciences, Inc. Diagnosis and monitoring of diseases
AU2004241101B2 (en) 2003-05-15 2010-05-13 Ampio Pharmaceuticals, Inc. Treatment of T-cell mediated diseases
GB0314738D0 (en) 2003-06-24 2003-07-30 Glaxo Group Ltd Novel compounds
WO2006105051A2 (en) * 2005-03-29 2006-10-05 Nereus Pharmaceuticals, Inc. Synthesis of diketopiperazines
US20070270464A1 (en) * 2006-02-24 2007-11-22 Emory University Prodrugs of curcumin analogs
US8129527B2 (en) 2006-11-03 2012-03-06 Nereus Pharmacuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
US8217047B2 (en) 2008-05-27 2012-07-10 Dmi Acquisition Corp. Therapeutic methods and compounds
WO2012033792A2 (en) 2010-09-07 2012-03-15 Dmi Acquisition Corp. Treatment of diseases
EP2673265B1 (de) * 2011-02-10 2016-10-19 MannKind Corporation Bildung von n-geschützten bis-3,6-(4-aminoalkyl-)2,5-diketopiperazin
JP2014530063A (ja) 2011-10-10 2014-11-17 アンピオ ファーマシューティカルズ，インコーポレイテッド 免疫寛容が高められた埋込み型医療用デバイス、ならびに製造方法および埋込み方法
WO2013055734A1 (en) 2011-10-10 2013-04-18 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
AU2012328605B9 (en) 2011-10-28 2017-08-03 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
SG11201506267XA (en) 2013-03-15 2015-09-29 Ampio Pharmaceuticals Inc Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
CN103396372B (zh) * 2013-08-09 2015-05-20 中国科学院南海海洋研究所 一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用
CN105272968B (zh) * 2014-06-10 2018-03-13 首都医科大学 (3s,6r)‑3,6二取代哌嗪‑2,5‑二酮,其制备及应用
CA2958080A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
CN104610170B (zh) * 2015-01-14 2017-02-01 中国科学院南海海洋研究所 2,5‑二酮哌嗪衍生物及其制备方法和应用
US10238650B2 (en) 2015-03-06 2019-03-26 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
CA2978679A1 (en) 2015-03-06 2016-09-15 Beyondspring Pharmaceuticals, Inc. Method of treating a brain tumor
EP3310375A4 (de) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. Verwendung von niedermolekularen fraktionen von humanem serumalbumin bei der behandlung von erkrankungen
WO2017011399A1 (en) 2015-07-13 2017-01-19 Beyondspring Pharmaceuticals, Inc Plinabulin compositions
IL260933B2 (en) 2016-02-08 2023-04-01 Beyondspring Pharmaceuticals Inc Preparations containing tocorsol or its analogues
EP3463337A4 (de) 2016-06-06 2020-02-12 Beyondspring Pharmaceuticals, Inc. Zusammensetzung und verfahren zur reduzierung von neutropenie
CN110431135A (zh) 2017-01-06 2019-11-08 大连万春布林医药有限公司 微管蛋白结合化合物及其治疗用途
CA3052190A1 (en) 2017-02-01 2018-08-09 Beyondspring Pharmaceuticals, Inc. Method of reducing neutropenia
CN110054619A (zh) * 2018-01-18 2019-07-26 西北农林科技大学 新型二酮哌嗪类组蛋白去乙酰化酶抑制剂
BR112020014960A2 (pt) 2018-01-24 2020-12-22 Beyondspring Pharmaceuticals, Inc. Composição e método para redução de trombocitopenia
WO2021195265A1 (en) 2020-03-24 2021-09-30 Ampio Pharmaceuticals, Inc. Methods for treating diseases associated with respiratory viruses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE621862C (de) * 1932-07-01 1935-11-14 Guenther Schiemann Dr Verfahren zur Darstellung von Kondensationsprodukten kernfluorierter Arylaldehyde
BE584914A (de) * 1958-11-24
JPS5747357A (en) * 1980-09-04 1982-03-18 Ricoh Co Ltd Novel disazo compound and its preparation
GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
CZ38195A3 (en) 1995-09-13
DK0655060T3 (da) 1998-02-09
RU95108759A (ru) 1996-12-10
JPH08504176A (ja) 1996-05-07
WO1994004513A1 (en) 1994-03-03
IL106696A0 (en) 1993-12-08
FI950617A0 (fi) 1995-02-13
AU693420B2 (en) 1998-07-02
BR9306905A (pt) 1998-12-08
HU9500436D0 (en) 1995-04-28
GB9217331D0 (en) 1992-09-30
CZ38395A3 (en) 1995-10-18
SK19595A3 (en) 1995-09-13
FI950617A (fi) 1995-04-13
BG99496A (en) 1995-12-29
ATE162186T1 (de) 1998-01-15
BR9306904A (pt) 1998-12-08
PL307437A1 (en) 1995-05-29
FI950616A0 (fi) 1995-02-13
KR950702967A (ko) 1995-08-23
ZA935968B (en) 1995-02-16
IL106695A0 (en) 1993-12-08
EP0672036A1 (de) 1995-09-20
GB2284420A (en) 1995-06-07
EP0655060B1 (de) 1998-01-14
CA2141938A1 (en) 1994-03-03
HUT71592A (en) 1996-01-29
CA2141939A1 (en) 1994-03-03
FI950616A (fi) 1995-04-13
EP0655060A1 (de) 1995-05-31
AU4726493A (en) 1994-03-15
GB2284420B (en) 1996-09-25
HU9500437D0 (en) 1995-04-28
US5700804A (en) 1997-12-23
AU4726593A (en) 1994-03-15
BG99495A (en) 1995-12-29
SK19495A3 (en) 1995-11-08
JPH08504175A (ja) 1996-05-07
HUT71593A (en) 1996-01-29
ES2111169T3 (es) 1998-03-01
GR3026272T3 (en) 1998-06-30
GB9502859D0 (en) 1995-04-05
PL307438A1 (en) 1995-05-29
KR950702968A (ko) 1995-08-23
ZA935969B (en) 1995-02-16
AU678172B2 (en) 1997-05-22
RU95108387A (ru) 1996-12-10
DE69316370T2 (de) 1998-07-16
WO1994004512A1 (en) 1994-03-03
TW334427B (en) 1998-06-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee