FI931763A0 - 4,1-bensoxazepinderivat och deras anvaendning - Google Patents

4,1-bensoxazepinderivat och deras anvaendning

Info

Publication number
FI931763A0
FI931763A0 FI931763A FI931763A FI931763A0 FI 931763 A0 FI931763 A0 FI 931763A0 FI 931763 A FI931763 A FI 931763A FI 931763 A FI931763 A FI 931763A FI 931763 A0 FI931763 A0 FI 931763A0
Authority
FI
Finland
Prior art keywords
group
optionally substituted
stands
hydrogen atom
optionally
Prior art date
Application number
FI931763A
Other languages
English (en)
Other versions
FI931763A (fi
FI119022B (fi
Inventor
Hidefumi Yukimasa
Ryuichi Tozawa
Masakuni Kori
Kazuaki Kitano
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FI931763A0 publication Critical patent/FI931763A0/fi
Publication of FI931763A publication Critical patent/FI931763A/fi
Application granted granted Critical
Publication of FI119022B publication Critical patent/FI119022B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI931763A 1992-04-20 1993-04-19 Menetelmä 4,1-bentsoksatsepiinijohdannaisten valmistamiseksi FI119022B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP9954192 1992-04-20
JP9954192 1992-04-20
JP33994792 1992-12-21
JP33994792 1992-12-21

Publications (3)

Publication Number Publication Date
FI931763A0 true FI931763A0 (fi) 1993-04-19
FI931763A FI931763A (fi) 1993-10-21
FI119022B FI119022B (fi) 2008-06-30

Family

ID=26440672

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931763A FI119022B (fi) 1992-04-20 1993-04-19 Menetelmä 4,1-bentsoksatsepiinijohdannaisten valmistamiseksi

Country Status (13)

