ATE235474T1 - 4,1-benzoxazepinderivate als squalen-synthetase inhibitoren und ihre verwendung zur behandlung von hypercholesterämie und als fungizide - Google Patents
4,1-benzoxazepinderivate als squalen-synthetase inhibitoren und ihre verwendung zur behandlung von hypercholesterämie und als fungizideInfo
- Publication number
- ATE235474T1 ATE235474T1 AT93106276T AT93106276T ATE235474T1 AT E235474 T1 ATE235474 T1 AT E235474T1 AT 93106276 T AT93106276 T AT 93106276T AT 93106276 T AT93106276 T AT 93106276T AT E235474 T1 ATE235474 T1 AT E235474T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- optionally substituted
- stands
- hydrogen atom
- optionally
- Prior art date
Links
- YAVSXFRYNGAFRN-UHFFFAOYSA-N 4,1-benzoxazepine Chemical class O1C=CN=C2C=CC=CC2=C1 YAVSXFRYNGAFRN-UHFFFAOYSA-N 0.000 title 1
- 208000035150 Hypercholesterolemia Diseases 0.000 title 1
- 239000000417 fungicide Substances 0.000 title 1
- 239000004059 squalene synthase inhibitor Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- VTYJANRVLSSNCJ-UHFFFAOYSA-N 4,1-benzoxazepin-2-one Chemical class O=C1COC=C2C=CC=CC2=N1 VTYJANRVLSSNCJ-UHFFFAOYSA-N 0.000 abstract 1
- 108010022535 Farnesyl-Diphosphate Farnesyltransferase Proteins 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9954192 | 1992-04-20 | ||
| JP33994792 | 1992-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE235474T1 true ATE235474T1 (de) | 2003-04-15 |
Family
ID=26440672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93106276T ATE235474T1 (de) | 1992-04-20 | 1993-04-17 | 4,1-benzoxazepinderivate als squalen-synthetase inhibitoren und ihre verwendung zur behandlung von hypercholesterämie und als fungizide |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0567026B1 (de) |
| KR (1) | KR100293338B1 (de) |
| CN (1) | CN1044237C (de) |
| AT (1) | ATE235474T1 (de) |
| AU (1) | AU659543B2 (de) |
| CA (1) | CA2094335C (de) |
| DE (1) | DE69332792T2 (de) |
| FI (1) | FI119022B (de) |
| HU (1) | HUT71482A (de) |
| NO (1) | NO304520B1 (de) |
| NZ (1) | NZ247429A (de) |
| RU (1) | RU2145603C1 (de) |
| SG (2) | SG48855A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726306A (en) * | 1992-04-20 | 1998-03-10 | Takeda Chemical Industries, Ltd. | 4,1-benzoxazepin derivatives and their use |
| AU678503B2 (en) * | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
| WO1995021834A1 (en) * | 1994-02-09 | 1995-08-17 | Takeda Chemical Industries, Ltd. | Optically active 4,1-benzoxazepine derivatives useful as squalene synthase inhibitors |
| FI963784A0 (fi) * | 1994-03-24 | 1996-09-23 | Merrell Pharma Inc | Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamididisulfidijohdannaisia |
| TW401301B (en) * | 1994-10-07 | 2000-08-11 | Takeda Chemical Industries Ltd | Antihypertriglyceridemic composition |
| US5770438A (en) * | 1994-11-01 | 1998-06-23 | Takeda Chemical Industries, Ltd. | Process for enantioselective hydrolysis of α-(2-amino)-phenyl-benzenemethanol ester type compounds using bacillus, pseudomonas or streptomyces |
