MX9707201A - Derivados de 1-carba-(detia)-cefalosporina. - Google Patents
Derivados de 1-carba-(detia)-cefalosporina.Info
- Publication number
- MX9707201A MX9707201A MX9707201A MX9707201A MX9707201A MX 9707201 A MX9707201 A MX 9707201A MX 9707201 A MX9707201 A MX 9707201A MX 9707201 A MX9707201 A MX 9707201A MX 9707201 A MX9707201 A MX 9707201A
- Authority
- MX
- Mexico
- Prior art keywords
- lower alkyl
- hydrogen
- alkyl
- cycloalkyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de 1-carba-(detia)-cefalosporina, de formula general I: en donde R1 es hidrogeno, alquilo inferior opcionalmente substituido con fluor, aralquilo, cicloalquilo, -COR4 o -C(R5R6) -C(R5R6)CONHR7; en donde R5 y R6 son cada uno independientemente entre sí, hidrogeno o alquilo inferior, o R5 y R6 tomados conjuntamente forman un grupo cicloalquilo; R4 es hidrogeno o alquilo inferior y R7 es hidrogeno, alquilo inferior, alquenilo inferior o un grupo protector de ácido carboxílico; es hidrogeno, hidroxilo, Qm-alquilo inferior, cicloalquilo, alcoxilo inferior, alquenilo inferior, cicloalquenilo, alquinilo inferior, Qm-aralquilo, Qm-arilo, ariloxilo, aralcoxilo, un anillo heterocíclico o heterociclilo alquilo inferior, alquilo inferior, cicloalquilo, alcoxilo inferior, alquenilo inferior, ciclo-alquenilo, alquinilo inferior, aralquilo, arilo, ariloxi, aralcoxilo estando el anillo heterocíclico sin substituir o substituido con por lo menos un grupo seleccionado entre carboxilo, amino, nitro, ciano, alquilo inferior substituido opcionalmente con fluor, alcoxilo inferior, hidroxilo, halogeno, -COR6 o -C(R5R6)CO2R7 -C(R5R6)CONR5R8, -CONR5R6, -N(R6) COOR10, R6OCO- o R6COO-, en donde R5 y R6 son hidrogeno o alquilo inferior; R7 es hidrogeno, alquilo inferior, alquenilo inferior o un grupo protector de ácido carboxílico; R8 es hidrogeno, alquilo inferior o fenilo opcionalmente substituido; R10 es alquilo inferior, alquenilo inferior o un grupo de proteccion de ácido carboxílico; Q es -CHR-, -CO- o SO2-; R es hidrogeno o alquilo inferior R3 es hidroxilo, -O-, alcoxilo inferior, -OM y M representan un metal alcalino; m es 0 o 1; n es 0, 1 o 2; x es CH o N así como ésteres de los mismos fácilmente hidrolizables, sales farmacéuticamente aceptables de dichos compuestos e hidratos de los compuestos de formula I y de sus ésteres y sales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96115210.5 | 1996-09-23 | ||
| EP96115210 | 1996-09-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9707201A true MX9707201A (es) | 1998-06-28 |
| MXPA97007201A MXPA97007201A (es) | 1998-10-30 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| BR9704770A (pt) | 1998-11-03 |
| CA2216222A1 (en) | 1998-03-23 |
| HU9701548D0 (en) | 1997-11-28 |
| NZ328595A (en) | 1999-01-28 |
| KR19980024863A (ko) | 1998-07-06 |
| HUP9701548A2 (hu) | 1999-05-28 |
| HRP970511A2 (en) | 1998-08-31 |
| AU723176B2 (en) | 2000-08-17 |
| KR100256473B1 (ko) | 2000-05-15 |
| JPH10101670A (ja) | 1998-04-21 |
| NO974366D0 (no) | 1997-09-22 |
| TR199701011A2 (xx) | 1998-04-21 |
| CN1184110A (zh) | 1998-06-10 |
| CO4900072A1 (es) | 2000-03-27 |
| CZ292097A3 (cs) | 1998-04-15 |
| HUP9701548A3 (en) | 2001-04-28 |
| SG53049A1 (en) | 1998-09-28 |
| ZA978332B (en) | 1998-03-23 |
| ID18323A (id) | 1998-03-26 |
| IL121798A0 (en) | 1998-02-22 |
| AR008450A1 (es) | 2000-01-19 |
| MA26442A1 (fr) | 2004-12-20 |
| NO974366L (no) | 1998-03-24 |
| AU3838297A (en) | 1998-01-15 |
| PE110098A1 (es) | 1999-01-13 |
| YU38497A (sh) | 1999-12-27 |
| US5939410A (en) | 1999-08-17 |
| PL322240A1 (en) | 1998-03-30 |
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