Country Link
EP (1) EP0567026B1 (fi)
KR (1) KR100293338B1 (fi)
CN (1) CN1044237C (fi)
AT (1) ATE235474T1 (fi)
AU (1) AU659543B2 (fi)
CA (1) CA2094335C (fi)
DE (1) DE69332792T2 (fi)
FI (1) FI119022B (fi)
HU (1) HUT71482A (fi)
NO (1) NO304520B1 (fi)
NZ (1) NZ247429A (fi)
RU (1) RU2145603C1 (fi)
SG (2) SG48855A1 (fi)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726306A (en) * 1992-04-20 1998-03-10 Takeda Chemical Industries, Ltd. 4,1-benzoxazepin derivatives and their use
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
WO1995021834A1 (en) * 1994-02-09 1995-08-17 Takeda Chemical Industries, Ltd. Optically active 4,1-benzoxazepine derivatives useful as squalene synthase inhibitors
CN1144482A (zh) * 1994-03-24 1997-03-05 默里尔药物公司 降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺二硫化物衍生物
TW401301B (en) * 1994-10-07 2000-08-11 Takeda Chemical Industries Ltd Antihypertriglyceridemic composition
US5770438A (en) * 1994-11-01 1998-06-23 Takeda Chemical Industries, Ltd. Process for enantioselective hydrolysis of α-(2-amino)-phenyl-benzenemethanol ester type compounds using bacillus, pseudomonas or streptomyces
SK158795A3 (en) * 1994-12-23 1997-01-08 Pfizer Benzazepines and pharmaceutical compositions on their base
AU6944296A (en) * 1995-09-13 1997-04-01 Takeda Chemical Industries Ltd. Benzoxazepine compounds, their production and use as lipid lowering agents
ATE401315T1 (de) * 1995-09-13 2008-08-15 Takeda Pharmaceutical 5-(2,3-dialkoxyphenyl)-4,1-benzoxazepin-2-one als anti-hyperlipidämische mittel
AU2401697A (en) * 1996-06-20 1998-01-07 Pfizer Inc. 4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors
WO1998047882A1 (en) * 1997-04-21 1998-10-29 Takeda Chemical Industries, Ltd. 4,1-benzoxazepines, their analogues, and their use as somatostatin agonists
AU9023998A (en) * 1997-09-02 1999-03-22 Du Pont Pharmaceuticals Company 5,5-disubstituted-1,5-dihydro-4,1-benzoxazepin-2(3h)-ones useful as hiv reverse transcriptase inhibitors
US6063921A (en) 1997-11-20 2000-05-16 Pharm-Eco Laboratories, Inc. Synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines
US6207664B1 (en) 1998-11-25 2001-03-27 Pfizer Inc. Squalene synthetase inhibitor agents
CZ20024151A3 (cs) * 2000-06-23 2003-05-14 Takeda Chemical Industries, Ltd. Benzoxazepinony, způsob jejich výroby a použití
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
JO2390B1 (en) 2001-04-06 2007-06-17 شركة جانسين فارماسوتيكا ان. في Diphenylcarboxamides act as lipid-lowering agents
EP1407782A4 (en) * 2001-06-28 2004-10-20 Takeda Chemical Industries Ltd DRUGS FOR THE PREVENTION / TREATMENT OF FUNCTIONAL ORGAN DISORDERS AND ORGAN DYSFUNCTION
GB0125532D0 (en) * 2001-10-24 2001-12-12 Burton Michael Enzyme activity indicators
UA79300C2 (en) 2002-08-12 2007-06-11 Janssen Pharmaceutica Nv N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion
CA2514547A1 (en) 2003-01-28 2004-08-12 Takeda Pharmaceutical Company Limited Receptor agonists
WO2005051298A2 (en) 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
US7323455B2 (en) 2004-03-24 2008-01-29 Wyeth 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators
WO2007048027A2 (en) 2005-10-21 2007-04-26 Novartis Ag Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
CN103965185B (zh) * 2014-03-28 2016-06-29 河北师范大学 含有噻唑基和酯基的1,5-苯并二氮杂卓化合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5735596A (en) * 1980-08-13 1982-02-26 Funai Corp Ester derivative of deoxyfluorouridine
US4374842A (en) * 1980-04-18 1983-02-22 Shionogi & Co., Ltd. 4,1-Benzoxazepines and compositions
JPS5735576A (en) * 1980-07-18 1982-02-26 Takeda Chem Ind Ltd 4,1-benzoxazepin-3-acetic derivative and its production
US4590187A (en) * 1983-11-17 1986-05-20 The Upjohn Company Phospholipase A2 inhibition using 4,1-benzoxazepine-2-(3H)-ones
DE3471101D1 (en) * 1983-11-17 1988-06-16 Upjohn Co N-substituted-5-phenyl-4,1-benzoxazepin-2(3h)-ones having therapeutic utility
US4758559A (en) * 1986-01-21 1988-07-19 Ciba-Geigy Corporation Pyrrolo[1,2-a] [4,1]benzoxazepine derivatives useful as calmodulin and histamine inhibitors
NZ239663A (en) * 1990-09-13 1993-07-27 Merck & Co Inc Ester derivatives of dioxabicyclo(3,2,1)-octane, medicaments, and a fungus which makes them
AU1752792A (en) * 1991-03-08 1992-10-06 Rhone-Poulenc Rorer International (Holdings) Inc. Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors

Also Published As

Publication number Publication date
AU659543B2 (en) 1995-05-18
CN1044237C (zh) 1999-07-21
FI931763A (fi) 1993-10-21
KR940005597A (ko) 1994-03-21
KR100293338B1 (ko) 2001-11-22
CN1083481A (zh) 1994-03-09
FI119022B (fi) 2008-06-30
HUT71482A (en) 1995-11-28
NO931433D0 (no) 1993-04-19
AU3700393A (en) 1993-10-21
DE69332792D1 (de) 2003-04-30
DE69332792T2 (de) 2004-01-15
RU2145603C1 (ru) 2000-02-20
SG82630A1 (en) 2001-08-21
SG48855A1 (en) 1998-05-18
ATE235474T1 (de) 2003-04-15
NZ247429A (en) 1995-06-27
HU9301164D0 (en) 1993-07-28
EP0567026B1 (en) 2003-03-26
CA2094335A1 (en) 1993-10-21
NO304520B1 (no) 1999-01-04
CA2094335C (en) 2005-07-12
EP0567026A1 (en) 1993-10-27
NO931433L (no) 1993-10-21

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