| BR9505995A (pt) * | 1994-12-23 | 1997-12-23 | Pfizer | Composto método para tratamentos e composição farmacêutica |
| CN1072649C (zh) * | 1995-09-13 | 2001-10-10 | 武田药品工业株式会社 | 苯并氧杂吖庚因化合物,其生产方法和用途 |
| ES2158344T3 (es) * | 1995-09-13 | 2001-09-01 | Takeda Chemical Industries Ltd | Compuestos benzoxazepinicos, su produccion y uso como agentes reductores de lipidos. |
| AU2401697A (en) * | 1996-06-20 | 1998-01-07 | Pfizer Inc. | 4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors |
| ATE309993T1 (de) | 1997-04-21 | 2005-12-15 | Takeda Pharmaceutical | 4,1-benzoxazepine, ihre analoga, und ihre verwendung als somatostatin-agonisten |
| BR9814933A (pt) | 1997-09-02 | 2001-01-30 | Du Pont Pharm Co | Composto, composicao farmaceutica e metodo de tratamento de infeccao por hiv. |
| US6063921A (en) * | 1997-11-20 | 2000-05-16 | Pharm-Eco Laboratories, Inc. | Synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines |
| US6207664B1 (en) | 1998-11-25 | 2001-03-27 | Pfizer Inc. | Squalene synthetase inhibitor agents |
| PL360243A1 (en) * | 2000-06-23 | 2004-09-06 | Takeda Chemical Industries,Ltd | Benzoxazepinones and their use as squalene synthase inhibitors |
| JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
| JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
| JO2390B1 (en) | 2001-04-06 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Diphenylcarboxamides act as lipid-lowering agents |
| US20040204500A1 (en) * | 2001-06-28 | 2004-10-14 | Yasuo Sugiyama | Preventives/remedies for organ functional disorders and organ dysfunction |
| GB0125532D0 (en) * | 2001-10-24 | 2001-12-12 | Burton Michael | Enzyme activity indicators |
| UA79300C2 (en) | 2002-08-12 | 2007-06-11 | Janssen Pharmaceutica Nv | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion |
| US7625887B2 (en) | 2003-01-28 | 2009-12-01 | Takeda Pharmaceutical Company Limited | Receptor agonists |
| TW200510356A (en) * | 2003-08-01 | 2005-03-16 | Takeda Chemical Industries Ltd | Benzoxaepine compounds |
| CN1882327A (zh) | 2003-11-19 | 2006-12-20 | 症变治疗公司 | 含磷的新的拟甲状腺素药 |
| US7323455B2 (en) | 2004-03-24 | 2008-01-29 | Wyeth | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators |
| JP2009512715A (ja) | 2005-10-21 | 2009-03-26 | ノバルティス アクチエンゲゼルシャフト | レニン阻害剤と抗異脂肪血症剤および／または抗肥満症剤の組み合わせ |
| WO2010093601A1 (en) | 2009-02-10 | 2010-08-19 | Metabasis Therapeutics, Inc. | Novel sulfonic acid-containing thyromimetics, and methods for their use |
| WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| CN103965185B (zh) * | 2014-03-28 | 2016-06-29 | 河北师范大学 | 含有噻唑基和酯基的1,5-苯并二氮杂卓化合物及其应用 |
| CN119817591B (zh) * | 2025-01-10 | 2025-11-21 | 河北农业大学 | 一种苯并-1,2,4-三嗪并氧氮杂䓬类化合物的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5572177A (en) * | 1978-11-27 | 1980-05-30 | Shionogi & Co Ltd | 4,1-benzoxazepine or 4,1-benzothiazepine |
| JPS5735596A (en) * | 1980-08-13 | 1982-02-26 | Funai Corp | Ester derivative of deoxyfluorouridine |
| US4374842A (en) * | 1980-04-18 | 1983-02-22 | Shionogi & Co., Ltd. | 4,1-Benzoxazepines and compositions |
| JPS5735576A (en) * | 1980-07-18 | 1982-02-26 | Takeda Chem Ind Ltd | 4,1-benzoxazepin-3-acetic derivative and its production |
| EP0142361B1 (de) * | 1983-11-17 | 1988-05-11 | The Upjohn Company | N-Substituierte 5-Phenyl-4,1-Benzoxazepin-2(3H)-one mit nützlicher therapeutischer Wirkung |
| US4590187A (en) * | 1983-11-17 | 1986-05-20 | The Upjohn Company | Phospholipase A2 inhibition using 4,1-benzoxazepine-2-(3H)-ones |
| US4758559A (en) * | 1986-01-21 | 1988-07-19 | Ciba-Geigy Corporation | Pyrrolo[1,2-a] [4,1]benzoxazepine derivatives useful as calmodulin and histamine inhibitors |
| US5096923A (en) * | 1990-03-21 | 1992-03-17 | Merck & Co., Inc. | Novel squalene synthetase inhibitors |
| NZ239663A (en) * | 1990-09-13 | 1993-07-27 | Merck & Co Inc | Ester derivatives of dioxabicyclo(3,2,1)-octane, medicaments, and a fungus which makes them |
| US5026554A (en) * | 1990-09-13 | 1991-06-25 | Merck & Co., Inc. | Method of inhibiting fungal growth using squalene synthetase inhibitors |
| AU1752792A (en) * | 1991-03-08 | 1992-10-06 | Rhone-Poulenc Rorer International (Holdings) Inc. | Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors |
-
1993
- 1993-04-17 EP EP93106276A patent/EP0567026B1/de not_active Expired - Lifetime
- 1993-04-17 SG SG1996003103A patent/SG48855A1/en unknown
- 1993-04-17 AT AT93106276T patent/ATE235474T1/de not_active IP Right Cessation
- 1993-04-17 SG SG9903981A patent/SG82630A1/en unknown
- 1993-04-17 DE DE69332792T patent/DE69332792T2/de not_active Expired - Fee Related
- 1993-04-19 NZ NZ247429A patent/NZ247429A/en not_active IP Right Cessation
- 1993-04-19 CA CA002094335A patent/CA2094335C/en not_active Expired - Fee Related
- 1993-04-19 NO NO931433A patent/NO304520B1/no unknown
- 1993-04-19 RU RU93005332/04A patent/RU2145603C1/ru not_active IP Right Cessation
- 1993-04-19 FI FI931763A patent/FI119022B/fi active IP Right Grant
- 1993-04-19 AU AU37003/93A patent/AU659543B2/en not_active Ceased
- 1993-04-20 KR KR1019930006653A patent/KR100293338B1/ko not_active Expired - Fee Related
- 1993-04-20 HU HU9301164A patent/HUT71482A/hu unknown
- 1993-04-20 CN CN93106358A patent/CN1044237C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2145603C1 (ru) | 2000-02-20 |
| NO931433L (no) | 1993-10-21 |
| SG48855A1 (en) | 1998-05-18 |
| HUT71482A (en) | 1995-11-28 |
| NO931433D0 (no) | 1993-04-19 |
| AU659543B2 (en) | 1995-05-18 |
| FI931763A0 (fi) | 1993-04-19 |
| SG82630A1 (en) | 2001-08-21 |
| KR100293338B1 (ko) | 2001-11-22 |
| CA2094335A1 (en) | 1993-10-21 |
| FI931763L (fi) | 1993-10-21 |
| KR940005597A (ko) | 1994-03-21 |
| DE69332792T2 (de) | 2004-01-15 |
| NO304520B1 (no) | 1999-01-04 |
| NZ247429A (en) | 1995-06-27 |
| AU3700393A (en) | 1993-10-21 |
| DE69332792D1 (de) | 2003-04-30 |
| CN1044237C (zh) | 1999-07-21 |
| HU9301164D0 (en) | 1993-07-28 |
| EP0567026B1 (de) | 2003-03-26 |
| EP0567026A1 (de) | 1993-10-27 |
| CN1083481A (zh) | 1994-03-09 |
| FI119022B (fi) | 2008-06-30 |
| CA2094335C (en) | 2005-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |